DK356285A - 4-(4-(dimethylamino)-1-(4'-fluorphenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitril, syreadditionssalte deraf, og fremgangsmaade til fremstilling af disse forbindelser - Google Patents

4-(4-(dimethylamino)-1-(4'-fluorphenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitril, syreadditionssalte deraf, og fremgangsmaade til fremstilling af disse forbindelser Download PDF

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Publication number
DK356285A
DK356285A DK356285A DK356285A DK356285A DK 356285 A DK356285 A DK 356285A DK 356285 A DK356285 A DK 356285A DK 356285 A DK356285 A DK 356285A DK 356285 A DK356285 A DK 356285A
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DK
Denmark
Prior art keywords
benzonitril
fluorphenyl
hydroxybutyl
hydroxymethyl
dimethylamino
Prior art date
Application number
DK356285A
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English (en)
Other versions
DK172450B1 (da
DK356285D0 (da
Inventor
Klaus Peter Boegesoe
Original Assignee
Lundbeck & Co As H
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK356285(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of DK356285D0 publication Critical patent/DK356285D0/da
Publication of DK356285A publication Critical patent/DK356285A/da
Application granted granted Critical
Publication of DK172450B1 publication Critical patent/DK172450B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
DK198503562A 1984-08-06 1985-08-05 4-[4-(Dimethylamino)-1-(4'-fluorphenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitril, syreadditionssalte deraf, og fremgan DK172450B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method
GB8419963 1984-08-06

Publications (3)

Publication Number Publication Date
DK356285D0 DK356285D0 (da) 1985-08-05
DK356285A true DK356285A (da) 1986-02-07
DK172450B1 DK172450B1 (da) 1998-08-10

Family

ID=10564974

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198503562A DK172450B1 (da) 1984-08-06 1985-08-05 4-[4-(Dimethylamino)-1-(4'-fluorphenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitril, syreadditionssalte deraf, og fremgan
DK199500895A DK172713B1 (da) 1984-08-06 1995-08-10 Fremgangsmåde til fremstilling af 1-(3-dimethylaminopropyl)-1-(4'-fluorphenyl)-1,3-dihydroisobenzofuran-5-carbonnitril

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199500895A DK172713B1 (da) 1984-08-06 1995-08-10 Fremgangsmåde til fremstilling af 1-(3-dimethylaminopropyl)-1-(4'-fluorphenyl)-1,3-dihydroisobenzofuran-5-carbonnitril

Country Status (18)

