PL1999109T3 - Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych - Google Patents

Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych

Info

Publication number
PL1999109T3
PL1999109T3 PL07753982T PL07753982T PL1999109T3 PL 1999109 T3 PL1999109 T3 PL 1999109T3 PL 07753982 T PL07753982 T PL 07753982T PL 07753982 T PL07753982 T PL 07753982T PL 1999109 T3 PL1999109 T3 PL 1999109T3
Authority
PL
Poland
Prior art keywords
binding
amyloid plaques
styrylpyridine
imaging amyloid
compounds
Prior art date
Application number
PL07753982T
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of PL1999109T3 publication Critical patent/PL1999109T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL07753982T 2006-03-30 2007-03-26 Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych PL1999109T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
EP07753982A EP1999109B1 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
PL1999109T3 true PL1999109T3 (pl) 2012-05-31

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
PL07753982T PL1999109T3 (pl) 2006-03-30 2007-03-26 Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
PL11152124T PL2363392T3 (pl) 2006-03-30 2007-03-26 Styrylopirydynowe pochodne i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL11152124T PL2363392T3 (pl) 2006-03-30 2007-03-26 Styrylopirydynowe pochodne i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Country Status (34)

Country Link
US (3) US7687052B2 (pl)
EP (3) EP2363392B1 (pl)
JP (1) JP5290954B2 (pl)
KR (1) KR101376807B1 (pl)
CN (1) CN101522624B (pl)
AT (1) ATE539060T1 (pl)
AU (1) AU2007243712B2 (pl)
BR (1) BRPI0710225B1 (pl)
CA (1) CA2644530C (pl)
CR (1) CR10329A (pl)
CY (3) CY1113048T1 (pl)
DK (2) DK2363392T3 (pl)
EA (1) EA017898B1 (pl)
EC (1) ECSP088783A (pl)
ES (2) ES2378785T3 (pl)
FR (1) FR13C0034I2 (pl)
GT (1) GT200800201A (pl)
HR (2) HRP20120135T1 (pl)
HU (2) HUE032660T2 (pl)
IL (1) IL193567A (pl)
LT (1) LT2363392T (pl)
LU (1) LU92232I2 (pl)
MX (1) MX2008012527A (pl)
NO (2) NO342090B1 (pl)
NZ (1) NZ570887A (pl)
PL (2) PL1999109T3 (pl)
PT (2) PT1999109E (pl)
RS (2) RS56171B1 (pl)
SG (1) SG173338A1 (pl)
SI (2) SI2363392T1 (pl)
TW (1) TWI399366B (pl)
UA (1) UA97802C2 (pl)
WO (1) WO2007126733A2 (pl)
ZA (1) ZA200807955B (pl)

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WO2010078370A1 (en) * 2008-12-31 2010-07-08 Avid Radiopharmaceuticals, Inc. Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
EP2451760A1 (en) * 2009-07-10 2012-05-16 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
EP2501696B1 (en) 2009-10-15 2016-12-28 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
CN102762229B9 (zh) * 2009-12-23 2020-12-01 皮拉马影像股份公司 适用于用疏水pet试剂pet成像的配方
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
CA2801530C (en) 2010-06-04 2017-09-12 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
MX2012014116A (es) * 2010-06-04 2013-08-08 Piramal Imaging Sa Metodo para la produccion de ligandos beta amiloide marcados con 18f.
CN103328011A (zh) 2010-06-04 2013-09-25 皮拉马影像股份公司 生产F-18标记的β-淀粉样蛋白配体的方法
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
WO2012051170A2 (en) * 2010-10-12 2012-04-19 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
KR20140012732A (ko) 2011-04-21 2014-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 작용화된 자성 나노입자, 그리고 아밀로이드 침착물 및 신경섬유매듭의 영상화에서의 용도
EP2768790A1 (en) 2011-10-19 2014-08-27 Piramal Imaging SA IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
CA2869398C (en) 2012-04-10 2019-10-22 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
LT3143011T (lt) 2014-05-13 2021-05-10 F. Hoffmann-La Roche Ag Deuterinti heterocikliniai junginiai ir jų naudojimas kaip vaizdinimo agentų
CN107949383B (zh) * 2015-08-18 2022-08-23 加利福尼亚大学董事会 用于成像的含氮氧化合物的淀粉样蛋白结合剂
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
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US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
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JP4436928B2 (ja) * 2001-08-27 2010-03-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
EA007525B1 (ru) 2002-06-06 2006-10-27 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Керамический анод и способ его изготовления
WO2004016271A1 (en) * 2002-08-14 2004-02-26 Axxima Pharmaceuticals Ag Pyrimidones as antiviral agents
JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
AU2005316421B2 (en) * 2004-12-17 2012-04-05 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
CA2617319A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
PT1999109E (pt) 2006-03-30 2012-03-16 Univ Pennsylvania Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
US20080253967A1 (en) 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

