IL147163A - Dinucleotide crystals - Google Patents

Dinucleotide crystals

Info

Publication number
IL147163A
IL147163A IL14716300A IL14716300A IL147163A IL 147163 A IL147163 A IL 147163A IL 14716300 A IL14716300 A IL 14716300A IL 14716300 A IL14716300 A IL 14716300A IL 147163 A IL147163 A IL 147163A
Authority
IL
Israel
Prior art keywords
dcp4u
present
crystals
monophosphate
raw material
Prior art date
Application number
IL14716300A
Other languages
English (en)
Other versions
IL147163A0 (en
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of IL147163A0 publication Critical patent/IL147163A0/xx
Publication of IL147163A publication Critical patent/IL147163A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14716300A 1999-06-30 2000-06-30 Dinucleotide crystals IL147163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18495099 1999-06-30
PCT/JP2000/004336 WO2001002416A1 (fr) 1999-06-30 2000-06-30 Cristaux dinucleotidiques

Publications (2)

Publication Number Publication Date
IL147163A0 IL147163A0 (en) 2002-08-14
IL147163A true IL147163A (en) 2005-11-20

Family

ID=16162200

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14716300A IL147163A (en) 1999-06-30 2000-06-30 Dinucleotide crystals

Country Status (22)

Country Link
US (1) US6617444B1 (fr)
EP (2) EP1362862B1 (fr)
JP (1) JP3421666B2 (fr)
KR (1) KR100593723B1 (fr)
CN (1) CN1144811C (fr)
AT (2) ATE300551T1 (fr)
AU (1) AU767136B2 (fr)
BR (1) BR0012205A (fr)
CA (1) CA2376860C (fr)
CZ (1) CZ303172B6 (fr)
DE (2) DE60021629T2 (fr)
EA (1) EA004707B1 (fr)
ES (2) ES2245431T3 (fr)
HU (1) HU229225B1 (fr)
IL (1) IL147163A (fr)
MX (1) MXPA02000035A (fr)
NO (1) NO321169B1 (fr)
NZ (1) NZ516301A (fr)
PL (2) PL202200B1 (fr)
SK (1) SK284178B6 (fr)
WO (1) WO2001002416A1 (fr)
ZA (1) ZA200110468B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7078391B2 (en) 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
US6548658B2 (en) * 1997-07-25 2003-04-15 Inspire Pharmaceuticals, Inc. Di-(uridine 5′)-tetraphosphate and salts thereof
DE60021629T2 (de) * 1999-06-30 2006-01-05 Yamasa Corp., Choshi Dinukleotid-Kristalle
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7161029B2 (en) * 2003-12-17 2007-01-09 Ajinomoto Co., Inc. DiL-lysine monosulfate trihydrate crystal and method of making
CN100363376C (zh) * 2006-06-12 2008-01-23 南京工业大学 一种5’-核苷三磷酸钠盐的结晶方法
EP3323824A4 (fr) * 2015-06-29 2019-02-20 Yamasa Corporation Procédé d'entreposage de cristaux p1, p4-bis(5'-uridyl) tétraphosphate
EP3546472B1 (fr) * 2016-10-25 2021-06-16 Yamasa Corporation Procédé de purification de p1, p4-di (uridine 5'-)tétraphosphate
CN111253456B (zh) * 2020-03-13 2021-05-11 广东先强药业有限公司 一种地纽福索钠的制备方法
CN111704637A (zh) * 2020-06-28 2020-09-25 南京工业大学 一种采用膜蒸馏结晶精制核苷酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07242685A (ja) * 1994-01-12 1995-09-19 Unitika Ltd ジアデノシン四リン酸水和物の製造方法
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
US5837861A (en) * 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
ATE325129T1 (de) * 1997-02-06 2006-06-15 Inspire Pharmaceuticals Inc Dinukleotide und ihre verwendungen
US6596725B2 (en) * 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
BRPI9810436B1 (pt) * 1997-07-25 2015-12-29 Inspire Pharmaceuticals Inc processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
ATE232733T1 (de) * 1998-05-22 2003-03-15 Inspire Pharmaceuticals Inc Therapeutische dinucleotide und deren derivate
KR100475008B1 (ko) * 1998-10-02 2005-03-08 야마사 쇼유 가부시키가이샤 디우리딘 테트라포스페이트 또는 그의 염의 결정 및 그의제조법, 그리고 그 화합물의 제조법
CA2355227A1 (fr) * 1998-12-23 2000-07-06 Richard C. Boucher, Jr. Transfert genique cible utilisant des recepteurs couples a une proteine g
DE60021629T2 (de) * 1999-06-30 2006-01-05 Yamasa Corp., Choshi Dinukleotid-Kristalle

Also Published As

Publication number Publication date
CZ20014502A3 (cs) 2002-05-15
HUP0201531A3 (en) 2005-02-28
DE60006814D1 (de) 2004-01-08
JP3421666B2 (ja) 2003-06-30
AU5706700A (en) 2001-01-22
CZ303172B6 (cs) 2012-05-09
NO20016381D0 (no) 2001-12-27
CA2376860A1 (fr) 2001-01-11
DE60021629D1 (de) 2005-09-01
DE60006814T2 (de) 2004-05-19
ES2211566T3 (es) 2004-07-16
HUP0201531A2 (en) 2002-08-28
ATE255123T1 (de) 2003-12-15
US6617444B1 (en) 2003-09-09
MXPA02000035A (es) 2003-07-21
AU767136B2 (en) 2003-10-30
ES2245431T3 (es) 2006-01-01
ZA200110468B (en) 2003-04-04
NO321169B1 (no) 2006-03-27
EA004707B1 (ru) 2004-06-24
NZ516301A (en) 2003-07-25
IL147163A0 (en) 2002-08-14
CN1144811C (zh) 2004-04-07
EP1191032A4 (fr) 2002-07-17
KR20020028903A (ko) 2002-04-17
EP1362862B1 (fr) 2005-07-27
EP1362862A1 (fr) 2003-11-19
WO2001002416A1 (fr) 2001-01-11
ATE300551T1 (de) 2005-08-15
PL202176B1 (pl) 2009-06-30
BR0012205A (pt) 2002-05-28
EA200200109A1 (ru) 2002-06-27
CN1359387A (zh) 2002-07-17
EP1191032B1 (fr) 2003-11-26
CA2376860C (fr) 2006-11-07
PL202200B1 (pl) 2009-06-30
NO20016381L (no) 2002-02-28
SK18702001A3 (sk) 2002-06-04
DE60021629T2 (de) 2006-01-05
PL352363A1 (en) 2003-08-25
SK284178B6 (sk) 2004-10-05
HU229225B1 (en) 2013-09-30
KR100593723B1 (ko) 2006-06-30
EP1191032A1 (fr) 2002-03-27

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees