IL147163A - Dinucleotide crystals - Google Patents

Dinucleotide crystals

Info

Publication number
IL147163A
IL147163A IL14716300A IL14716300A IL147163A IL 147163 A IL147163 A IL 147163A IL 14716300 A IL14716300 A IL 14716300A IL 14716300 A IL14716300 A IL 14716300A IL 147163 A IL147163 A IL 147163A
Authority
IL
Israel
Prior art keywords
dcp4u
present
crystals
monophosphate
raw material
Prior art date
Application number
IL14716300A
Other languages
English (en)
Other versions
IL147163A0 (en
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of IL147163A0 publication Critical patent/IL147163A0/xx
Publication of IL147163A publication Critical patent/IL147163A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14716300A 1999-06-30 2000-06-30 Dinucleotide crystals IL147163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18495099 1999-06-30
PCT/JP2000/004336 WO2001002416A1 (fr) 1999-06-30 2000-06-30 Cristaux dinucleotidiques

Publications (2)

Publication Number Publication Date
IL147163A0 IL147163A0 (en) 2002-08-14
IL147163A true IL147163A (en) 2005-11-20

Family

ID=16162200

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14716300A IL147163A (en) 1999-06-30 2000-06-30 Dinucleotide crystals

Country Status (22)

Country Link
US (1) US6617444B1 (pl)
EP (2) EP1191032B1 (pl)
JP (1) JP3421666B2 (pl)
KR (1) KR100593723B1 (pl)
CN (1) CN1144811C (pl)
AT (2) ATE300551T1 (pl)
AU (1) AU767136B2 (pl)
BR (1) BR0012205A (pl)
CA (1) CA2376860C (pl)
CZ (1) CZ303172B6 (pl)
DE (2) DE60006814T2 (pl)
EA (1) EA004707B1 (pl)
ES (2) ES2211566T3 (pl)
HU (1) HU229225B1 (pl)
IL (1) IL147163A (pl)
MX (1) MXPA02000035A (pl)
NO (1) NO321169B1 (pl)
NZ (1) NZ516301A (pl)
PL (2) PL202200B1 (pl)
SK (1) SK284178B6 (pl)
WO (1) WO2001002416A1 (pl)
ZA (1) ZA200110468B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US7078391B2 (en) 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US6548658B2 (en) * 1997-07-25 2003-04-15 Inspire Pharmaceuticals, Inc. Di-(uridine 5′)-tetraphosphate and salts thereof
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
SK284178B6 (sk) * 1999-06-30 2004-10-05 Yamasa Corporation Kryštalická forma P1-(2'-deoxycytidín-5'-)P4-(uridín-5'- )tetrafosfátu a spôsob ich prípravy
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7161029B2 (en) * 2003-12-17 2007-01-09 Ajinomoto Co., Inc. DiL-lysine monosulfate trihydrate crystal and method of making
CN100363376C (zh) * 2006-06-12 2008-01-23 南京工业大学 一种5’-核苷三磷酸钠盐的结晶方法
JPWO2017002827A1 (ja) * 2015-06-29 2018-04-26 ヤマサ醤油株式会社 Ｐ１，ｐ４−ビス（５’−ウリジル）テトラホスフェート結晶の保管方法
CN109843901B (zh) * 2016-10-25 2022-04-26 Yamasa 酱油株式会社 P1,p4-二(尿苷5’-)四磷酸的纯化方法
CN111253456B (zh) * 2020-03-13 2021-05-11 广东先强药业有限公司 一种地纽福索钠的制备方法
CN111704637A (zh) * 2020-06-28 2020-09-25 南京工业大学 一种采用膜蒸馏结晶精制核苷酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07242685A (ja) * 1994-01-12 1995-09-19 Unitika Ltd ジアデノシン四リン酸水和物の製造方法
US5837861A (en) * 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
CN1262556C (zh) * 1997-02-06 2006-07-05 印斯拜尔药品股份有限公司 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用
US6596725B2 (en) * 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
DK1012154T3 (da) * 1997-07-25 2004-07-26 Inspire Pharmaceuticals Inc Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf
WO1999061012A2 (en) * 1998-05-22 1999-12-02 Inspire Pharmaceuticals, Inc. Therapeutic dinucleotide and derivatives
SK283729B6 (sk) * 1998-10-02 2003-12-02 Yamasa Corporation Kryštály P1, P4-di(uridín-5')-tetrafosfátu alebo kryštály jeho soli, spôsob ich výroby, kryštály tetrasodnej soli P1, P4-di(uridín-5')-tetrafosfátu a kryštály jej hydrátov
WO2000039145A1 (en) * 1998-12-23 2000-07-06 The University Of North Carolina At Chapel Hill Targeted gene transfer using g protein coupled receptors
SK284178B6 (sk) * 1999-06-30 2004-10-05 Yamasa Corporation Kryštalická forma P1-(2'-deoxycytidín-5'-)P4-(uridín-5'- )tetrafosfátu a spôsob ich prípravy

Also Published As

Publication number Publication date
DE60006814T2 (de) 2004-05-19
EP1191032A4 (en) 2002-07-17
DE60021629T2 (de) 2006-01-05
CN1144811C (zh) 2004-04-07
PL202200B1 (pl) 2009-06-30
CN1359387A (zh) 2002-07-17
BR0012205A (pt) 2002-05-28
KR100593723B1 (ko) 2006-06-30
EP1362862A1 (en) 2003-11-19
EP1191032B1 (en) 2003-11-26
CZ20014502A3 (cs) 2002-05-15
ZA200110468B (en) 2003-04-04
EP1191032A1 (en) 2002-03-27
US6617444B1 (en) 2003-09-09
PL202176B1 (pl) 2009-06-30
ES2245431T3 (es) 2006-01-01
PL352363A1 (en) 2003-08-25
JP3421666B2 (ja) 2003-06-30
NO20016381D0 (no) 2001-12-27
AU767136B2 (en) 2003-10-30
CA2376860A1 (en) 2001-01-11
AU5706700A (en) 2001-01-22
IL147163A0 (en) 2002-08-14
ATE255123T1 (de) 2003-12-15
NO321169B1 (no) 2006-03-27
DE60021629D1 (de) 2005-09-01
HUP0201531A3 (en) 2005-02-28
CA2376860C (en) 2006-11-07
HUP0201531A2 (en) 2002-08-28
EP1362862B1 (en) 2005-07-27
HU229225B1 (en) 2013-09-30
SK18702001A3 (sk) 2002-06-04
NZ516301A (en) 2003-07-25
WO2001002416A1 (fr) 2001-01-11
EA200200109A1 (ru) 2002-06-27
ATE300551T1 (de) 2005-08-15
NO20016381L (no) 2002-02-28
ES2211566T3 (es) 2004-07-16
CZ303172B6 (cs) 2012-05-09
MXPA02000035A (es) 2003-07-21
KR20020028903A (ko) 2002-04-17
DE60006814D1 (de) 2004-01-08
EA004707B1 (ru) 2004-06-24
SK284178B6 (sk) 2004-10-05

Similar Documents

Publication Publication Date Title
IL147163A (en) Dinucleotide crystals
HUP9900808A2 (hu) Eljárás nukleozid-5'-foszfát-észterek előállítására
NO20011634D0 (no) Krystall av diuridintetrafosfat eller salter derav, og fremgangsmåte for fremstilling av samme og fremgangsmåte for fremstilling av nevnte forbindelse
SG63554A1 (en) 5-methyluridine process for large scale preparation of 2 ,3- didehydro-3' deoxythymidine (d4t)
AU2660988A (en) A process for the production of solid or paste-form products
CA2135853A1 (en) Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
RU95108553A (ru) Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктов
EP1460065A4 (en) METHOD FOR THE PRODUCTION OF CYCLIC DIAMINO COMPOUNDS BZW. THE SALTS
KR100243440B1 (ko) 세코-누클레오시드의 리포누클레오티드, 이들의 제조방법 및 항바이러스제로서 이들을 사용하는 방법
SE9103609L (sv) Foerfarande foer framstaellning av alkalimetallfosfat
EP0590539A3 (en) Tetrathiafulvalene derivative precursors, tetrathiafulvalene derivatives, and processes for producing them
EP1179598A4 (en) PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND
JPH08837B2 (ja) サイクリツクａｍｐ誘導体
JPS565458A (en) Preparation of 1-ethyl-2- 2-methoxy-5- sulfamoylbenzamidemethyl pyrrolidine
RU95103392A (ru) Способ получения 1-гидроксиадамантана
JPS5692238A (en) Separation and recovery of hydroquinone derivative
SU1529695A1 (ru) Способ получения 2-фенокси-5,7-диметил-2,6-диоксо-1,3-диаза-2-фосфаадамантана
RO113859B1 (ro) Procedeu pentru prepararea diclorurii bis(2-cloretil) amidofosforice
JPS6490161A (en) Production of optically active cyanohydrin or its enantiomer
JPS55122790A (en) Preparation of 9-phosphabicyclononane
CA2024796A1 (en) Process for producing chlorosulfonyl isocyanate
JPS6414199A (en) Production of high purity beta-form silicon nitride whisker
JPH0667940B2 (ja) ２’，３’‐ジデオキシプリンヌクレオシド類の製造方法
TH36855A (th) กระบวนการสำหรับการเตรียมกรดแอล-แอสคอร์บิก

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees