BRPI0516408B8 - derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide - Google Patents

derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide

Info

Publication number
BRPI0516408B8
BRPI0516408B8 BRPI0516408A BRPI0516408A BRPI0516408B8 BR PI0516408 B8 BRPI0516408 B8 BR PI0516408B8 BR PI0516408 A BRPI0516408 A BR PI0516408A BR PI0516408 A BRPI0516408 A BR PI0516408A BR PI0516408 B8 BRPI0516408 B8 BR PI0516408B8
Authority
BR
Brazil
Prior art keywords
imaging
binding
stilbene derivatives
amyloid plaques
amyloid
Prior art date
Application number
BRPI0516408A
Other languages
English (en)
Inventor
F Kung Hank
Kung Mei-Ping
Zhuang Zhi-Ping
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of BRPI0516408A publication Critical patent/BRPI0516408A/pt
Publication of BRPI0516408B1 publication Critical patent/BRPI0516408B1/pt
Publication of BRPI0516408B8 publication Critical patent/BRPI0516408B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide. a presente invenção refere-se a um método de formação de imagem de depósitos de amilóide e aos compostos rotulados, e métodos de preparação de compostos rotulados úteis em formação de imagem de depósitos de amilóide. esta invenção também refere-se aos compostos, e métodos de preparação de compostos para inibição da agregação de proteínas amilóides para formar depósitos amilóides, e um método de liberação de um agente terapêutico aos depósitos de amilóide.
BRPI0516408A 2004-12-17 2005-12-19 derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide BRPI0516408B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US60/636,696 2004-12-17
US68639505P 2005-06-02 2005-06-02
US60/686,395 2005-06-02
PCT/US2005/045682 WO2006066104A2 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (3)

Publication Number Publication Date
BRPI0516408A BRPI0516408A (pt) 2008-09-02
BRPI0516408B1 BRPI0516408B1 (pt) 2021-03-23
BRPI0516408B8 true BRPI0516408B8 (pt) 2021-05-25

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516408A BRPI0516408B8 (pt) 2004-12-17 2005-12-19 derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide

Country Status (24)

Country Link
US (2) US7807135B2 (pt)
EP (3) EP1838298A4 (pt)
JP (1) JP5128956B2 (pt)
KR (1) KR101321619B1 (pt)
AU (1) AU2005316421B2 (pt)
BR (1) BRPI0516408B8 (pt)
CA (1) CA2591534C (pt)
DK (1) DK2213652T3 (pt)
EA (1) EA012334B1 (pt)
ES (1) ES2526655T3 (pt)
FR (1) FR15C0012I2 (pt)
HU (1) HUS1500014I1 (pt)
IL (2) IL183946A (pt)
LT (1) LTC2213652I2 (pt)
LU (1) LU92647I2 (pt)
MX (1) MX2007007380A (pt)
NL (1) NL300719I2 (pt)
NO (1) NO339195B1 (pt)
NZ (1) NZ555942A (pt)
PL (1) PL2213652T3 (pt)
PT (1) PT2213652E (pt)
SG (1) SG194363A1 (pt)
SI (1) SI2213652T1 (pt)
WO (1) WO2006066104A2 (pt)

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WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
PT1999109E (pt) 2006-03-30 2012-03-16 Univ Pennsylvania Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
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HUE033649T2 (en) * 2008-12-31 2017-12-28 Avid Radiopharmaceuticals Inc Synthesis of 18F-labeled styryl pyridines from tosylate precursors and their stable pharmaceutical preparations
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US8968701B2 (en) 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
MX336896B (es) * 2009-12-23 2016-02-05 Piramal Imaging Sa Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos.
SG185782A1 (en) * 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
CN103328011A (zh) 2010-06-04 2013-09-25 皮拉马影像股份公司 生产F-18标记的β-淀粉样蛋白配体的方法
EA201201647A1 (ru) 2010-06-04 2013-05-30 Пирамаль Имэджинг Са Способ получения f-18 меченных лигандов бета-амилоида
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
CA2831331C (en) * 2011-04-21 2019-10-15 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
PL2723394T3 (pl) 2011-06-21 2018-11-30 Piramal Imaging Sa Preparaty fluorowanego stylbenu odpowiednie do zastosowań w obrazowaniu PET
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
BR112014009013A2 (pt) 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
EP2836241B1 (en) 2012-04-10 2019-02-20 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
WO2018062588A1 (ko) 2016-09-29 2018-04-05 한국원자력연구원 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제
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Also Published As

Publication number Publication date
NZ555942A (en) 2011-01-28
CA2591534C (en) 2013-08-06
EP1838298A2 (en) 2007-10-03
IL206091A (en) 2013-08-29
ES2526655T3 (es) 2015-01-14
EP1841465A2 (en) 2007-10-10
PL2213652T3 (pl) 2015-04-30
JP5128956B2 (ja) 2013-01-23
NO20073650L (no) 2007-09-14
SG194363A1 (en) 2013-11-29
MX2007007380A (es) 2007-10-11
US7807135B2 (en) 2010-10-05
IL183946A (en) 2011-08-31
IL183946A0 (en) 2007-10-31
KR101321619B1 (ko) 2013-10-30
KR20070093427A (ko) 2007-09-18
AU2005316421B2 (en) 2012-04-05
US20100266500A1 (en) 2010-10-21
BRPI0516408A (pt) 2008-09-02
FR15C0012I2 (fr) 2015-11-20
WO2006066104A3 (en) 2006-08-03
JP2008524243A (ja) 2008-07-10
HUS1500014I1 (hu) 2016-11-28
CA2591534A1 (en) 2006-06-22
NL300719I1 (pt) 2015-12-29
US8465726B2 (en) 2013-06-18
LTC2213652I2 (lt) 2016-12-27
SI2213652T1 (sl) 2015-03-31
US20060269473A1 (en) 2006-11-30
NL300719I2 (pt) 2015-12-29
DK2213652T3 (en) 2015-01-26
FR15C0012I1 (pt) 2015-03-20
EP2213652B1 (en) 2014-10-22
EP1841465A4 (en) 2009-04-01
EA200701299A1 (ru) 2007-12-28
PT2213652E (pt) 2015-01-02
EP1838298A4 (en) 2009-03-04
LU92647I2 (fr) 2015-11-03
NO339195B1 (no) 2016-11-14
BRPI0516408B1 (pt) 2021-03-23
EA012334B1 (ru) 2009-08-28
AU2005316421A1 (en) 2006-06-22
WO2006066104A2 (en) 2006-06-22
EP2213652A1 (en) 2010-08-04

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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