ECSP088783A - Derivados de estirilpiridina y sus usos para unión a placas amiloides y obtención de imágenes de las mismas - Google Patents

Derivados de estirilpiridina y sus usos para unión a placas amiloides y obtención de imágenes de las mismas

Info

Publication number
ECSP088783A
ECSP088783A EC2008008783A ECSP088783A ECSP088783A EC SP088783 A ECSP088783 A EC SP088783A EC 2008008783 A EC2008008783 A EC 2008008783A EC SP088783 A ECSP088783 A EC SP088783A EC SP088783 A ECSP088783 A EC SP088783A
Authority
EC
Ecuador
Prior art keywords
obtaining images
stirilpiridina
amiloid
joining
derivatives
Prior art date
Application number
EC2008008783A
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of ECSP088783A publication Critical patent/ECSP088783A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Abstract

Esta invención se relaciona con un método para obtener imágenes de depósitos amiloides y con compuestos de estirilpiridina, y métodos para preparar compuestos radiomarcados de estirilpiridina útiles para obtener imágenes de depósitos amiloides. Esta invención también se relaciona con compuestos y métodos para preparar compuestos para inhibir la agregación de proteínas amiloides que forma los depósitos amiloides, y un método para administrar un agente terapéutico a los depósitos amiloides.
EC2008008783A 2006-03-30 2008-09-30 Derivados de estirilpiridina y sus usos para unión a placas amiloides y obtención de imágenes de las mismas ECSP088783A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30

Publications (1)

Publication Number Publication Date
ECSP088783A true ECSP088783A (es) 2008-10-31

Family

ID=38326579

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008783A ECSP088783A (es) 2006-03-30 2008-09-30 Derivados de estirilpiridina y sus usos para unión a placas amiloides y obtención de imágenes de las mismas

Country Status (34)

Country Link
US (3) US7687052B2 (es)
EP (3) EP2363391A1 (es)
JP (1) JP5290954B2 (es)
KR (1) KR101376807B1 (es)
CN (1) CN101522624B (es)
AT (1) ATE539060T1 (es)
AU (1) AU2007243712B2 (es)
BR (1) BRPI0710225B1 (es)
CA (1) CA2644530C (es)
CR (1) CR10329A (es)
CY (3) CY1113048T1 (es)
DK (2) DK2363392T3 (es)
EA (1) EA017898B1 (es)
EC (1) ECSP088783A (es)
ES (2) ES2628882T3 (es)
FR (1) FR13C0034I2 (es)
GT (1) GT200800201A (es)
HR (2) HRP20120135T1 (es)
HU (2) HUE032660T2 (es)
IL (1) IL193567A (es)
LT (1) LT2363392T (es)
LU (1) LU92232I2 (es)
MX (1) MX2008012527A (es)
NO (2) NO342090B1 (es)
NZ (1) NZ570887A (es)
PL (2) PL2363392T3 (es)
PT (2) PT1999109E (es)
RS (2) RS52222B (es)
SG (1) SG173338A1 (es)
SI (2) SI2363392T1 (es)
TW (1) TWI399366B (es)
UA (1) UA97802C2 (es)
WO (1) WO2007126733A2 (es)
ZA (1) ZA200807955B (es)

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TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
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CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
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JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
RS61810B1 (sr) 2014-05-13 2021-06-30 Hoffmann La Roche Deuterisana heterociklična jedinjenja i njihova upotreba kao sredstva za snimanje
WO2017031239A1 (en) * 2015-08-18 2017-02-23 The Regents Of The University Of California Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
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Also Published As

Publication number Publication date
IL193567A0 (en) 2009-05-04
NO20084590L (no) 2008-12-29
US20080038195A1 (en) 2008-02-14
TWI399366B (zh) 2013-06-21
CY1113048T1 (el) 2015-11-04
LT2363392T (lt) 2017-07-25
ES2378785T3 (es) 2012-04-17
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
CR10329A (es) 2008-10-29
EP2363392B1 (en) 2017-05-03
US8840866B2 (en) 2014-09-23
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
CA2644530A1 (en) 2007-11-08
GT200800201A (es) 2009-08-20
EP1999109B1 (en) 2011-12-28
US20090123369A1 (en) 2009-05-14
IL193567A (en) 2014-03-31
BRPI0710225A2 (pt) 2011-08-02
CY2013024I1 (el) 2015-11-04
US7687052B2 (en) 2010-03-30
RS56171B1 (sr) 2017-11-30
CY2013024I2 (el) 2015-11-04
CN101522624B (zh) 2013-11-06
JP2009532349A (ja) 2009-09-10
EA200870389A1 (ru) 2009-04-28
ES2628882T3 (es) 2017-08-04
FR13C0034I2 (fr) 2014-03-07
TW200838852A (en) 2008-10-01
MX2008012527A (es) 2008-10-14
CN101522624A (zh) 2009-09-02
EP1999109A2 (en) 2008-12-10
HRP20170857T1 (hr) 2017-12-01
EP2363391A1 (en) 2011-09-07
KR101376807B1 (ko) 2014-03-20
US20130129624A1 (en) 2013-05-23
DK2363392T3 (en) 2017-07-03
LU92232I2 (fr) 2013-08-26
EP2363392A1 (en) 2011-09-07
HUE032660T2 (en) 2017-10-30
WO2007126733A2 (en) 2007-11-08
HRP20120135T1 (hr) 2012-03-31
SI1999109T1 (sl) 2012-04-30
FR13C0034I1 (es) 2013-08-09
PT1999109E (pt) 2012-03-16
RS52222B (en) 2012-10-31
UA97802C2 (uk) 2012-03-26
WO2007126733A3 (en) 2008-03-06
AU2007243712A1 (en) 2007-11-08
JP5290954B2 (ja) 2013-09-18
PL2363392T3 (pl) 2017-10-31
HUS1300028I1 (hu) 2017-08-28
KR20080106564A (ko) 2008-12-08
DK1999109T3 (da) 2012-04-02
EA017898B1 (ru) 2013-04-30
AU2007243712B2 (en) 2013-01-10
ATE539060T1 (de) 2012-01-15
CY1119048T1 (el) 2018-01-10
NZ570887A (en) 2011-05-27
CA2644530C (en) 2015-05-19
LU92232I9 (es) 2019-01-15
US8506929B2 (en) 2013-08-13
NO342090B1 (no) 2018-03-19
NO2018030I1 (no) 2018-09-11
BRPI0710225B1 (pt) 2021-07-13
SG173338A1 (en) 2011-08-29

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