MX345069B - Método para la producción de ligandos beta amiloide marcados con 18f. - Google Patents

Método para la producción de ligandos beta amiloide marcados con 18f.

Info

Publication number
MX345069B
MX345069B MX2012014117A MX2012014117A MX345069B MX 345069 B MX345069 B MX 345069B MX 2012014117 A MX2012014117 A MX 2012014117A MX 2012014117 A MX2012014117 A MX 2012014117A MX 345069 B MX345069 B MX 345069B
Authority
MX
Mexico
Prior art keywords
production
amyloid beta
beta ligands
labeled amyloid
labeled
Prior art date
Application number
MX2012014117A
Other languages
English (en)
Other versions
MX2012014117A (es
Inventor
Berndt Mathias
Friebe Matthias
Samson Fabrice
Braun Rainer
Garke Gunnar
Patt Marianne
Schildan Andreas
Smuda Christoph
Original Assignee
Piramal Imaging Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44584930&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX345069(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Piramal Imaging Sa filed Critical Piramal Imaging Sa
Publication of MX2012014117A publication Critical patent/MX2012014117A/es
Publication of MX345069B publication Critical patent/MX345069B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Esta invención se refiere a métodos, que proporcionan acceso a derivados de amina de (aril/heteroaril vinil)-metil fenilo fluoropegilada [18F].
MX2012014117A 2010-06-04 2011-05-30 Método para la producción de ligandos beta amiloide marcados con 18f. MX345069B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10164949 2010-06-04
PCT/EP2011/058820 WO2011151283A1 (en) 2010-06-04 2011-05-30 Method for production of f-18 labeled amyloid beta ligands

Publications (2)

Publication Number Publication Date
MX2012014117A MX2012014117A (es) 2013-07-03
MX345069B true MX345069B (es) 2017-01-16

Family

ID=44584930

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014117A MX345069B (es) 2010-06-04 2011-05-30 Método para la producción de ligandos beta amiloide marcados con 18f.

Country Status (22)

Country Link
US (2) US20130209363A1 (es)
EP (1) EP2579902B2 (es)
JP (2) JP5869562B2 (es)
KR (1) KR101761451B1 (es)
CN (1) CN103269724B (es)
AU (1) AU2011260421B2 (es)
BR (1) BR112012030935B1 (es)
CA (1) CA2801530C (es)
DK (1) DK2579902T4 (es)
EA (1) EA022897B1 (es)
ES (1) ES2642086T5 (es)
HR (1) HRP20171397T4 (es)
HU (1) HUE033237T2 (es)
IL (1) IL223358A (es)
LT (1) LT2579902T (es)
MX (1) MX345069B (es)
PL (1) PL2579902T5 (es)
PT (1) PT2579902T (es)
SG (1) SG185782A1 (es)
SI (1) SI2579902T2 (es)
TW (1) TWI583397B (es)
WO (1) WO2011151283A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022897B1 (ru) 2010-06-04 2016-03-31 Пирамаль Имэджинг Са СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕНЫХ Аβ ЛИГАНДОВ
EP2575898B8 (en) * 2010-06-04 2021-04-21 Life Molecular Imaging SA Method for production of f-18 labeled amyloid beta ligand
CN108218650A (zh) * 2010-12-29 2018-06-29 通用电气健康护理有限公司 洗脱溶液
DK2723394T3 (en) * 2011-06-21 2018-08-13 Piramal Imaging Sa FORMULA OF FLUORED STYLBONE SUITABLE FOR PET IMAGINATION
IN2014MN00875A (es) * 2011-10-19 2015-04-17 Piramal Imaging Sa
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
GB201318450D0 (en) * 2013-10-18 2013-12-04 Ge Healthcare Ltd Closed evaporation system
WO2018089491A1 (en) * 2016-11-08 2018-05-17 The Regents Of The University Of California Methods for multi-dose synthesis of [f-18]fddnp for clinical settings
WO2018168643A1 (ja) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 イオフルパンの製造方法
US20210038747A1 (en) * 2018-01-24 2021-02-11 Ac Immune Sa Novel method of preparing an imaging compound
CN109867591B (zh) * 2019-03-12 2020-11-06 浙江大学 18f标记的aie荧光/pet双模态探针及其制备方法和应用
WO2024107620A1 (en) * 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
ES2347535T3 (es) † 2002-11-05 2010-11-02 Ion Beam Applications S.A. Estabilizacion de composiciones acuosas de 2-fluoro-2-desoxi-d-glucosa marcada con el isotopo 18f con etanol.
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
SI2213652T1 (sl) 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
NZ570887A (en) 2006-03-30 2011-05-27 Univ Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
WO2008009444A1 (en) † 2006-07-19 2008-01-24 Van Dulmen, Adrianus, A. Use of ethanol for stabilizing a single-vial liquid formulation of a radiolabeled peptide
BRPI0820438A2 (pt) † 2007-11-07 2015-06-16 Ge Healthcare Bv Composição radiofarmacêutica estabilizada, método para a preparação da mesma, e, uso de ácido gentísico ou um sal do mesmo com um cátion biocompatível.
PL2381967T3 (pl) 2008-12-31 2017-06-30 Avid Radiopharmaceuticals, Inc. Synteza styrylopirydyn radioznakowanych 18F z prekursorów tosylanowych i ich stabilne kompozycje farmaceutyczne
JP2012532164A (ja) * 2009-07-10 2012-12-13 バイエル ファーマ アクチエンゲゼルシャフト 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用
EA022897B1 (ru) 2010-06-04 2016-03-31 Пирамаль Имэджинг Са СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕНЫХ Аβ ЛИГАНДОВ

Also Published As

Publication number Publication date
EA022897B1 (ru) 2016-03-31
EP2579902B2 (en) 2019-08-14
EP2579902B1 (en) 2017-07-12
SG185782A1 (en) 2013-01-30
PL2579902T5 (pl) 2020-08-10
ES2642086T5 (es) 2020-04-13
SI2579902T2 (sl) 2019-10-30
EA201201645A1 (ru) 2013-05-30
US9592308B2 (en) 2017-03-14
LT2579902T (lt) 2017-09-25
JP2016047831A (ja) 2016-04-07
US20160184465A1 (en) 2016-06-30
BR112012030935B1 (pt) 2020-11-17
CA2801530C (en) 2017-09-12
US20130209363A1 (en) 2013-08-15
KR101761451B1 (ko) 2017-07-25
PL2579902T3 (pl) 2017-12-29
ES2642086T3 (es) 2017-11-15
WO2011151283A1 (en) 2011-12-08
KR20130136423A (ko) 2013-12-12
TWI583397B (zh) 2017-05-21
EP2579902A1 (en) 2013-04-17
CA2801530A1 (en) 2011-12-08
AU2011260421A1 (en) 2013-01-10
JP5869562B2 (ja) 2016-02-24
HRP20171397T4 (hr) 2019-11-15
DK2579902T3 (en) 2017-08-28
HUE033237T2 (hu) 2017-11-28
JP2013532137A (ja) 2013-08-15
IL223358A (en) 2015-09-24
PT2579902T (pt) 2017-08-17
DK2579902T4 (da) 2019-10-21
SI2579902T1 (sl) 2017-10-30
CN103269724A (zh) 2013-08-28
AU2011260421B2 (en) 2015-06-04
CN103269724B (zh) 2017-06-23
TW201204395A (en) 2012-02-01
HRP20171397T1 (hr) 2017-11-03
MX2012014117A (es) 2013-07-03
BR112012030935A2 (pt) 2016-11-01

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