IL158419A0 - Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs - Google Patents

Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs

Info

Publication number
IL158419A0
IL158419A0 IL15841902A IL15841902A IL158419A0 IL 158419 A0 IL158419 A0 IL 158419A0 IL 15841902 A IL15841902 A IL 15841902A IL 15841902 A IL15841902 A IL 15841902A IL 158419 A0 IL158419 A0 IL 158419A0
Authority
IL
Israel
Prior art keywords
trna
orthoganal
composition
production
methods
Prior art date
Application number
IL15841902A
Other languages
English (en)
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of IL158419A0 publication Critical patent/IL158419A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
IL15841902A 2001-04-19 2002-04-19 Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs IL158419A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28503001P 2001-04-19 2001-04-19
US35551402P 2002-02-06 2002-02-06
PCT/US2002/012635 WO2002086075A2 (fr) 2001-04-19 2002-04-19 Procedes et compositions permettant la production de paires orthogonales de synthethases trna et de synthetases aminoacyl-trna

Publications (1)

Publication Number Publication Date
IL158419A0 true IL158419A0 (en) 2004-05-12

Family

ID=26962950

Family Applications (7)

Application Number Title Priority Date Filing Date
IL15841802A IL158418A0 (en) 2001-04-19 2002-04-19 In vivo incorporation of unnatural amino acids
IL15841902A IL158419A0 (en) 2001-04-19 2002-04-19 Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs
IL158419A IL158419A (en) 2001-04-19 2003-10-15 Cell containing orthogonal trna synthase (ors) and orthogonal trna (otrna)
IL187588A IL187588A (en) 2001-04-19 2007-11-22 ISOLATED OR CULTURED EUKARYOTIC CELL COMPRISING AN ORTHOGONAL tRNA SYNTHASE AMINOACYLATING ENDOGENOUS tRNA AND AN ORTHOGONAL tRNA THAT IS AMINOACYLATED BY THE ENDOGENOUS tRNA SYNTHASE
IL187775A IL187775A0 (en) 2001-04-19 2007-11-29 Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs
IL196714A IL196714A (en) 2001-04-19 2009-01-26 Methods for producing pairs of orthogonal-amino-trna and trna synthetase
IL196762A IL196762A (en) 2001-04-19 2009-01-28 Compositions containing a translation system including orthogonal (o – trna) and aminoacyl trna (o – rs) orthogonal synthetase, methods of using them and cells containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL15841802A IL158418A0 (en) 2001-04-19 2002-04-19 In vivo incorporation of unnatural amino acids

Family Applications After (5)

Application Number Title Priority Date Filing Date
IL158419A IL158419A (en) 2001-04-19 2003-10-15 Cell containing orthogonal trna synthase (ors) and orthogonal trna (otrna)
IL187588A IL187588A (en) 2001-04-19 2007-11-22 ISOLATED OR CULTURED EUKARYOTIC CELL COMPRISING AN ORTHOGONAL tRNA SYNTHASE AMINOACYLATING ENDOGENOUS tRNA AND AN ORTHOGONAL tRNA THAT IS AMINOACYLATED BY THE ENDOGENOUS tRNA SYNTHASE
IL187775A IL187775A0 (en) 2001-04-19 2007-11-29 Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs
IL196714A IL196714A (en) 2001-04-19 2009-01-26 Methods for producing pairs of orthogonal-amino-trna and trna synthetase
IL196762A IL196762A (en) 2001-04-19 2009-01-28 Compositions containing a translation system including orthogonal (o – trna) and aminoacyl trna (o – rs) orthogonal synthetase, methods of using them and cells containing them

Country Status (11)

Country Link
US (19) US7083970B2 (fr)
EP (5) EP2796546B1 (fr)
JP (7) JP2005502322A (fr)
AU (2) AU2002303431C1 (fr)
CA (2) CA2443757C (fr)
DK (4) DK2128246T3 (fr)
ES (1) ES2464532T3 (fr)
HK (4) HK1065065A1 (fr)
IL (7) IL158418A0 (fr)
MX (2) MXPA03009566A (fr)
WO (2) WO2002085923A2 (fr)

