HUS1300028I1 - Sztiril-piridin-származékok és alkalmazásuk amyloid-plakkok megkötésére és leképezésére - Google Patents

Sztiril-piridin-származékok és alkalmazásuk amyloid-plakkok megkötésére és leképezésére

Info

Publication number
HUS1300028I1
HUS1300028I1 HUS1300028C HUS1300028C HUS1300028I1 HU S1300028 I1 HUS1300028 I1 HU S1300028I1 HU S1300028 C HUS1300028 C HU S1300028C HU S1300028 C HUS1300028 C HU S1300028C HU S1300028 I1 HUS1300028 I1 HU S1300028I1
Authority
HU
Hungary
Prior art keywords
binding
amyloid plaques
styrylpyridine
imaging amyloid
compounds
Prior art date
Application number
HUS1300028C
Other languages
English (en)
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of HUS1300028I1 publication Critical patent/HUS1300028I1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUS1300028C 2006-03-30 2013-06-27 Sztiril-piridin-származékok és alkalmazásuk amyloid-plakkok megkötésére és leképezésére HUS1300028I1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
EP07753982A EP1999109B1 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
HUS1300028I1 true HUS1300028I1 (hu) 2017-08-28

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE11152124A HUE032660T2 (hu) 2006-03-30 2007-03-26 Sztirilpiridin-származékok és azok alkalmazása amiloid plakkok megkötésére és leképezésére
HUS1300028C HUS1300028I1 (hu) 2006-03-30 2013-06-27 Sztiril-piridin-származékok és alkalmazásuk amyloid-plakkok megkötésére és leképezésére

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HUE11152124A HUE032660T2 (hu) 2006-03-30 2007-03-26 Sztirilpiridin-származékok és azok alkalmazása amiloid plakkok megkötésére és leképezésére

Country Status (34)

Country Link
US (3) US7687052B2 (hu)
EP (3) EP2363391A1 (hu)
JP (1) JP5290954B2 (hu)
KR (1) KR101376807B1 (hu)
CN (1) CN101522624B (hu)
AT (1) ATE539060T1 (hu)
AU (1) AU2007243712B2 (hu)
BR (1) BRPI0710225B1 (hu)
CA (1) CA2644530C (hu)
CR (1) CR10329A (hu)
CY (3) CY1113048T1 (hu)
DK (2) DK2363392T3 (hu)
EA (1) EA017898B1 (hu)
EC (1) ECSP088783A (hu)
ES (2) ES2628882T3 (hu)
FR (1) FR13C0034I2 (hu)
GT (1) GT200800201A (hu)
HR (2) HRP20120135T1 (hu)
HU (2) HUE032660T2 (hu)
IL (1) IL193567A (hu)
LT (1) LT2363392T (hu)
LU (1) LU92232I2 (hu)
MX (1) MX2008012527A (hu)
NO (2) NO342090B1 (hu)
NZ (1) NZ570887A (hu)
PL (2) PL1999109T3 (hu)
PT (2) PT2363392T (hu)
RS (2) RS56171B1 (hu)
SG (1) SG173338A1 (hu)
SI (2) SI2363392T1 (hu)
TW (1) TWI399366B (hu)
UA (1) UA97802C2 (hu)
WO (1) WO2007126733A2 (hu)
ZA (1) ZA200807955B (hu)

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EP2172444A4 (en) * 2007-07-04 2010-12-22 Univ Tohoku PET SENSOR HAVING ALCOXY GROUP SUBSTITUTED BY FLUORIN ATOM AND HYDROXY GROUP
US8557222B2 (en) * 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
PT2381967T (pt) * 2008-12-31 2017-02-24 Avid Radiopharmaceuticals Inc Síntese de estirilpiridinas radiomarcadas com 18f a partir de precursores tosilato e as suas composições farmacêuticas estáveis
JP2012532164A (ja) * 2009-07-10 2012-12-13 バイエル ファーマ アクチエンゲゼルシャフト 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用
WO2011045415A2 (en) 2009-10-15 2011-04-21 Guerbet New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
EA022447B1 (ru) * 2009-12-23 2016-01-29 Пирамаль Имэджинг Са Композиции, приемлемые для рет-визуализации при помощи гидрофобных рет-агентов
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
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EP3345545B1 (en) 2011-04-21 2021-10-20 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
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JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
SG10201805628TA (en) * 2014-05-13 2018-08-30 Hoffmann La Roche Deuterated heterocyclic compounds and their use as imaging agents
JP7114074B2 (ja) * 2015-08-18 2022-08-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
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Publication number Publication date
HRP20170857T1 (hr) 2017-12-01
BRPI0710225B1 (pt) 2021-07-13
GT200800201A (es) 2009-08-20
CY2013024I1 (el) 2015-11-04
BRPI0710225A2 (pt) 2011-08-02
PL2363392T3 (pl) 2017-10-31
EA200870389A1 (ru) 2009-04-28
CY2013024I2 (el) 2015-11-04
CN101522624B (zh) 2013-11-06
UA97802C2 (uk) 2012-03-26
US8506929B2 (en) 2013-08-13
CY1119048T1 (el) 2018-01-10
ECSP088783A (es) 2008-10-31
KR101376807B1 (ko) 2014-03-20
IL193567A0 (en) 2009-05-04
NO2018030I1 (no) 2018-09-11
EP2363392A1 (en) 2011-09-07
SI2363392T1 (sl) 2017-09-29
TW200838852A (en) 2008-10-01
ZA200807955B (en) 2012-11-28
LT2363392T (lt) 2017-07-25
MX2008012527A (es) 2008-10-14
SG173338A1 (en) 2011-08-29
CA2644530A1 (en) 2007-11-08
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
DK2363392T3 (en) 2017-07-03
FR13C0034I1 (hu) 2013-08-09
CA2644530C (en) 2015-05-19
HRP20120135T1 (hr) 2012-03-31
HUE032660T2 (hu) 2017-10-30
ES2628882T3 (es) 2017-08-04
NZ570887A (en) 2011-05-27
FR13C0034I2 (fr) 2014-03-07
EP2363391A1 (en) 2011-09-07
CN101522624A (zh) 2009-09-02
AU2007243712B2 (en) 2013-01-10
RS52222B (en) 2012-10-31
CY1113048T1 (el) 2015-11-04
US20080038195A1 (en) 2008-02-14
EP2363392B1 (en) 2017-05-03
RS56171B1 (sr) 2017-11-30
WO2007126733A2 (en) 2007-11-08
AU2007243712A1 (en) 2007-11-08
EP1999109B1 (en) 2011-12-28
LU92232I2 (fr) 2013-08-26
EP1999109A2 (en) 2008-12-10
NO342090B1 (no) 2018-03-19
IL193567A (en) 2014-03-31
DK1999109T3 (da) 2012-04-02
US7687052B2 (en) 2010-03-30
WO2007126733A3 (en) 2008-03-06
US20130129624A1 (en) 2013-05-23
CR10329A (es) 2008-10-29
KR20080106564A (ko) 2008-12-08
ATE539060T1 (de) 2012-01-15
PT1999109E (pt) 2012-03-16
JP2009532349A (ja) 2009-09-10
LU92232I9 (hu) 2019-01-15
ES2378785T3 (es) 2012-04-17
TWI399366B (zh) 2013-06-21
EA017898B1 (ru) 2013-04-30
US20090123369A1 (en) 2009-05-14
SI1999109T1 (sl) 2012-04-30
US8840866B2 (en) 2014-09-23
JP5290954B2 (ja) 2013-09-18
NO20084590L (no) 2008-12-29

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