HRP20120135T1 - Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova - Google Patents
Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova Download PDFInfo
- Publication number
- HRP20120135T1 HRP20120135T1 HR20120135T HRP20120135T HRP20120135T1 HR P20120135 T1 HRP20120135 T1 HR P20120135T1 HR 20120135 T HR20120135 T HR 20120135T HR P20120135 T HRP20120135 T HR P20120135T HR P20120135 T1 HRP20120135 T1 HR P20120135T1
- Authority
- HR
- Croatia
- Prior art keywords
- halogen substituted
- image
- halogen
- compound according
- formula
- Prior art date
Links
- 208000037259 Amyloid Plaque Diseases 0.000 title claims 6
- BIAWAXVRXKIUQB-UHFFFAOYSA-N 2-(2-phenylethenyl)pyridine Chemical class C=1C=CC=CC=1C=CC1=CC=CC=N1 BIAWAXVRXKIUQB-UHFFFAOYSA-N 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 claims abstract 14
- 150000002367 halogens Chemical group 0.000 claims abstract 14
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 claims abstract 2
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 2
- 238000012800 visualization Methods 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78715606P | 2006-03-30 | 2006-03-30 | |
PCT/US2007/007400 WO2007126733A2 (en) | 2006-03-30 | 2007-03-26 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120135T1 true HRP20120135T1 (hr) | 2012-03-31 |
Family
ID=38326579
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120135T HRP20120135T1 (hr) | 2006-03-30 | 2012-02-10 | Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova |
HRP20170857TT HRP20170857T1 (hr) | 2006-03-30 | 2017-06-06 | Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170857TT HRP20170857T1 (hr) | 2006-03-30 | 2017-06-06 | Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga |
Country Status (34)
Country | Link |
---|---|
US (3) | US7687052B2 (es) |
EP (3) | EP2363391A1 (es) |
JP (1) | JP5290954B2 (es) |
KR (1) | KR101376807B1 (es) |
CN (1) | CN101522624B (es) |
AT (1) | ATE539060T1 (es) |
AU (1) | AU2007243712B2 (es) |
BR (1) | BRPI0710225B1 (es) |
CA (1) | CA2644530C (es) |
CR (1) | CR10329A (es) |
CY (3) | CY1113048T1 (es) |
DK (2) | DK2363392T3 (es) |
EA (1) | EA017898B1 (es) |
EC (1) | ECSP088783A (es) |
ES (2) | ES2628882T3 (es) |
FR (1) | FR13C0034I2 (es) |
GT (1) | GT200800201A (es) |
HR (2) | HRP20120135T1 (es) |
HU (2) | HUE032660T2 (es) |
IL (1) | IL193567A (es) |
LT (1) | LT2363392T (es) |
LU (1) | LU92232I2 (es) |
MX (1) | MX2008012527A (es) |
NO (2) | NO342090B1 (es) |
NZ (1) | NZ570887A (es) |
PL (2) | PL1999109T3 (es) |
PT (2) | PT2363392T (es) |
RS (2) | RS52222B (es) |
SG (1) | SG173338A1 (es) |
SI (2) | SI1999109T1 (es) |
TW (1) | TWI399366B (es) |
UA (1) | UA97802C2 (es) |
WO (1) | WO2007126733A2 (es) |
ZA (1) | ZA200807955B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1999109T1 (sl) * | 2006-03-30 | 2012-04-30 | Univ Pennsylvania | Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov |
JP5322180B2 (ja) * | 2007-07-04 | 2013-10-23 | 国立大学法人東北大学 | フッ素およびヒドロキシ基で置換されたアルコキシ基を有するpetプローブ |
JP5603855B2 (ja) * | 2008-04-04 | 2014-10-08 | アビッド レディオファーマシューティカルズ、インク. | 神経変成疾患の放射性薬剤による画像化 |
NZ593848A (en) * | 2008-12-31 | 2013-09-27 | Avid Radiopharmaceuticals Inc | Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof |
EP2451760A1 (en) * | 2009-07-10 | 2012-05-16 | Bayer Pharma Aktiengesellschaft | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers |
WO2011045415A2 (en) | 2009-10-15 | 2011-04-21 | Guerbet | New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
MX336896B (es) * | 2009-12-23 | 2016-02-05 | Piramal Imaging Sa | Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos. |
BR112012030935B1 (pt) | 2010-04-06 | 2020-11-17 | Life Molecular Imaging Sa | método para a produção de ligantes de beta-amiloide marcados com f-18 |
WO2011141515A1 (en) | 2010-05-14 | 2011-11-17 | Bayer Pharma Aktiengesellschaft | Diagnostic agents for amyloid beta imaging |
TWI504414B (zh) | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產F-18標記之Aβ配位體之方法 |
EA201201647A1 (ru) * | 2010-06-04 | 2013-05-30 | Пирамаль Имэджинг Са | Способ получения f-18 меченных лигандов бета-амилоида |
US20130217920A1 (en) * | 2010-06-04 | 2013-08-22 | Piramal Imaging Sa | Method for production of f-18 labeled amyloid beta ligands |
CN101891674B (zh) * | 2010-06-24 | 2012-11-14 | 山东大学 | 4-苯乙烯基吡啶类化合物及其制备方法与应用 |
WO2012051170A2 (en) * | 2010-10-12 | 2012-04-19 | Mayo Foundation For Medical Education And Research | Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives |
US20140079635A1 (en) * | 2011-03-30 | 2014-03-20 | Case Western Reserve University | Molecular probes for detecting lipid composition |
JP6038122B2 (ja) | 2011-04-21 | 2016-12-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用 |
SG11201401640QA (en) | 2011-10-19 | 2014-07-30 | Piramal Imaging Sa | IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS |
ES2725314T3 (es) | 2012-04-10 | 2019-09-23 | Lantheus Medical Imaging Inc | Métodos de síntesis radiofarmacéutica |
JP6099045B2 (ja) * | 2013-04-30 | 2017-03-22 | 国立大学法人京都大学 | トリアゾロピリミジン誘導体化合物 |
JP6041751B2 (ja) * | 2013-05-07 | 2016-12-14 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
JP2014218454A (ja) * | 2013-05-07 | 2014-11-20 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
CN106459059B (zh) * | 2014-05-13 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 氘化杂环化合物和其作为成像剂的用途 |
KR20180052611A (ko) * | 2015-08-18 | 2018-05-18 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 영상화 및 치료 용도를 위한 니트록사이드 함유 아밀로이드 결합 제제 |
US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
CN108299287A (zh) * | 2018-01-02 | 2018-07-20 | 北京师范大学 | 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物 |
CN114805190A (zh) * | 2022-06-08 | 2022-07-29 | 吉林大学第一医院 | 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法 |
WO2024107620A1 (en) | 2022-11-14 | 2024-05-23 | Eli Lilly And Company | Polymorphic forms of florbetapir precursor av-105 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992000963A1 (en) | 1990-07-12 | 1992-01-23 | Yoshitomi Pharmaceutical Industries, Ltd. | Styryl compounds and use thereof as medicine |
JPH0545875A (ja) * | 1991-08-08 | 1993-02-26 | Konica Corp | 感光性組成物 |
US6020436A (en) * | 1993-03-09 | 2000-02-01 | The Chromaline Corporation | Photosensitive resin composition |
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
EP1266884A4 (en) * | 2000-03-22 | 2003-04-23 | Bf Res Inst Inc | IMAGE DIAGNOSIS PROBE, BASED ON SUBSTITUTED AZOBENZOL OR ITS ANALOGA, FOR DISEASES WHICH ARE ATTRIBUTED TO AMYLOID ACCUMULATION, AND MIXTURES CONTAINING THIS IMAGE |
US8007954B2 (en) | 2000-11-09 | 2011-08-30 | The Trustees Of The University Of Pennsylvania | Use of sulfur-containing fuels for direct oxidation fuel cells |
JP2002182254A (ja) | 2000-12-18 | 2002-06-26 | Fuji Photo Film Co Ltd | 非線形光学材料とその製造方法 |
EP1432453B1 (en) * | 2001-08-27 | 2013-08-14 | The Trustees of The University of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
JP2005529464A (ja) | 2002-06-06 | 2005-09-29 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | セラミックアノード及びそれを生産する方法 |
WO2004016271A1 (en) * | 2002-08-14 | 2004-02-26 | Axxima Pharmaceuticals Ag | Pyrimidones as antiviral agents |
JP4482352B2 (ja) | 2004-03-11 | 2010-06-16 | 本田技研工業株式会社 | 固体高分子型燃料電池 |
ES2526655T3 (es) * | 2004-12-17 | 2015-01-14 | The Trustees Of The University Of Pennsylvania | Derivados de estilbeno y su uso para la unión y la visualización de placas amiloides |
US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
SI1999109T1 (sl) | 2006-03-30 | 2012-04-30 | Univ Pennsylvania | Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov |
US20080253967A1 (en) * | 2007-04-13 | 2008-10-16 | Kung Hank F | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques |
-
2007
- 2007-03-26 SI SI200730865T patent/SI1999109T1/sl unknown
- 2007-03-26 PT PT111521241T patent/PT2363392T/pt unknown
- 2007-03-26 PL PL07753982T patent/PL1999109T3/pl unknown
- 2007-03-26 DK DK11152124.1T patent/DK2363392T3/en active
- 2007-03-26 AU AU2007243712A patent/AU2007243712B2/en active Active
- 2007-03-26 HU HUE11152124A patent/HUE032660T2/en unknown
- 2007-03-26 US US11/727,401 patent/US7687052B2/en active Active
- 2007-03-26 DK DK07753982.3T patent/DK1999109T3/da active
- 2007-03-26 RS RS20120077A patent/RS52222B/en unknown
- 2007-03-26 SG SG2011048477A patent/SG173338A1/en unknown
- 2007-03-26 ES ES11152124.1T patent/ES2628882T3/es active Active
- 2007-03-26 EA EA200870389A patent/EA017898B1/ru not_active IP Right Cessation
- 2007-03-26 PT PT07753982T patent/PT1999109E/pt unknown
- 2007-03-26 EP EP11152115A patent/EP2363391A1/en not_active Withdrawn
- 2007-03-26 CN CN2007800116909A patent/CN101522624B/zh active Active
- 2007-03-26 ES ES07753982T patent/ES2378785T3/es active Active
- 2007-03-26 CA CA2644530A patent/CA2644530C/en active Active
- 2007-03-26 JP JP2009502912A patent/JP5290954B2/ja active Active
- 2007-03-26 PL PL11152124T patent/PL2363392T3/pl unknown
- 2007-03-26 LT LTEP11152124.1T patent/LT2363392T/lt unknown
- 2007-03-26 WO PCT/US2007/007400 patent/WO2007126733A2/en active Application Filing
- 2007-03-26 EP EP07753982A patent/EP1999109B1/en active Active
- 2007-03-26 SI SI200731938T patent/SI2363392T1/sl unknown
- 2007-03-26 AT AT07753982T patent/ATE539060T1/de active
- 2007-03-26 UA UAA200812698A patent/UA97802C2/uk unknown
- 2007-03-26 BR BRPI0710225-9A patent/BRPI0710225B1/pt active IP Right Grant
- 2007-03-26 EP EP11152124.1A patent/EP2363392B1/en active Active
- 2007-03-26 NZ NZ570887A patent/NZ570887A/en unknown
- 2007-03-26 MX MX2008012527A patent/MX2008012527A/es active IP Right Grant
- 2007-03-26 RS RS20170578A patent/RS56171B1/sr unknown
- 2007-04-26 TW TW096114833A patent/TWI399366B/zh active