Families Citing this family (402)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002303431C1 (en) 2001-04-19 2008-03-06 The Regents Of The University Of California Methods and composition for the production of orthoganal tRNA-aminoacyltRNA synthetase pairs
WO2003033521A1 (fr) 2001-10-16 2003-04-24 Massachusetts Institute Of Technology Systeme d'arn de transfert suppresseur dans des cellules mammiferes, permettant d'introduire des acides amines naturels dans des polypeptides
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US7112435B1 (en) 2002-08-07 2006-09-26 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US20040038273A1 (en) * 2002-06-17 2004-02-26 Whitehead Institute For Biomedical Research Bifunctional tRNA for in vitro selection
WO2004011902A2 (fr) * 2002-07-25 2004-02-05 Mds Proteomics Inc. Systemes et procedes ameliores servant a analyser la modification apres traduction de proteines
US7833741B2 (en) * 2002-08-07 2010-11-16 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US7897381B2 (en) * 2002-08-07 2011-03-01 Ambit Biosciences Corporation Uncoupling of DNA insert propagation and expression of protein for phage display
US7563600B2 (en) * 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
ES2333422T3 (es) 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
ATE429500T1 (de) 2002-10-16 2009-05-15 Scripps Research Inst Stellenspezifischer einbau von ketoaminosäuren in proteine
EP1583816A4 (fr) * 2002-12-22 2007-06-13 Scripps Research Inst Reseaux de proteines
WO2004060403A2 (fr) 2003-01-06 2004-07-22 Angiochem Inc. Methode de transport d'un compose a travers une barriere sang/cerveau
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2006180701A (ja) * 2003-02-10 2006-07-13 Institute Of Physical & Chemical Research チロシルｔＲＮＡ合成酵素の変異体及びその作製方法
AU2013201487B2 (en) * 2003-04-17 2014-09-18 The Scripps Research Institute Expanding the eukaryotic genetic code
CA2520750A1 (fr) 2003-04-17 2004-11-04 The Scripps Research Institute Extension du code genetique eucaryote
WO2004110964A2 (fr) * 2003-06-16 2004-12-23 Nuevolution A/S Molecules codees par traduction genetique (emt)
EP2410331B1 (fr) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-ARNt synthétase d'tARN aminoacylation avec acides aminés non naturels
EP1704242A4 (fr) * 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS DE PAIRES ORTHOGONALES DE LEUCYL-tRNA ET AMINOACYL-tRNA-SYNTHETASE ET LEURS UTILISATIONS
ES2301099T3 (es) * 2003-07-07 2008-06-16 The Scripps Research Institute Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas.
US7527943B2 (en) 2003-07-07 2009-05-05 The Scripps Research Institute Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
ATE447611T1 (de) 2003-08-18 2009-11-15 Univ California Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon
JP5657850B2 (ja) 2003-10-14 2015-01-21 ザ スクリプス リサーチ インスティテュート 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ
JP2007530013A (ja) * 2003-12-12 2007-11-01 コンジュゴン インコーポレーティッド 緻密に調節された遺伝子発現のためのシステム
MXPA06006868A (es) 2003-12-18 2007-03-21 Scripps Research Inst Incorporacion selectiva de 5-hiroxitriptofano en proteinas de celulas de mamiferos.
US8906676B2 (en) * 2004-02-02 2014-12-09 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
JP2007534320A (ja) * 2004-02-27 2007-11-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ポリヌクレオチド合成法
FR2868081A1 (fr) * 2004-03-23 2005-09-30 Libragen Sa Methode d'identification de famille de voie metabolique par selection positive
US20050260711A1 (en) * 2004-03-30 2005-11-24 Deepshikha Datta Modulating pH-sensitive binding using non-natural amino acids
JP4799405B2 (ja) * 2004-04-09 2011-10-26 中外製薬株式会社 細胞死誘導剤
US20050287639A1 (en) * 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
US7399619B2 (en) 2004-05-25 2008-07-15 The Scripps Research Institute Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
US20060008844A1 (en) * 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
CN1968712B (zh) * 2004-06-18 2012-05-16 Ambrx公司 新颖抗原结合多肽和其用途
KR101699142B1 (ko) * 2004-06-18 2017-01-23 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
BRPI0513534A (pt) 2004-07-20 2008-05-06 Genentech Inc inibidores de proteìna 4 semelhante à angiopoietina, combinações, e seu uso
JP2008507280A (ja) * 2004-07-21 2008-03-13 アンブレツクス・インコーポレイテツド 非天然コードアミノ酸を用いた生合成ポリペプチド
ES2519444T3 (es) * 2004-09-21 2014-11-07 The Scripps Research Institute Incorporación in vivo de alquinil aminoácidos a proteínas en eubacterias
US20060110784A1 (en) * 2004-09-22 2006-05-25 The Scripps Research Institute Site-specific labeling of proteins for NMR studies
US20070122817A1 (en) * 2005-02-28 2007-05-31 George Church Methods for assembly of high fidelity synthetic polynucleotides
AU2005295351A1 (en) * 2004-10-18 2006-04-27 Codon Devices, Inc. Methods for assembly of high fidelity synthetic polynucleotides
EP1809758A4 (fr) 2004-10-20 2009-04-01 Scripps Research Inst Introduction<i>in vivo</i>specifique au site d'acides amines n-acetyl-galactosamine chez les eubacteries
CN101048506B (zh) * 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
AU2011204773B2 (en) * 2004-10-27 2012-02-02 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
DK2586456T3 (en) 2004-10-29 2016-03-21 Ratiopharm Gmbh Conversion and glycopegylation of fibroblast growth factor (FGF)
WO2006055898A2 (fr) * 2004-11-20 2006-05-26 Massachusetts Institute Of Technology Arnt de suppression orthogonale et aminoacyl-arnt synthetases, et leurs utilisations
WO2006054807A1 (fr) * 2004-11-22 2006-05-26 Gifu University PROCÉDÉ DE TRANSFERT SPÉCIFIQUE AU SITE D’ACIDE AMINÉ NON NATUREL DANS UNE PROTÉINE EN UTILISANT UNE PROTÉINE MITOCHONDRIALE ET PROCÉDÉ DE PRÉPARATION EFFICACE D’ARNt
MX2007007591A (es) 2004-12-22 2007-07-25 Ambrx Inc Metodos para expresion y purificacion de hormona de crecimiento humano recombinante.
CA2590429C (fr) 2004-12-22 2014-10-07 Ambrx, Inc. Compositions de synthetase d'aminoacyl-arnt et utilisations correspondantes
SG158148A1 (en) 2004-12-22 2010-01-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
CN103520735B (zh) 2004-12-22 2015-11-25 Ambrx公司 包含非天然编码的氨基酸的人生长激素配方
AU2013205042B2 (en) * 2004-12-22 2016-05-12 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
JP2008525473A (ja) * 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド 修飾されたヒト成長ホルモン
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
WO2006107813A2 (fr) * 2005-04-05 2006-10-12 Yale University Incorporation specifique a un site de phosphoserine dans des polypeptides a l'aide de la phosphoseryl-trna synthetase
EP2386571B1 (fr) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
US8293517B2 (en) * 2005-05-11 2012-10-23 Wayne State University Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance in Pseudomonas aeruginosa
KR20080026120A (ko) * 2005-06-03 2008-03-24 암브룩스, 인코포레이티드 비천연적으로 코딩된 아미노산의 단백질로의 도입
JP2008541769A (ja) * 2005-06-03 2008-11-27 アンブレツクス・インコーポレイテツド 改善されたヒトインターフェロン分子及びそれらの使用
KR101367544B1 (ko) * 2005-06-10 2014-02-26 추가이 세이야쿠 가부시키가이샤 메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용
WO2007005053A1 (fr) * 2005-06-30 2007-01-11 Codon Devices, Inc. Procédés d'assemblage hiérarchique pour l'ingénierie des génomes
CA2614687C (fr) 2005-07-15 2016-03-22 Angiochem Inc. Utilisation de polypeptides de l'aprotinine comme vehicules dans des conjugues pharmaceutiques
CA2614326C (fr) * 2005-07-15 2012-09-18 Medical Research Council Compositions et procedes relatifs a des paires d'arnm de ribosomes orthogonaux
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
CN102703446B (zh) * 2005-08-18 2014-05-28 Ambrx公司 tRNA组合物和其用途
AU2006284651C1 (en) 2005-08-31 2013-09-12 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
BRPI0617191A2 (pt) * 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
PT2339014E (pt) 2005-11-16 2015-10-13 Ambrx Inc Métodos e composições compreendendo aminoácidos não-naturais
CA2882445A1 (fr) * 2005-12-14 2007-06-21 Ambrx, Inc. Compositions contenant des acides amines et polypeptides non naturels, procedes mettant en jeu ceux-ci et utilisations de ceux-ci
EP3056575B1 (fr) 2005-12-22 2017-10-11 Pacific Biosciences Of California, Inc. Polymérases pour l'incorporation d'analogues de nucléotides
US20090240029A1 (en) * 2005-12-30 2009-09-24 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
CN101384711A (zh) * 2006-01-19 2009-03-11 Ambrx公司 具有经调节的免疫原性的非天然氨基酸多肽
WO2007090198A2 (fr) * 2006-02-01 2007-08-09 Encode Bio, Inc. Essais fluorescents faisant intervenir des paires orthogonales aminoacyle-arnt synthétases
US20070178554A1 (en) * 2006-02-01 2007-08-02 Nima Shiva Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins
US7776535B2 (en) 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
WO2007103307A2 (fr) * 2006-03-03 2007-09-13 California Institute Of Technology Incorporation spécifique de site d'acides aminés dans des molécules
PL1991680T3 (pl) * 2006-03-09 2014-01-31 Scripps Research Inst Układ do ekspresji ortogonalnych składników translacji w eubakteryjnych komórkach gospodarza
US7790847B2 (en) * 2006-03-16 2010-09-07 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
EP2444499A3 (fr) 2006-05-02 2012-05-09 Allozyne, Inc. Molécules d'acide aminé substituées
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
KR20090024706A (ko) * 2006-05-23 2009-03-09 더 스크립스 리서치 인스티튜트 유전자적으로 코딩된 형광 쿠마린 아미노산
UA97953C2 (uk) * 2006-06-09 2012-04-10 Новартіс Аг Стабілізовані поліпептиди інсуліноподібного фактора росту
WO2008001947A1 (fr) * 2006-06-28 2008-01-03 Riken SepRS MUTANTE, ET PROCÉDÉ D'INTRODUCTION SITO-SPÉCIFIQUE D'UNE PHOSPHOSÉRINE DANS UNE PROTÉINE EN UTILISANT CETTE SepRS
DK2035554T3 (da) * 2006-06-29 2013-06-17 Univ Leland Stanford Junior Celle-fri syntese af proteiner indeholdende ikke-naturlige aminosyrer
BRPI0714209A2 (pt) * 2006-07-13 2014-06-24 Chugai Pharmaceutical Co Ltd Induzidor de morte celular
AU2012203737B2 (en) * 2006-09-08 2014-06-19 Ambrx, Inc. Modified human plasma polypeptide or Fc scaffolds and their uses
KR20090060294A (ko) * 2006-09-08 2009-06-11 암브룩스, 인코포레이티드 변형된 인간 혈장 폴리펩티드 또는 Ｆｃ 스캐폴드 및 그의 용도
WO2008030613A2 (fr) 2006-09-08 2008-03-13 Ambrx, Inc. Arnt suppresseur hybride pour cellules de vertébrés
AU2013202770B2 (en) * 2006-09-08 2015-08-20 Ambrx, Inc. Modified human plasma polypeptide or Fc scaffolds and their uses
CN101528914B (zh) * 2006-09-08 2014-12-03 Ambrx公司 通过脊椎动物细胞位点特异性并入非天然氨基酸
ES2465473T3 (es) 2006-09-08 2014-06-05 Ambrx, Inc. Transcripción de arnt supresor en células de vertebrado
BRPI0716963A2 (pt) * 2006-09-21 2013-11-05 Scripps Research Inst Expressão geneticamente programada de proteínas seletivamente sulfatadas em eubactéria
AU2007333010A1 (en) 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
EP2120998B1 (fr) 2006-11-28 2013-08-07 HanAll Biopharma Co., Ltd. Polypeptides d'érythropoïétine modifiés et utilisation de ceux-ci dans des traitements
EP1936340A1 (fr) * 2006-12-21 2008-06-25 Koninklijke Philips Electronics N.V. Ouverture inferieure aux longueurs d`ondes
EP2112928A4 (fr) * 2007-02-22 2014-01-08 Univ Utah Res Found Synthèse de nouveaux xylosides et leurs utilisations potentielles
CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
CN104163864B (zh) 2007-03-30 2017-08-01 Ambrx公司 经修饰fgf‑21多肽和其用途
US8183037B2 (en) * 2007-04-13 2012-05-22 The Salk Institute For Biological Studies Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs
AU2008247815B2 (en) * 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8293685B2 (en) * 2007-07-26 2012-10-23 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
CA2707840A1 (fr) 2007-08-20 2009-02-26 Allozyne, Inc. Molecules substituees par des acides amines
US20110178029A1 (en) * 2007-09-14 2011-07-21 Ambrx, Inc. Modified Human Apolipoprotein A-1 and Their Uses
EP2217700A4 (fr) * 2007-10-08 2011-02-16 Synthetic Genomics Inc Système et procédé pour produire des micro-organismes synthétiques capables de traduire des protéines contenant des acides aminés non standards
RU2010116872A (ru) * 2007-10-25 2011-11-27 Зе Скрипс Ресеч Инститьют (Us) Генетическое включение 3-аминотирозина в редуктазы
US20090148887A1 (en) * 2007-11-02 2009-06-11 The Scripps Research Institute Genetically encoded boronate amino acid
EP2209491B1 (fr) 2007-11-02 2015-10-28 Novartis AG Molécules et méthodes de modulation de la protéine 6 liée au récepteur des lipoprotéines de basse densité (lrp6)
JP5513398B2 (ja) * 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
WO2009064416A2 (fr) * 2007-11-15 2009-05-22 The Scripps Research Institute Incorporation génétique d'un acide alpha-hydroxy dans des protéines pour générer des liaisons de squelette ester à des sites définis
JP5547083B2 (ja) 2007-11-20 2014-07-09 アンブルックス，インコーポレイテッド 修飾されたインスリンポリペプチドおよびそれらの使用
US8647840B2 (en) * 2007-12-11 2014-02-11 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris
CN104651381A (zh) 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
WO2009099763A1 (fr) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Promédicaments peptidiques à base d’esters
CN103694337B (zh) 2008-02-08 2016-03-02 Ambrx公司 经修饰瘦素多肽和其用途
EP2249865A4 (fr) * 2008-02-08 2012-04-04 Scripps Research Inst Rupture de la tolérance immunologique avec un acide aminé non naturel génétiquement codé
WO2009117622A2 (fr) * 2008-03-19 2009-09-24 Ambrx, Inc. Polypeptides fgf-23 modifiés et leurs utilisations
US8940506B2 (en) * 2008-03-21 2015-01-27 The Regents Of The University Of California High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins
DK2274008T3 (da) 2008-03-27 2014-05-12 Zymogenetics Inc Sammensætninger og fremgangsmåder til hæmning af PDGFRBETA og VEGF-A
WO2009145820A2 (fr) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Génération de polymérases modifiées pour une précision améliorée dans le séquençage d'une seule molécule
EP3173424A1 (fr) 2008-05-02 2017-05-31 Novartis Ag Molécules de liaison améliorées à base de fibronectine et utilisations associées
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
JP6146949B2 (ja) 2008-06-20 2017-06-21 ノバルティス アーゲー 凝集が低減された免疫グロブリン
CN102159708B (zh) 2008-06-26 2016-08-31 Atyr医药公司 包含具有非常规生物活性的甘氨酰-tRNA合成酶的组合物和方法
KR101678925B1 (ko) * 2008-06-30 2016-11-24 에스바테크 - 어 노바티스 컴파니 엘엘씨 기능화 폴리펩티드
BRPI0915460A2 (pt) * 2008-07-10 2015-11-10 Esbatech Alcon Biomed Res Unit métodos e composições para a liberação intensificada de macromoléculas
WO2010009319A2 (fr) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
UA118536C2 (uk) 2008-07-23 2019-02-11 Амбркс, Інк. Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2010022171A1 (fr) * 2008-08-19 2010-02-25 Ferring International Center S.A. Agonistes du récepteur de pth peptidique
NZ607477A (en) 2008-09-26 2014-09-26 Ambrx Inc Non-natural amino acid replication-dependent microorganisms and vaccines
KR101647164B1 (ko) 2008-09-26 2016-08-09 암브룩스, 인코포레이티드 변형된 동물 에리트로포이에틴 폴리펩티드 및 이의 용도
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
CN102264697B (zh) 2008-10-24 2015-09-09 Irm责任有限公司 生物合成产生的吡咯啉-羧基-赖氨酸以及通过吡咯啉-羧基-赖氨酸和吡咯赖氨酸残基化学衍生化的位点特异性蛋白修饰
CA2745524C (fr) 2008-12-05 2020-06-09 Angiochem Inc. Conjugues de neurotensine ou d'analogues de neurotensine et leurs applications
CN102307905B (zh) 2008-12-10 2015-11-25 斯克利普斯研究院 利用化学反应性非天然氨基酸产生载体-肽偶联物
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
BRPI0922611A2 (pt) 2008-12-17 2018-11-06 Angiochem Inc inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
CA2747195A1 (fr) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Agents medicinaux lies par dipeptides
JP5789515B2 (ja) * 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン類似体
WO2010071807A1 (fr) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Promédicaments peptidiques de la superfamille du glucagon à base d'amide
WO2010096394A2 (fr) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Véhicules de médicaments à base de protéine marqués par aldéhyde et procédés d'utilisation
EP2403864B1 (fr) 2009-02-27 2015-08-12 Atyr Pharma, Inc. Motifs structuraux de polypeptides associés à une activité de signalisation cellulaire
WO2010120509A2 (fr) 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions et procédés impliquant des aspartyl-arnt synthétases présentant des activités biologiques non canoniques
CA2759129C (fr) 2009-04-20 2018-12-11 Angiochem Inc. Traitement d'un cancer de l'ovaire a l'aide d'un agent anticancereux conjugue a un analogue d'angiopep-2
AU2010247938B2 (en) 2009-05-11 2016-02-18 Pelican Technology Holdings, Inc. Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein
PL2896404T3 (pl) 2009-06-04 2017-12-29 Novartis Ag Sposoby identyfikacji miejsc koniugacji IgG
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
US20110054019A1 (en) * 2009-09-01 2011-03-03 Pedro Anastacio Serrano-Ojeda Cancer Starvation Therapy
US10292956B2 (en) 2009-09-01 2019-05-21 Serbig Pharmaceutics Corp. Cancer starvation therapy
EP2311947A1 (fr) * 2009-10-14 2011-04-20 Ludwig-Maximilians-Universität München Synthèse de protéines par chimie haute affinité
WO2011056497A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions de récepteur de l'activine de type iib et leurs méthodes d'utilisation
WO2011056502A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions du gene recepteur de proteine morphogenetique osseuse type ii et procedes d'utilisation
WO2011056494A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Combinaisons d'antagonistes de la kinase-1 du type récepteur de l'activine et d'antagonistes vegfr3
WO2011051327A2 (fr) 2009-10-30 2011-05-05 Novartis Ag Petites protéines à chaîne unique de type anticorps
WO2011051466A1 (fr) 2009-11-02 2011-05-05 Novartis Ag Molécules de liaison anti-idiotypiques à base de fibronectine et leurs utilisations
EP2496944A2 (fr) 2009-11-05 2012-09-12 Novartis AG Marqueurs biologiques prédictifs de l'évolution d'une fibrose
CN107674121A (zh) 2009-12-21 2018-02-09 Ambrx 公司 经过修饰的牛促生长素多肽和其用途
CN107056929A (zh) 2009-12-21 2017-08-18 Ambrx 公司 经过修饰的猪促生长素多肽和其用途
