EA201201645A1 - СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕННЫХ Аβ-ЛИГАНДОВ - Google Patents

СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕННЫХ Аβ-ЛИГАНДОВ

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Publication number
EA201201645A1
EA201201645A1 EA201201645A EA201201645A EA201201645A1 EA 201201645 A1 EA201201645 A1 EA 201201645A1 EA 201201645 A EA201201645 A EA 201201645A EA 201201645 A EA201201645 A EA 201201645A EA 201201645 A1 EA201201645 A1 EA 201201645A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sanded
ligands
obtaining
pegylated
fluorinated
Prior art date
Application number
EA201201645A
Other languages
English (en)
Other versions
EA022897B1 (ru
Inventor
Матиас Берндт
Маттиас Фрибе
Фабрис Самсон
Райнер Браун
Гуннар Гарке
Марианне Патт
Андреас Шильдан
Кристоф Смуда
Original Assignee
Пирамаль Имэджинг Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44584930&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201645(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пирамаль Имэджинг Са filed Critical Пирамаль Имэджинг Са
Publication of EA201201645A1 publication Critical patent/EA201201645A1/ru
Publication of EA022897B1 publication Critical patent/EA022897B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретение относится к способам, которые обеспечивают [F-18]фторпегилированные производные (арил/гетероарил винил)фенил метил амина.
EA201201645A 2010-06-04 2011-05-30 СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕНЫХ Аβ ЛИГАНДОВ EA022897B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10164949 2010-06-04
PCT/EP2011/058820 WO2011151283A1 (en) 2010-06-04 2011-05-30 Method for production of f-18 labeled amyloid beta ligands

Publications (2)

Publication Number Publication Date
EA201201645A1 true EA201201645A1 (ru) 2013-05-30
EA022897B1 EA022897B1 (ru) 2016-03-31

Family

ID=44584930

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201645A EA022897B1 (ru) 2010-06-04 2011-05-30 СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕНЫХ Аβ ЛИГАНДОВ

Country Status (22)

Country Link
US (2) US20130209363A1 (ru)
EP (1) EP2579902B2 (ru)
JP (2) JP5869562B2 (ru)
KR (1) KR101761451B1 (ru)
CN (1) CN103269724B (ru)
AU (1) AU2011260421B2 (ru)
BR (1) BR112012030935B1 (ru)
CA (1) CA2801530C (ru)
DK (1) DK2579902T4 (ru)
EA (1) EA022897B1 (ru)
ES (1) ES2642086T5 (ru)
HR (1) HRP20171397T4 (ru)
HU (1) HUE033237T2 (ru)
IL (1) IL223358A (ru)
LT (1) LT2579902T (ru)
MX (1) MX345069B (ru)
PL (1) PL2579902T5 (ru)
PT (1) PT2579902T (ru)
SG (1) SG185782A1 (ru)
SI (1) SI2579902T2 (ru)
TW (1) TWI583397B (ru)
WO (1) WO2011151283A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012014115A (es) * 2010-06-04 2013-07-03 Piramal Imaging Sa Metodo para la produccion de ligandos beta amiloide marcados con 18f.
SI2579902T2 (sl) 2010-06-04 2019-10-30 Life Molecular Imaging Sa Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18
EP2658831B1 (en) * 2010-12-29 2017-02-15 GE Healthcare Limited Eluent solution
EP2723394B1 (en) * 2011-06-21 2018-05-23 Piramal Imaging SA Formulations of fluorinated stilbene suitable for pet imaging
BR112014009013A2 (pt) * 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
GB201318450D0 (en) * 2013-10-18 2013-12-04 Ge Healthcare Ltd Closed evaporation system
EP3538161B1 (en) 2016-11-08 2022-07-27 The Regents of The University of California Methods for multi-dose synthesis of [f-18]fddnp for clinical settings
WO2018168643A1 (ja) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 イオフルパンの製造方法
KR20200113234A (ko) * 2018-01-24 2020-10-06 에이씨 이뮨 에스.에이. 이미징 화합물을 제조하는 신규한 방법
CN109867591B (zh) * 2019-03-12 2020-11-06 浙江大学 18f标记的aie荧光/pet双模态探针及其制备方法和应用
WO2024107620A1 (en) * 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
DE60236971D1 (de) † 2002-11-05 2010-08-19 Ion Beam Applic Sa Stabilisierung von wässerigen zusammensetzungen von 18f-markiertem 2-fluoro-2-deoxy-d-glukose mit ethanol
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
MX2007007380A (es) * 2004-12-17 2007-10-11 Univ Pennsylvania Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
EP2363391A1 (en) 2006-03-30 2011-09-07 The Trustees of The University of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
WO2008009444A1 (en) † 2006-07-19 2008-01-24 Van Dulmen, Adrianus, A. Use of ethanol for stabilizing a single-vial liquid formulation of a radiolabeled peptide
MX2010005122A (es) † 2007-11-07 2010-08-18 Ge Healthcare Bv Estabilizacion de radiofarmaceuticos.
NZ593848A (en) 2008-12-31 2013-09-27 Avid Radiopharmaceuticals Inc Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
EP2451760A1 (en) * 2009-07-10 2012-05-16 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
SI2579902T2 (sl) 2010-06-04 2019-10-30 Life Molecular Imaging Sa Postopek za izdelavo amiloidnih beta ligandov, označenih s F-18

Also Published As

Publication number Publication date
BR112012030935B1 (pt) 2020-11-17
CA2801530C (en) 2017-09-12
CN103269724A (zh) 2013-08-28
SG185782A1 (en) 2013-01-30
DK2579902T3 (en) 2017-08-28
CA2801530A1 (en) 2011-12-08
JP5869562B2 (ja) 2016-02-24
MX345069B (es) 2017-01-16
JP2016047831A (ja) 2016-04-07
SI2579902T2 (sl) 2019-10-30
US20160184465A1 (en) 2016-06-30
ES2642086T5 (es) 2020-04-13
LT2579902T (lt) 2017-09-25
IL223358A (en) 2015-09-24
JP2013532137A (ja) 2013-08-15
KR101761451B1 (ko) 2017-07-25
EP2579902B2 (en) 2019-08-14
AU2011260421B2 (en) 2015-06-04
TWI583397B (zh) 2017-05-21
EP2579902B1 (en) 2017-07-12
EP2579902A1 (en) 2013-04-17
EA022897B1 (ru) 2016-03-31
SI2579902T1 (sl) 2017-10-30
KR20130136423A (ko) 2013-12-12
US20130209363A1 (en) 2013-08-15
MX2012014117A (es) 2013-07-03
HRP20171397T4 (hr) 2019-11-15
CN103269724B (zh) 2017-06-23
WO2011151283A1 (en) 2011-12-08
US9592308B2 (en) 2017-03-14
DK2579902T4 (da) 2019-10-21
HRP20171397T1 (hr) 2017-11-03
TW201204395A (en) 2012-02-01
ES2642086T3 (es) 2017-11-15
PT2579902T (pt) 2017-08-17
BR112012030935A2 (pt) 2016-11-01
PL2579902T5 (pl) 2020-08-10
PL2579902T3 (pl) 2017-12-29
HUE033237T2 (hu) 2017-11-28
AU2011260421A1 (en) 2013-01-10

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Designated state(s): AM AZ BY KZ KG MD TJ TM

TC4A Change in name of a patent proprietor in a eurasian patent