EA200200109A1 - Кристаллы динуклеотида - Google Patents

Кристаллы динуклеотида

Info

Publication number
EA200200109A1
EA200200109A1 EA200200109A EA200200109A EA200200109A1 EA 200200109 A1 EA200200109 A1 EA 200200109A1 EA 200200109 A EA200200109 A EA 200200109A EA 200200109 A EA200200109 A EA 200200109A EA 200200109 A1 EA200200109 A1 EA 200200109A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dcp4u
crystals
present
deoxycytidine
uridine
Prior art date
Application number
EA200200109A
Other languages
English (en)
Other versions
EA004707B1 (ru
Inventor
Кенйа Мори
Таканори Миясита
Хидеаки Маеда
Хироси Сато
Ютака Нода
Original Assignee
Ямаса Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ямаса Корпорейшн filed Critical Ямаса Корпорейшн
Publication of EA200200109A1 publication Critical patent/EA200200109A1/ru
Publication of EA004707B1 publication Critical patent/EA004707B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к кристаллам P-(2'-дезоксицитидин 5'-)Р-(уридин 5'-) тетрафосфата (dCP4U) или его солей и к способу получения кристаллов. Настоящее изобретение предоставляет также способ получения dCP4U, включающий реакцию уридин 5'-монофосфата (UMP), 2'-дезоксицитидин 5'-монофосфата (dCMP), дифенилфосфохлоридата (DPC) и пирофосфата (PPi). Кристаллы dCP4U по способу настоящего изобретения имеют высокую чистоту и высокую стабильность, а также не гигроскопичны по сравнению с продуктом, высушенным вымораживанием, и поэтому служат в качестве полезного сырьевого материала для получения лекарств. Способ получения dCP4U в соответствии с настоящим изобретением позволяет использовать в качестве сырьевого материала недорогой UMP и обеспечивает высокий выход. Таким образом, процесс является подходящим для крупномасштабного синтеза dCP4U.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200109A 1999-06-30 2000-06-30 Кристаллы динуклеотида EA004707B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18495099 1999-06-30
PCT/JP2000/004336 WO2001002416A1 (fr) 1999-06-30 2000-06-30 Cristaux dinucleotidiques

Publications (2)

Publication Number Publication Date
EA200200109A1 true EA200200109A1 (ru) 2002-06-27
EA004707B1 EA004707B1 (ru) 2004-06-24

Family

ID=16162200

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200109A EA004707B1 (ru) 1999-06-30 2000-06-30 Кристаллы динуклеотида

Country Status (22)