US9051593B2 (en) 2009-12-21 2015-06-09 Trustees Of Dartmouth College Recombinant prokaryotes and use thereof for production of O-glycosylated proteins
AU2011210840B2 (en) 2010-01-27 2014-12-11 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
WO2011092233A1 (fr) 2010-01-29 2011-08-04 Novartis Ag Conjugaison de levures pour produire des combinaisons de liants à base de fibronectine à haute affinité
IN2012DN06588A (fr) 2010-02-10 2015-10-23 Novartis Ag
US8674064B2 (en) * 2010-03-03 2014-03-18 Onkologix Ltd Immunogenic compositions against human progastrin peptides
US8464858B2 (en) 2010-03-12 2013-06-18 Cabin Creek Inc. Conveyor belt scraper and system for the same
US20130078660A1 (en) * 2010-03-23 2013-03-28 Salk Institute For Biological Studies Methods and compositions for detecting protein modifications
EP2563380B1 (fr) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps se rapportant à des fragments protéiques de la cystéinyl-arnt synthétase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
ES2638311T3 (es) 2010-04-27 2017-10-19 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CA2797393C (fr) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Decouverte innovatrice de compositions therapeutiques, diagnostiques, et d'anticorps associees aux fragments proteiques des valyle arnt synthesases
WO2011140132A2 (fr) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées à des fragments protéiques de phénylalanyl-alpha-arnt-synthétases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
WO2011139986A2 (fr) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à des fragments protéiques d'arginyle-arnt synthétases
US8946157B2 (en) 2010-05-03 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103096909A (zh) 2010-05-04 2013-05-08 Atyr医药公司 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ， インコーポレイテッド フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6027965B2 (ja) 2010-05-17 2016-11-16 エータイアー ファーマ， インコーポレイテッド ロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP5906237B2 (ja) 2010-06-01 2016-04-20 エータイアー ファーマ， インコーポレイテッド リジルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2584037B1 (fr) * 2010-06-16 2016-08-10 Riken Procédé de construction d'une bactérie recombinante pour la production d'une protéine non native, et son utilisation
CA2802485C (fr) 2010-06-16 2019-09-17 Indiana University Research And Technology Corporation Agonistes de l'insuline a une seule chaine tres actifs au niveau du recepteur a l'insuline
KR20130102470A (ko) 2010-06-24 2013-09-17 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 아미드계 글루카곤 슈퍼패밀리 펩티드 프로드러그
US8946147B2 (en) 2010-06-24 2015-02-03 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
JP5991973B2 (ja) * 2010-07-12 2016-09-14 エータイアー ファーマ， インコーポレイテッド アスパルチルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
JP6116479B2 (ja) * 2010-07-12 2017-04-19 エータイアー ファーマ， インコーポレイテッド グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
AU2011289833C1 (en) * 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Histidyl-tRNA synthetases
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
MX346786B (es) 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
CA2808539C (fr) 2010-08-25 2021-05-25 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, diagnostiques et d'anticorps associees a des fragments proteiniques des tyrosyl-arnt synthetases
EP2640745B1 (fr) 2010-09-10 2018-11-07 MedImmune Limited Anticorps bivalents et bispécifiques dirigés contre il-6 et il-23
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AR083006A1 (es) 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
CA2812795C (fr) * 2010-10-06 2021-08-31 Atyr Pharma, Inc. Decouverte innovante de fragments de proteine de tryptophanyle arnt synthetases associes a des compositions therapeutiques, diagnostiques et d'anticorps
WO2012048249A1 (fr) 2010-10-07 2012-04-12 Yale University Incorporation site-spécifique de phosphosérine dans des protéines dans escherichia coli
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
JP6162606B2 (ja) 2011-01-14 2017-07-12 レッドウッド バイオサイエンス， インコーポレイテッド アルデヒド−タグ付き免疫グロブリンポリペプチド及びその使用方法
DK2670767T3 (en) 2011-02-03 2018-03-26 European Molecular Biology Laboratory Non-naturally occurring amino acids comprising a cyclooctynyl or transcyclooctynyl analog group and uses thereof
WO2012129347A1 (fr) 2011-03-21 2012-09-27 Biodesy, Llc Classification d'inhibiteurs de kinase à l'aide de techniques optiques non linéaires
WO2012131109A2 (fr) 2011-04-01 2012-10-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V. Peptides et compositions pharmaceutiques utilisés dans un traitement par voie nasale, destiné à des patients atteints d'anxiété et de troubles du sommeil
WO2012138941A1 (fr) 2011-04-05 2012-10-11 Longevity Biotech, Inc. Compositions comprenant des analogues du glucagon et leurs procédés de fabrication et d'utilisation
EA201391756A1 (ru) 2011-05-27 2014-05-30 Амбркс, Инк. Композиции, содержащие, способы, включающие, и применение производных доластатина, связанных с неприродными аминокислотами
MX345538B (es) 2011-05-27 2017-02-03 Ambrx Inc Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales.
WO2013009868A1 (fr) 2011-07-11 2013-01-17 Yale University Compositions et procédés de fabrication de polypeptides contenant de la sélénocystéine
US11788111B2 (en) 2011-07-11 2023-10-17 Yale University Compositions and methods for making selenocysteine containing polypeptides
US10240158B2 (en) 2011-07-11 2019-03-26 Yale University Compositions and methods for making selenocysteine containing polypeptides
US10876142B2 (en) 2011-07-11 2020-12-29 Yale University Compositions and methods for making selenocysteine containing polypeptides
CN102888387B (zh) * 2011-07-21 2015-03-18 中国科学院生物物理研究所 3-氯代酪氨酸翻译系统及其应用
CA2853829C (fr) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation et amelioration de la specificite de clivage des nucleases
CN102925427B (zh) * 2011-08-08 2014-01-22 中国科学院生物物理研究所 丙烯酰赖氨酸翻译系统及其应用
US9714419B2 (en) 2011-08-09 2017-07-25 Atyr Pharma, Inc. PEGylated tyrosyl-tRNA synthetase polypeptides
UY34347A (es) 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
WO2013068874A1 (fr) 2011-11-11 2013-05-16 Pfizer Inc. Conjugués anticorps-médicament
US9822353B2 (en) 2011-12-06 2017-11-21 Atyr Pharma, Inc. PEGylated aspartyl-tRNA synthetase polypeptides
WO2013086216A1 (fr) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Aspartyl-arnt synthétases améliorées
BR112014015156A2 (pt) 2011-12-20 2020-10-27 Indiana University Research And Technology Corporation análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira
EP3974563A1 (fr) 2011-12-28 2022-03-30 Chugai Seiyaku Kabushiki Kaisha Peptides cycliques
WO2013115926A2 (fr) 2011-12-29 2013-08-08 Atyr Pharma, Inc. Conjugués aspartyl-arnt synthétase-fc
US9395358B2 (en) 2012-02-05 2016-07-19 Biodesy, Inc. Methods for detecting allosteric modulators of protein
EP2814514B1 (fr) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-arnt synthétases pour le traitement de maladies auto-immunes et inflammatoires
EP3492101A3 (fr) 2012-05-10 2019-10-23 Massachusetts Institute Of Technology Agents de neutralisation de la grippe
US10800856B2 (en) 2012-06-07 2020-10-13 Ambrx, Inc. Prostate-specific membrane antigen antibody drug conjugates
DK2859017T3 (da) 2012-06-08 2019-05-13 Sutro Biopharma Inc Antistoffer omfattrende stedsspecifikke ikke-naturlige aminosyrerester, fremgangsmåder til fremstilling heraf og fremgangsmåder til anvendelse heraf
EP2861262B1 (fr) 2012-06-19 2018-11-28 Ambrx, Inc. Conjugués de médicament anticorps anti-cd70
US9732161B2 (en) 2012-06-26 2017-08-15 Sutro Biopharma, Inc. Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
CN103571804B (zh) * 2012-08-10 2015-08-12 中国科学院生物物理研究所 3-吡唑基酪氨酸翻译系统及其应用
WO2014031861A1 (fr) 2012-08-22 2014-02-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Toxine létale d'anthrax génétiquement modifiée pour administration ciblée
US8859735B2 (en) 2012-08-27 2014-10-14 Empire Technology Development Llc Gelatin alkyd peptides and uses thereof
ES2728864T3 (es) 2012-08-31 2019-10-29 Sutro Biopharma Inc Aminoácidos modificados que comprenden un grupo azido
KR102155389B1 (ko) 2012-09-24 2020-09-11 메디뮨 리미티드 세포주
WO2014052451A2 (fr) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Dimères analogues de l'insuline
CN102875733B (zh) * 2012-10-25 2014-06-11 西安科技大学 具有仿细胞外层膜结构的纳米颗粒及其制备方法
US20140120116A1 (en) 2012-10-26 2014-05-01 The Chinese University Of Hong Kong Treatment of cancer using smad3 inhibitor
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
ES2756330T3 (es) 2012-12-18 2020-04-27 Novartis Ag Polipéptidos de factor de crecimiento insulínico estabilizados
CA2936092A1 (fr) 2013-01-23 2014-07-31 The Board Of Trustees Of The Leland Stanford Junior University Polypeptide cƒur d'hepatite b stabilise
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9255255B2 (en) 2013-03-04 2016-02-09 The Board Of Trustees Of The Leland Stanford Junior University Synthesis of linear and branched polymers of polypeptides through direct conjugation
