BR0011902A - Compostos derivados de ciclopentano substituìdo, respectivos processos de preparação e formas cristalinas - Google Patents

Compostos derivados de ciclopentano substituìdo, respectivos processos de preparação e formas cristalinas

Info

Publication number
BR0011902A
BR0011902A BR0011902-4A BR0011902A BR0011902A BR 0011902 A BR0011902 A BR 0011902A BR 0011902 A BR0011902 A BR 0011902A BR 0011902 A BR0011902 A BR 0011902A
Authority
BR
Brazil
Prior art keywords
substituted
crystalline forms
preparation processes
respective preparation
formula
Prior art date
Application number
BR0011902-4A
Other languages
English (en)
Inventor
Ahmed F Abdel-Magid
Cynthia Maryanoff
Hans-Ulrich Bichsel
Gunther G Laufer
Daniel J Korey
Erja A Lehto
Sebastiano Mattei
Max Rey
Thomas W Schultz
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of BR0011902A publication Critical patent/BR0011902A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTOS DERIVADOS DE CICLOPENTANO SUBSTITUìDOS RESPECTIVOS PROCESSOS DE PREPARAçãO E FORMAS CRISTALINAS". A invenção refere-se a um processo de preparação de derivados de ciclopentano substituído representados pela fórmula (I), em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, X e Y são conforme descritos no Relatório Descritivo, e seus sais farmaceuticamente aceitáveis. A invenção ainda se refere a um processo de purificação do composto de fórmula (Ia) e novas formas cristalinas do composto de fórmula (Ia).
BR0011902-4A 1999-06-28 2000-06-09 Compostos derivados de ciclopentano substituìdo, respectivos processos de preparação e formas cristalinas BR0011902A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14130199P 1999-06-28 1999-06-28
PCT/US2000/016013 WO2001000571A1 (en) 1999-06-28 2000-06-09 Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof

Publications (1)

Publication Number Publication Date
BR0011902A true BR0011902A (pt) 2002-03-19

Family

ID=22495095

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011902-4A BR0011902A (pt) 1999-06-28 2000-06-09 Compostos derivados de ciclopentano substituìdo, respectivos processos de preparação e formas cristalinas

Country Status (16)

Country Link
US (1) US6576786B2 (pt)
EP (1) EP1214294A1 (pt)
JP (2) JP4262920B2 (pt)
KR (1) KR20020022727A (pt)
CN (1) CN1367776A (pt)
AR (1) AR024494A1 (pt)
AU (1) AU5732700A (pt)
BR (1) BR0011902A (pt)
CA (1) CA2377240A1 (pt)
CZ (1) CZ20014657A3 (pt)
HU (1) HUP0202097A2 (pt)
IL (1) IL147244A0 (pt)
NO (1) NO20016389L (pt)
PL (1) PL213231B1 (pt)
SK (1) SK19042001A3 (pt)
WO (1) WO2001000571A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000571A1 (en) * 1999-06-28 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
AU2001243253A1 (en) * 2000-02-24 2001-09-03 Biocryst Pharmaceuticals, Inc. Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
US7405336B2 (en) * 2004-10-18 2008-07-29 Fina Technology, Inc. Promoters for controlling acidity and pore size of zeolite catalysts for use in alkylation
WO2007087056A2 (en) * 2006-01-13 2007-08-02 Scolr Pharma, Inc. Peramivir derivative for oral administration
CN101420948A (zh) 2006-02-13 2009-04-29 拜奥克里斯特制药公司 静脉内抗病毒治疗
US20070244193A1 (en) * 2006-04-12 2007-10-18 Babu Yarlagadda S Intramuscular antiviral treatments
JP2008162935A (ja) * 2006-12-28 2008-07-17 Daicel Chem Ind Ltd アミド又はラクタムの製造法
CN101367750B (zh) 2007-08-14 2012-05-23 中国人民解放军军事医学科学院毒物药物研究所 (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途
CN102584637B (zh) * 2011-01-17 2014-07-09 天津药物研究院 帕拉米韦水合物晶体、制备方法、药用组合物及其用途
CN102757365B (zh) * 2011-04-29 2013-10-30 上海泓博智源医药技术有限公司 一种制备帕拉米韦关键中间体的方法
CN102372657B (zh) * 2011-11-14 2014-04-09 暨南大学 一种抗流感及禽流感病毒药物帕拉米韦的合成方法
CN102863359B (zh) * 2012-05-16 2014-05-07 常州制药厂有限公司 一种抗流感药物的合成方法
CN105198827A (zh) * 2015-04-13 2015-12-30 广州南新制药有限公司 一种帕拉米韦中间体的合成方法
CN108997171B (zh) * 2018-06-21 2020-11-27 苏州正济医药研究有限公司 一种3+2关环的合成方法
CN112250601B (zh) * 2020-09-08 2022-09-27 天津应天成科技有限公司 安全无毒去除帕拉米韦三水合物中间体m9中镍离子杂质的方法
CN114181117B (zh) * 2020-09-15 2023-05-05 南京正济医药研究有限公司 一种帕拉米韦中间体的制备方法
CN116425659B (zh) * 2023-03-02 2023-11-03 浙江康聚药业有限公司 一种合成帕拉米韦的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9813480A (pt) * 1997-12-17 2000-10-10 Biocryst Pharm Inc Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
WO2001000571A1 (en) * 1999-06-28 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof

Also Published As

Publication number Publication date
IL147244A0 (en) 2002-08-14
CZ20014657A3 (cs) 2002-10-16
HUP0202097A2 (en) 2002-10-28
CN1367776A (zh) 2002-09-04
JP4597237B2 (ja) 2010-12-15
US6576786B2 (en) 2003-06-10
NO20016389L (no) 2002-02-21
JP2009073859A (ja) 2009-04-09
KR20020022727A (ko) 2002-03-27
US20020061930A1 (en) 2002-05-23
NO20016389D0 (no) 2001-12-27
AU5732700A (en) 2001-01-31
WO2001000571A1 (en) 2001-01-04
JP2003503384A (ja) 2003-01-28
EP1214294A1 (en) 2002-06-19
PL352992A1 (en) 2003-09-22
JP4262920B2 (ja) 2009-05-13
PL213231B1 (pl) 2013-01-31
AR024494A1 (es) 2002-10-02
SK19042001A3 (sk) 2002-04-04
CA2377240A1 (en) 2001-01-04

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]