DE60021629D1 - Dinukleotid-Kristalle - Google Patents
Dinukleotid-KristalleInfo
- Publication number
- DE60021629D1 DE60021629D1 DE60021629T DE60021629T DE60021629D1 DE 60021629 D1 DE60021629 D1 DE 60021629D1 DE 60021629 T DE60021629 T DE 60021629T DE 60021629 T DE60021629 T DE 60021629T DE 60021629 D1 DE60021629 D1 DE 60021629D1
- Authority
- DE
- Germany
- Prior art keywords
- dcp4u
- present
- crystals
- monophosphate
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18495099 | 1999-06-30 | ||
JP18495099 | 1999-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60021629D1 true DE60021629D1 (de) | 2005-09-01 |
DE60021629T2 DE60021629T2 (de) | 2006-01-05 |
Family
ID=16162200
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60021629T Expired - Lifetime DE60021629T2 (de) | 1999-06-30 | 2000-06-30 | Dinukleotid-Kristalle |
DE60006814T Expired - Lifetime DE60006814T2 (de) | 1999-06-30 | 2000-06-30 | Dinucleotid-kristalle |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60006814T Expired - Lifetime DE60006814T2 (de) | 1999-06-30 | 2000-06-30 | Dinucleotid-kristalle |
Country Status (22)
Country | Link |
---|---|
US (1) | US6617444B1 (de) |
EP (2) | EP1362862B1 (de) |
JP (1) | JP3421666B2 (de) |
KR (1) | KR100593723B1 (de) |
CN (1) | CN1144811C (de) |
AT (2) | ATE255123T1 (de) |
AU (1) | AU767136B2 (de) |
BR (1) | BR0012205A (de) |
CA (1) | CA2376860C (de) |
CZ (1) | CZ303172B6 (de) |
DE (2) | DE60021629T2 (de) |
EA (1) | EA004707B1 (de) |
ES (2) | ES2211566T3 (de) |
HU (1) | HU229225B1 (de) |
IL (1) | IL147163A (de) |
MX (1) | MXPA02000035A (de) |
NO (1) | NO321169B1 (de) |
NZ (1) | NZ516301A (de) |
PL (2) | PL202176B1 (de) |
SK (1) | SK284178B6 (de) |
WO (1) | WO2001002416A1 (de) |
ZA (1) | ZA200110468B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
US6818629B2 (en) | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
CZ303172B6 (cs) * | 1999-06-30 | 2012-05-09 | Inspire Pharmaceuticals, Inc. | Krystalická forma P1-(2'-deoxycytidin-5'-)P4-(uridin-5'-)tetrafosfátu |
US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
US7161029B2 (en) * | 2003-12-17 | 2007-01-09 | Ajinomoto Co., Inc. | DiL-lysine monosulfate trihydrate crystal and method of making |
CN100363376C (zh) * | 2006-06-12 | 2008-01-23 | 南京工业大学 | 一种5’-核苷三磷酸钠盐的结晶方法 |
WO2017002827A1 (ja) | 2015-06-29 | 2017-01-05 | ヤマサ醤油株式会社 | P1,p4-ビス(5'-ウリジル)テトラホスフェート結晶の保管方法 |
EP3546472B1 (de) * | 2016-10-25 | 2021-06-16 | Yamasa Corporation | Verfahren zur reinigung von p1,p4-di(uridin 5'-)tetraphosphat |
CN111253456B (zh) * | 2020-03-13 | 2021-05-11 | 广东先强药业有限公司 | 一种地纽福索钠的制备方法 |
CN111704637A (zh) * | 2020-06-28 | 2020-09-25 | 南京工业大学 | 一种采用膜蒸馏结晶精制核苷酸的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07242685A (ja) * | 1994-01-12 | 1995-09-19 | Unitika Ltd | ジアデノシン四リン酸水和物の製造方法 |
US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
DK0981534T3 (da) * | 1997-02-06 | 2006-09-04 | Inspire Pharmaceuticals Inc | Dinukleotider og deres anvendelser |
US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
TW593331B (en) * | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
JP3723227B2 (ja) * | 1997-07-25 | 2005-12-07 | インスパイアー ファーマシューティカルズ,インコーポレイティド | ジ(ウリジン5’)−テトラホスフェート及びその塩の大規模生産のための方法 |