UY35368A (es) 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
KR20150131213A (ko) 2013-03-14 2015-11-24 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 인슐린-인크레틴 접합체들
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
DK3460054T3 (da) 2013-03-15 2021-01-18 Atyr Pharma Inc Histidyl-tRNA-syntetase-Fc-konjugater
WO2014145654A1 (fr) * 2013-03-15 2014-09-18 The Trustees Of The University Of Pennsylvania Procede de reticulation covalente specifique d'un site d'anticorps a des surfaces
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
EP2968469A4 (fr) 2013-03-15 2016-08-31 Longevity Biotech Inc Peptides comprenant des acides aminés non endogènes et procédés de fabrication et d'utilisation associés
WO2014146575A1 (fr) 2013-03-19 2014-09-25 Beijing Shenogen Pharma Group Ltd. Anticorps et procédés permettant de traiter des maladies associées aux récepteurs des œstrogènes
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR101568336B1 (ko) 2013-07-02 2015-11-12 서강대학교산학협력단 목적 단백질의 돌연변이체를 생성하는 세포, 상기 세포의 제조 방법, 및 상기 세포를 이용한 목적 단백질의 돌연변이체의 제조 방법
ES2658039T3 (es) 2013-07-10 2018-03-08 Sutro Biopharma, Inc. Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
WO2015009948A1 (fr) 2013-07-19 2015-01-22 Regents Of The University Of California Le facteur épidermique des globules gras du lait régule l'absorption des acides gras
PE20160991A1 (es) 2013-07-25 2016-10-15 Novartis Ag Bioconjugados de polipeptidos de apelina sintetica
CN105612172A (zh) 2013-07-25 2016-05-25 诺华股份有限公司 用于治疗心力衰竭的环状多肽
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US10011649B2 (en) 2013-08-26 2018-07-03 Arizona Board Of Regents On Behalf Of Arizona State University High affinity synbodies for influenza
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US20160220630A1 (en) 2013-10-10 2016-08-04 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
US9840493B2 (en) 2013-10-11 2017-12-12 Sutro Biopharma, Inc. Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
EP3057605A1 (fr) 2013-10-18 2016-08-24 Novartis AG Méthodes de traitement du diabete et de troubles associés
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
EP3094977B1 (fr) 2014-01-14 2018-08-22 European Molecular Biology Laboratory Réactions de cycloaddition multiples pour le marquage de molécules
US10501734B2 (en) 2014-02-06 2019-12-10 Yale University Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids
KR102246800B1 (ko) 2014-05-13 2021-04-30 바이오아트라, 인코퍼레이티드 조건부 활성 생체 단백질
EP3157942B1 (fr) 2014-06-23 2020-06-17 Novartis AG Modifications de protéines spécifiques à un site
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2016004024A1 (fr) 2014-07-02 2016-01-07 Sutro Biopharma, Inc. Escherichia coli auxotrophe ayant une forte capacité de croissance et procédés d'utilisation
EP3169776A4 (fr) 2014-07-14 2018-07-04 The Regents of The University of California Modulation transcriptionnelle par crispr/cas
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
AU2015311911B2 (en) 2014-09-03 2019-01-24 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
EP3206710B1 (fr) 2014-09-24 2020-05-06 Indiana University Research & Technology Corporation Conjugués d'insuline-incrétines
JP6701208B2 (ja) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化アミド系インスリンプロドラッグ
WO2016073079A2 (fr) 2014-09-26 2016-05-12 Yale University Compositions et procédés pour le confinement biologique de microorganismes
PL3412302T3 (pl) 2014-10-24 2021-11-02 Bristol-Myers Squibb Company Zmodyfikowane polipeptydy fgf-21 i ich zastosowania
EP4289483A3 (fr) 2014-12-04 2024-02-28 Celgene Corporation Conjugués de biomolécules
WO2016106286A1 (fr) 2014-12-23 2016-06-30 Biodesy, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
SE538541C2 (en) * 2015-01-19 2016-09-13 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
BR112017014194A2 (pt) 2015-01-23 2018-01-09 Novartis Ag conjugados de ácido graxo de apelina sintéticos com meia-vida melhorada
EP3250693B2 (fr) 2015-01-30 2023-12-20 The Regents of The University of California Livraison de protéines dans des cellules hématopoïétiques primaires
JP7020910B2 (ja) 2015-03-13 2022-02-16 中外製薬株式会社 改変アミノアシルｔＲＮＡ合成酵素およびその用途
US10483262B2 (en) * 2015-05-15 2019-11-19 Taiwan Semiconductor Manufacturing Co., Ltd. Dual nitride stressor for semiconductor device and method of manufacturing
WO2016199801A1 (fr) * 2015-06-09 2016-12-15 国立研究開発法人産業技術総合研究所 Acide nucléique modifié par acide aminé et son utilisation
ES2826827T3 (es) 2015-06-15 2021-05-19 Angiochem Inc Métodos para el tratamiento de carcinomatosis leptomeníngea
US10813979B2 (en) 2015-07-10 2020-10-27 The Hong Kong University Of Science And Technology Methods and compositions for treating neurodegenerative and neuroinflammatory conditions
US10800826B2 (en) 2015-10-05 2020-10-13 Merck Sharp & Dohme Corp. Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
IL294014B2 (en) 2015-10-23 2024-07-01 Harvard College Nucleobase editors and their uses
EP3393494A1 (fr) 2015-12-22 2018-10-31 Novartis Ag Méthodes de traitement ou d'amélioration de troubles métaboliques à l'aide du facteur-15 de croissance et de différenciation (gdf-15)
MY197023A (en) 2015-12-23 2023-05-22 Amgen Inc Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
CN106929482A (zh) * 2015-12-31 2017-07-07 北京大学 定点突变的流感病毒、其活疫苗及其制备方法和应用
US10653744B2 (en) 2016-01-11 2020-05-19 Bausch Health Ireland Limited Formulations and methods for treating ulcerative colitis
WO2017132617A1 (fr) 2016-01-27 2017-08-03 Sutro Biopharma, Inc. Conjugués d'anticorps anti-cd74, compositions comprenant des conjugués d'anticorps anti-cd74 et méthodes d'utilisations desdits conjugués d'anticorps anti-cd74
WO2017189432A1 (fr) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Conjugués d'anticorps et méthodes de fabrication et d'utilisation de ceux-ci
EP3455628A4 (fr) 2016-05-09 2019-12-04 Biodesy, Inc. Méthodes et dispositifs de détection d'interactions de protéines membranaires périphériques à l'aide de techniques optiques non linéaires
EP3465204B1 (fr) 2016-05-25 2023-08-02 Kromnigon AB Procédé de préparation d'un échantillon biologique destiné à être utilisé dans un procédé d'immunomarquage
EP3471759A1 (fr) 2016-06-15 2019-04-24 Novartis AG Méthodes de traitement de maladie à l'aide d'inhibiteurs de la protéine morphogénétique osseuse 6 (bmp6)
IL308426A (en) 2016-08-03 2024-01-01 Harvard College Adenosine nuclear base editors and their uses
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
EP3309260A1 (fr) 2016-10-14 2018-04-18 European Molecular Biology Laboratory Synthétase trna pyrrolysine archéale pour utilisation orthogonale
SG11201903089RA (en) 2016-10-14 2019-05-30 Harvard College Aav delivery of nucleobase editors
US11339209B2 (en) 2016-11-14 2022-05-24 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
CN109963579A (zh) 2016-11-14 2019-07-02 诺华股份有限公司 用于治疗软骨损伤和关节炎的方法和组合物
MX2019007248A (es) 2016-12-19 2019-08-16 Quantum Si Inc Enzimas de polimerizacion para reacciones de secuenciacion.
WO2018119359A1 (fr) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Édition du gène récepteur ccr5 pour protéger contre l'infection par le vih
CN118662649A (zh) 2016-12-30 2024-09-20 Vaxcyte公司 具有非天然氨基酸的多肽-抗原缀合物
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
JOP20190177A1 (ar) 2017-01-17 2019-07-16 Amgen Inc طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
EP3592777A1 (fr) 2017-03-10 2020-01-15 President and Fellows of Harvard College Éditeur de base cytosine à guanine
JP7191388B2 (ja) 2017-03-23 2022-12-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸によってプログラム可能なｄｎａ結合蛋白質を含む核酸塩基編集因子
EP3381932A1 (fr) 2017-03-28 2018-10-03 Technische Universität Berlin Protéines moulières modifiées, leurs utilisations et composés apparentés
US11767520B2 (en) 2017-04-20 2023-09-26 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
PL3630977T3 (pl) 2017-06-02 2024-06-24 Ambrx, Inc. Sposoby i kompozycje promujące produkcję białek zawierających nienaturalne aminokwasy
JP7229158B2 (ja) 2017-06-09 2023-02-27 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
AU2018300069A1 (en) * 2017-07-11 2020-02-27 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
EP3658588A1 (fr) 2017-07-26 2020-06-03 Sutro Biopharma, Inc. Méthodes d'utilisation d'anticorps anti-cd74 et de conjugués d'anticorps dans le traitement d'un lymphome à cellules t
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
CA3071013A1 (fr) 2017-08-03 2019-02-07 Synthorx, Inc. Conjugues de cytokine destines au traitement de maladies proliferatives et infectieuses
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
CA3074839A1 (fr) 2017-09-07 2019-03-14 Cue Biopharma, Inc. Polypeptide multimere modulateur de lymphocyte t ayant des sites de conjugaison et procedes d'utilisation associes
JP7423513B2 (ja) 2017-09-18 2024-01-29 ストロ バイオファーマ インコーポレーテッド 抗葉酸受容体α抗体コンジュゲート及びその使用
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
EP3725796A4 (fr) 2017-12-15 2021-09-15 Chugai Seiyaku Kabushiki Kaisha Procédé de fabrication de peptide, et procédé de traitement de base
BR112020022288A2 (pt) 2018-05-01 2021-02-23 Ambrx, Inc. método para otimizar a expressão de anticorpos
WO2019237119A1 (fr) 2018-06-08 2019-12-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nouvelles compositions et procédés de détection d'une infection par onchocerca volvulus
WO2020051331A1 (fr) * 2018-09-07 2020-03-12 Medimmune, Llc Méthodes de sélection de cellules
PL3849614T3 (pl) 2018-09-11 2024-04-22 Ambrx, Inc. Koniugaty polipeptydu interleukiny-2 i ich zastosowania
US20220047716A1 (en) 2018-09-17 2022-02-17 Sutro Biopharma, Inc. Combination therapies with anti-folate receptor antibody conjugates
US20220009986A1 (en) 2018-10-19 2022-01-13 Ambrx, Inc. Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
WO2020097261A1 (fr) 2018-11-06 2020-05-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nouvelles compositions et nouveaux procédés de traitement de globinopathies
KR20210098476A (ko) 2018-11-30 2021-08-10 추가이 세이야쿠 가부시키가이샤 펩티드 화합물 또는 아마이드 화합물의 탈보호법 및 고상 반응에 있어서의 탈수지 방법, 및 펩티드 화합물의 제조 방법
BR112021014415A2 (pt) 2019-02-06 2021-09-21 Synthorx, Inc. Conjugados de il-2 e métodos de uso dos mesmos
MX2021009644A (es) 2019-02-12 2021-09-08 Ambrx Inc Composiciones que contienen, metodos y usos de conjugados de anticuerpo-agonista de tlr.
EP3696189A1 (fr) * 2019-02-14 2020-08-19 European Molecular Biology Laboratory Moyens et procédés de préparation de protéines cibles modifiées par dilatation de code génétique dans une protéine cible de manière sélective
WO2020180971A1 (fr) * 2019-03-04 2020-09-10 The Texas A&M University System Procédés de fabrication et d'utilisation de bibliothèques d'affichage de bactériophages à ambre imposé
JP7472101B2 (ja) 2019-03-15 2024-04-22 中外製薬株式会社 芳香族アミノ酸誘導体の製造方法
WO2020191243A1 (fr) 2019-03-19 2020-09-24 The Broad Institute, Inc. Procédés et compositions pour l'édition de séquences de nucléotides
US20220362394A1 (en) 2019-05-03 2022-11-17 Sutro Biopharma, Inc. Anti-bcma antibody conjugates
WO2020236907A1 (fr) * 2019-05-20 2020-11-26 Albert Einstein College Of Medicine Composés et procédés pour le traitement d'infections bactériennes
US20220233673A1 (en) 2019-06-04 2022-07-28 Institut Curie METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
JP2022536490A (ja) 2019-06-10 2022-08-17 ストロ バイオファーマ インコーポレーテッド ５Ｈ－ピロロ［３，２－ｄ］ピリミジン－２，４－ジアミノ化合物およびその抗体コンジュゲート
JP2022536800A (ja) 2019-06-17 2022-08-18 ストロ バイオファーマ インコーポレーテッド Ｔｏｌｌ様受容体（ｔｌｒ）７／８アゴニストとしての１－（４－（アミノメチル）ベンジル）－２－ブチル－２ｈ－ピラゾロ［３，４－ｃ］キノリン－４－アミン誘導体および関連化合物、ならびにがん療法および診断に使用するためのその抗体薬物コンジュゲート
KR20220029708A (ko) 2019-06-28 2022-03-08 퀀텀-에스아이 인코포레이티드 서열분석 반응을 위한 중합 효소
WO2021072129A2 (fr) 2019-10-08 2021-04-15 Trustees Of Boston College Protéines contenant de multiples acides aminés non naturels différents et procédés de fabrication et d'utilisation de telles protéines
TW202128996A (zh) * 2019-10-10 2021-08-01 美商史基普研究協會 用於活體內合成非天然多肽的組合物及方法
US11149280B2 (en) 2019-10-29 2021-10-19 Yale University Engineering organisms resistant to viruses and horizontally transferred genetic elements
WO2021092162A1 (fr) * 2019-11-05 2021-05-14 Aditya Kunjapur Biosynthèse de para-nitro-l-phénylalanine
CN115260313B (zh) 2019-12-31 2023-07-18 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
JP2023510195A (ja) 2020-01-03 2023-03-13 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 歯周の健康を促進するために局所投与されるｔｎａｐ
WO2021139744A1 (fr) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugués de protéines de fusion du glp-1 et du fgf21
EP4107258A4 (fr) * 2020-02-20 2024-04-17 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University Aminoacyl-arnt synthétases mutantes
EP3868882A1 (fr) 2020-02-21 2021-08-25 European Molecular Biology Laboratory Synthétases trna pyrrolysine archéale pour utilisation orthogonale
EP4114852A1 (fr) 2020-03-03 2023-01-11 Sutro Biopharma, Inc. Anticorps comprenant des étiquettes de glutamine spécifiques à un site, leurs procédés de préparation et d'utilisation
WO2021183832A1 (fr) 2020-03-11 2021-09-16 Ambrx, Inc. Conjugués polypeptidiques d'interleukine-2 et leurs procédés d'utilisation
CN111302975A (zh) * 2020-03-30 2020-06-19 滨海吉尔多肽有限公司 一种n-叔丁氧羰基-o-烯丙基-l-酪氨酸的制备方法
CR20220530A (es) 2020-04-22 2022-12-15 Merck Sharp & Dohme Llc CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 ß¿c Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO.
US20210340586A1 (en) 2020-04-30 2021-11-04 Sutro Biopharma, Inc. Methods of Producing Full-Length Antibodies Using E. coli
CN115551875A (zh) 2020-05-05 2022-12-30 基因泰克公司 用于酪氨酸酶介导的位点特异性蛋白质缀合的系统和方法
DE112021002672T5 (de) 2020-05-08 2023-04-13 President And Fellows Of Harvard College Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
WO2021234458A1 (fr) 2020-05-22 2021-11-25 Takeda Pharmaceutical Company Limited Compositions d'adamts13 et méthodes de traitement et de diagnostic de complications d'une maladie à coronavirus
US20230302150A1 (en) 2020-08-20 2023-09-28 Ambrx, Inc. Antibody-tlr agonist conjugates, methods and uses thereof
JP2023544254A (ja) * 2020-09-14 2023-10-23 ストロ バイオファーマ， インコーポレイテッド 無細胞タンパク質合成系を用いた抗体の大規模産生方法
CA3193453A1 (fr) 2020-09-30 2022-04-07 Beijing Ql Biopharmaceutical Co., Ltd. Conjugues polypeptidiques et leurs procedes d'utilisation
WO2022212899A1 (fr) 2021-04-03 2022-10-06 Ambrx, Inc. Conjugués anticorps-médicament anti-her2 et leurs utilisations
US20230016731A1 (en) * 2021-05-21 2023-01-19 The Regents Of The University Of California Affinity purification sequencing
US20230181754A1 (en) 2021-07-09 2023-06-15 Bright Peak Therapeutics Ag Modified checkpoint inhibitors and uses thereof
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
US20240158537A1 (en) 2021-07-09 2024-05-16 Bright Peak Therapeutics Ag Synthetic il-7 and il-7 immunocytokines
CA3222357A1 (fr) 2021-07-09 2023-01-12 Bertolt Kreft Polypeptides il-2 modifies pour le traitement de maladies inflammatoires et auto-immunes
AU2022306145A1 (en) 2021-07-09 2024-02-01 Bright Peak Therapeutics Ag Antibody conjugates and manufacture thereof
WO2023031445A2 (fr) 2021-09-06 2023-03-09 Veraxa Biotech Gmbh Nouveaux variants d'aminoacyl-arnt synthétase pour l'expansion de code génétique dans des eucaryotes
AU2022348582A1 (en) * 2021-09-17 2024-04-11 Absci Corporation Composition of transfer rnas and use in production of proteins containing non-standard amino acids
WO2023069816A2 (fr) 2021-09-20 2023-04-27 The Broad Institute, Inc. Compositions et méthodes de décodage multiplex de codons quadruplets
EP4419545A2 (fr) 2021-10-20 2024-08-28 Synthekine, Inc. Cytokines fc hétérodimères et leurs utilisations
WO2023081167A2 (fr) 2021-11-02 2023-05-11 The Regents Of The University Of California Mutants de p-sélectine et modulation de signalisation médiée par intégrine
AU2022395626A1 (en) 2021-11-25 2024-05-30 Veraxa Biotech Gmbh Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
EP4186529A1 (fr) 2021-11-25 2023-05-31 Veraxa Biotech GmbH Conjugués anticorps-charge utile améliorés (apcs) préparés par conjugaison spécifique à un site à l'aide d'une expansion de code génétique
CA3239713A1 (fr) 2021-12-08 2023-06-15 Edward A. LEMKE Charges utiles hydrophiles fonctionnalisees a la tetrazine destinees a la preparation de conjugues de ciblage
WO2023146807A1 (fr) 2022-01-25 2023-08-03 The Regents Of The University Of California Mutants de vegf et modulation de signalisation médiée par intégrine
AU2023226512A1 (en) 2022-02-23 2024-08-29 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof
US20240132563A1 (en) 2022-02-23 2024-04-25 Bright Peak Therapeutics Ag Bifunctional cytokine compositions
US20240058465A1 (en) 2022-06-30 2024-02-22 Sutro Biopharma, Inc. Anti-ror1 antibody conjugates, compositions comprising anti ror1 antibody conjugates, and methods of making and using anti-ror1 antibody conjugates
NL2033185B1 (en) 2022-09-29 2024-04-08 Stichting Vu Compounds for rna stabilisation and delivery
WO2024077277A1 (fr) 2022-10-07 2024-04-11 Ambrx, Inc. Lieurs de médicaments et conjugués d'anticorps associés
WO2024091824A1 (fr) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Différenciation et reprogrammation de chondrocyte
WO2024141087A1 (fr) * 2022-12-31 2024-07-04 康码（上海）生物科技有限公司 Système in-vitro de synthèse protéique acellulaire pour l'insertion d'un acide aminé non naturel, ainsi que son procédé et son utilisation
WO2024150175A1 (fr) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Protéines activées de manière conditionnelle et procédés d'utilisation
WO2024155627A1 (fr) 2023-01-16 2024-07-25 Ambrx, Inc. Conjugués anticorps-médicament anti-cd70
WO2024178310A1 (fr) 2023-02-23 2024-08-29 Ambrx, Inc. Conjugués anticorps-médicament dirigés contre trop2 et utilisations associées
WO2024211306A1 (fr) 2023-04-03 2024-10-10 Sutro Biopharma, Inc. Souches de rf1 ko e. coli

