IL292270B2 - Injector and method of assembly - Google Patents
Injector and method of assemblyInfo
- Publication number
- IL292270B2 IL292270B2 IL292270A IL29227022A IL292270B2 IL 292270 B2 IL292270 B2 IL 292270B2 IL 292270 A IL292270 A IL 292270A IL 29227022 A IL29227022 A IL 29227022A IL 292270 B2 IL292270 B2 IL 292270B2
- Authority
- IL
- Israel
- Prior art keywords
- container
- injector
- needle
- wall
- assembling
- Prior art date
Links
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- A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
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Landscapes
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- Mechanical Engineering (AREA)
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Applications Claiming Priority (2)
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|---|---|---|---|
| US201361804619P | 2013-03-22 | 2013-03-22 | |
| PCT/US2014/017641 WO2014149357A1 (en) | 2013-03-22 | 2014-02-21 | Injector and method of assembly |
Publications (3)
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| IL292270A IL292270A (en) | 2022-06-01 |
| IL292270B1 IL292270B1 (en) | 2023-12-01 |
| IL292270B2 true IL292270B2 (en) | 2024-04-01 |
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| IL292270A IL292270B2 (en) | 2013-03-22 | 2014-02-21 | Injector and method of assembly |
| IL239799A IL239799B (en) | 2013-03-22 | 2015-07-06 | Injector and assembly method |
| IL281356A IL281356B (en) | 2013-03-22 | 2021-03-09 | Injector and assembly method |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| IL239799A IL239799B (en) | 2013-03-22 | 2015-07-06 | Injector and assembly method |
| IL281356A IL281356B (en) | 2013-03-22 | 2021-03-09 | Injector and assembly method |
Country Status (15)
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|---|---|
| US (2) | US10850037B2 (enExample) |
| EP (2) | EP2976117B1 (enExample) |
| JP (3) | JP6670740B2 (enExample) |
| KR (1) | KR102287687B1 (enExample) |
| CN (2) | CN105377327B (enExample) |
| AU (3) | AU2014238267B2 (enExample) |
| BR (1) | BR112015024282B1 (enExample) |
| CA (1) | CA2897825C (enExample) |
| ES (1) | ES2853748T3 (enExample) |
| IL (3) | IL292270B2 (enExample) |
| LT (1) | LT2976117T (enExample) |
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| SG (1) | SG11201507878SA (enExample) |
| TW (2) | TWI635880B (enExample) |
| WO (1) | WO2014149357A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| EP3335747B1 (en) | 2011-10-14 | 2021-04-07 | Amgen Inc. | Injector and method of assembly |
| PL4201327T3 (pl) | 2012-03-30 | 2024-11-04 | Insulet Corporation | Urządzenie do dostarczania płynu z narzędziem dostępu przezskórnego, mechanizmem wprowadzającym i monitorowaniem poziomu glukozy we krwi do stosowania z nim |
| EP2976117B1 (en) * | 2013-03-22 | 2020-12-30 | Amgen Inc. | Injector and method of assembly |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| SG11201602876WA (en) * | 2013-10-24 | 2016-05-30 | Amgen Inc | Injector and method of assembly |
| MA41101A (fr) * | 2014-12-03 | 2017-10-10 | Lilly Co Eli | Dispositif d'injection de médicament automatique comportant une indication audible de progression d'injection |
| KR102634489B1 (ko) * | 2015-03-10 | 2024-02-07 | 리제너론 파아마슈티컬스, 인크. | 무균 관통 시스템 및 방법 |
| WO2017123525A1 (en) | 2016-01-13 | 2017-07-20 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| EP3402548B1 (en) | 2016-01-14 | 2025-03-12 | Insulet Corporation | Occlusion resolution in medication delivery devices, systems, and methods |
| JP6876046B2 (ja) | 2016-01-14 | 2021-05-26 | ビッグフット バイオメディカル インコーポレイテッドＢｉｇｆｏｏｔ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． | インスリン・デリバリ量の調節 |
| JOP20170042B1 (ar) | 2016-02-12 | 2022-09-15 | Amgen Inc | وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه |
| EP3439715B1 (en) | 2016-04-08 | 2021-03-10 | Amgen Inc. | Drug delivery device |
| US11238150B2 (en) | 2016-05-16 | 2022-02-01 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| WO2017205816A1 (en) | 2016-05-26 | 2017-11-30 | Insulet Corporation | Single dose drug delivery device |
| WO2018031891A1 (en) | 2016-08-12 | 2018-02-15 | Insulet Corporation | Plunger for drug delivery device |
| EP3496789A1 (en) | 2016-08-14 | 2019-06-19 | Insulet Corporation | Automatic drug delivery device with trigger mechanism |
| EP3522951A1 (en) * | 2016-10-07 | 2019-08-14 | Insulet Corporation | Multi-stage delivery system |
| US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
| CA3037432A1 (en) | 2016-12-12 | 2018-06-21 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and related systems and methods |
| WO2018132754A1 (en) | 2017-01-13 | 2018-07-19 | Mazlish Bryan | System and method for adjusting insulin delivery |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568860B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568859B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| WO2018136699A1 (en) | 2017-01-19 | 2018-07-26 | Insulet Corporation | Cartridge hold-up volume reduction |
| US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
| ES2919934T3 (es) | 2017-05-05 | 2022-07-29 | Regeneron Pharma | Autoinyector y procedimientos de uso relacionados |
| EP4375504A3 (en) | 2017-08-03 | 2024-06-26 | Insulet Corporation | Micro piston pump |
| US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
| WO2019236818A1 (en) | 2018-06-06 | 2019-12-12 | Insulet Corporation | Linear shuttle pump for drug delivery |
| JP7161618B2 (ja) | 2018-11-28 | 2022-10-26 | インスレット コーポレイション | 薬物送達シャトルポンプシステムと弁アセンブリ |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| KR20220088701A (ko) | 2019-09-25 | 2022-06-28 | 얀센 파마슈티칼즈, 인코포레이티드 | 약물 투여 시스템의 상호 연결 |
| US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
| EP3939896A1 (de) | 2020-07-17 | 2022-01-19 | Pharma Integration S.R.L. | Funktionsmodul zum heranführen an eine in einem prozessraum eines containments positionierte dosierstation und verfahren dazu |
| US12491316B2 (en) | 2020-12-18 | 2025-12-09 | Insulet Corporation | Scheduling of medicament bolus deliveries by a medicament delivery device at future dates and times with a computing device |
| CN116782966A (zh) | 2021-01-08 | 2023-09-19 | 英赛罗公司 | 单致动精确剂量中间泵送室 |
| US12440617B2 (en) | 2021-01-11 | 2025-10-14 | Insulet Corporation | Linear activated drug dosing pump system |
| US11311666B1 (en) | 2021-02-18 | 2022-04-26 | Fresenius Kabi Deutschland Gmbh | Modular wearable medicament delivery device and method of use thereof |
| US11872369B1 (en) | 2021-02-18 | 2024-01-16 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof |
| US11464902B1 (en) | 2021-02-18 | 2022-10-11 | Fresenius Kabi Deutschland Gmbh | Wearable medicament delivery device with compressible reservoir and method of use thereof |
| US11426523B1 (en) | 2021-02-19 | 2022-08-30 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a removable cartridge |
| US11633537B1 (en) | 2021-02-19 | 2023-04-25 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including a pre-filled cartridge |
| US11497847B1 (en) | 2021-02-19 | 2022-11-15 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive substrate |
| US11406755B1 (en) | 2021-02-19 | 2022-08-09 | Fresenius Kabi Deutschland Gmbh | Sensing fluid flow irregularities in an on-body injector |
| US11607505B1 (en) | 2021-02-19 | 2023-03-21 | Fresenius Kabi Deutschland Gmbh | Wearable injector with sterility sensors |
| US11344682B1 (en) | 2021-02-19 | 2022-05-31 | Fresenius Kabi Deutschland Gmbh | Drug supply cartridge with visual use indicator and delivery devices that use the same |
| US11413394B1 (en) | 2021-02-19 | 2022-08-16 | Fresenius Kabi Deutschland Gmbh | Display for wearable drug delivery device |
| US11504470B1 (en) | 2021-04-30 | 2022-11-22 | Fresenius Kabi Deutschland Gmbh | Deformable drug reservoir for wearable drug delivery device |
| US11419976B1 (en) | 2021-04-30 | 2022-08-23 | Fresenius Kabi Deutschland Gmbh | Wearable drug delivery device with pressurized fluid dispensing |
| US11529459B1 (en) | 2021-04-30 | 2022-12-20 | Fresenius Kabi Deutschland Gmbh | Wearable injector with adhesive module |
| US11351300B1 (en) | 2021-04-30 | 2022-06-07 | Fresenius Kabl Deutschland GmbH | Drug dispensing system with replaceable drug supply cartridges |
| US11717608B1 (en) | 2021-05-03 | 2023-08-08 | Fresenius Kabi Deutschland Gmbh | Drug delivery assembly including an adhesive pad |
| US11484646B1 (en) | 2021-05-04 | 2022-11-01 | Fresenius Kabi Deutschland Gmbh | Sealing systems for a reservoir of an on-body injector |
| EP4346945A1 (en) | 2021-05-28 | 2024-04-10 | Insulet Corporation | Spring-based status sensors |
| USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
| CA3275991A1 (en) | 2023-01-06 | 2024-07-11 | Insulet Corp | Automatic or manual administration of meal boluses with subsequent automatic relaxation of safety constraints |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3605744A (en) * | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
| US20130006213A1 (en) * | 2009-11-03 | 2013-01-03 | Theo Arnitz | Device for substantially germ-free provision of a fluid medium |
Family Cites Families (435)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2371086A (en) | 1940-11-14 | 1945-03-06 | Watson | Hypodermic injector |
| US2627270A (en) * | 1946-02-09 | 1953-02-03 | Antonina S Glass | Self-propelled automatic syringe |
| US2591706A (en) | 1950-09-29 | 1952-04-08 | Compule Corp | Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations |
| GB718837A (en) | 1951-07-18 | 1954-11-24 | Cook Waite Lab Inc | Improvements in or relating to hypodermic syringe |
| GB722166A (en) * | 1951-10-25 | 1955-01-19 | Pfizer & Co C | Improvements in or relating to disposable cartridge for hypodermic syringe |
| BE515202A (enExample) | 1951-11-01 | |||
| US2677373A (en) | 1952-05-19 | 1954-05-04 | P M Ind Inc | Plastic injection device |
| US2688967A (en) | 1953-06-02 | 1954-09-14 | Huber Jennie | Metal aspirating syringe |
| US2842126A (en) | 1954-03-16 | 1958-07-08 | Frederick M Turnbull | Syringe assembly |
| GB989185A (en) | 1961-08-25 | 1965-04-14 | Glaxo Group Ltd | Improvements in or relating to hypodermic syringes |
| US3187749A (en) | 1962-01-04 | 1965-06-08 | Stanley J Sarnoff | Hypodermic cartridge |
| US3336924A (en) | 1964-02-20 | 1967-08-22 | Sarnoff | Two compartment syringe package |
| US3342180A (en) | 1964-04-24 | 1967-09-19 | American Cyanamid Co | Disposable liquid-powder package and hypodermic syringe |
| DK108590C (da) | 1964-05-28 | 1968-01-08 | Novo Terapeutisk Labor As | Sprøjteampul. |
| US3368558A (en) | 1964-08-21 | 1968-02-13 | Sarnoff | Two compartment cartridge |
| GB1159664A (en) | 1965-07-23 | 1969-07-30 | Robert Walter Ogle | Improvements in or relating to Component Parts for Medicament Injectors |
| US3378008A (en) | 1965-07-23 | 1968-04-16 | Min I Jet Corp | Hypodermic syringe with vial |
| US3557787A (en) | 1968-05-28 | 1971-01-26 | Milton J Cohen | Disposable syringe |
| AT318132B (de) | 1969-08-01 | 1974-09-25 | Dentaire Ivoclar Ets | Mischbehälter für die Aufnahme von miteinander reagierenden Substanzen für die Herstellung von gebrauchsfertigen pastenförmigen Dentalpräparaten |
| BE757195A (fr) | 1969-10-07 | 1971-03-16 | Century Disposable Devices | Seringue servant a injecter un melange fraichement prepare de poudre etde liquide |
| US3640278A (en) | 1969-10-13 | 1972-02-08 | Benjamin Friedman | Hypodermic syringe device which maintains sterile condition of needle |
| US3739779A (en) | 1970-04-28 | 1973-06-19 | Medical Electroscience & Pharm | Hypodermic syringe and needle construction |
| US3662753A (en) | 1970-05-25 | 1972-05-16 | Kitchener B Tassell | Syringe |
| US3757779A (en) | 1971-05-24 | 1973-09-11 | Century Labor Inc | Filter syringe |
| US3872867A (en) | 1971-06-02 | 1975-03-25 | Upjohn Co | Wet-dry additive assembly |
| US3785379A (en) | 1971-08-12 | 1974-01-15 | M Cohen | Syringe for injection of freshly mixed liquid-powder |
| US3835855A (en) | 1972-10-10 | 1974-09-17 | C Barr | Multi-chambered syringe |
| US3825003A (en) | 1972-12-26 | 1974-07-23 | Vca Metal Fab Inc | Sealed-hypodermic syringe |
| DE2315367A1 (de) | 1973-03-28 | 1974-10-17 | Hoechst Ag | Injektionsspritze zur einmaligen verwendung |
| US3872864A (en) | 1973-07-06 | 1975-03-25 | Jr Robert E Allen | Double syringe |
| DE2434046C3 (de) | 1974-07-16 | 1979-10-18 | Lothar 7500 Karlsruhe Schwarz | Nadelhalterung für medizinische Spritzen |
| NL173477C (nl) | 1974-09-12 | 1984-02-01 | Duphar Int Res | Injektiespuit met teleskopisch orgaan tussen patroon en medicamentflesje. |
| US4055177A (en) | 1976-05-28 | 1977-10-25 | Cohen Milton J | Hypodermic syringe |
| US4188949A (en) | 1977-07-05 | 1980-02-19 | Becton, Dickinson & Company | Sequential injection syringe |
| US4215689A (en) | 1977-07-27 | 1980-08-05 | Koken Co., Ltd. | Injecting apparatus for medical liquid |
| US4178930A (en) | 1977-10-31 | 1979-12-18 | Fisher Frank R Jr | Combined cap and needle structure |
| AT360139B (de) | 1978-10-16 | 1980-12-29 | Immuno Ag | Kombinierte ampullen-einweg-injektionsspritze |
| US4196732A (en) * | 1978-12-26 | 1980-04-08 | Wardlaw Stephen C | Automatic disposable syringe and method of filling the same |
| US4296786A (en) | 1979-09-28 | 1981-10-27 | The West Company | Transfer device for use in mixing a primary solution and a secondary or additive substance |
| US4411163A (en) | 1981-07-27 | 1983-10-25 | American Hospital Supply Corporation | Ventable sample collection device |
| JPS5831673A (ja) | 1981-08-20 | 1983-02-24 | Sanyo Electric Co Ltd | 固体撮像素子 |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| IT1173370B (it) | 1984-02-24 | 1987-06-24 | Erba Farmitalia | Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa |
| US4523679A (en) | 1984-03-05 | 1985-06-18 | Sterling Drug Inc. | Pre-sterilized medical procedure kit packages |
| US4619651A (en) | 1984-04-16 | 1986-10-28 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
| US4626244A (en) | 1985-02-01 | 1986-12-02 | Consolidated Controls Corporation | Implantable medication infusion device |
| GB8509301D0 (en) | 1985-04-11 | 1985-05-15 | Clinical Products Dev Ltd | Device for surgical procedures |
| DE3514815A1 (de) | 1985-04-24 | 1986-11-06 | Bayerische Motoren Werke AG, 8000 München | Unabhaengige fahrzeug-radaufhaengung |
| US4838857A (en) | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
| US4632672A (en) | 1985-10-07 | 1986-12-30 | Minnesota Mining And Manufacturing Company | Self venting syringe plunger |
| FR2589738A1 (fr) | 1985-11-14 | 1987-05-15 | Lascar Marcel | Seringue a double chambre |
| US4655747A (en) | 1986-01-30 | 1987-04-07 | Allen Jr Robert E | Dual chambered syringe |
| FR2604363A1 (fr) * | 1986-09-30 | 1988-04-01 | Merieux Inst | Dispositif d'injection de substances, notamment medicamenteuses |
| US4883473A (en) | 1987-04-29 | 1989-11-28 | Path | Single use injection device |
| ES1002629Y (es) | 1987-06-05 | 1989-01-16 | Badia Marcelo Segura | Conexion para cateteres, equipos de perfusion y frascos de liquidos a perfundir |
| US5364369A (en) * | 1987-07-08 | 1994-11-15 | Reynolds David L | Syringe |
| CH673775A5 (enExample) | 1987-07-10 | 1990-04-12 | Jacques Verlier | |
| US4784156A (en) | 1987-09-16 | 1988-11-15 | Garg Rakesh K | Cannula including a valve structure and associated instrument elements and method for using same |
| US5135489A (en) | 1988-01-25 | 1992-08-04 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
| US4915690A (en) | 1988-02-02 | 1990-04-10 | C. R. Bard, Inc. | Micro-injection port |
| CA2016734C (en) | 1989-06-02 | 1994-03-22 | Thomas J. Dragosits | Syringe assembly |
| US5205820A (en) | 1989-06-16 | 1993-04-27 | Science, Incorporated | Fluid delivery apparatus |
| US5716343A (en) | 1989-06-16 | 1998-02-10 | Science Incorporated | Fluid delivery apparatus |
| US5019047A (en) | 1989-06-16 | 1991-05-28 | Science Incorporated | Fluid delivery apparatus |
| US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
| US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| KR100221066B1 (ko) | 1989-10-13 | 1999-10-01 | 스튜어트 엘.왓트 | 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물 |
| JPH03168154A (ja) | 1989-11-29 | 1991-07-19 | Ajinomoto Takara Corp:Kk | 注射器 |
| US5078691A (en) | 1990-03-01 | 1992-01-07 | Hamacher Edward N | Multiple-dose fluid delivery system and method |
| US5334197A (en) | 1990-09-25 | 1994-08-02 | Science Incorporated | Flexible base fluid delivery apparatus |
| SE9101022D0 (sv) | 1991-01-09 | 1991-04-08 | Paal Svedman | Medicinsk suganordning |
| US5593391A (en) | 1992-02-13 | 1997-01-14 | Stanners; Sydney D. | Ampule safety syringe |
| US5267974A (en) * | 1992-06-04 | 1993-12-07 | Lambert William S | Hypodermic syringe with foam sponge reservoir |
| US5807323A (en) | 1992-08-13 | 1998-09-15 | Science Incorporated | Mixing and delivery syringe assembly |
| CH689443A5 (fr) | 1992-09-16 | 1999-04-30 | Debiotech Sa | Ensemble constituant une pompe à usage médical. |
| US5250037A (en) | 1992-12-18 | 1993-10-05 | Becton, Dickinson And Company | Syringe having needle isolation features |
| US5312336A (en) | 1993-04-14 | 1994-05-17 | Habley Medical Technology Corporation | Component mixing syringe |
| ZA946122B (en) | 1993-08-17 | 1995-03-20 | Amgen Inc | Erythropoietin analogs |
| US5665066A (en) | 1993-09-03 | 1997-09-09 | Ultradent Products, Inc. | Methods and apparatus for mixing and dispensing multi-part compositions |
| US5358491A (en) | 1993-09-13 | 1994-10-25 | Sterling Winthrop Inc. | Cartridge-needle unit having retractable needle |
| JPH07124256A (ja) | 1993-10-29 | 1995-05-16 | Ajinomoto Takara Corp:Kk | 注射器 |
| US5620425A (en) | 1993-11-03 | 1997-04-15 | Bracco International B.V. | Method for the preparation of pre-filled plastic syringes |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
| CA2154853C (en) | 1994-07-27 | 2007-01-16 | John Glyndwr Wilmot | Nipple plunger |
| ATE306930T1 (de) | 1994-08-12 | 2005-11-15 | Immunomedics Inc | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
| US5496284A (en) | 1994-09-27 | 1996-03-05 | Waldenburg; Ottfried | Dual-chamber syringe & method |
| US5624402A (en) | 1994-12-12 | 1997-04-29 | Becton, Dickinson And Company | Syringe tip cap |
| US5962794A (en) | 1995-05-01 | 1999-10-05 | Science Incorporated | Fluid delivery apparatus with reservior fill assembly |
| US5618269A (en) | 1995-05-04 | 1997-04-08 | Sarcos, Inc. | Pressure-driven attachable topical fluid delivery system |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5693018A (en) | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
| US5735818A (en) | 1995-10-11 | 1998-04-07 | Science Incorporated | Fluid delivery device with conformable ullage |
| US5921962A (en) | 1995-10-11 | 1999-07-13 | Science Incorporated | Fluid delivery device with flow indicator and rate control |
| US5957891A (en) | 1995-10-11 | 1999-09-28 | Science Incorporated | Fluid delivery device with fill adapter |
| AT404556B (de) | 1995-11-23 | 1998-12-28 | Pharma Consult Gmbh | Einrichtung zum dichten verschliessen eines glas- oder kunststoffbehälters zur aufnahme flüssiger pharmazeutischer produkte |
| US5749857A (en) | 1996-04-25 | 1998-05-12 | Cuppy; Michael J. | Catheter system |
| US5865744A (en) | 1996-09-16 | 1999-02-02 | Lemelson; Jerome H. | Method and system for delivering therapeutic agents |
| DE19652708C2 (de) * | 1996-12-18 | 1999-08-12 | Schott Glas | Verfahren zum Herstellen eines befüllten Kunststoff-Spritzenkorpus für medizinische Zwecke |
| US5840071A (en) | 1996-12-18 | 1998-11-24 | Science Incorporated | Fluid delivery apparatus with flow indicator and vial fill |
| US6355019B1 (en) | 1996-12-18 | 2002-03-12 | Science Incorporated | Variable rate infusion apparatus with indicator and adjustable rate control |
| DE69826003D1 (de) | 1997-06-16 | 2004-10-07 | Elan Corp Plc | Vorgefüllte medikamentenabgabevorrichtung |
| US6500150B1 (en) * | 1997-06-16 | 2002-12-31 | Elan Pharma International Limited | Pre-filled drug-delivery device and method of manufacture and assembly of same |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| EP1012184B1 (en) | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| PT986644E (pt) | 1997-07-23 | 2007-01-31 | Roche Diagnostics Gmbh | Preparação de eritropoietina por activação genética endógena com promotores virais |
