MX2012014115A - Metodo para la produccion de ligandos beta amiloide marcados con 18f. - Google Patents

Metodo para la produccion de ligandos beta amiloide marcados con 18f.

Info

Publication number
MX2012014115A
MX2012014115A MX2012014115A MX2012014115A MX2012014115A MX 2012014115 A MX2012014115 A MX 2012014115A MX 2012014115 A MX2012014115 A MX 2012014115A MX 2012014115 A MX2012014115 A MX 2012014115A MX 2012014115 A MX2012014115 A MX 2012014115A
Authority
MX
Mexico
Prior art keywords
production
amyloid beta
beta ligand
labeled amyloid
labeled
Prior art date
Application number
MX2012014115A
Other languages
English (en)
Inventor
Berndt Mathias
Friebe Matthias
Hultsch Christina
Samson Fabrice
Seung Jun Oh
Christoph; Smuda
Original Assignee
Piramal Imaging Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Imaging Sa filed Critical Piramal Imaging Sa
Publication of MX2012014115A publication Critical patent/MX2012014115A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a métodos, que proporcionan acceso a derivados de amina de (aril/heteroaril vinil)-metil fenilo fluoropegilada [18F].
MX2012014115A 2010-06-04 2011-05-30 Metodo para la produccion de ligandos beta amiloide marcados con 18f. MX2012014115A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10164948 2010-06-04
PCT/EP2011/058819 WO2011151282A1 (en) 2010-06-04 2011-05-30 Method for production of f-18 labeled amyloid beta ligand

Publications (1)

Publication Number Publication Date
MX2012014115A true MX2012014115A (es) 2013-07-03

Family

ID=44119328

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014115A MX2012014115A (es) 2010-06-04 2011-05-30 Metodo para la produccion de ligandos beta amiloide marcados con 18f.

Country Status (13)

Country Link
US (1) US20130217920A1 (es)
EP (1) EP2575898B8 (es)
JP (1) JP2013532136A (es)
KR (1) KR20130088117A (es)
CN (1) CN103328011A (es)
AU (1) AU2011260420A1 (es)
BR (1) BR112012030946A2 (es)
CA (1) CA2801534A1 (es)
EA (1) EA025823B1 (es)
MX (1) MX2012014115A (es)
SG (1) SG185785A1 (es)
TW (1) TWI556832B (es)
WO (1) WO2011151282A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015501305A (ja) * 2011-10-19 2015-01-15 ピラマル イメージング ソシエテ アノニム Ｆ‐１８標識Ａβリガンドの改良された製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100789847B1 (ko) 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
US7807135B2 (en) * 2004-12-17 2010-10-05 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US20070031328A1 (en) 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
UA97802C2 (uk) * 2006-03-30 2012-03-26 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Стирилпіридинові похідні і їх застосування для зв'язування і візуалізації амілоїдних бляшок
WO2008124812A1 (en) 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
CA2729635A1 (en) * 2008-07-03 2010-01-07 Ananth Srinivasan Compounds and processes for production of radiopharmaceuticals
CN102271716B (zh) * 2008-12-31 2014-11-19 阿维德放射性药品公司 由甲苯磺酸酯前体合成18f-放射性标记的苯乙烯基吡啶及其稳定的药物组合物
US8968701B2 (en) * 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
US20130209363A1 (en) * 2010-06-04 2013-08-15 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法

Also Published As

Publication number Publication date
EA201201646A1 (ru) 2013-05-30
JP2013532136A (ja) 2013-08-15
CA2801534A1 (en) 2011-12-08
BR112012030946A2 (pt) 2016-11-01
EA025823B1 (ru) 2017-02-28
EP2575898B8 (en) 2021-04-21
US20130217920A1 (en) 2013-08-22
WO2011151282A1 (en) 2011-12-08
SG185785A1 (en) 2013-01-30
KR20130088117A (ko) 2013-08-07
CN103328011A (zh) 2013-09-25
TWI556832B (zh) 2016-11-11
TW201210620A (en) 2012-03-16
EP2575898A1 (en) 2013-04-10
AU2011260420A1 (en) 2013-01-10
EP2575898B1 (en) 2020-09-30

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Legal Events

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