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652145A5 (de) 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4634666A (en) 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
US5001065A (en) 1987-05-27 1991-03-19 Cetus Corporation Human cell line and triomas, antibodies, and transformants derived therefrom
DE9115660U1 (de) * 1991-12-18 1992-07-30 Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen
KR19990008000A (ko) 1995-04-24 1999-01-25 로버트 에스. 화이트 헤드 새로운 대사 경로를 만들고 이를 스크리닝하는 방법
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5756316A (en) 1995-11-02 1998-05-26 Genencor International, Inc. Molecular cloning by multimerization of plasmids
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US5783431A (en) 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
AU2002303431C1 (en) 2001-04-19 2008-03-06 The Regents Of The University Of California Methods and composition for the production of orthoganal tRNA-aminoacyltRNA synthetase pairs
DE10151556A1 (de) * 2001-10-23 2003-04-30 Bosch Gmbh Robert Vorrichtung zum Öffnen und Schließen eines beweglichen Teils
ITTO20020441A1 (it) * 2002-05-24 2003-11-24 Telecom Italia Lab Spa Metodo per determinare l'installazione di costo minimo per le apparecchiature di una rete fissa di telecomunicazione.
ATE429500T1 (de) * 2002-10-16 2009-05-15 Scripps Research Inst Stellenspezifischer einbau von ketoaminosäuren in proteine
ES2333422T3 (es) 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
EP1583816A4 (fr) 2002-12-22 2007-06-13 Scripps Research Inst Reseaux de proteines
CA2520750A1 (fr) 2003-04-17 2004-11-04 The Scripps Research Institute Extension du code genetique eucaryote
EP2410331B1 (fr) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-ARNt synthétase d'tARN aminoacylation avec acides aminés non naturels
EP1704242A4 (fr) 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS DE PAIRES ORTHOGONALES DE LEUCYL-tRNA ET AMINOACYL-tRNA-SYNTHETASE ET LEURS UTILISATIONS
US7527943B2 (en) 2003-07-07 2009-05-05 The Scripps Research Institute Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
ES2301099T3 (es) 2003-07-07 2008-06-16 The Scripps Research Institute Composiciones de parejas ortogonales lisil-arnt y aminoacil-arnt sintetasa y usos de las mismas.
JP5657850B2 (ja) 2003-10-14 2015-01-21 ザ スクリプス リサーチ インスティテュート 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ
MXPA06006868A (es) 2003-12-18 2007-03-21 Scripps Research Inst Incorporacion selectiva de 5-hiroxitriptofano en proteinas de celulas de mamiferos.
US7399619B2 (en) 2004-05-25 2008-07-15 The Scripps Research Institute Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
ES2519444T3 (es) 2004-09-21 2014-11-07 The Scripps Research Institute Incorporación in vivo de alquinil aminoácidos a proteínas en eubacterias
US20090181858A1 (en) 2004-09-21 2009-07-16 The Scripps Research Institute Adding photoregulated amino acids to the genetic code
US20060110784A1 (en) 2004-09-22 2006-05-25 The Scripps Research Institute Site-specific labeling of proteins for NMR studies
EP1809758A4 (fr) 2004-10-20 2009-04-01 Scripps Research Inst Introduction<i>in vivo</i>specifique au site d'acides amines n-acetyl-galactosamine chez les eubacteries
CN101048506B (zh) 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
FR2888097B1 (fr) * 2005-07-06 2007-10-05 Oreal Dispositif de conditionnement et d'application comportant un organe d'essorage
BRPI0617191A2 (pt) 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
PL1991680T3 (pl) 2006-03-09 2014-01-31 Scripps Research Inst Układ do ekspresji ortogonalnych składników translacji w eubakteryjnych komórkach gospodarza
US7790847B2 (en) 2006-03-16 2010-09-07 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
KR20090024706A (ko) 2006-05-23 2009-03-09 더 스크립스 리서치 인스티튜트 유전자적으로 코딩된 형광 쿠마린 아미노산
US7421795B2 (en) * 2006-08-04 2008-09-09 Seagate Technology Llc Sapphire alignment fixture
BRPI0716963A2 (pt) 2006-09-21 2013-11-05 Scripps Research Inst Expressão geneticamente programada de proteínas seletivamente sulfatadas em eubactéria
AU2007333010A1 (en) 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
TWI334126B (en) * 2007-07-17 2010-12-01 Au Optronics Corp Voltage adjusting circuit, method, and display apparatus having the same
JP4978419B2 (ja) * 2007-10-23 2012-07-18 富士ゼロックス株式会社 光送受信モジュール
RU2010116872A (ru) 2007-10-25 2011-11-27 Зе Скрипс Ресеч Инститьют (Us) Генетическое включение 3-аминотирозина в редуктазы
US20090148887A1 (en) 2007-11-02 2009-06-11 The Scripps Research Institute Genetically encoded boronate amino acid
JP5513398B2 (ja) 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
WO2009064416A2 (fr) 2007-11-15 2009-05-22 The Scripps Research Institute Incorporation génétique d'un acide alpha-hydroxy dans des protéines pour générer des liaisons de squelette ester à des sites définis
US8218509B2 (en) * 2008-01-15 2012-07-10 Apple Inc. Dynamic allocation of communication resources in a wireless system
EP2249865A4 (fr) 2008-02-08 2012-04-04 Scripps Research Inst Rupture de la tolérance immunologique avec un acide aminé non naturel génétiquement codé
WO2009151491A2 (fr) 2008-02-27 2009-12-17 The Scripps Research Institute Incorporation in vivo d'un acide aminé non naturel comprenant un groupe 1,2-aminothiol
US20090197339A1 (en) 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
CN102307905B (zh) 2008-12-10 2015-11-25 斯克利普斯研究院 利用化学反应性非天然氨基酸产生载体-肽偶联物
WO2010114615A2 (fr) 2009-04-03 2010-10-07 The Scripps Research Institute Système pratique d'encodage d'acides aminés non naturels dans des cellules de mammifères

