SI2579902T2 - Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18 - Google Patents

Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18

Info

Publication number
SI2579902T2
SI2579902T2 SI201131295T SI201131295T SI2579902T2 SI 2579902 T2 SI2579902 T2 SI 2579902T2 SI 201131295 T SI201131295 T SI 201131295T SI 201131295 T SI201131295 T SI 201131295T SI 2579902 T2 SI2579902 T2 SI 2579902T2
Authority
SI
Slovenia
Prior art keywords
production
amyloid beta
beta ligands
labeled amyloid
labeled
Prior art date
Application number
SI201131295T
Other languages
English (en)
Other versions
SI2579902T1 (sl
Inventor
Mathias Berndt
Matthias Friebe
Fabrice Samson
Rainer Braun
Gunnar Garke
Marianne Patt
Andreas Schildan
Christoph Smuda
Original Assignee
Life Molecular Imaging Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44584930&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2579902(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Life Molecular Imaging Sa filed Critical Life Molecular Imaging Sa
Publication of SI2579902T1 publication Critical patent/SI2579902T1/sl
Publication of SI2579902T2 publication Critical patent/SI2579902T2/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121Solutions, i.e. homogeneous liquid formulation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201131295T 2010-06-04 2011-05-30 Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18 SI2579902T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10164949 2010-06-04
EP11723431.0A EP2579902B2 (en) 2010-06-04 2011-05-30 Method for production of f-18 labeled amyloid beta ligands
PCT/EP2011/058820 WO2011151283A1 (en) 2010-06-04 2011-05-30 Method for production of f-18 labeled amyloid beta ligands

Publications (2)

Publication Number Publication Date
SI2579902T1 SI2579902T1 (sl) 2017-10-30
SI2579902T2 true SI2579902T2 (sl) 2019-10-30

Family

ID=44584930

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131295T SI2579902T2 (sl) 2010-06-04 2011-05-30 Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18

Country Status (22)

Country Link
US (2) US20130209363A1 (sl)
EP (1) EP2579902B2 (sl)
JP (2) JP5869562B2 (sl)
KR (1) KR101761451B1 (sl)
CN (1) CN103269724B (sl)
AU (1) AU2011260421B2 (sl)
BR (1) BR112012030935B1 (sl)
CA (1) CA2801530C (sl)
DK (1) DK2579902T4 (sl)
EA (1) EA022897B1 (sl)
ES (1) ES2642086T5 (sl)
HR (1) HRP20171397T4 (sl)
HU (1) HUE033237T2 (sl)
IL (1) IL223358A (sl)
LT (1) LT2579902T (sl)
MX (1) MX345069B (sl)
PL (1) PL2579902T5 (sl)
PT (1) PT2579902T (sl)
SG (1) SG185782A1 (sl)
SI (1) SI2579902T2 (sl)
TW (1) TWI583397B (sl)
WO (1) WO2011151283A1 (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012030935B1 (pt) 2010-04-06 2020-11-17 Life Molecular Imaging Sa método para a produção de ligantes de beta-amiloide marcados com f-18
JP2013532136A (ja) * 2010-06-04 2013-08-15 ピラマル イメージング ソシエテ アノニム F−18標識アミロイド・ベータ・リガンドの製造方法
AU2011351550B2 (en) * 2010-12-29 2017-02-02 Ge Healthcare Limited Eluent solution
PT2723394T (pt) 2011-06-21 2018-07-30 Life Molecular Imaging Sa Formulações de estilbeno fluorado, apropriadas para a imagiologia por pet
IN2014MN00875A (sl) * 2011-10-19 2015-04-17 Piramal Imaging Sa
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
GB201318450D0 (en) * 2013-10-18 2013-12-04 Ge Healthcare Ltd Closed evaporation system
WO2018089491A1 (en) * 2016-11-08 2018-05-17 The Regents Of The University Of California Methods for multi-dose synthesis of [f-18]fddnp for clinical settings
WO2018168643A1 (ja) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 イオフルパンの製造方法
CN111868062B (zh) * 2018-01-24 2023-07-07 Ac免疫有限公司 制备显像化合物的方法
CN109867591B (zh) * 2019-03-12 2020-11-06 浙江大学 18f标记的aie荧光/pet双模态探针及其制备方法和应用
WO2024107620A1 (en) * 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
ATE473019T1 (de) 2002-11-05 2010-07-15 Ion Beam Applic Sa Stabilisierung von wässerigen zusammensetzungen von 18f-markiertem 2-fluoro-2-deoxy-d-glukose mit ethanol
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
JP4738419B2 (ja) * 2005-11-30 2011-08-03 富士フイルムRiファーマ株式会社 アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬
EP2363392B1 (en) 2006-03-30 2017-05-03 The Trustees Of The University Of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
WO2008009444A1 (en) 2006-07-19 2008-01-24 Van Dulmen, Adrianus, A. Use of ethanol for stabilizing a single-vial liquid formulation of a radiolabeled peptide
AU2008324186B2 (en) 2007-11-07 2014-02-13 Ge Healthcare Bv Stabilization of radiopharmaceuticals
PE20120007A1 (es) 2008-12-31 2012-01-16 Avid Radiopharmaceuticals Inc Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de estas
WO2011003591A1 (en) * 2009-07-10 2011-01-13 Bayer Schering Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
BR112012030935B1 (pt) 2010-04-06 2020-11-17 Life Molecular Imaging Sa método para a produção de ligantes de beta-amiloide marcados com f-18

Also Published As

Publication number Publication date
TW201204395A (en) 2012-02-01
CN103269724B (zh) 2017-06-23
WO2011151283A1 (en) 2011-12-08
BR112012030935B1 (pt) 2020-11-17
CA2801530C (en) 2017-09-12
EP2579902A1 (en) 2013-04-17
US9592308B2 (en) 2017-03-14
EP2579902B2 (en) 2019-08-14
AU2011260421B2 (en) 2015-06-04
EP2579902B1 (en) 2017-07-12
ES2642086T3 (es) 2017-11-15
LT2579902T (lt) 2017-09-25
PT2579902T (pt) 2017-08-17
TWI583397B (zh) 2017-05-21
CN103269724A (zh) 2013-08-28
PL2579902T5 (pl) 2020-08-10
US20160184465A1 (en) 2016-06-30
MX345069B (es) 2017-01-16
HRP20171397T1 (hr) 2017-11-03
AU2011260421A1 (en) 2013-01-10
SI2579902T1 (sl) 2017-10-30
JP5869562B2 (ja) 2016-02-24
IL223358A (en) 2015-09-24
ES2642086T5 (es) 2020-04-13
JP2016047831A (ja) 2016-04-07
US20130209363A1 (en) 2013-08-15
KR20130136423A (ko) 2013-12-12
JP2013532137A (ja) 2013-08-15
PL2579902T3 (pl) 2017-12-29
EA201201645A1 (ru) 2013-05-30
DK2579902T4 (da) 2019-10-21
CA2801530A1 (en) 2011-12-08
KR101761451B1 (ko) 2017-07-25
HUE033237T2 (hu) 2017-11-28
BR112012030935A2 (pt) 2016-11-01
MX2012014117A (es) 2013-07-03
HRP20171397T4 (hr) 2019-11-15
DK2579902T3 (en) 2017-08-28
EA022897B1 (ru) 2016-03-31
SG185782A1 (en) 2013-01-30

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