| US5957896A (en) | 1997-08-11 | 1999-09-28 | Becton, Dickinson And Company | Medication delivery pen |
| US6482176B1 (en) | 1997-11-27 | 2002-11-19 | Disetronic Licensing Ag | Method and device for controlling the introduction depth of an injection needle |
| US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
| US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| US6030086A (en) | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
| US6221055B1 (en) | 1998-03-04 | 2001-04-24 | Retractable Technologies, Inc. | Retractable dental syringe |
| US6189292B1 (en) | 1998-03-13 | 2001-02-20 | Becton Dickinson And Company | Method and apparatus for manufacturing, filling and packaging medical devices and medical containers |
| AU3050499A (en) | 1998-03-23 | 1999-10-18 | Elan Corporation, Plc | Drug delivery device |
| US6310078B1 (en) | 1998-04-20 | 2001-10-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as erythropoietin mimetics |
| US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| AU775422B2 (en) | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
| DK1783222T3 (da) | 1998-10-23 | 2012-07-09 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| JP4809977B2 (ja) | 1998-10-23 | 2011-11-09 | アムジエン・インコーポレーテツド | 貧血の予防および治療用の方法および組成物 |
| DK1716884T3 (en) | 1998-10-29 | 2014-03-10 | Medtronic Minimed Inc | reservoir Connection |
| US6395511B1 (en) | 1998-11-27 | 2002-05-28 | Darwin Discovery, Ltd. | Nucleic acids encoding a novel family of TGF-β binding proteins from humans |
| EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
| DE19909824A1 (de) * | 1999-03-05 | 2000-09-07 | Vetter & Co Apotheker | Spritze für medizinische Zwecke und Verfahren zu ihrer Montage |
| EP1169352A4 (en) | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
| US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| ATE308354T1 (de) | 1999-04-16 | 2005-11-15 | Becton Dickinson Co | Stiftförmiger injektor mit merkmalen zur automatischen substanzkombination |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| DE19939936A1 (de) | 1999-08-23 | 2001-03-08 | Beru Ag | Einrichtung zum Überwachen und drahtlosen Signalisieren des Drucks in Luftreifen an Fahrzeugen |
| US6491667B1 (en) | 1999-08-31 | 2002-12-10 | Becton, Dickinson And Company | Syringe tip cap |
| US6840291B2 (en) | 1999-10-15 | 2005-01-11 | Becton Dickinson And Company | Attachment for a medical device |
| CA2388617A1 (en) | 1999-10-22 | 2001-05-03 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules derived from rat brain and programmed cell death models |
| WO2001030424A1 (en) | 1999-10-22 | 2001-05-03 | Antares Pharma, Inc. | Medicament cartridge and injection device |
| US7063684B2 (en) | 1999-10-28 | 2006-06-20 | Medtronic Minimed, Inc. | Drive system seal |
| US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| AUPQ526200A0 (en) * | 2000-01-25 | 2000-02-17 | Ferrier International Limited | Delivery system and apparatus thereof |
| US7243689B2 (en) | 2000-02-11 | 2007-07-17 | Medical Instill Technologies, Inc. | Device with needle penetrable and laser resealable portion and related method |
| AUPQ599700A0 (en) | 2000-03-03 | 2000-03-23 | Super Internet Site System Pty Ltd | On-line geographical directory |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001255516B2 (en) | 2000-04-21 | 2007-01-18 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| CN1458846A (zh) | 2000-09-08 | 2003-11-26 | 格莱风治疗公司 | 促红细胞生成性合成蛋白 |
| US7621887B2 (en) | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| US7271689B1 (en) | 2000-11-22 | 2007-09-18 | Fonar Corporation | Magnet structure |
| US6537249B2 (en) | 2000-12-18 | 2003-03-25 | Science, Incorporated | Multiple canopy |
| ATE505204T1 (de) | 2000-12-20 | 2011-04-15 | Hoffmann La Roche | Konjugate von erythropoietin (epo) mit polyethylenglykol (peg) |
| AR032028A1 (es) | 2001-01-05 | 2003-10-22 | Pfizer | Anticuerpos contra el receptor del factor de crecimiento similar a insulina |
| US20020139088A1 (en) | 2001-03-08 | 2002-10-03 | Archie Woodworth | Polymeric syringe body and stopper |
| WO2002074361A2 (en) | 2001-03-15 | 2002-09-26 | Mdc Investment Holdings, Inc. | Retractable needle medical device for injecting fluid from a pre-filled cartridge |
| FR2822710B1 (fr) * | 2001-03-27 | 2004-04-02 | Lab Contactologie Appl Lca | Seringue pour solutions viscoleastiques |
| DE60232870D1 (de) | 2001-04-04 | 2009-08-20 | Genodyssee | Neue polynukleotide und polypeptide des erythropoietingens |
| ES2387546T3 (es) | 2001-05-11 | 2012-09-25 | Amgen Inc. | Péptidos y moléculas relacionadas que se unen a TALL-1 |
| US20120209197A1 (en) | 2002-01-04 | 2012-08-16 | Lanigan Richard J | Infusion pump assembly |
| US8034026B2 (en) | 2001-05-18 | 2011-10-11 | Deka Products Limited Partnership | Infusion pump assembly |
| ES2706902T3 (es) | 2001-06-26 | 2019-04-01 | Amgen Inc | Anticuerpos para OPGL |
| US6900292B2 (en) | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| JP4838955B2 (ja) | 2001-08-21 | 2011-12-14 | 武田薬品工業株式会社 | ２室型プレフィルドシリンジ |
| IL160358A0 (en) | 2001-08-23 | 2004-07-25 | Genmab As | Human antibodies specific for interleukin 15 (il-15) |
| US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US20030055380A1 (en) | 2001-09-19 | 2003-03-20 | Flaherty J. Christopher | Plunger for patient infusion device |
| US7112188B2 (en) | 2001-09-25 | 2006-09-26 | Ottfried Waldenburg | Medication capsule, syringe used with medication capsule and method of administrating medication |
| US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US20040078028A1 (en) * | 2001-11-09 | 2004-04-22 | Flaherty J. Christopher | Plunger assembly for patient infusion device |
| US6802828B2 (en) | 2001-11-23 | 2004-10-12 | Duoject Medical Systems, Inc. | System for filling and assembling pharmaceutical delivery devices |
| WO2003055526A2 (en) | 2001-12-21 | 2003-07-10 | Maxygen Aps | Erythropoietin conjugates |
| DK1461359T3 (da) | 2002-01-18 | 2007-07-09 | Pf Medicament | Hidtil ukendte anti-IGF-IR-antistoffer og anvendelser deraf |
| US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| GB0202252D0 (en) | 2002-01-31 | 2002-03-20 | Oxford Biomedica Ltd | Anemia |
| EP1470232A1 (en) | 2002-01-31 | 2004-10-27 | Oxford Biomedica (UK) Limited | Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia |
| US6828908B2 (en) | 2002-02-06 | 2004-12-07 | Ronald Scott Clark | Locator system with an implanted transponder having an organically-rechargeable battery |
| KR100507593B1 (ko) | 2002-02-08 | 2005-08-10 | 주식회사 이화양행 | 액체공급장치 |