Country Link
US (1) US4650884A (da)
EP (1) EP0171943B1 (da)
JP (1) JPH0625099B2 (da)
AT (1) ATE38661T1 (da)
AU (1) AU574819B2 (da)
CA (1) CA1237147A (da)
DE (1) DE3566251D1 (da)
DK (2) DK172450B1 (da)
ES (1) ES8606257A1 (da)
FI (2) FI81338C (da)
GB (1) GB8419963D0 (da)
GR (1) GR851894B (da)
IE (1) IE57817B1 (da)
IL (1) IL75690A (da)
NO (1) NO160364C (da)
NZ (1) NZ212541A (da)
PT (1) PT80913B (da)
ZA (1) ZA855026B (da)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH0675987U (ja) * 1993-04-09 1994-10-25 日立造船株式会社 貨物輸送船におけるバラストタンクへのアクセス用トランク構造
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
DE1015416T1 (de) 1997-07-08 2000-10-05 H. Lundbeck A/S, Kobenhavn-Valby Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
JP3892667B2 (ja) 1998-10-20 2007-03-14 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
BR9917346A (pt) 1999-04-14 2002-02-26 Lundbeck & Co As H Método para preparação de citalopram intermadiário e utilização do mesmo
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
NZ512406A (en) * 1999-10-25 2004-01-30 H Method for the preparation of citalopram
ES2169709A1 (es) * 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
ES2219095T3 (es) 1999-12-28 2004-11-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
KR100653141B1 (ko) * 1999-12-30 2006-12-01 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AU2006201612B2 (en) * 2000-01-14 2008-03-13 H Lundbeck A/S Method for the preparation of 5-cyanophthalide
DE60006163T2 (de) 2000-01-14 2004-04-15 H. Lundbeck A/S, Valby Verfahren zur herstellung von 5-cyanophthalid
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
BR0109364A (pt) * 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
IL151490A0 (en) * 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
DE60101786T2 (de) 2000-03-14 2004-07-15 H. Lundbeck A/S, Valby Verfahren zur herstellung von citalopram
IL151487A0 (en) * 2000-03-16 2003-04-10 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-flourophenyl)-1,3-dihydroisobenzofurans
US6494503B1 (en) * 2000-03-25 2002-12-17 Non Metallic Resources, Inc. Pipe joint assembly and method for using same
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BG64901B1 (bg) * 2000-05-29 2006-08-31 H. Lundbeck A/S Метод за получаване на циталопрам
CA2353693C (en) 2000-08-10 2003-07-22 H. Lundbeck A/S Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
FI20011622A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
WO2001045483A2 (en) 2000-12-22 2001-06-28 H. Lundbeck A/S Method for the preparation of pure citalopram
EP1181272B1 (en) * 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050066373A1 (en) * 2001-02-02 2005-03-24 Matthew Rabinowitz Position location using broadcast digital television signals
MEP5908A (xx) * 2001-05-01 2010-02-10 Lundbeck & Co As H Upotreba enantiomerno čistog escitaloprama
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
AU2002355624B2 (en) * 2001-07-31 2006-02-02 H. Lundbeck A/S Crystalline composition containing escitalopram
ES2234797T3 (es) * 2001-08-02 2005-07-01 Infosint Sa Procedimiento para la preparacion de citalopram partiendo de 5-formilftalida.
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US7192939B2 (en) * 2002-01-30 2007-03-20 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
BG65516B1 (bg) * 2002-07-31 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
AU2002330730A1 (en) * 2002-08-14 2004-03-03 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
PL207847B1 (pl) 2002-12-23 2011-02-28 Lundbeck & Co As H Sposób wytwarzania racemicznego 4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1- hydroksybutylo]-3-(hydroksymetylo)-benzonitrylu) i /lub R-lub S-4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1-hydroksybutylo]-3-( hydroksymetylo)- benzonitrylu) i sposób wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu
ES2298595T3 (es) 2002-12-23 2008-05-16 H. Lundbeck A/S Hidrobromuro de escitalopram y un metodo para su preparacion.
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
US7687645B2 (en) * 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
JP2007505097A (ja) 2003-09-12 2007-03-08 ファイザー・インク アルファ−２−デルタリガンドとセロトニン／ノルアドレナリン再取込み阻害薬を含む組合せ
PT1506963E (pt) * 2003-10-28 2005-08-31 Adorkem Technology Spa Processo para a preparacao de citalopram
EP1678122A4 (en) * 2003-10-28 2007-05-23 Wockhardt Ltd IMPROVED PROCESS FOR THE PREPARATION OF CITALOPRAM HYDROBROMIDE
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005070914A1 (en) * 2004-01-23 2005-08-04 Jubilant Organosys Limited A method for the preparation of citalopram acid addition salts
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2005263741A (ja) * 2004-03-19 2005-09-29 Sumitomo Chemical Co Ltd シタロプラムの製造方法ならびにその中間体およびその製造方法
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
ITMI20041872A1 (it) 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
EP1987016A1 (en) * 2005-07-27 2008-11-05 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2010004575A2 (en) * 2008-06-16 2010-01-14 Shodhana Laboratories Limited Preparation of escitalopram, its salts and intermediates
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
EP3309142B1 (en) * 2015-06-09 2020-08-05 Zhejiang Huahai Pharmaceutical Co., Ltd Method for preparing citalopram diol intermediate
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
KR102134179B1 (ko) * 2018-09-17 2020-07-16 (주)유케이케미팜 카보네이트를 이용한 시탈로프람 및 에스시탈로프람의 새로운 제조 방법
CN112409212B (zh) * 2020-11-30 2023-03-14 四川新迪医药化工有限公司 西酞普兰二醇中间体氢溴酸盐的制备方法及西酞普兰二醇中间体氢溴酸盐、西酞普兰

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Also Published As

Publication number Publication date
FI81338B (fi) 1990-06-29
DK172450B1 (da) 1998-08-10
EP0171943B1 (en) 1988-11-17
CA1237147A (en) 1988-05-24
AU574819B2 (en) 1988-07-14
IL75690A (en) 1988-10-31
DE3566251D1 (en) 1988-12-22
EP0171943A1 (en) 1986-02-19
IE57817B1 (en) 1993-04-21
DK89595A (da) 1995-08-10
JPH0625099B2 (ja) 1994-04-06
PT80913A (en) 1985-09-01
FI852902A0 (fi) 1985-07-25
NO160364C (no) 1989-04-12
DK172713B1 (da) 1999-06-14
NO160364B (no) 1989-01-02
JPS6187654A (ja) 1986-05-06
GR851894B (da) 1985-12-03
FI852902L (fi) 1986-02-07
NO853091L (no) 1986-02-07
ATE38661T1 (de) 1988-12-15
NZ212541A (en) 1988-05-30
GB8419963D0 (en) 1984-09-12
AU4577685A (en) 1986-02-13
DK356285D0 (da) 1985-08-05
US4650884A (en) 1987-03-17
ZA855026B (en) 1986-06-25
FI115300B (fi) 2005-04-15
ES8606257A1 (es) 1986-04-01
FI81338C (fi) 1990-10-10
IE851603L (en) 1986-02-06
FI20031369A (fi) 2003-09-23
ES545885A0 (es) 1986-04-01
PT80913B (pt) 1987-09-30

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B1 Patent granted (law 1993)
PUP Patent expired