EP1087777B1 (de) * | 1998-05-22 | 2003-02-19 | Inspire Pharmaceuticals, Inc. | Therapeutische dinucleotide und deren derivate |
US6458946B1 (en) * | 1998-10-02 | 2002-10-01 | Yamasa Corporation | Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds |
WO2000039145A1 (en) * | 1998-12-23 | 2000-07-06 | The University Of North Carolina At Chapel Hill | Targeted gene transfer using g protein coupled receptors |
CZ303172B6 (cs) * | 1999-06-30 | 2012-05-09 | Inspire Pharmaceuticals, Inc. | Krystalická forma P1-(2'-deoxycytidin-5'-)P4-(uridin-5'-)tetrafosfátu |
-
2000
- 2000-06-30 CZ CZ20014502A patent/CZ303172B6/cs not_active IP Right Cessation
- 2000-06-30 AU AU57067/00A patent/AU767136B2/en not_active Ceased
- 2000-06-30 ES ES00942412T patent/ES2211566T3/es not_active Expired - Lifetime
- 2000-06-30 HU HU0201531A patent/HU229225B1/hu not_active IP Right Cessation
- 2000-06-30 DE DE60021629T patent/DE60021629T2/de not_active Expired - Lifetime
- 2000-06-30 DE DE60006814T patent/DE60006814T2/de not_active Expired - Lifetime
- 2000-06-30 IL IL14716300A patent/IL147163A/xx not_active IP Right Cessation
- 2000-06-30 CN CNB008097356A patent/CN1144811C/zh not_active Expired - Fee Related
- 2000-06-30 SK SK1870-2001A patent/SK284178B6/sk not_active IP Right Cessation
- 2000-06-30 CA CA002376860A patent/CA2376860C/en not_active Expired - Fee Related
- 2000-06-30 BR BR0012205-0A patent/BR0012205A/pt not_active Application Discontinuation
- 2000-06-30 EP EP03018399A patent/EP1362862B1/de not_active Expired - Lifetime
- 2000-06-30 EP EP00942412A patent/EP1191032B1/de not_active Expired - Lifetime
- 2000-06-30 WO PCT/JP2000/004336 patent/WO2001002416A1/ja not_active Application Discontinuation
- 2000-06-30 ES ES03018399T patent/ES2245431T3/es not_active Expired - Lifetime
- 2000-06-30 NZ NZ516301A patent/NZ516301A/en not_active IP Right Cessation
- 2000-06-30 AT AT00942412T patent/ATE255123T1/de not_active IP Right Cessation
- 2000-06-30 MX MXPA02000035A patent/MXPA02000035A/es active IP Right Grant
- 2000-06-30 PL PL384307A patent/PL202176B1/pl unknown
- 2000-06-30 KR KR1020017016184A patent/KR100593723B1/ko not_active IP Right Cessation
- 2000-06-30 AT AT03018399T patent/ATE300551T1/de not_active IP Right Cessation
- 2000-06-30 PL PL352363A patent/PL202200B1/pl unknown
- 2000-06-30 EA EA200200109A patent/EA004707B1/ru not_active IP Right Cessation
- 2000-06-30 US US09/700,728 patent/US6617444B1/en not_active Expired - Lifetime
- 2000-06-30 JP JP2001507852A patent/JP3421666B2/ja not_active Expired - Fee Related
-
2001
- 2001-12-20 ZA ZA200110468A patent/ZA200110468B/en unknown
- 2001-12-27 NO NO20016381A patent/NO321169B1/no not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R081 | Change of applicant/patentee |
Ref document number: 1362862 Country of ref document: EP Owner name: INSPIRE PHARMACEUTICALS, INC., US Free format text: FORMER OWNER: YAMASA CORP., CHOSHI, JP Effective date: 20110630 |
|
R082 | Change of representative |
Ref document number: 1362862 Country of ref document: EP Representative=s name: WAECHTERSHAEUSER UND KOLLEGEN, 80333 MUENCHEN, DE |