HUP0203133A2 - Stabilizált folyékony polipeptid tartalmú gyógyszerkészítmények - Google Patents

Stabilizált folyékony polipeptid tartalmú gyógyszerkészítmények

Info

Publication number
HUP0203133A2
HUP0203133A2 HU0203133A HUP0203133A HUP0203133A2 HU P0203133 A2 HUP0203133 A2 HU P0203133A2 HU 0203133 A HU0203133 A HU 0203133A HU P0203133 A HUP0203133 A HU P0203133A HU P0203133 A2 HUP0203133 A2 HU P0203133A2
Authority
HU
Hungary
Prior art keywords
acid
salt
polypeptide
stabilized liquid
pharmaceutical compositions
Prior art date
Application number
HU0203133A
Other languages
English (en)
Inventor
Bao-Lu Chen
Maninder Hora
Original Assignee
Chiron Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp. filed Critical Chiron Corp.
Publication of HUP0203133A2 publication Critical patent/HUP0203133A2/hu
Publication of HUP0203133A3 publication Critical patent/HUP0203133A3/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
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  • Molecular Biology (AREA)
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  • Transplantation (AREA)
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Abstract

A találmány tárgya stabilizált folyékony gyógyszerkészítmény, melyáll: gyógyászati hatóanyagként egy, a folyékony készítményben atárolás alatt aggregátumot képező polipeptidből vagy változatából; egyaminosav bázisnak a nevezett polipeptid vagy változata tárolás alattiaggregátum képződésének csökkentéséhez szükséges mennyiségéből, ahol anevezett aminosav bázis az arginin, lizin, aszparaginsav, glutaminsavaminosavak legalább egyike; és egy pufferből, ahol a puffer egysójától lényegében mentes sav vagy egy sav sója vagy egy sav éssójának keveréke. Ó
HU0203133A 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions HUP0203133A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15769699P 1999-10-04 1999-10-04
PCT/US2000/027156 WO2001024814A1 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions

Publications (2)

Publication Number Publication Date
HUP0203133A2 true HUP0203133A2 (hu) 2002-12-28
HUP0203133A3 HUP0203133A3 (en) 2005-07-28

Family

ID=22564882

Family Applications (3)

Application Number Title Priority Date Filing Date
HU0401975A HU227347B1 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions
HU0203133A HUP0203133A3 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions
HU0800692A HU0800692D0 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0401975A HU227347B1 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0800692A HU0800692D0 (en) 1999-10-04 2000-10-03 Stabilized liquid polypeptide-containing pharmaceutical compositions

Country Status (18)

Country Link
US (4) US6525102B1 (hu)
EP (2) EP1220682B1 (hu)
JP (2) JP2003510368A (hu)
CN (2) CN100389821C (hu)
AT (2) ATE464062T1 (hu)
AU (2) AU783306B2 (hu)
BR (2) BRPI0017437B8 (hu)
CA (2) CA2477857C (hu)
CZ (2) CZ20021186A3 (hu)
DE (2) DE60044213D1 (hu)
ES (1) ES2276698T3 (hu)
HU (3) HU227347B1 (hu)
IL (3) IL149008A0 (hu)
NO (2) NO20021567L (hu)
NZ (2) NZ535205A (hu)
PL (2) PL354987A1 (hu)
PT (1) PT1491208E (hu)
WO (1) WO2001024814A1 (hu)

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