| WO2003080852A1 (en) | 2002-03-26 | 2003-10-02 | Lek Pharmaceutical And Chemical Company D.D. | Process for the preparation of a desired erythropoietin glyco-isoform profile |
| US20050283855A1 (en) | 2002-03-29 | 2005-12-22 | Koichiro Kaku | Genes encoding acetolactate synthase |
| EP1572079A4 (en) | 2002-03-29 | 2006-09-06 | Centocor Inc | MAMMAL-CDR MIMETIC BODIES, COMPOSITIONS, PROCESSES AND APPLICATION PURPOSES |
| US6808507B2 (en) | 2002-05-10 | 2004-10-26 | Cambridge Biostability Ltd. | Safety injectors |
| AU2003232122A1 (en) | 2002-05-13 | 2003-11-11 | Technion Entrepreneurial Incubator Company Ltd. | Ctp-extended erythropoietin |
| EP2316922B1 (en) | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| JP2006504406A (ja) | 2002-06-28 | 2006-02-09 | セントカー・インコーポレーテツド | 哺乳動物のｃｈ１欠失ミメティボディ、組成物、方法および使用 |
| EP1575499A2 (en) | 2002-06-28 | 2005-09-21 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
| US7338465B2 (en) | 2002-07-02 | 2008-03-04 | Patton Medical Devices, Lp | Infusion device and method thereof |
| US20040010207A1 (en) | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
| WO2004009627A1 (en) | 2002-07-19 | 2004-01-29 | Cangene Corporation | Pegylated erythropoietic compounds |
| WO2004032990A2 (en) | 2002-07-22 | 2004-04-22 | Becton, Dickinson And Company | Patch-like infusion device |
| US6811547B2 (en) | 2002-07-22 | 2004-11-02 | Becton, Dickinson & Company | Needle shielding assembly |
| AU2003254950A1 (en) | 2002-08-26 | 2004-03-11 | Kirin Beer Kabushiki Kaisha | Peptides and drugs containing the same |
| PL377091A1 (pl) | 2002-09-06 | 2006-01-23 | Amgen, Inc. | Ludzkie monoklonalne przeciwciało przeciw-IL-1R1, o właściwościach terapeutycznych |
| AU2003255406B2 (en) | 2002-09-11 | 2009-09-10 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch derivatives |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| AU2003275353A1 (en) | 2002-10-01 | 2004-04-23 | Becton, Dickinson And Company | Medication delivery pen |
| TWI320716B (en) | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
| US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
| US7396913B2 (en) | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
| US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| WO2004034988A2 (en) | 2002-10-16 | 2004-04-29 | Amgen Inc. | Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors |
| US20040091961A1 (en) | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
| EP2272864A3 (en) | 2002-12-20 | 2011-02-16 | Amgen Inc. | Binding agents which inhibit myostatin |
| US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
| EP1603948A1 (en) | 2003-03-14 | 2005-12-14 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
| US8021333B2 (en) | 2003-03-20 | 2011-09-20 | Unitract Syringe Pty Ltd. | Syringe spring retainer |
| JP4473257B2 (ja) | 2003-04-02 | 2010-06-02 | エフ．ホフマン−ラ ロシュ アーゲー | インスリン様成長因子ｉ受容体に対する抗体及びその使用 |
| JP2004305621A (ja) | 2003-04-10 | 2004-11-04 | Jms Co Ltd | 針アダプタ |
| US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
| US7963956B2 (en) | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
| EP1631496B1 (en) | 2003-04-28 | 2014-02-26 | Medical Instill Technologies, Inc. | Container with valve assembly for filling and dispensing substances, and apparatus and method for filling |
| US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| EP1625156B1 (en) | 2003-05-12 | 2012-09-19 | Affymax, Inc. | Peptides that bind to the erythropoietin receptor |
| EP1626983B8 (en) | 2003-05-12 | 2010-12-22 | Affymax, Inc. | Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof |
| AU2004238870B8 (en) | 2003-05-12 | 2010-04-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
| BRPI0410863A (pt) | 2003-05-30 | 2006-07-04 | Centocor Inc | formação de novos conjugados de eritropoietina usando transglutaminase |
| US20050037390A1 (en) | 2003-06-04 | 2005-02-17 | Irm Llc, A Delaware Limited Liability Company | Methods and compositions for modulating erythropoietin expression |
| GB0315953D0 (en) | 2003-07-08 | 2003-08-13 | Glaxosmithkline Biolog Sa | Process |
| AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| EA013614B1 (ru) | 2003-07-15 | 2010-06-30 | Амджен Инк. | Изолированное антитело к фактору роста нервов (ngf) и способы его применения |
| RS53476B (sr) | 2003-07-18 | 2014-12-31 | Amgen Fremont Inc. | Sredstva za specifično vezivanje faktora rasta hepatocita |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| US7220244B2 (en) | 2003-08-04 | 2007-05-22 | Bioquiddity, Inc. | Infusion apparatus with constant force spring energy source |
| JP2007512001A (ja) | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Ｅｐｏミメティックペプチドおよび融合タンパク質 |
| CN1882355A (zh) | 2003-09-09 | 2006-12-20 | 沃伦药品公司 | 保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素 |
| UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
| WO2005081687A2 (en) | 2003-09-30 | 2005-09-09 | Centocor, Inc. | Human hinge core mimetibodies, compositions, methods and uses |
| KR20060099520A (ko) | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | 의료용 피부 장착 장치 |
| WO2005047331A2 (en) | 2003-11-07 | 2005-05-26 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| TWM261223U (en) | 2003-11-14 | 2005-04-11 | Life Shueld Products Inc | Retractable safety syringe |
| TW200526684A (en) | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| US20070254834A1 (en) | 2003-11-24 | 2007-11-01 | Defrees Shawn | Glycopegylated Erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| WO2005058967A2 (en) | 2003-12-16 | 2005-06-30 | Pierre Fabre Medicament | Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof |
| EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| CN1902311A (zh) | 2003-12-31 | 2007-01-24 | 森托科尔公司 | 具有n－末端游离硫羟基的新的重组蛋白 |
| US7794436B2 (en) | 2004-01-13 | 2010-09-14 | Lloyd Jay Pinel | Controlled gastric bolus feeding device |
| US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
| US20050187158A1 (en) | 2004-01-22 | 2005-08-25 | Ranby Mats G. | Pharmaceutical composition |
| US20050177108A1 (en) | 2004-02-10 | 2005-08-11 | Animas Corporation | External infusion device having a casing with multiple cross-vented hermetically-sealed housings |
| WO2005084711A1 (en) | 2004-03-02 | 2005-09-15 | Chengdu Institute Of Biological Products | A pegylated recombinant erythropoietin that has in vivo activity |
| WO2005092369A2 (en) | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyethyl starch and erythropoietin |
| US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
| AU2005235794A1 (en) | 2004-04-23 | 2005-11-03 | Cambridge Antibody Technology Limited | Erythropoietin protein variants |
| US20050267422A1 (en) | 2004-05-26 | 2005-12-01 | Kriesel Marshall S | Fluid delivery apparatus |
| US7220245B2 (en) | 2004-05-26 | 2007-05-22 | Kriesel Marshall S | Infusion apparatus |
