AR024494A1 - Proceso para la preparacion de derivados de ciclopentano sustituido y novedosas estructuras cristalinas de los mismos - Google Patents

Proceso para la preparacion de derivados de ciclopentano sustituido y novedosas estructuras cristalinas de los mismos

Info

Publication number
AR024494A1
AR024494A1 ARP000103219A ARP000103219A AR024494A1 AR 024494 A1 AR024494 A1 AR 024494A1 AR P000103219 A ARP000103219 A AR P000103219A AR P000103219 A ARP000103219 A AR P000103219A AR 024494 A1 AR024494 A1 AR 024494A1
Authority
AR
Argentina
Prior art keywords
preparation
novels
new
same
crystal structures
Prior art date
Application number
ARP000103219A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR024494A1 publication Critical patent/AR024494A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un proceso para la preparacion de derivados de ciclopentano sustituido representados por la formula 1 en la cual R1, R2, R3, R4, X e Y son como se losdescribe en la memoria descriptiva, y las sales farmacéuticametne aceptables de los mismos. Serelac iona asimismo con un proceso para purificar el compuesto dela formula 1a y con novedosas formas cristalinas del compuesto de la formula 1a.
ARP000103219A 1999-06-28 2000-06-27 Proceso para la preparacion de derivados de ciclopentano sustituido y novedosas estructuras cristalinas de los mismos AR024494A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14130199P 1999-06-28 1999-06-28

Publications (1)

Publication Number Publication Date
AR024494A1 true AR024494A1 (es) 2002-10-02

Family

ID=22495095

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103219A AR024494A1 (es) 1999-06-28 2000-06-27 Proceso para la preparacion de derivados de ciclopentano sustituido y novedosas estructuras cristalinas de los mismos

Country Status (16)

Country Link
US (1) US6576786B2 (es)
EP (1) EP1214294A1 (es)
JP (2) JP4262920B2 (es)
KR (1) KR20020022727A (es)
CN (1) CN1367776A (es)
AR (1) AR024494A1 (es)
AU (1) AU5732700A (es)
BR (1) BR0011902A (es)
CA (1) CA2377240A1 (es)
CZ (1) CZ20014657A3 (es)
HU (1) HUP0202097A2 (es)
IL (1) IL147244A0 (es)
NO (1) NO20016389L (es)
PL (1) PL213231B1 (es)
SK (1) SK19042001A3 (es)
WO (1) WO2001000571A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020022727A (ko) * 1999-06-28 2002-03-27 다우 케네드 제이. 치환된 시클로펜탄 유도체들과 그것의 새로운 결정구조를만드는 제조 공정
AU2001243253A1 (en) * 2000-02-24 2001-09-03 Biocryst Pharmaceuticals, Inc. Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
US7405336B2 (en) * 2004-10-18 2008-07-29 Fina Technology, Inc. Promoters for controlling acidity and pore size of zeolite catalysts for use in alkylation
WO2007087056A2 (en) * 2006-01-13 2007-08-02 Scolr Pharma, Inc. Peramivir derivative for oral administration
CN101420948A (zh) 2006-02-13 2009-04-29 拜奥克里斯特制药公司 静脉内抗病毒治疗
US20070244193A1 (en) * 2006-04-12 2007-10-18 Babu Yarlagadda S Intramuscular antiviral treatments
JP2008162935A (ja) * 2006-12-28 2008-07-17 Daicel Chem Ind Ltd アミド又はラクタムの製造法
CN101367750B (zh) * 2007-08-14 2012-05-23 中国人民解放军军事医学科学院毒物药物研究所 (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途
CN102584637B (zh) * 2011-01-17 2014-07-09 天津药物研究院 帕拉米韦水合物晶体、制备方法、药用组合物及其用途
CN102757365B (zh) * 2011-04-29 2013-10-30 上海泓博智源医药技术有限公司 一种制备帕拉米韦关键中间体的方法
CN102372657B (zh) * 2011-11-14 2014-04-09 暨南大学 一种抗流感及禽流感病毒药物帕拉米韦的合成方法
CN102863359B (zh) * 2012-05-16 2014-05-07 常州制药厂有限公司 一种抗流感药物的合成方法
CN105198827A (zh) * 2015-04-13 2015-12-30 广州南新制药有限公司 一种帕拉米韦中间体的合成方法
CN108997171B (zh) * 2018-06-21 2020-11-27 苏州正济医药研究有限公司 一种3+2关环的合成方法
CN112250601B (zh) * 2020-09-08 2022-09-27 天津应天成科技有限公司 安全无毒去除帕拉米韦三水合物中间体m9中镍离子杂质的方法
CN114181117B (zh) * 2020-09-15 2023-05-05 南京正济医药研究有限公司 一种帕拉米韦中间体的制备方法
CN116425659B (zh) * 2023-03-02 2023-11-03 浙江康聚药业有限公司 一种合成帕拉米韦的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1282316A (zh) * 1997-12-17 2001-01-31 生物晶体药品股份有限公司 用作神经氨酸酶抑制剂的取代环戊烷和环戊烯化合物
KR20020022727A (ko) * 1999-06-28 2002-03-27 다우 케네드 제이. 치환된 시클로펜탄 유도체들과 그것의 새로운 결정구조를만드는 제조 공정

Also Published As

Publication number Publication date
CN1367776A (zh) 2002-09-04
NO20016389L (no) 2002-02-21
JP4262920B2 (ja) 2009-05-13
BR0011902A (pt) 2002-03-19
US20020061930A1 (en) 2002-05-23
JP4597237B2 (ja) 2010-12-15
WO2001000571A1 (en) 2001-01-04
HUP0202097A2 (en) 2002-10-28
JP2003503384A (ja) 2003-01-28
PL213231B1 (pl) 2013-01-31
NO20016389D0 (no) 2001-12-27
CZ20014657A3 (cs) 2002-10-16
AU5732700A (en) 2001-01-31
US6576786B2 (en) 2003-06-10
KR20020022727A (ko) 2002-03-27
EP1214294A1 (en) 2002-06-19
PL352992A1 (en) 2003-09-22
CA2377240A1 (en) 2001-01-04
IL147244A0 (en) 2002-08-14
JP2009073859A (ja) 2009-04-09
SK19042001A3 (sk) 2002-04-04

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