PL2213652T3 - Pochodne stilbenu i ich zastosowanie do wiązania i obrazowania płytek amyloidowych - Google Patents

Pochodne stilbenu i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Info

Publication number
PL2213652T3
PL2213652T3 PL10161604T PL10161604T PL2213652T3 PL 2213652 T3 PL2213652 T3 PL 2213652T3 PL 10161604 T PL10161604 T PL 10161604T PL 10161604 T PL10161604 T PL 10161604T PL 2213652 T3 PL2213652 T3 PL 2213652T3
Authority
PL
Poland
Prior art keywords
binding
amyloid plaques
stilbene derivatives
imaging amyloid
imaging
Prior art date
Application number
PL10161604T
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of PL2213652T3 publication Critical patent/PL2213652T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL10161604T 2004-12-17 2005-12-19 Pochodne stilbenu i ich zastosowanie do wiązania i obrazowania płytek amyloidowych PL2213652T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
EP05854410A EP1841465A4 (en) 2004-12-17 2005-12-19 STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE
EP10161604.3A EP2213652B1 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
PL2213652T3 true PL2213652T3 (pl) 2015-04-30

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10161604T PL2213652T3 (pl) 2004-12-17 2005-12-19 Pochodne stilbenu i ich zastosowanie do wiązania i obrazowania płytek amyloidowych

Country Status (24)

Country Link
US (2) US7807135B2 (pl)
EP (3) EP1841465A4 (pl)
JP (1) JP5128956B2 (pl)
KR (1) KR101321619B1 (pl)
AU (1) AU2005316421B2 (pl)
BR (1) BRPI0516408B8 (pl)
CA (1) CA2591534C (pl)
DK (1) DK2213652T3 (pl)
EA (1) EA012334B1 (pl)
ES (1) ES2526655T3 (pl)
FR (1) FR15C0012I2 (pl)
HU (1) HUS1500014I1 (pl)
IL (2) IL183946A (pl)
LT (1) LTC2213652I2 (pl)
LU (1) LU92647I2 (pl)
MX (1) MX2007007380A (pl)
NL (1) NL300719I2 (pl)
NO (1) NO339195B1 (pl)
NZ (1) NZ555942A (pl)
PL (1) PL2213652T3 (pl)
PT (1) PT2213652E (pl)
SG (1) SG194363A1 (pl)
SI (1) SI2213652T1 (pl)
WO (1) WO2006066104A2 (pl)

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AU2002323417B2 (en) * 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
CA2617319A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
EP2363392B1 (en) 2006-03-30 2017-05-03 The Trustees Of The University Of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
GB2463436A (en) * 2007-06-22 2010-03-17 Univ Aberdeen (11C)methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (TMS) and its preparation and use
US20100272642A1 (en) * 2007-07-04 2010-10-28 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
WO2009052116A1 (en) * 2007-10-15 2009-04-23 The Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
PL2247558T3 (pl) * 2008-02-14 2022-05-02 Eli Lilly And Company Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych
EP2247944A1 (en) * 2008-02-27 2010-11-10 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
US8557222B2 (en) 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
JP2012508889A (ja) * 2008-11-13 2012-04-12 アビッド レディオファーマシューティカルズ、インク． 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法
EP2379757A2 (en) 2008-12-22 2011-10-26 Bayer Pharma Aktiengesellschaft A method for the synthesis of a radionuclide-labeled compound
PE20120007A1 (es) * 2008-12-31 2012-01-16 Avid Radiopharmaceuticals Inc Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de estas
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
WO2011003591A1 (en) * 2009-07-10 2011-01-13 Bayer Schering Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
US20120328521A1 (en) * 2009-12-23 2012-12-27 Piramal Imaging Sa Formulations suitable for pet imaging with hydrophobic pet agents
BR112012030935B1 (pt) 2010-04-06 2020-11-17 Life Molecular Imaging Sa método para a produção de ligantes de beta-amiloide marcados com f-18
KR20130088118A (ko) 2010-06-04 2013-08-07 피라말 이미징 에스에이 Ｆ-18 표지된 아밀로이드 베타 리간드의 제조 방법
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
JP2013532136A (ja) * 2010-06-04 2013-08-15 ピラマル イメージング ソシエテ アノニム Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
CA3058702C (en) * 2011-04-21 2023-11-07 Massoud Akhtari Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
PT2723394T (pt) 2011-06-21 2018-07-30 Life Molecular Imaging Sa Formulações de estilbeno fluorado, apropriadas para a imagiologia por pet
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
IN2014MN00875A (pl) 2011-10-19 2015-04-17 Piramal Imaging Sa
CN109125745B (zh) 2012-04-10 2022-07-26 蓝瑟斯医学影像公司 放射性药物合成方法
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
WO2018062588A1 (ko) 2016-09-29 2018-04-05 한국원자력연구원 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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JPS60247244A (ja) * 1984-05-22 1985-12-06 Mitsubishi Paper Mills Ltd 電子写真感光体
DD231432A1 (de) * 1984-11-01 1985-12-24 Univ Leipzig Material zur silberfreien bildaufzeichnung
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JPH06329566A (ja) 1993-05-21 1994-11-29 Asahi Glass Co Ltd ジフルオロスチルベン誘導体化合物およびそれを含有する液晶組成物
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AU2002323417B2 (en) * 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
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US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
CA2617319A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents

Also Published As

Publication number Publication date
HUS1500014I1 (hu) 2016-11-28
JP2008524243A (ja) 2008-07-10
EP1838298A4 (en) 2009-03-04
IL206091A (en) 2013-08-29
KR20070093427A (ko) 2007-09-18
BRPI0516408A (pt) 2008-09-02
NL300719I1 (pl) 2015-12-29
PT2213652E (pt) 2015-01-02
EP1838298A2 (en) 2007-10-03
AU2005316421B2 (en) 2012-04-05
MX2007007380A (es) 2007-10-11
SG194363A1 (en) 2013-11-29
US20100266500A1 (en) 2010-10-21
JP5128956B2 (ja) 2013-01-23
EP1841465A2 (en) 2007-10-10
BRPI0516408B1 (pt) 2021-03-23
NZ555942A (en) 2011-01-28
SI2213652T1 (sl) 2015-03-31
EA012334B1 (ru) 2009-08-28
WO2006066104A3 (en) 2006-08-03
WO2006066104A2 (en) 2006-06-22
EA200701299A1 (ru) 2007-12-28
CA2591534A1 (en) 2006-06-22
NO20073650L (no) 2007-09-14
US7807135B2 (en) 2010-10-05
BRPI0516408B8 (pt) 2021-05-25
IL183946A (en) 2011-08-31
FR15C0012I1 (pl) 2015-03-20
NL300719I2 (pl) 2015-12-29
ES2526655T3 (es) 2015-01-14
FR15C0012I2 (fr) 2015-11-20
DK2213652T3 (en) 2015-01-26
US20060269473A1 (en) 2006-11-30
EP1841465A4 (en) 2009-04-01
EP2213652A1 (en) 2010-08-04
NO339195B1 (no) 2016-11-14
KR101321619B1 (ko) 2013-10-30
CA2591534C (en) 2013-08-06
AU2005316421A1 (en) 2006-06-22
LU92647I2 (fr) 2015-11-03
IL183946A0 (en) 2007-10-31
US8465726B2 (en) 2013-06-18
LTC2213652I2 (lt) 2016-12-27
EP2213652B1 (en) 2014-10-22

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