Also Published As

Publication number Publication date
JP2009077731A (ja) 2009-04-16
AU2002256292B2 (en) 2007-12-06
DK1456360T3 (en) 2015-08-31
US20120101006A1 (en) 2012-04-26
EP1490483B1 (fr) 2015-06-03
EP2322631B1 (fr) 2014-11-12
US20110027867A1 (en) 2011-02-03
IL158418A0 (en) 2004-05-12
EP1456360A2 (fr) 2004-09-15
IL187588A (en) 2011-11-30
IL196714A (en) 2013-10-31
US8173392B2 (en) 2012-05-08
IL196762A (en) 2015-03-31
US20090053791A1 (en) 2009-02-26
JP2009132704A (ja) 2009-06-18
US20080261311A1 (en) 2008-10-23
EP2128246B1 (fr) 2014-03-12
JP2005502322A (ja) 2005-01-27
AU2002303431B2 (en) 2007-10-04
CA2444098C (fr) 2016-06-21
US20080227152A1 (en) 2008-09-18
US7083970B2 (en) 2006-08-01
US20060233744A1 (en) 2006-10-19
US20050250183A1 (en) 2005-11-10
US20060234367A1 (en) 2006-10-19
US8114648B2 (en) 2012-02-14
US20060063244A1 (en) 2006-03-23
IL196714A0 (en) 2009-11-18
US9163271B2 (en) 2015-10-20
US8173364B2 (en) 2012-05-08
US7045337B2 (en) 2006-05-16
CA2444098A1 (fr) 2002-10-31
HK1065065A1 (en) 2005-02-08
US7713721B2 (en) 2010-05-11
MXPA03009566A (es) 2004-12-06
US7638300B2 (en) 2009-12-29
WO2002086075A2 (fr) 2002-10-31
JP2011030571A (ja) 2011-02-17
JP6294368B2 (ja) 2018-03-14
US20120202243A1 (en) 2012-08-09
US7368275B2 (en) 2008-05-06
JP2013255502A (ja) 2013-12-26
WO2002085923A2 (fr) 2002-10-31
DK2128246T3 (da) 2014-05-12
EP2796546A1 (fr) 2014-10-29
AU2002303431C1 (en) 2008-03-06
EP1490483A4 (fr) 2007-02-07
US8030074B2 (en) 2011-10-04
DK1490483T3 (en) 2015-09-07
US20130309720A1 (en) 2013-11-21
US20080166783A1 (en) 2008-07-10
US20030082575A1 (en) 2003-05-01
IL196762A0 (en) 2011-07-31
JP5766925B2 (ja) 2015-08-19
MXPA03009563A (es) 2004-12-06
EP2796546B1 (fr) 2017-08-09
EP2128246A1 (fr) 2009-12-02
US8183012B2 (en) 2012-05-22
US20050208536A1 (en) 2005-09-22
US20080167243A1 (en) 2008-07-10
US20030108885A1 (en) 2003-06-12
JP2016112021A (ja) 2016-06-23
EP1456360A4 (fr) 2005-05-25
US8012739B2 (en) 2011-09-06
EP1490483A2 (fr) 2004-12-29
HK1158259A1 (en) 2012-07-13
IL187775A0 (en) 2011-08-01
EP2322631A1 (fr) 2011-05-18
US20090227002A1 (en) 2009-09-10
JP6239888B2 (ja) 2017-11-29
HK1069848A1 (en) 2005-06-03
WO2002086075A3 (fr) 2004-06-24
IL158419A (en) 2013-05-30
CA2443757A1 (fr) 2002-10-31
EP1456360B1 (fr) 2015-06-03
DK2322631T3 (en) 2015-01-12
CA2443757C (fr) 2016-09-27
US7354761B2 (en) 2008-04-08
US20090068717A1 (en) 2009-03-12
HK1203558A1 (en) 2015-10-30
ES2464532T3 (es) 2014-06-03
US7915025B2 (en) 2011-03-29
JP2004537984A (ja) 2004-12-24
WO2002085923A3 (fr) 2004-05-27
US20070117184A1 (en) 2007-05-24
AU2002256292C1 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
IL158419A0 (en) Methods and composition for the production of orthoganal trna-aminoacyl trna synthetase pairs
ZA200407942B (en) Methods of including terminal differentiation
AU2002364528A8 (en) Bio-implant and method of making the same
PL375691A1 (en) Imidazolopyridines and methods of making and using the same
IL164851A0 (en) Process for the preparation of 7-substituted-3-quinoline and 3-quinol-4-one carbonitriles
EP1596656A4 (fr) Pyrazoles et leurs methodes de fabrication et d&#39;utilisation
AU2002368052A1 (en) Nano-composite electrodes and method of making the same
EP1411748A4 (fr) Haut-parleur et son procede de fabrication
HK1098737A1 (en) Process for the preparation of 1,1,1,3,3-pentafluoro-2-chloropropene and 1,1,1,3,3,3-hexafluoro-2-chloropropane
AU2003301066A8 (en) Al2o3-la2o3-y2o3-mgo ceramics, and methods of making the same
PL369221A1 (en) Method and apparatus for the production of metal powder
AU2003303926A8 (en) Ceramics and methods of making the same
PL364600A1 (en) Method for the production of hydrogen and applications thereof
GB0113788D0 (en) Furnace and process
GB0126643D0 (en) Composition and process
GB0123961D0 (en) Process and intermediates
AU2002219713A1 (en) Process and apparatus for the production of ammonia
GB2371731B (en) Method of alignment
GB0306479D0 (en) Lasers and methods of making them
AU7400401A (en) Method for the production of 2- coumarone and substituted 2-coumarones
EP1399012A4 (fr) Compositions et procedes de production de lipides de la betaine
AU2002361654A1 (en) Mbcats as modifiers of the beta-catenin pathway and methods of use
AU2002355897B2 (en) Casting installation that is intended, in particular, for the production of electrodes and the method used in one such installation
AU2002325450A1 (en) Method in the manufacture of steel
AU2002355897A1 (en) Casting installation that is intended, in particular, for the production of electrodes and the method used in one such installation