SI1999109T1 - Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov - Google Patents

Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov

Info

Publication number
SI1999109T1
SI1999109T1 SI200730865T SI200730865T SI1999109T1 SI 1999109 T1 SI1999109 T1 SI 1999109T1 SI 200730865 T SI200730865 T SI 200730865T SI 200730865 T SI200730865 T SI 200730865T SI 1999109 T1 SI1999109 T1 SI 1999109T1
Authority
SI
Slovenia
Prior art keywords
binding
amyloid plaques
styrylpyridine
imaging amyloid
compounds
Prior art date
Application number
SI200730865T
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of SI1999109T1 publication Critical patent/SI1999109T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
SI200730865T 2006-03-30 2007-03-26 Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov SI1999109T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
EP07753982A EP1999109B1 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
SI1999109T1 true SI1999109T1 (sl) 2012-04-30

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200731938T SI2363392T1 (sl) 2006-03-30 2007-03-26 Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov
SI200730865T SI1999109T1 (sl) 2006-03-30 2007-03-26 Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200731938T SI2363392T1 (sl) 2006-03-30 2007-03-26 Derivati stirilpiridina in njihova uporaba za vezavo in prikazovanje amiloidnih plakov

Country Status (34)

Country Link
US (3) US7687052B2 (sl)
EP (3) EP2363391A1 (sl)
JP (1) JP5290954B2 (sl)
KR (1) KR101376807B1 (sl)
CN (1) CN101522624B (sl)
AT (1) ATE539060T1 (sl)
AU (1) AU2007243712B2 (sl)
BR (1) BRPI0710225B1 (sl)
CA (1) CA2644530C (sl)
CR (1) CR10329A (sl)
CY (3) CY1113048T1 (sl)
DK (2) DK1999109T3 (sl)
EA (1) EA017898B1 (sl)
EC (1) ECSP088783A (sl)
ES (2) ES2378785T3 (sl)
FR (1) FR13C0034I2 (sl)
GT (1) GT200800201A (sl)
HR (2) HRP20120135T1 (sl)
HU (2) HUE032660T2 (sl)
IL (1) IL193567A (sl)
LT (1) LT2363392T (sl)
LU (1) LU92232I2 (sl)
MX (1) MX2008012527A (sl)
NO (2) NO342090B1 (sl)
NZ (1) NZ570887A (sl)
PL (2) PL1999109T3 (sl)
PT (2) PT1999109E (sl)
RS (2) RS56171B1 (sl)
SG (1) SG173338A1 (sl)
SI (2) SI2363392T1 (sl)
TW (1) TWI399366B (sl)
UA (1) UA97802C2 (sl)
WO (1) WO2007126733A2 (sl)
ZA (1) ZA200807955B (sl)

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NZ570887A (en) 2006-03-30 2011-05-27 Univ Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
JP5322180B2 (ja) * 2007-07-04 2013-10-23 国立大学法人東北大学 フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
CA2748705C (en) * 2008-12-31 2017-05-02 Avid Radiopharmaceuticals, Inc. Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
CN102471177A (zh) * 2009-07-10 2012-05-23 拜耳医药股份有限公司 低至中压液相色谱在放射性示踪剂纯化中的应用
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
EP2515948A1 (en) * 2009-12-23 2012-10-31 Piramal Imaging SA Formulations suitable for pet imaging with hydrophobic pet agents
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
JP2013527211A (ja) * 2010-06-04 2013-06-27 ピラマル イメージング ソシエテ アノニム Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
MX2012014115A (es) 2010-06-04 2013-07-03 Piramal Imaging Sa Metodo para la produccion de ligandos beta amiloide marcados con 18f.
ES2642086T5 (es) 2010-06-04 2020-04-13 Life Molecular Imaging Sa Procedimiento para la producción de ligandos de beta amiloide marcados con F-18
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
KR20140012732A (ko) * 2011-04-21 2014-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 작용화된 자성 나노입자, 그리고 아밀로이드 침착물 및 신경섬유매듭의 영상화에서의 용도
CA2852840A1 (en) 2011-10-19 2013-04-25 Piramal Imaging Sa Improved method for production of f-18 labeled a.beta. ligands
AU2013263297B2 (en) 2012-04-10 2017-11-30 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
SI3143011T1 (sl) * 2014-05-13 2021-08-31 F. Hoffmann-La Roche Ag Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva
AU2016308189B2 (en) * 2015-08-18 2021-03-11 The Regents Of The University Of California Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法

