CY2013024I1 - Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους - Google Patents

Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους

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Publication number
CY2013024I1
CY2013024I1 CY2013024C CY2013024C CY2013024I1 CY 2013024 I1 CY2013024 I1 CY 2013024I1 CY 2013024 C CY2013024 C CY 2013024C CY 2013024 C CY2013024 C CY 2013024C CY 2013024 I1 CY2013024 I1 CY 2013024I1
Authority
CY
Cyprus
Prior art keywords
styrylopyridine
derivatives
binding
amyloid plaques
imaging amyloid
Prior art date
Application number
CY2013024C
Other languages
English (en)
Other versions
CY2013024I2 (el
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of CY2013024I2 publication Critical patent/CY2013024I2/el
Publication of CY2013024I1 publication Critical patent/CY2013024I1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CY2013024C 2006-03-30 2013-06-27 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους CY2013024I1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (2)

Publication Number Publication Date
CY2013024I2 CY2013024I2 (el) 2015-11-04
CY2013024I1 true CY2013024I1 (el) 2015-11-04

Family

ID=38326579

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20121100225T CY1113048T1 (el) 2006-03-30 2012-03-07 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους
CY2013024C CY2013024I1 (el) 2006-03-30 2013-06-27 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους
CY20171100664T CY1119048T1 (el) 2006-03-30 2017-06-22 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20121100225T CY1113048T1 (el) 2006-03-30 2012-03-07 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20171100664T CY1119048T1 (el) 2006-03-30 2017-06-22 Παραγωγα στυρυλοπυριδινης και η χρηση τους για συνδεση κι απεικονιση πλακων αμυλοειδους

Country Status (34)

Country Link
US (3) US7687052B2 (el)
EP (3) EP2363391A1 (el)
JP (1) JP5290954B2 (el)
KR (1) KR101376807B1 (el)
CN (1) CN101522624B (el)
AT (1) ATE539060T1 (el)
AU (1) AU2007243712B2 (el)
BR (1) BRPI0710225B1 (el)
CA (1) CA2644530C (el)
CR (1) CR10329A (el)
CY (3) CY1113048T1 (el)
DK (2) DK2363392T3 (el)
EA (1) EA017898B1 (el)
EC (1) ECSP088783A (el)
ES (2) ES2378785T3 (el)
FR (1) FR13C0034I2 (el)
GT (1) GT200800201A (el)
HR (2) HRP20120135T1 (el)
HU (2) HUE032660T2 (el)
IL (1) IL193567A (el)
LT (1) LT2363392T (el)
LU (1) LU92232I2 (el)
MX (1) MX2008012527A (el)
NO (2) NO342090B1 (el)
NZ (1) NZ570887A (el)
PL (2) PL1999109T3 (el)
PT (2) PT1999109E (el)
RS (2) RS56171B1 (el)
SG (1) SG173338A1 (el)
SI (2) SI1999109T1 (el)
TW (1) TWI399366B (el)
UA (1) UA97802C2 (el)
WO (1) WO2007126733A2 (el)
ZA (1) ZA200807955B (el)

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EP2501696B1 (en) 2009-10-15 2016-12-28 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
MX336896B (es) * 2009-12-23 2016-02-05 Piramal Imaging Sa Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos.
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
CN103328011A (zh) 2010-06-04 2013-09-25 皮拉马影像股份公司 生产F-18标记的β-淀粉样蛋白配体的方法
SG185782A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
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CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
CA2831331C (en) 2011-04-21 2019-10-15 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
BR112014009013A2 (pt) 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
EP2836241B1 (en) 2012-04-10 2019-02-20 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
CN110483522B (zh) * 2014-05-13 2022-05-03 豪夫迈·罗氏有限公司 氘化杂环化合物和其作为成像剂的用途
KR20180052611A (ko) * 2015-08-18 2018-05-18 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 영상화 및 치료 용도를 위한 니트록사이드 함유 아밀로이드 결합 제제
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
WO2024107620A1 (en) 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

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US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja) 2000-12-18 2002-06-26 Fuji Photo Film Co Ltd 非線形光学材料とその製造方法
CA2456411C (en) * 2001-08-27 2011-02-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
JP2005529464A (ja) 2002-06-06 2005-09-29 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア セラミックアノード及びそれを生産する方法
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JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
PT1999109E (pt) * 2006-03-30 2012-03-16 Univ Pennsylvania Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
US20080253967A1 (en) 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

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HRP20170857T1 (hr) 2017-12-01
TWI399366B (zh) 2013-06-21
US8506929B2 (en) 2013-08-13
KR20080106564A (ko) 2008-12-08
RS56171B1 (sr) 2017-11-30
ATE539060T1 (de) 2012-01-15
US20090123369A1 (en) 2009-05-14
EP1999109A2 (en) 2008-12-10
BRPI0710225A2 (pt) 2011-08-02
US20130129624A1 (en) 2013-05-23
MX2008012527A (es) 2008-10-14
ES2628882T3 (es) 2017-08-04
GT200800201A (es) 2009-08-20
PT1999109E (pt) 2012-03-16
CA2644530C (en) 2015-05-19
PL2363392T3 (pl) 2017-10-31
AU2007243712A1 (en) 2007-11-08
NO342090B1 (no) 2018-03-19
NZ570887A (en) 2011-05-27
EP2363391A1 (en) 2011-09-07
CY2013024I2 (el) 2015-11-04
SI2363392T1 (sl) 2017-09-29
RS52222B (en) 2012-10-31
LU92232I9 (el) 2019-01-15
NO20084590L (no) 2008-12-29
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
KR101376807B1 (ko) 2014-03-20
CN101522624B (zh) 2013-11-06
SG173338A1 (en) 2011-08-29
SI1999109T1 (sl) 2012-04-30
CY1113048T1 (el) 2015-11-04
JP2009532349A (ja) 2009-09-10
EA017898B1 (ru) 2013-04-30
EP2363392A1 (en) 2011-09-07
ECSP088783A (es) 2008-10-31
UA97802C2 (uk) 2012-03-26
US8840866B2 (en) 2014-09-23
FR13C0034I2 (fr) 2014-03-07
EP2363392B1 (en) 2017-05-03
CA2644530A1 (en) 2007-11-08
BRPI0710225B1 (pt) 2021-07-13
FR13C0034I1 (el) 2013-08-09
DK1999109T3 (da) 2012-04-02
IL193567A (en) 2014-03-31
HUS1300028I1 (hu) 2017-08-28
HUE032660T2 (en) 2017-10-30
ES2378785T3 (es) 2012-04-17
WO2007126733A3 (en) 2008-03-06
ZA200807955B (en) 2012-11-28
US20080038195A1 (en) 2008-02-14
EP1999109B1 (en) 2011-12-28
US7687052B2 (en) 2010-03-30
DK2363392T3 (en) 2017-07-03
IL193567A0 (en) 2009-05-04
LU92232I2 (fr) 2013-08-26
EA200870389A1 (ru) 2009-04-28
LT2363392T (lt) 2017-07-25
JP5290954B2 (ja) 2013-09-18
TW200838852A (en) 2008-10-01
CY1119048T1 (el) 2018-01-10
CR10329A (es) 2008-10-29
HRP20120135T1 (hr) 2012-03-31
CN101522624A (zh) 2009-09-02
WO2007126733A2 (en) 2007-11-08
NO2018030I1 (no) 2018-09-11
AU2007243712B2 (en) 2013-01-10

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