IE57817B1 - Novel intermediate and method for its preparation - Google Patents

Novel intermediate and method for its preparation

Info

Publication number
IE57817B1
IE57817B1 IE1603/85A IE160385A IE57817B1 IE 57817 B1 IE57817 B1 IE 57817B1 IE 1603/85 A IE1603/85 A IE 1603/85A IE 160385 A IE160385 A IE 160385A IE 57817 B1 IE57817 B1 IE 57817B1
Authority
IE
Ireland
Prior art keywords
preparation
compound
acid addition
mixture
addition salt
Prior art date
Application number
IE1603/85A
Other languages
English (en)
Other versions
IE851603L (en
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE57817(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IE851603L publication Critical patent/IE851603L/xx
Publication of IE57817B1 publication Critical patent/IE57817B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IE1603/85A 1984-08-06 1985-06-26 Novel intermediate and method for its preparation IE57817B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method

Publications (2)

Publication Number Publication Date
IE851603L IE851603L (en) 1986-02-06
IE57817B1 true IE57817B1 (en) 1993-04-21

Family

ID=10564974

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1603/85A IE57817B1 (en) 1984-08-06 1985-06-26 Novel intermediate and method for its preparation

Country Status (18)

Country Link
US (1) US4650884A (cg-RX-API-DMAC10.html)
EP (1) EP0171943B1 (cg-RX-API-DMAC10.html)
JP (1) JPH0625099B2 (cg-RX-API-DMAC10.html)
AT (1) ATE38661T1 (cg-RX-API-DMAC10.html)
AU (1) AU574819B2 (cg-RX-API-DMAC10.html)
CA (1) CA1237147A (cg-RX-API-DMAC10.html)
DE (1) DE3566251D1 (cg-RX-API-DMAC10.html)
DK (2) DK172450B1 (cg-RX-API-DMAC10.html)
ES (1) ES8606257A1 (cg-RX-API-DMAC10.html)
FI (2) FI81338C (cg-RX-API-DMAC10.html)
GB (1) GB8419963D0 (cg-RX-API-DMAC10.html)
GR (1) GR851894B (cg-RX-API-DMAC10.html)
IE (1) IE57817B1 (cg-RX-API-DMAC10.html)
IL (1) IL75690A (cg-RX-API-DMAC10.html)
NO (1) NO160364C (cg-RX-API-DMAC10.html)
NZ (1) NZ212541A (cg-RX-API-DMAC10.html)
PT (1) PT80913B (cg-RX-API-DMAC10.html)
ZA (1) ZA855026B (cg-RX-API-DMAC10.html)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH0675987U (ja) * 1993-04-09 1994-10-25 日立造船株式会社 貨物輸送船におけるバラストタンクへのアクセス用トランク構造
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
SK283309B6 (sk) * 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EP1140886B1 (en) 1998-12-23 2003-04-02 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
HK1043129B (zh) * 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
EP1228056B1 (en) * 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CN1398263A (zh) 1999-12-28 2003-02-19 H·隆德贝克有限公司 制备西酞普兰的方法
HK1052512B (zh) * 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
AU2006201612B2 (en) * 2000-01-14 2008-03-13 H Lundbeck A/S Method for the preparation of 5-cyanophthalide
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NZ521204A (en) * 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
US6494503B1 (en) * 2000-03-25 2002-12-17 Non Metallic Resources, Inc. Pipe joint assembly and method for using same
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BG64901B1 (bg) * 2000-05-29 2006-08-31 H. Lundbeck A/S Метод за получаване на циталопрам
CA2353693C (en) 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
SK284418B6 (sk) * 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050066373A1 (en) * 2001-02-02 2005-03-24 Matthew Rabinowitz Position location using broadcast digital television signals
JP2004527551A (ja) * 2001-05-01 2004-09-09 ハー・ルンドベック・アクチエゼルスカベット エナンチオ純粋なエスシタロプラムの使用方法
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
WO2003011278A1 (en) 2001-07-31 2003-02-13 H. Lundbeck A/S Crystalline composition containing escitalopram
DE60108105T2 (de) * 2001-08-02 2005-12-08 Infosint Sa Verfahren zur Herstellung von 5-substituierten Isobenzofuranen
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
AU2003207774A1 (en) * 2002-01-30 2003-09-02 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
BG65516B1 (bg) * 2002-07-31 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US7390913B2 (en) 2002-12-23 2008-06-24 H. Lundbeck A/S Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
EP1578738B1 (en) * 2002-12-23 2008-03-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
CN101362743A (zh) * 2003-03-21 2009-02-11 H.隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
WO2005025675A1 (en) 2003-09-12 2005-03-24 Pfizer Limited Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
BR0318581A (pt) * 2003-10-28 2006-10-10 Wockhardt Ltd processo melhorando para fabriacação de bromidrato de citalopram
SI1506963T1 (en) * 2003-10-28 2005-10-31 Adorkem Technology Spa Method for the preparation of citalopram
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005070914A1 (en) * 2004-01-23 2005-08-04 Jubilant Organosys Limited A method for the preparation of citalopram acid addition salts
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20080119662A1 (en) * 2004-02-16 2008-05-22 Jubilant Organosys Limted One Spot Synthesis of Citalopram from 5-Cyanophthalide
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2005263741A (ja) * 2004-03-19 2005-09-29 Sumitomo Chemical Co Ltd シタロプラムの製造方法ならびにその中間体およびその製造方法
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ITMI20041872A1 (it) * 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2010004575A2 (en) * 2008-06-16 2010-01-14 Shodhana Laboratories Limited Preparation of escitalopram, its salts and intermediates
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2016197320A1 (zh) 2015-06-09 2016-12-15 浙江华海药业股份有限公司 一种西酞普兰二醇中间体的制备方法
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
KR102134179B1 (ko) * 2018-09-17 2020-07-16 (주)유케이케미팜 카보네이트를 이용한 시탈로프람 및 에스시탈로프람의 새로운 제조 방법
CN112409212B (zh) * 2020-11-30 2023-03-14 四川新迪医药化工有限公司 西酞普兰二醇中间体氢溴酸盐的制备方法及西酞普兰二醇中间体氢溴酸盐、西酞普兰

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (cg-RX-API-DMAC10.html) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.

Also Published As

Publication number Publication date
NO853091L (no) 1986-02-07
GB8419963D0 (en) 1984-09-12
AU574819B2 (en) 1988-07-14
DK172713B1 (da) 1999-06-14
FI20031369A7 (fi) 2003-09-23
DK172450B1 (da) 1998-08-10
JPS6187654A (ja) 1986-05-06
DK356285A (da) 1986-02-07
FI852902A0 (fi) 1985-07-25
FI81338B (fi) 1990-06-29
DE3566251D1 (en) 1988-12-22
EP0171943B1 (en) 1988-11-17
EP0171943A1 (en) 1986-02-19
JPH0625099B2 (ja) 1994-04-06
FI115300B (fi) 2005-04-15
US4650884A (en) 1987-03-17
IL75690A (en) 1988-10-31
DK356285D0 (da) 1985-08-05
NO160364B (no) 1989-01-02
DK89595A (da) 1995-08-10
IE851603L (en) 1986-02-06
NZ212541A (en) 1988-05-30
PT80913B (pt) 1987-09-30
AU4577685A (en) 1986-02-13
ATE38661T1 (de) 1988-12-15
FI81338C (fi) 1990-10-10
ES545885A0 (es) 1986-04-01
FI852902L (fi) 1986-02-07
GR851894B (cg-RX-API-DMAC10.html) 1985-12-03
ES8606257A1 (es) 1986-04-01
PT80913A (en) 1985-09-01
CA1237147A (en) 1988-05-24
NO160364C (no) 1989-04-12
ZA855026B (en) 1986-06-25

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