BR0318581A - processo melhorando para fabriacação de bromidrato de citalopram - Google Patents

processo melhorando para fabriacação de bromidrato de citalopram

Info

Publication number
BR0318581A
BR0318581A BRPI0318581-8A BR0318581A BR0318581A BR 0318581 A BR0318581 A BR 0318581A BR 0318581 A BR0318581 A BR 0318581A BR 0318581 A BR0318581 A BR 0318581A
Authority
BR
Brazil
Prior art keywords
citalopram
manufacturing
dimethylaminopropyl
fluorophenyl
improved process
Prior art date
Application number
BRPI0318581-8A
Other languages
English (en)
Inventor
Siddiqui Mohammed Jaw Mukarram
Bhargav Krishnaji Upadhye
Krishna Gopalji Mishra
Mohammed Ismail Farooqui
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of BR0318581A publication Critical patent/BR0318581A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO MELHORADO PARA FABRICAçãO DE BROMIDRATO DE CITALOPRAM". A presente invenção refere-se a um processo melhorado para preparação de 1-(4<39>-fluorfenil)-1-(3-dimetilaminopropli)-5-ftalanocarbonitrila extremamente puro e seu sal bromato (bromidrato de citalopram), que é um antidepressivo bem conhecido. Outro aspecto da invenção são isolamento de (4-Bromo-2-hidroximetil)fenil-(4-fluorofenil)-3-(dimetilaminopropil)meta nol (Bromodiol) cristalino e conversão de desmetilcitalopram que é formado durante a reação de troca com cianeto, a Citalopram por aquecimento com uma mistura de formaldeído e ácido fórmico em clorofórmio. O citalopram resultante é convencionalmente purificado usando metodologia de extração.
BRPI0318581-8A 2003-10-28 2003-10-28 processo melhorando para fabriacação de bromidrato de citalopram BR0318581A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/004757 WO2005042473A1 (en) 2003-10-28 2003-10-28 Improved process for the manufacture of citalopram hydrobromide

Publications (1)

Publication Number Publication Date
BR0318581A true BR0318581A (pt) 2006-10-10

Family

ID=34531835

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318581-8A BR0318581A (pt) 2003-10-28 2003-10-28 processo melhorando para fabriacação de bromidrato de citalopram

Country Status (6)

Country Link
US (1) US20060293530A1 (pt)
EP (1) EP1678122A4 (pt)
AU (1) AU2003278409A1 (pt)
BR (1) BR0318581A (pt)
CA (1) CA2546422A1 (pt)
WO (1) WO2005042473A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008142379A2 (en) * 2007-05-18 2008-11-27 Cipla Limited Process for the preparation of escitalopram via desmethylcitalopram, optical resolution and methylation of the s-isomer
CN105439990A (zh) * 2015-12-09 2016-03-30 山东潍坊润丰化工股份有限公司 一种从格氏反应废渣中回收醚类溶剂的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
DK1181713T3 (da) * 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
WO2002060886A1 (en) * 2001-01-30 2002-08-08 Orion Corporation, Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram

Also Published As

Publication number Publication date
CA2546422A1 (en) 2005-05-12
EP1678122A1 (en) 2006-07-12
EP1678122A4 (en) 2007-05-23
AU2003278409A1 (en) 2005-05-19
US20060293530A1 (en) 2006-12-28
WO2005042473A1 (en) 2005-05-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A,4A,5A, 6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.