Also Published As

Publication number Publication date
FR13C0034I1 (pl) 2013-08-09
CY1113048T1 (el) 2015-11-04
EP1999109B1 (en) 2011-12-28
MX2008012527A (es) 2008-10-14
NO2018030I1 (no) 2018-09-11
ES2378785T3 (es) 2012-04-17
LU92232I9 (pl) 2019-01-15
WO2007126733A3 (en) 2008-03-06
AU2007243712A1 (en) 2007-11-08
US20090123369A1 (en) 2009-05-14
ECSP088783A (es) 2008-10-31
NZ570887A (en) 2011-05-27
HRP20170857T1 (hr) 2017-12-01
UA97802C2 (uk) 2012-03-26
EP1999109A2 (en) 2008-12-10
GT200800201A (es) 2009-08-20
EP2363392B1 (en) 2017-05-03
PL2363392T3 (pl) 2017-10-31
RS52222B (en) 2012-10-31
BRPI0710225B1 (pt) 2021-07-13
EP2363391A1 (en) 2011-09-07
US20130129624A1 (en) 2013-05-23
IL193567A0 (en) 2009-05-04
AU2007243712B2 (en) 2013-01-10
DK1999109T3 (da) 2012-04-02
LU92232I2 (fr) 2013-08-26
TWI399366B (zh) 2013-06-21
JP5290954B2 (ja) 2013-09-18
CY2013024I1 (el) 2015-11-04
PT1999109E (pt) 2012-03-16
CY1119048T1 (el) 2018-01-10
US8840866B2 (en) 2014-09-23
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
TW200838852A (en) 2008-10-01
CY2013024I2 (el) 2015-11-04
JP2009532349A (ja) 2009-09-10
EA200870389A1 (ru) 2009-04-28
HRP20120135T1 (hr) 2012-03-31
LT2363392T (lt) 2017-07-25
CN101522624B (zh) 2013-11-06
DK2363392T3 (en) 2017-07-03
KR20080106564A (ko) 2008-12-08
NO342090B1 (no) 2018-03-19
PT2363392T (pt) 2017-06-15
SG173338A1 (en) 2011-08-29
US20080038195A1 (en) 2008-02-14
CR10329A (es) 2008-10-29
ES2628882T3 (es) 2017-08-04
WO2007126733A2 (en) 2007-11-08
KR101376807B1 (ko) 2014-03-20
RS56171B1 (sr) 2017-11-30
US7687052B2 (en) 2010-03-30
SI1999109T1 (sl) 2012-04-30
BRPI0710225A2 (pt) 2011-08-02
NO20084590L (no) 2008-12-29
EP2363392A1 (en) 2011-09-07
FR13C0034I2 (fr) 2014-03-07
EA017898B1 (ru) 2013-04-30
US8506929B2 (en) 2013-08-13
CN101522624A (zh) 2009-09-02
CA2644530C (en) 2015-05-19
ATE539060T1 (de) 2012-01-15
HUS1300028I1 (hu) 2017-08-28
CA2644530A1 (en) 2007-11-08
IL193567A (en) 2014-03-31
HUE032660T2 (en) 2017-10-30

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