WO2008050133A3 - Inhibition of beta-amyloid aggregation - Google Patents

Inhibition of beta-amyloid aggregation Download PDF

Info

Publication number
WO2008050133A3
WO2008050133A3 PCT/GB2007/004079 GB2007004079W WO2008050133A3 WO 2008050133 A3 WO2008050133 A3 WO 2008050133A3 GB 2007004079 W GB2007004079 W GB 2007004079W WO 2008050133 A3 WO2008050133 A3 WO 2008050133A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibition
beta
amyloid aggregation
aggregation
inhibitors
Prior art date
Application number
PCT/GB2007/004079
Other languages
French (fr)
Other versions
WO2008050133A2 (en
Inventor
Jesus Zurdo
Susan Fowler
Ernest Giralt
Meritxell Teixido
Original Assignee
Zyentia Ltd
Carulla Natalia
Jesus Zurdo
Susan Fowler
Ernest Giralt
Meritxell Teixido
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyentia Ltd, Carulla Natalia, Jesus Zurdo, Susan Fowler, Ernest Giralt, Meritxell Teixido filed Critical Zyentia Ltd
Priority to EP07824323A priority Critical patent/EP2089419A2/en
Publication of WO2008050133A2 publication Critical patent/WO2008050133A2/en
Publication of WO2008050133A3 publication Critical patent/WO2008050133A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic

Abstract

This invention relates to the peptidyl inhibitors of ABeta1-42 aggregation. These inhibitors may be useful, for example, in the treatment of Alzheimer's disease
PCT/GB2007/004079 2006-10-27 2007-10-26 Inhibition of beta-amyloid aggregation WO2008050133A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07824323A EP2089419A2 (en) 2006-10-27 2007-10-26 Inhibition of beta-amyloid aggregation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85469406P 2006-10-27 2006-10-27
US60/854,694 2006-10-27

Publications (2)

Publication Number Publication Date
WO2008050133A2 WO2008050133A2 (en) 2008-05-02
WO2008050133A3 true WO2008050133A3 (en) 2008-06-19

Family

ID=38962885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/004079 WO2008050133A2 (en) 2006-10-27 2007-10-26 Inhibition of beta-amyloid aggregation

Country Status (2)

Country Link
EP (1) EP2089419A2 (en)
WO (1) WO2008050133A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ724348A (en) 2010-11-30 2019-12-20 Genentech Inc Low affinity blood brain barrier receptor antibodies and uses therefor
ES2617853T3 (en) 2012-02-27 2017-06-20 Universitat De Barcelona Protease resistant compounds useful as transporters across the blood brain barrier and transporter-load constructs
HU231182B1 (en) * 2013-05-17 2021-08-30 Szegedi Tudományegyetem Small peptide inhibitors of ß-amyloid toxicity
EP3035969B1 (en) 2013-08-19 2022-08-03 S.M. Discovery Holdings Inc. Peptidic nanodelivery composition targeting two receptors
GB201414038D0 (en) * 2014-08-07 2014-09-24 Univ Sussex The Alzheimer's disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008868A1 (en) * 1996-08-27 1998-03-05 Praecis Pharmaceuticals Incorporated MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS
WO2000068263A2 (en) * 1999-05-05 2000-11-16 Neurochem, Inc. Stereoselective antifibrillogenic peptides and peptidomimetics thereof
WO2003018609A2 (en) * 2001-08-23 2003-03-06 Stanley Stein Application of peptide conjugates to alzheimer's disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008868A1 (en) * 1996-08-27 1998-03-05 Praecis Pharmaceuticals Incorporated MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS
WO2000068263A2 (en) * 1999-05-05 2000-11-16 Neurochem, Inc. Stereoselective antifibrillogenic peptides and peptidomimetics thereof
WO2003018609A2 (en) * 2001-08-23 2003-03-06 Stanley Stein Application of peptide conjugates to alzheimer's disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CRUZ M ET AL: "Inhibition of beta-amyloid toxicity by short peptides containing N-methyl amino acids.", THE JOURNAL OF PEPTIDE RESEARCH : OFFICIAL JOURNAL OF THE AMERICAN PEPTIDE SOCIETY MAR 2004, vol. 63, no. 3, March 2004 (2004-03-01), pages 324 - 328, XP002467773, ISSN: 1397-002X *
KOKKONI NICOLETA ET AL: "N-methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 45, no. 32, August 2006 (2006-08-01), pages 9906 - 9918, XP002419875, ISSN: 0006-2960 *
WOOD S J ET AL: "PROLINES AND AMYLOIDOGENICITY IN FRAGMENTS OF THE ALZHEIMER'S PEPTIDE BETA/A4", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 3, 24 January 1995 (1995-01-24), pages 724 - 730, XP002050228, ISSN: 0006-2960 *
ZHANG GUOBAO ET AL: "Multiple-peptide conjugates for binding beta-amyloid plaques of Alzheimer's disease.", BIOCONJUGATE CHEMISTRY 2003 JAN-FEB, vol. 14, no. 1, January 2003 (2003-01-01), pages 86 - 92, XP002467772, ISSN: 1043-1802 *

Also Published As

Publication number Publication date
EP2089419A2 (en) 2009-08-19
WO2008050133A2 (en) 2008-05-02

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