| US20050277883A1 (en) | 2004-05-26 | 2005-12-15 | Kriesel Marshall S | Fluid delivery device |
| EP1781697B1 (en) | 2004-07-07 | 2009-04-22 | H.Lundbeck A/S | Novel carbamylated epo and method for its production |
| AU2005263180B2 (en) | 2004-07-16 | 2010-05-27 | Unitract Syringe Pty Ltd | Syringe needle sheath |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US20060073563A1 (en) | 2004-09-02 | 2006-04-06 | Xencor, Inc. | Erythropoietin derivatives with altered immunogenicity |
| JP2008519589A (ja) | 2004-11-10 | 2008-06-12 | アプラゲン ゲーエムベーハー | 造血を促進する分子 |
| GB0426479D0 (en) | 2004-12-02 | 2005-01-05 | Glaxosmithkline Biolog Sa | Novel device |
| US20060178638A1 (en) | 2004-12-03 | 2006-08-10 | Reynolds David L | Device and method for pharmaceutical mixing and delivery |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| CN101312759B (zh) | 2004-12-24 | 2013-04-10 | 科林专利控股有限公司 | 安全注射器 |
| EP1841455A1 (en) | 2005-01-24 | 2007-10-10 | Amgen Inc. | Humanized anti-amyloid antibody |
| US8029468B2 (en) | 2005-02-15 | 2011-10-04 | Bioquiddity, Inc. | Fluid delivery and mixing apparatus with flow rate control |
| US20080009835A1 (en) | 2005-02-17 | 2008-01-10 | Kriesel Marshall S | Fluid dispensing apparatus with flow rate control |
| US7837653B2 (en) | 2005-02-18 | 2010-11-23 | Bioquiddity, Inc. | Fluid delivery apparatus with vial fill |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US7641649B2 (en) | 2005-05-06 | 2010-01-05 | Medtronic Minimed, Inc. | Reservoir support and method for infusion device |
| US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
| US7905868B2 (en) | 2006-08-23 | 2011-03-15 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
| PT2100614E (pt) | 2005-06-17 | 2013-12-16 | Imclone Llc | Antagonistas de receptor para tratamento de cancro ósseo metastático |
| WO2007000328A1 (en) | 2005-06-27 | 2007-01-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof |
| US8603034B2 (en) | 2005-07-12 | 2013-12-10 | Applied Diabetes Research, Inc. | One piece sealing reservoir for an insulin infusion pump |
| CA2854576A1 (en) | 2005-07-18 | 2007-01-25 | Haichun Huang | Human anti-b7rp1 neutralizing antibodies |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| DE102005038368A1 (de) | 2005-08-13 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Doppelkammer-Behälter zur Lyophilisation, Verfahren zu dessen Befüllung und dessen Verwendung |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| JP4150389B2 (ja) | 2005-09-05 | 2008-09-17 | 日本ケミカルリサーチ株式会社 | 注射装置 |
| US8105279B2 (en) | 2005-09-26 | 2012-01-31 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
| US8409142B2 (en) | 2005-09-26 | 2013-04-02 | Asante Solutions, Inc. | Operating an infusion pump system |
| EP1933902B1 (en) | 2005-09-26 | 2014-12-17 | Asante Solutions, Inc. | Infusion pump with a drive having a ratchet and pawl combination |
| CA2625041C (en) | 2005-10-13 | 2014-11-25 | Becton, Dickinson And Company | Disposable needle and hub assembly |
| JP4943690B2 (ja) | 2005-10-27 | 2012-05-30 | 前田産業株式会社 | シリンジホルダー及び注射器 |
| US20150057615A1 (en) | 2005-11-08 | 2015-02-26 | Asante Solutions | Infusion Pump System |
| US9839743B2 (en) | 2006-02-09 | 2017-12-12 | Deka Products Limited Partnership | Apparatus, system and method for fluid delivery |
| JP2007209675A (ja) * | 2006-02-13 | 2007-08-23 | Chemo Sero Therapeut Res Inst | プレフィルドシリンジの製造方法 |
| DE502006001489D1 (de) | 2006-02-14 | 2008-10-16 | Gerresheimer Buende Gmbh | Verfahren zum Herstellen von vorfüllbaren Spritzen |
| US7828772B2 (en) | 2006-03-15 | 2010-11-09 | Bioquiddity, Inc. | Fluid dispensing device |
| US20080097306A1 (en) | 2006-08-29 | 2008-04-24 | Jeffrey Smith | Sterilized syringe |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| US7851438B2 (en) | 2006-05-19 | 2010-12-14 | GlycoFi, Incorporated | Erythropoietin compositions |
| TW200743500A (en) | 2006-05-26 | 2007-12-01 | ming-zheng Xu | Disposable syringe |
| US20070282269A1 (en) | 2006-05-31 | 2007-12-06 | Seattle Medical Technologies | Cannula delivery apparatus and method for a disposable infusion device |
| US8292848B2 (en) | 2006-07-31 | 2012-10-23 | Bio Quiddity, Inc. | Fluid dispensing device with additive |
| US7682338B2 (en) | 2006-08-23 | 2010-03-23 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
| CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
| US8337483B2 (en) | 2006-11-02 | 2012-12-25 | Becton, Dickinson And Company | Vascular access device chamber replacement |
| JP5588175B2 (ja) | 2006-11-07 | 2014-09-10 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｐｃｓｋ９のアンタゴニスト |
| CA2667989A1 (en) | 2006-11-07 | 2008-11-06 | Merck & Co., Inc. | Antagonists of pcsk9 |
| CA2668131A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| CA2667869A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| US7938801B2 (en) | 2006-11-22 | 2011-05-10 | Calibra Medical, Inc. | Disposable infusion device filling apparatus and method |
| EP1927372B1 (en) | 2006-11-29 | 2009-06-03 | Ming-Jeng Shue | Disposable syringe with built-in carpule |
| WO2008067467A2 (en) | 2006-11-29 | 2008-06-05 | West Pharmaceutical Services, Inc. | Syringe cartridge system |
| US20080154243A1 (en) | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| HUE065830T2 (hu) | 2006-12-22 | 2024-06-28 | Hoffmann La Roche | Eszköz terápiás folyadék tartós bejuttatására |
| WO2008083209A2 (en) * | 2006-12-29 | 2008-07-10 | Amir Genosar | Hypodermic drug delivery reservoir and apparatus |
| DK2107917T3 (da) | 2007-02-02 | 2020-10-26 | Unomedical As | Injektionssted til injektion af lægemiddel |
| US8251960B2 (en) | 2007-03-24 | 2012-08-28 | The Alfred E. Mann Foundation For Scientific Research | Valves, valved fluid transfer devices and ambulatory infusion devices including the same |
| US20080249505A1 (en) | 2007-03-30 | 2008-10-09 | Animas Corporation | Method for mounting an infusion set with user-controlled 360-degree rotary motion hub to an infusion site |
| US20080243084A1 (en) | 2007-03-30 | 2008-10-02 | Animas Corporation | User-releasable side-attach rotary infusion set |
| TW200906439A (en) | 2007-04-13 | 2009-02-16 | Novartis Ag | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| WO2008136845A2 (en) | 2007-04-30 | 2008-11-13 | Medtronic Minimed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
| US7794426B2 (en) | 2007-05-21 | 2010-09-14 | Asante Solutions, Inc. | Infusion pump system with contamination-resistant features |
| US8226609B2 (en) | 2007-06-25 | 2012-07-24 | Bioquiddity, Inc. | Fluid dispenser with additive sub-system |
| US8211059B2 (en) | 2007-06-25 | 2012-07-03 | Kriesel Marshall S | Fluid dispenser with additive sub-system |
| US20080319385A1 (en) | 2007-06-25 | 2008-12-25 | Kriesel Marshall S | Fluid dispenser with additive sub-system |
| CN101815464A (zh) | 2007-07-20 | 2010-08-25 | 梅丁格有限公司 | 用于流体配送设备的能量供应 |
| DE102007034871A1 (de) | 2007-07-24 | 2009-01-29 | Lts Lohmann Therapie-Systeme Ag | Einweginjektor mit handbetätigbarem Kolben |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| US11154698B2 (en) | 2007-08-24 | 2021-10-26 | Deka Products Limited Partnership | Microneedle systems and apparatus |
| JP5615176B2 (ja) | 2007-08-30 | 2014-10-29 | カルメル ファルマ アクチボラゲット | 流体移送装置 |
| MX2010002249A (es) | 2007-08-31 | 2010-03-17 | Amgen Inc | Formulacion de proteina de estado solido. |
| US7717903B2 (en) | 2007-09-06 | 2010-05-18 | M2 Group Holdings, Inc. | Operating an infusion pump system |
| US7935105B2 (en) | 2007-09-07 | 2011-05-03 | Asante Solutions, Inc. | Data storage for an infusion pump system |
| US7879026B2 (en) | 2007-09-07 | 2011-02-01 | Asante Solutions, Inc. | Controlled adjustment of medicine dispensation from an infusion pump device |
| CN102232088A (zh) | 2007-10-26 | 2011-11-02 | 先灵公司 | 用于治疗脂类和胆固醇疾病的抗pcsk9及方法 |
| EP2244765B1 (en) | 2007-12-31 | 2019-08-14 | DEKA Products Limited Partnership | Infusion pump assembly |
| US10188787B2 (en) | 2007-12-31 | 2019-01-29 | Deka Products Limited Partnership | Apparatus, system and method for fluid delivery |
| EP2254621A2 (en) | 2008-02-04 | 2010-12-01 | Nilimedix Ltd. | Drug delivery system with wireless monitor |
| AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| US8629104B2 (en) | 2008-02-18 | 2014-01-14 | Jiangsu Hengrui Medicine Co. Ltd. | G-CSF and water-soluble polymer conjugate |
| JP2009207619A (ja) | 2008-03-03 | 2009-09-17 | Terumo Corp | 医療用容器 |
| KR101188946B1 (ko) | 2008-04-01 | 2012-10-08 | 감브로 룬디아 아베 | 의료용 커넥터 |
| US8597269B2 (en) | 2008-04-11 | 2013-12-03 | Medtronic Minimed, Inc. | Reservoir seal retainer systems and methods |
| US8414554B2 (en) | 2008-05-14 | 2013-04-09 | J & J Solutions, Inc. | Systems and methods for safe medicament transport |
| EP2326365B1 (en) | 2008-08-18 | 2020-01-01 | Calibra Medical LLC | Drug infusion system with reusable and disposable components |
| US7772006B2 (en) | 2008-08-21 | 2010-08-10 | Paul Tornambe | Agent detection and/or quantitation in a biological fluid |
| JP5854836B2 (ja) | 2008-08-30 | 2016-02-09 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | カートリッジ及びそのための針システム |
| BRPI0918297A2 (pt) | 2008-09-10 | 2016-05-03 | Hoffmann La Roche | "dispositivo de distribuição de droga para bombear a medicação para dentro do corpo de um usuário" |
| WO2010030593A1 (en) | 2008-09-10 | 2010-03-18 | Thomasevans, LLC | Multi-chambered mixing syringe device and methods of use |
| TWI516501B (zh) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Ｐｃｓｋ９拮抗劑類 |
| US8728024B2 (en) | 2008-10-10 | 2014-05-20 | Deka Products Limited Partnership | Infusion pump methods, systems and apparatus |
| CA2745376A1 (en) | 2008-12-01 | 2010-06-10 | Lifespan Extension Llc | Methods and compositions for altering health, wellbeing, and lifespan |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US9370621B2 (en) | 2008-12-16 | 2016-06-21 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| EP2201976A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Apparatus for holding a cover of a needle unit and method |
| US9375529B2 (en) | 2009-09-02 | 2016-06-28 | Becton, Dickinson And Company | Extended use medical device |
| EP2601934A1 (en) | 2009-01-22 | 2013-06-12 | Ludwig-Maximilians-Universität München | Vesicular phospholipid gels comprising proteinaceous substances |
| US9370619B2 (en) | 2009-02-21 | 2016-06-21 | Incumed, Llc | Partially implantable medical devices and delivery/manifold tube for use with same |
| US9125981B2 (en) | 2009-02-21 | 2015-09-08 | Incumed, Llc | Fluid cartridges including a power source and partially implantable medical devices for use with same |
| US20100249753A1 (en) | 2009-02-25 | 2010-09-30 | Gaisser David M | Vented syringe system and method for the containment, mixing and ejection of wetted particulate material |
| WO2010098323A1 (ja) | 2009-02-25 | 2010-09-02 | テルモ株式会社 | プレフィルドシリンジの製造方法およびプレフィルドシリンジ |
| EP2403563A1 (en) | 2009-03-06 | 2012-01-11 | Sanofi-Aventis Deutschland GmbH | Seal member for syringe with retractable needle |
| US8894608B2 (en) | 2009-05-22 | 2014-11-25 | Michael P. Connair | Steroid delivery system |
| AR076716A1 (es) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | Modulo medicado con medicamento de premezcla |
| AR076719A1 (es) * | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | Modulo medicinal con derivacion y protector de aguja |
| TW201100135A (en) | 2009-06-19 | 2011-01-01 | Addino B V | Hypodermic syringe with retractable needle |
| GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
| US9179710B2 (en) | 2009-06-30 | 2015-11-10 | Inhale, Inc. | Hookah with multiple tobacco bowls |
| GB2471726B (en) | 2009-07-10 | 2013-09-11 | Oval Medical Technologies Ltd | A pre-filled syringe including an oxygen absorber |
| US8401585B2 (en) | 2009-09-03 | 2013-03-19 | Telefonaktiebolaget L M Ericsson (Publ) | Method and apparatus for uplink power control in a wireless communication network |
| US9238102B2 (en) | 2009-09-10 | 2016-01-19 | Medipacs, Inc. | Low profile actuator and improved method of caregiver controlled administration of therapeutics |
| WO2011037791A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Antagonists of pcsk9 |
| US9592341B2 (en) | 2009-10-16 | 2017-03-14 | Sanofi-Aventis Deutschland Gmbh | Arrangement for use in a drug delivery device |
| AU2010310457B2 (en) | 2009-10-23 | 2015-07-02 | Amgen Inc. | Vial adapter and system |
| US8802827B2 (en) | 2009-10-30 | 2014-08-12 | Merck Sharp & Dohme Corp. | AX1 PCSK9 antagonists |
| IN2012DN03824A (enExample) | 2009-10-30 | 2015-08-28 | Merck Sharp & Dohme | |
| US8449504B2 (en) | 2009-11-11 | 2013-05-28 | Calibra Medical, Inc. | Wearable infusion device and system |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| EP3085402B1 (en) | 2009-12-31 | 2018-05-09 | DEKA Products Limited Partnership | Infusion pump assembley |
| WO2011082370A1 (en) | 2009-12-31 | 2011-07-07 | Abbott Diabetes Care Inc. | Injection port device adapted for use with insulin pump |
| WO2011108575A1 (ja) | 2010-03-05 | 2011-09-09 | テルモ株式会社 | 医療器具 |
| CN105218674A (zh) | 2010-03-11 | 2016-01-06 | 瑞纳神经科学公司 | 呈pH依赖性抗原结合的抗体 |
| EP2550044A1 (en) | 2010-03-25 | 2013-01-30 | Sanofi-Aventis Deutschland GmbH | Medicated module with automatic reservoir engagement |
| JPWO2011122395A1 (ja) | 2010-03-31 | 2013-07-08 | テルモ株式会社 | プレフィルドシリンジ |
| EP2371408B1 (en) | 2010-03-31 | 2013-07-31 | Roche Diagnostics GmbH | Liquid drug degasing devise and ambulatory infusion system including a degasing device |
| CN104906656B (zh) | 2010-04-21 | 2020-01-10 | 艾伯维生物技术有限公司 | 用于治疗药剂的受控输送的可佩戴自动注射装置 |
| US8821454B2 (en) | 2010-05-12 | 2014-09-02 | Bioquiddity, Inc. | Apparatus for dispensing medicinal fluids and method of making same |
| KR102513760B1 (ko) | 2010-06-07 | 2023-03-27 | 암젠 인크 | 약물 전달 장치 |
| EP2608825B1 (en) | 2010-08-27 | 2014-08-13 | Novo Nordisk A/S | Medical injection device |
| CN103118721A (zh) | 2010-09-24 | 2013-05-22 | 泰尔茂株式会社 | 药剂注射装置的组装方法 |
| US8142398B1 (en) | 2010-10-12 | 2012-03-27 | Bioquiddity, Inc. | Fluid dispenser |
| CN103260675B (zh) | 2010-10-13 | 2016-01-20 | 赛诺菲-安万特德国有限公司 | 剂量设定机构和使用该剂量设定机构的方法 |
| JP2013546057A (ja) | 2010-10-18 | 2013-12-26 | ブルー インフュージョン テクノロジーズ， エルエルシー | 電子的制御グローブ |
| WO2012054438A1 (en) | 2010-10-22 | 2012-04-26 | Schering Corporation | Anti-pcsk9 |
| DK2635334T3 (en) | 2010-11-03 | 2014-11-17 | Sanofi Aventis Deutschland | System for prevention of leak of a drug |
| RU2603426C2 (ru) | 2010-11-19 | 2016-11-27 | Байер Консьюмер Кеэр Аг | Аппликаторное устройство типа нажимной ручки и способ его применения |
| WO2012088313A1 (en) | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Anti-pcsk9 antibodies and methods of use |
| US20120191074A1 (en) | 2011-01-21 | 2012-07-26 | Palyon Medical (Bvi) Limited | Reduced sized programmable pump |
| HRP20180959T1 (hr) | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| WO2012108956A2 (en) | 2011-02-09 | 2012-08-16 | Becton, Dickinson And Company | Improvements in infusion systems |
| CN203915611U (zh) | 2011-02-09 | 2014-11-05 | 贝克顿·迪金森公司 | 与输注基部附接的套节及用于传送药物的传送系统 |
| EP2673302A1 (en) | 2011-02-11 | 2013-12-18 | Irm Llc | Pcsk9 antagonists |
| US20120215183A1 (en) | 2011-02-22 | 2012-08-23 | Medtronic Minimed, Inc. | Fluid infusion device having a sealing assembly for a fluid reservoir |
| US9339639B2 (en) | 2011-02-22 | 2016-05-17 | Medtronic Minimed, Inc. | Sealing assembly for a fluid reservoir of a fluid infusion device |
| EP2691065B1 (en) | 2011-03-31 | 2017-03-01 | Amgen Inc. | Vial adapter and system |
| CA2832729A1 (en) | 2011-04-21 | 2012-10-26 | Abbvie Inc. | Wearable automatic injection device for controlled administration of therapeutic agents |
| US8795231B2 (en) | 2011-05-10 | 2014-08-05 | Medtronic Minimed, Inc. | Automated reservoir fill system |
| CA2836234C (en) | 2011-05-18 | 2020-06-09 | Becton, Dickinson And Company | Injection device |
| JP6088499B2 (ja) | 2011-06-23 | 2017-03-01 | デバイオテック・ソシエテ・アノニム | Ｍｅｍｓマイクロポンプの機能不全検出のための方法及びシステム |
| EP2736565B1 (en) | 2011-07-25 | 2017-07-05 | Preciflex SA | Fluid dispenser |
| AU2012292953B2 (en) | 2011-08-05 | 2016-07-14 | Unitract Syringe Pty Ltd | Dual chamber mixing device for a syringe |
| EP2747809B1 (en) | 2011-08-26 | 2016-04-06 | Eli Lilly and Company | Refill module for an injection device |
| US20150258273A1 (en) | 2011-08-31 | 2015-09-17 | Forrest W. Payne | Electrochemically-Actuated Microfluidic Devices |
| US9821118B2 (en) | 2011-09-02 | 2017-11-21 | Unl Holdings Llc | Automatic reconstitution for dual chamber syringe |
| JP6411888B2 (ja) | 2011-09-07 | 2018-10-24 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイのための送達システム |
| EP3335747B1 (en) | 2011-10-14 | 2021-04-07 | Amgen Inc. | Injector and method of assembly |
| CN103127579B (zh) | 2011-11-21 | 2017-06-16 | 上海泽生科技开发股份有限公司 | 便携式注射泵的驱动系统 |
| WO2013089105A1 (ja) | 2011-12-15 | 2013-06-20 | テルモ株式会社 | プレフィルドシリンジ用筒状体、プレフィルドシリンジ用穿刺具、プレフィルドシリンジ用注射器およびプレフィルドシリンジ |
| WO2013114221A2 (en) | 2012-01-31 | 2013-08-08 | Preciflex Sa | Injection device using dry carrier |
| WO2013127428A1 (en) | 2012-02-27 | 2013-09-06 | F. Hoffmann-La Roche Ag | Spring force assembly for biasing or actuating stoppers of syringes, injection pen cartridges and the like |
| CA2866843C (en) | 2012-03-12 | 2020-04-21 | Unitract Syringe Pty Ltd | Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges |
| US9155866B2 (en) | 2012-09-13 | 2015-10-13 | Becton, Dickinson And Company | Luer securement device |
| US9463280B2 (en) | 2012-03-26 | 2016-10-11 | Medimop Medical Projects Ltd. | Motion activated septum puncturing drug delivery device |
| US10780228B2 (en) * | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
| CN202723859U (zh) | 2012-06-28 | 2013-02-13 | 河南曙光健士医疗器械集团股份有限公司 | 安全采血器 |
| EP2872203B1 (en) | 2012-07-11 | 2020-11-25 | UNL Holdings LLC | Insertion mechanisms having vented fluid pathways for drug delivery pumps |
| US8454562B1 (en) | 2012-07-20 | 2013-06-04 | Asante Solutions, Inc. | Infusion pump system and method |
| WO2014029416A1 (en) | 2012-08-20 | 2014-02-27 | Roche Diagnostics Gmbh | Therapeutic system with an adaptor for an infusion set |
| EP2712651A1 (en) | 2012-09-27 | 2014-04-02 | F. Hoffmann-La Roche AG | Venting device for use in ambulatory infusion system |
| EP2908881A2 (en) | 2012-10-16 | 2015-08-26 | SwissInnov Product Sàrl | Fluid delivery system and methods |
| JP2014087449A (ja) | 2012-10-30 | 2014-05-15 | Seiko Epson Corp | 液体輸送装置及びカテーテルの抜け判定方法 |
| IL281709B (en) | 2013-01-25 | 2022-07-01 | Unitract Syringe Pty Ltd | Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps |
| US10080839B2 (en) | 2013-03-14 | 2018-09-25 | Becton, Dickinson And Company | Angled inserter for drug infusion |
| US9821113B2 (en) | 2013-03-15 | 2017-11-21 | Becton, Dickinson And Company | Automatic angled infusion set assembly |
| EP2976117B1 (en) | 2013-03-22 | 2020-12-30 | Amgen Inc. | Injector and method of assembly |
| US20140323989A1 (en) | 2013-04-24 | 2014-10-30 | Calibra Medical, Inc. | Wearable infusion device with low profile handle |
| DK2815778T3 (da) | 2013-06-21 | 2017-11-20 | Hoffmann La Roche | Bærbar infusionsindretning til børn med genopfyldelig doseringsenhed med lille volumen |
| US9737655B2 (en) | 2013-08-23 | 2017-08-22 | Unitract Syringe Pty Ltd | Integrated pierceable seal fluid pathway connection and drug containers for drug delivery pumps |
| US9375537B2 (en) | 2013-10-14 | 2016-06-28 | Medtronic Minimed, Inc. | Therapeutic agent injection device |
| SG11201602876WA (en) * | 2013-10-24 | 2016-05-30 | Amgen Inc | Injector and method of assembly |
| US9463889B2 (en) | 2013-10-25 | 2016-10-11 | Medtronic, Inc. | Prefilled reservoir apparatus for ambulatory infusion device |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3605744A (en) * | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
| US20130006213A1 (en) * | 2009-11-03 | 2013-01-03 | Theo Arnitz | Device for substantially germ-free provision of a fluid medium |
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| US12329943B2 (en) | Injector and method of assembly | |
| HK1196956B (en) | Injector and method of assembly | |
| HK1196956A (en) | Injector and method of assembly |