NO20073650L - Stilbenderivater og deres anvendelse til binding og avbilding av amyloidplakker - Google Patents

Stilbenderivater og deres anvendelse til binding og avbilding av amyloidplakker

Info

Publication number
NO20073650L
NO20073650L NO20073650A NO20073650A NO20073650L NO 20073650 L NO20073650 L NO 20073650L NO 20073650 A NO20073650 A NO 20073650A NO 20073650 A NO20073650 A NO 20073650A NO 20073650 L NO20073650 L NO 20073650L
Authority
NO
Norway
Prior art keywords
imaging
bonding
amyloid plaques
stilbene derivatives
amyloid deposits
Prior art date
Application number
NO20073650A
Other languages
English (en)
Other versions
NO339195B1 (no
Inventor
Hank F Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of NO20073650L publication Critical patent/NO20073650L/no
Publication of NO339195B1 publication Critical patent/NO339195B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Denne oppfinnelsen vedrører en fremgangsmåte for avbilding av amyloidavsetninger, og merkede forbindelser og fremgangsmåter for fremstilling av merkede forbindelser som kan anvendes ved avbilding av amyloidavsetninger. Denne oppfinnelsen vedrører også forbindelser og fremgangsmåter for fremstilling av forbindelser for hemming av aggregasjonen av amyloidproteiner slik at amyloidavsetninger dannes, og en fremgangsmåte for avlevering av et terapeutisk middel til amyloidavsetninger.
NO20073650A 2004-12-17 2007-07-16 Stilbenderivater og deres anvendelse til binding og avbilding av amyloide plakk, fremgangsmåte for fremstilling av derivatene, farmasøytiske og diagnostiske preparater derav, og deres anvendelse ved hemming av amyloidplakkaggregering hos pattedyr. NO339195B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
PCT/US2005/045682 WO2006066104A2 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (2)

Publication Number Publication Date
NO20073650L true NO20073650L (no) 2007-09-14
NO339195B1 NO339195B1 (no) 2016-11-14

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073650A NO339195B1 (no) 2004-12-17 2007-07-16 Stilbenderivater og deres anvendelse til binding og avbilding av amyloide plakk, fremgangsmåte for fremstilling av derivatene, farmasøytiske og diagnostiske preparater derav, og deres anvendelse ved hemming av amyloidplakkaggregering hos pattedyr.

Country Status (25)

Country Link
US (2) US7807135B2 (no)
EP (3) EP1841465A4 (no)
JP (1) JP5128956B2 (no)
KR (1) KR101321619B1 (no)
AU (1) AU2005316421B2 (no)
BE (1) BE2015C015I2 (no)
BR (1) BRPI0516408B8 (no)
CA (1) CA2591534C (no)
DK (1) DK2213652T3 (no)
EA (1) EA012334B1 (no)
ES (1) ES2526655T3 (no)
FR (1) FR15C0012I2 (no)
HU (1) HUS1500014I1 (no)
IL (2) IL183946A (no)
LT (1) LTC2213652I2 (no)
LU (1) LU92647I2 (no)
MX (1) MX2007007380A (no)
NL (1) NL300719I2 (no)
NO (1) NO339195B1 (no)
NZ (1) NZ555942A (no)
PL (1) PL2213652T3 (no)
PT (1) PT2213652E (no)
SG (1) SG194363A1 (no)
SI (1) SI2213652T1 (no)
WO (1) WO2006066104A2 (no)

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WO2012145169A2 (en) * 2011-04-21 2012-10-26 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
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RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
JP2015501305A (ja) 2011-10-19 2015-01-15 ピラマル イメージング ソシエテ アノニム Ｆ‐１８標識Ａβリガンドの改良された製造方法
PT2836241T (pt) 2012-04-10 2019-05-30 Lantheus Medical Imaging Inc Métodos de síntese de radiofármacos
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
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US20070031328A1 (en) * 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents

Also Published As

Publication number Publication date
LU92647I2 (fr) 2015-11-03
BE2015C015I2 (no) 2025-04-29
ES2526655T3 (es) 2015-01-14
IL183946A0 (en) 2007-10-31
EP1841465A2 (en) 2007-10-10
FR15C0012I1 (no) 2015-03-20
SI2213652T1 (sl) 2015-03-31
BRPI0516408A (pt) 2008-09-02
PL2213652T3 (pl) 2015-04-30
CA2591534C (en) 2013-08-06
US20100266500A1 (en) 2010-10-21
NZ555942A (en) 2011-01-28
HUS1500014I1 (hu) 2016-11-28
IL206091A (en) 2013-08-29
DK2213652T3 (en) 2015-01-26
NL300719I1 (no) 2015-12-29
US8465726B2 (en) 2013-06-18
LTC2213652I2 (lt) 2016-12-27
IL183946A (en) 2011-08-31
EP2213652A1 (en) 2010-08-04
SG194363A1 (en) 2013-11-29
WO2006066104A2 (en) 2006-06-22
KR20070093427A (ko) 2007-09-18
PT2213652E (pt) 2015-01-02
WO2006066104A3 (en) 2006-08-03
EP1838298A4 (en) 2009-03-04
BRPI0516408B1 (pt) 2021-03-23
EP2213652B1 (en) 2014-10-22
JP5128956B2 (ja) 2013-01-23
MX2007007380A (es) 2007-10-11
KR101321619B1 (ko) 2013-10-30
US7807135B2 (en) 2010-10-05
EA200701299A1 (ru) 2007-12-28
JP2008524243A (ja) 2008-07-10
EA012334B1 (ru) 2009-08-28
AU2005316421A1 (en) 2006-06-22
NO339195B1 (no) 2016-11-14
FR15C0012I2 (fr) 2015-11-20
NL300719I2 (no) 2015-12-29
US20060269473A1 (en) 2006-11-30
BRPI0516408B8 (pt) 2021-05-25
CA2591534A1 (en) 2006-06-22
EP1841465A4 (en) 2009-04-01
EP1838298A2 (en) 2007-10-03
AU2005316421B2 (en) 2012-04-05

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