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JPH0545875A (ja) * 1991-08-08 1993-02-26 Konica Corp 感光性組成物
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TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
AU2001239544A1 (en) * 2000-03-22 2001-10-03 Bf Research Institute, Inc. Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same
US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja) 2000-12-18 2002-06-26 Fuji Photo Film Co Ltd 非線形光学材料とその製造方法
AU2002323417B2 (en) * 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
IL165386A0 (en) 2002-06-06 2006-01-15 Univ Pennsylvania Ceramic anodes and method of producing the same
AU2003258612A1 (en) * 2002-08-14 2004-03-03 4Sc Ag Pyrimidones as antiviral agents
JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
PL2213652T3 (pl) * 2004-12-17 2015-04-30 Univ Pennsylvania Pochodne stilbenu i ich zastosowanie do wiązania i obrazowania płytek amyloidowych
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
AU2006261917A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
NZ570887A (en) * 2006-03-30 2011-05-27 Univ Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

Also Published As

Publication number Publication date
TWI399366B (zh) 2013-06-21
TW200838852A (en) 2008-10-01
NO2018030I1 (no) 2018-09-11
US8840866B2 (en) 2014-09-23
FR13C0034I2 (fr) 2014-03-07
ES2628882T3 (es) 2017-08-04
HRP20120135T1 (hr) 2012-03-31
KR101376807B1 (ko) 2014-03-20
US7687052B2 (en) 2010-03-30
CN101522624A (zh) 2009-09-02
US8506929B2 (en) 2013-08-13
DK2363392T3 (en) 2017-07-03
MX2008012527A (es) 2008-10-14
WO2007126733A3 (en) 2008-03-06
US20090123369A1 (en) 2009-05-14
WO2007126733A2 (en) 2007-11-08
ATE539060T1 (de) 2012-01-15
CA2644530A1 (en) 2007-11-08
SG173338A1 (en) 2011-08-29
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
NO342090B1 (no) 2018-03-19
PT1999109E (pt) 2012-03-16
DK1999109T3 (da) 2012-04-02
HUE032660T2 (en) 2017-10-30
NO20084590L (no) 2008-12-29
JP5290954B2 (ja) 2013-09-18
US20080038195A1 (en) 2008-02-14
EA017898B1 (ru) 2013-04-30
LU92232I2 (fr) 2013-08-26
CA2644530C (en) 2015-05-19
PL2363392T3 (pl) 2017-10-31
UA97802C2 (uk) 2012-03-26
US20130129624A1 (en) 2013-05-23
IL193567A0 (en) 2009-05-04
LT2363392T (lt) 2017-07-25
EP2363391A1 (en) 2011-09-07
GT200800201A (es) 2009-08-20
AU2007243712A1 (en) 2007-11-08
RS52222B (en) 2012-10-31
FR13C0034I1 (sl) 2013-08-09
CR10329A (es) 2008-10-29
NZ570887A (en) 2011-05-27
KR20080106564A (ko) 2008-12-08
RS56171B1 (sr) 2017-11-30
BRPI0710225B1 (pt) 2021-07-13
JP2009532349A (ja) 2009-09-10
EP1999109B1 (en) 2011-12-28
HUS1300028I1 (hu) 2017-08-28
EP2363392A1 (en) 2011-09-07
BRPI0710225A2 (pt) 2011-08-02
CY2013024I2 (el) 2015-11-04
AU2007243712B2 (en) 2013-01-10
CN101522624B (zh) 2013-11-06
ECSP088783A (es) 2008-10-31
LU92232I9 (sl) 2019-01-15
IL193567A (en) 2014-03-31
ES2378785T3 (es) 2012-04-17
EP1999109A2 (en) 2008-12-10
EP2363392B1 (en) 2017-05-03
CY1113048T1 (el) 2015-11-04
EA200870389A1 (ru) 2009-04-28
CY2013024I1 (el) 2015-11-04
CY1119048T1 (el) 2018-01-10
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
HRP20170857T1 (hr) 2017-12-01

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