HRP20120135T1 - Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova - Google Patents
Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova Download PDFInfo
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- HRP20120135T1 HRP20120135T1 HR20120135T HRP20120135T HRP20120135T1 HR P20120135 T1 HRP20120135 T1 HR P20120135T1 HR 20120135 T HR20120135 T HR 20120135T HR P20120135 T HRP20120135 T HR P20120135T HR P20120135 T1 HRP20120135 T1 HR P20120135T1
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- Prior art keywords
- halogen substituted
- image
- halogen
- compound according
- formula
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- 208000037259 Amyloid Plaque Diseases 0.000 title claims 6
- BIAWAXVRXKIUQB-UHFFFAOYSA-N 2-(2-phenylethenyl)pyridine Chemical class C=1C=CC=CC=1C=CC1=CC=CC=N1 BIAWAXVRXKIUQB-UHFFFAOYSA-N 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 claims abstract 14
- 150000002367 halogens Chemical group 0.000 claims abstract 14
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 claims abstract 2
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 2
- 238000012800 visualization Methods 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Spoj Formule I, ili njegova farmaceutski prihvatljiva sol; naznačen time šton je jedan; najmanje jedan, a najviše tri, od A1, A2, A3, A4 i A5 je N, a drugi su -CH ili -CR2, kako je dopušteno; R1 je NRaRb(CH2)p-, gdje Ra i Rb su neovisno vodici ili C1-4alkil, a p je 0; R2 je;gdje q je cijeli broj od 1 do 5; R30, R31, R32 i R33 su, u svakom slučaju, vodici; Z se bira između halogena, halogenom supstituiranog benzoiloksi, halogenom supstituiranog benziloksi, halogenom supstituiranog fenil(C1-4)alkila, halogenom supstituiranog ariloksi i halogenom supstituiranog C6-10 arila; svaki od R7 i R8 je vodik; te gdje se navedeni halogen, u svakom slučaju, bira između I, 123I, 125I, 131I, Br, 76Br, 77Br, F i 18F. Patent sadrži još 8 patentnih zahtjeva.
Claims (9)
1. Spoj Formule I,
[image]
ili njegova farmaceutski prihvatljiva sol;
naznačen time što
n je jedan;
najmanje jedan, a najviše tri, od A1, A2, A3, A4 i A5 je N, a drugi su -CH ili -CR2, kako je dopušteno;
R1 je NRaRb(CH2)p-, gdje Ra i Rb su neovisno vodici ili C1-4alkil, a p je 0;
R2 je
[image]
;
gdje q je cijeli broj od 1 do 5;
R30, R31, R32 i R33 su, u svakom slučaju, vodici;
Z se bira između halogena, halogenom supstituiranog benzoiloksi, halogenom supstituiranog benziloksi, halogenom supstituiranog fenil(C1-4)alkila, halogenom supstituiranog ariloksi i halogenom supstituiranog C6-10 arila;
svaki od R7 i R8 je vodik;
te gdje se navedeni halogen, u svakom slučaju, bira između I, 123I, 125I, 131I, Br, 76Br, 77Br, F i 18F.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što ima strukturu:
[image]
.
3. Spoj u skladu s patentnim zahtjevom 1, gdje A4 je N, naznačen time što ima formulu:
[image]
gdje Z je I, 123I, 125I, 131I, Br, 76Br, 77Br, F ili 18F.
4. Spoj u skladu s patentnim zahtjevom 1, naznačen time što ima formulu:
[image]
.
5. Spoj u skladu s patentnim zahtjevom 1, naznačen time što ima formulu:
[image]
.
6. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 5.
7. Dijagnostički pripravak namijenjen vizualizaciji amiloidnih naslaga, naznačen time što sadrži radioaktivno obilježeni spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 5.
8. Postupak vizualizacije amiloidnih naslaga, naznačen time što se sastoji u:
a. unošenju u sisavca detektabilne količine dijagnostičkog pripravka u skladu s patentnim zahtjevom 7;
b. ostavljanju dovoljno vremena da se obilježeni spoj veže s amiloidnim naslagama; i
c. detektiranju obilježenig spoja vezanog na jednu ili više amiloidnih naslaga.
9. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 5 ili pripravak u skladu s patentnim zahtjevom 6, naznačen time što je namijenjen upotrebi u inhibiranju agregiranja amiloidnih plakova kod sisavca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78715606P | 2006-03-30 | 2006-03-30 | |
PCT/US2007/007400 WO2007126733A2 (en) | 2006-03-30 | 2007-03-26 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120135T1 true HRP20120135T1 (hr) | 2012-03-31 |
Family
ID=38326579
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120135T HRP20120135T1 (hr) | 2006-03-30 | 2012-02-10 | Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova |
HRP20170857TT HRP20170857T1 (hr) | 2006-03-30 | 2017-06-06 | Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20170857TT HRP20170857T1 (hr) | 2006-03-30 | 2017-06-06 | Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga |
Country Status (34)
Country | Link |
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US (3) | US7687052B2 (hr) |
EP (3) | EP2363391A1 (hr) |
JP (1) | JP5290954B2 (hr) |
KR (1) | KR101376807B1 (hr) |
CN (1) | CN101522624B (hr) |
AT (1) | ATE539060T1 (hr) |
AU (1) | AU2007243712B2 (hr) |
BR (1) | BRPI0710225B1 (hr) |
CA (1) | CA2644530C (hr) |
CR (1) | CR10329A (hr) |
CY (3) | CY1113048T1 (hr) |
DK (2) | DK2363392T3 (hr) |
EA (1) | EA017898B1 (hr) |
EC (1) | ECSP088783A (hr) |
ES (2) | ES2628882T3 (hr) |
FR (1) | FR13C0034I2 (hr) |
GT (1) | GT200800201A (hr) |
HR (2) | HRP20120135T1 (hr) |
HU (2) | HUE032660T2 (hr) |
IL (1) | IL193567A (hr) |
LT (1) | LT2363392T (hr) |
LU (1) | LU92232I2 (hr) |
MX (1) | MX2008012527A (hr) |
NO (2) | NO342090B1 (hr) |
NZ (1) | NZ570887A (hr) |
PL (2) | PL2363392T3 (hr) |
PT (2) | PT1999109E (hr) |
RS (2) | RS56171B1 (hr) |
SG (1) | SG173338A1 (hr) |
SI (2) | SI1999109T1 (hr) |
TW (1) | TWI399366B (hr) |
UA (1) | UA97802C2 (hr) |
WO (1) | WO2007126733A2 (hr) |
ZA (1) | ZA200807955B (hr) |
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AU2007243712B2 (en) * | 2006-03-30 | 2013-01-10 | The Trustees Of The University Of Pennsylvania | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques |
JP5322180B2 (ja) * | 2007-07-04 | 2013-10-23 | 国立大学法人東北大学 | フッ素およびヒドロキシ基で置換されたアルコキシ基を有するpetプローブ |
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UA105914C2 (uk) * | 2008-12-31 | 2014-07-10 | Евід Рейдіофармасьютікалз, Інк. | Синтез стирилпіридину, міченого радіоізотопом 18f, з тозилатного прекурсора та стабільна фармацевтична композиція на його основі |
CA2767475A1 (en) * | 2009-07-10 | 2011-01-13 | Bayer Pharma Aktiengesellschaft | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers |
US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
EA022447B1 (ru) * | 2009-12-23 | 2016-01-29 | Пирамаль Имэджинг Са | Композиции, приемлемые для рет-визуализации при помощи гидрофобных рет-агентов |
WO2011141515A1 (en) | 2010-05-14 | 2011-11-17 | Bayer Pharma Aktiengesellschaft | Diagnostic agents for amyloid beta imaging |
MX2012014116A (es) * | 2010-06-04 | 2013-08-08 | Piramal Imaging Sa | Metodo para la produccion de ligandos beta amiloide marcados con 18f. |
SG185785A1 (en) * | 2010-06-04 | 2013-01-30 | Piramal Imaging Sa | Method for production of f-18 labeled amyloid beta ligand |
ES2642086T5 (es) | 2010-06-04 | 2020-04-13 | Life Molecular Imaging Sa | Procedimiento para la producción de ligandos de beta amiloide marcados con F-18 |
TWI504414B (zh) | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產F-18標記之Aβ配位體之方法 |
CN101891674B (zh) * | 2010-06-24 | 2012-11-14 | 山东大学 | 4-苯乙烯基吡啶类化合物及其制备方法与应用 |
EP2627361B1 (en) * | 2010-10-12 | 2017-09-20 | Mayo Foundation For Medical Education And Research | Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives |
US20140079635A1 (en) * | 2011-03-30 | 2014-03-20 | Case Western Reserve University | Molecular probes for detecting lipid composition |
CA3058702C (en) | 2011-04-21 | 2023-11-07 | Massoud Akhtari | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
MX2014004274A (es) | 2011-10-19 | 2014-07-09 | Piramal Imaging Sa | METODO MEJORADO PARA LA PRODUCCION DE LIGANDOS Aß MARCADOS CON F-18. |
SG10201608370TA (en) | 2012-04-10 | 2016-11-29 | Lantheus Medical Imaging Inc | Radiopharmaceutical synthesis methods |
JP6099045B2 (ja) * | 2013-04-30 | 2017-03-22 | 国立大学法人京都大学 | トリアゾロピリミジン誘導体化合物 |
JP2014218454A (ja) * | 2013-05-07 | 2014-11-20 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
JP6041751B2 (ja) * | 2013-05-07 | 2016-12-14 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
HUE053939T2 (hu) | 2014-05-13 | 2021-08-30 | Hoffmann La Roche | Deuterált heterociklikus vegyületek és képalkotó kontrasztanyagként való használatuk |
AU2016308189B2 (en) | 2015-08-18 | 2021-03-11 | The Regents Of The University Of California | Nitroxide containing amyloid binding agents for imaging and therapeutic uses |
US10300155B2 (en) | 2015-12-31 | 2019-05-28 | Washington University | Alpha-synuclein ligands |
CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
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JP2002182254A (ja) | 2000-12-18 | 2002-06-26 | Fuji Photo Film Co Ltd | 非線形光学材料とその製造方法 |
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