-
2008
- 2008-08-05 US US12/186,072 patent/US8506929B2/en active Active
- 2008-08-20 IL IL193567A patent/IL193567A/en active IP Right Grant
- 2008-09-16 ZA ZA2008/07955A patent/ZA200807955B/en unknown
- 2008-09-29 KR KR1020087023884A patent/KR101376807B1/ko active IP Right Grant
- 2008-09-30 CR CR10329A patent/CR10329A/es unknown
- 2008-09-30 GT GT200800201A patent/GT200800201A/es unknown
- 2008-09-30 EC EC2008008783A patent/ECSP088783A/es unknown
- 2008-10-29 NO NO20084590A patent/NO342090B1/no active Protection Beyond IP Right Term
-
2012
- 2012-02-10 HR HR20120135T patent/HRP20120135T1/hr unknown
- 2012-03-07 CY CY20121100225T patent/CY1113048T1/el unknown
-
2013
- 2013-01-07 US US13/735,609 patent/US8840866B2/en active Active
- 2013-06-26 LU LU92232C patent/LU92232I2/fr unknown
- 2013-06-26 FR FR13C0034C patent/FR13C0034I2/fr active Active
- 2013-06-27 CY CY2013024C patent/CY2013024I2/el unknown
- 2013-06-27 HU HUS1300028C patent/HUS1300028I1/hu unknown
-
2017
- 2017-06-06 HR HRP20170857TT patent/HRP20170857T1/hr unknown
- 2017-06-22 CY CY20171100664T patent/CY1119048T1/el unknown
-
2018
- 2018-09-11 NO NO2018030C patent/NO2018030I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20120135T1 (hr) | Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova | |
RU2008150377A (ru) | Новое соединение, обладающее сродством к амилоиду | |
HRP20171175T1 (hr) | Novi triciklički spojevi | |
BR112015021965A2 (pt) | pirrolobenzodiazepinas e conjugados das mesmas | |
HRP20140501T1 (hr) | Derivati benzazepina korisni kao antagonisti vazopresina | |
EP3777898A3 (en) | Compounds for positron emission tomography | |
MX367292B (es) | Ligandos para formacion de imagen de inervacion cardiaca. | |
HRP20191482T1 (hr) | 18f-označeni psma ciljani pet reagensi | |
RU2016118399A (ru) | Производные 4-аминометилбензойной кислоты | |
JP2010524857A5 (es) | ||
EA201000333A1 (ru) | Диагностические вещества на основе композиций наночастиц для тестирования посредством оптической визуализации | |
AR064136A1 (es) | Derivados de espiro-piperidina, metodos para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades relacionadas con la accion antagonista del receptor v1a. | |
RU2008147002A (ru) | Новые соединения, обладающие сродством к амилоиду | |
RU2020119562A (ru) | Хиназолиноновое соединение и его применение | |
SV2009003205A (es) | Derivados de silicio para obtencion de imagenes por tomografia de emision de positrones (pet) | |
JP2013513607A5 (es) | ||
AR039557A1 (es) | Inhibidores novedosos de la farnesil proteina transferasa como agentes antitumorales | |
RS54096B1 (en) | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and their uses | |
RU2007135882A (ru) | Производные фенилоксианилина, меченные радиоактивным галогеном | |
RU2005131872A (ru) | Производные бензотиазола (варианты), фармацевтическая композиция для детекции отложений амилоида и способ их детекции у млекопитающего | |
AR045700A1 (es) | Derivados de combretastatina que presentan actividad citotoxica | |
DE602006017026D1 (de) | Kontrastmittel | |
DK1648440T3 (da) | Halvfaste formuleringer til den orale indgivelse af taxoider | |
JP2006517932A5 (es) | ||
RU2010151143A (ru) | Замещенные хиназолины |