Country Link
US (1) US6617444B1 (ru)
EP (2) EP1191032B1 (ru)
JP (1) JP3421666B2 (ru)
KR (1) KR100593723B1 (ru)
CN (1) CN1144811C (ru)
AT (2) ATE300551T1 (ru)
AU (1) AU767136B2 (ru)
BR (1) BR0012205A (ru)
CA (1) CA2376860C (ru)
CZ (1) CZ303172B6 (ru)
DE (2) DE60006814T2 (ru)
EA (1) EA004707B1 (ru)
ES (2) ES2211566T3 (ru)
HU (1) HU229225B1 (ru)
IL (1) IL147163A (ru)
MX (1) MXPA02000035A (ru)
NO (1) NO321169B1 (ru)
NZ (1) NZ516301A (ru)
PL (2) PL202200B1 (ru)
SK (1) SK284178B6 (ru)
WO (1) WO2001002416A1 (ru)
ZA (1) ZA200110468B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US7078391B2 (en) 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US6548658B2 (en) * 1997-07-25 2003-04-15 Inspire Pharmaceuticals, Inc. Di-(uridine 5′)-tetraphosphate and salts thereof
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
SK284178B6 (sk) * 1999-06-30 2004-10-05 Yamasa Corporation Kryštalická forma P1-(2'-deoxycytidín-5'-)P4-(uridín-5'- )tetrafosfátu a spôsob ich prípravy
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7161029B2 (en) * 2003-12-17 2007-01-09 Ajinomoto Co., Inc. DiL-lysine monosulfate trihydrate crystal and method of making
CN100363376C (zh) * 2006-06-12 2008-01-23 南京工业大学 一种5’-核苷三磷酸钠盐的结晶方法
JPWO2017002827A1 (ja) * 2015-06-29 2018-04-26 ヤマサ醤油株式会社 Ｐ１，ｐ４−ビス（５’−ウリジル）テトラホスフェート結晶の保管方法
CN109843901B (zh) * 2016-10-25 2022-04-26 Yamasa 酱油株式会社 P1,p4-二(尿苷5’-)四磷酸的纯化方法
CN111253456B (zh) * 2020-03-13 2021-05-11 广东先强药业有限公司 一种地纽福索钠的制备方法
CN111704637A (zh) * 2020-06-28 2020-09-25 南京工业大学 一种采用膜蒸馏结晶精制核苷酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07242685A (ja) * 1994-01-12 1995-09-19 Unitika Ltd ジアデノシン四リン酸水和物の製造方法
US5837861A (en) * 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
CN1262556C (zh) * 1997-02-06 2006-07-05 印斯拜尔药品股份有限公司 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用
US6596725B2 (en) * 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
DK1012154T3 (da) * 1997-07-25 2004-07-26 Inspire Pharmaceuticals Inc Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf
WO1999061012A2 (en) * 1998-05-22 1999-12-02 Inspire Pharmaceuticals, Inc. Therapeutic dinucleotide and derivatives
SK283729B6 (sk) * 1998-10-02 2003-12-02 Yamasa Corporation Kryštály P1, P4-di(uridín-5')-tetrafosfátu alebo kryštály jeho soli, spôsob ich výroby, kryštály tetrasodnej soli P1, P4-di(uridín-5')-tetrafosfátu a kryštály jej hydrátov
WO2000039145A1 (en) * 1998-12-23 2000-07-06 The University Of North Carolina At Chapel Hill Targeted gene transfer using g protein coupled receptors
SK284178B6 (sk) * 1999-06-30 2004-10-05 Yamasa Corporation Kryštalická forma P1-(2'-deoxycytidín-5'-)P4-(uridín-5'- )tetrafosfátu a spôsob ich prípravy

Also Published As

Publication number Publication date
DE60006814T2 (de) 2004-05-19
EP1191032A4 (en) 2002-07-17
DE60021629T2 (de) 2006-01-05
CN1144811C (zh) 2004-04-07
PL202200B1 (pl) 2009-06-30
CN1359387A (zh) 2002-07-17
BR0012205A (pt) 2002-05-28
KR100593723B1 (ko) 2006-06-30
EP1362862A1 (en) 2003-11-19
EP1191032B1 (en) 2003-11-26
CZ20014502A3 (cs) 2002-05-15
ZA200110468B (en) 2003-04-04
EP1191032A1 (en) 2002-03-27
US6617444B1 (en) 2003-09-09
PL202176B1 (pl) 2009-06-30
ES2245431T3 (es) 2006-01-01
PL352363A1 (en) 2003-08-25
JP3421666B2 (ja) 2003-06-30
NO20016381D0 (no) 2001-12-27
AU767136B2 (en) 2003-10-30
CA2376860A1 (en) 2001-01-11
AU5706700A (en) 2001-01-22
IL147163A0 (en) 2002-08-14
ATE255123T1 (de) 2003-12-15
NO321169B1 (no) 2006-03-27
DE60021629D1 (de) 2005-09-01
HUP0201531A3 (en) 2005-02-28
CA2376860C (en) 2006-11-07
HUP0201531A2 (en) 2002-08-28
EP1362862B1 (en) 2005-07-27
HU229225B1 (en) 2013-09-30
SK18702001A3 (sk) 2002-06-04
NZ516301A (en) 2003-07-25
WO2001002416A1 (fr) 2001-01-11
ATE300551T1 (de) 2005-08-15
NO20016381L (no) 2002-02-28
ES2211566T3 (es) 2004-07-16
IL147163A (en) 2005-11-20
CZ303172B6 (cs) 2012-05-09
MXPA02000035A (es) 2003-07-21
KR20020028903A (ko) 2002-04-17
DE60006814D1 (de) 2004-01-08
EA004707B1 (ru) 2004-06-24
SK284178B6 (sk) 2004-10-05

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU