LU92647I2 - Florbetaben (18f) - Google Patents

Florbetaben (18f) Download PDF

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Publication number
LU92647I2
LU92647I2 LU92647C LU92647C LU92647I2 LU 92647 I2 LU92647 I2 LU 92647I2 LU 92647 C LU92647 C LU 92647C LU 92647 C LU92647 C LU 92647C LU 92647 I2 LU92647 I2 LU 92647I2
Authority
LU
Luxembourg
Prior art keywords
florbetaben
Prior art date
Application number
LU92647C
Other languages
English (en)
French (fr)
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of LU92647I2 publication Critical patent/LU92647I2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU92647C 2004-12-17 2015-02-04 Florbetaben (18f) LU92647I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
EP05854410A EP1841465A4 (en) 2004-12-17 2005-12-19 STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE

Publications (1)

Publication Number Publication Date
LU92647I2 true LU92647I2 (fr) 2015-11-03

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92647C LU92647I2 (fr) 2004-12-17 2015-02-04 Florbetaben (18f)

Country Status (24)

Country Link
US (2) US7807135B2 (pl)
EP (3) EP1838298A4 (pl)
JP (1) JP5128956B2 (pl)
KR (1) KR101321619B1 (pl)
AU (1) AU2005316421B2 (pl)
BR (1) BRPI0516408B8 (pl)
CA (1) CA2591534C (pl)
DK (1) DK2213652T3 (pl)
EA (1) EA012334B1 (pl)
ES (1) ES2526655T3 (pl)
FR (1) FR15C0012I2 (pl)
HU (1) HUS1500014I1 (pl)
IL (2) IL183946A (pl)
LT (1) LTC2213652I2 (pl)
LU (1) LU92647I2 (pl)
MX (1) MX2007007380A (pl)
NL (1) NL300719I2 (pl)
NO (1) NO339195B1 (pl)
NZ (1) NZ555942A (pl)
PL (1) PL2213652T3 (pl)
PT (1) PT2213652E (pl)
SG (1) SG194363A1 (pl)
SI (1) SI2213652T1 (pl)
WO (1) WO2006066104A2 (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2456411C (en) * 2001-08-27 2011-02-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
PT1999109E (pt) 2006-03-30 2012-03-16 Univ Pennsylvania Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
CA2699965A1 (en) * 2007-07-04 2009-01-08 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
EP2205072B1 (en) * 2007-10-15 2013-11-20 The Salk Institute for Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
ES2907992T3 (es) * 2008-02-14 2022-04-27 Lilly Co Eli Agentes novedosos de obtención de imágenes para detectar disfunciones neurológicas
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
CA2716524A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
US8557222B2 (en) 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
US20100145194A1 (en) * 2008-11-13 2010-06-10 Avid Radiopharmaceuticals, Inc. Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases
US20110305618A1 (en) 2008-12-22 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Method for synthesis of a radionuclide-labeled compound using an exchange resin
HUE033649T2 (en) * 2008-12-31 2017-12-28 Avid Radiopharmaceuticals Inc Synthesis of 18F-labeled styryl pyridines from tosylate precursors and their stable pharmaceutical preparations
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
US8968701B2 (en) 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
MX336896B (es) * 2009-12-23 2016-02-05 Piramal Imaging Sa Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos.
SG185782A1 (en) * 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
CN103328011A (zh) 2010-06-04 2013-09-25 皮拉马影像股份公司 生产F-18标记的β-淀粉样蛋白配体的方法
EA201201647A1 (ru) 2010-06-04 2013-05-30 Пирамаль Имэджинг Са Способ получения f-18 меченных лигандов бета-амилоида
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
CA2831331C (en) * 2011-04-21 2019-10-15 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
PL2723394T3 (pl) 2011-06-21 2018-11-30 Piramal Imaging Sa Preparaty fluorowanego stylbenu odpowiednie do zastosowań w obrazowaniu PET
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
BR112014009013A2 (pt) 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
EP2836241B1 (en) 2012-04-10 2019-02-20 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
WO2018062588A1 (ko) 2016-09-29 2018-04-05 한국원자력연구원 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500507A (en) * 1981-10-30 1985-02-19 Wong Dennis W Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation
JPS60247244A (ja) 1984-05-22 1985-12-06 Mitsubishi Paper Mills Ltd 電子写真感光体
DD231432A1 (de) * 1984-11-01 1985-12-24 Univ Leipzig Material zur silberfreien bildaufzeichnung
DD234666A1 (de) 1984-11-01 1986-04-09 Univ Leipzig Verfahren zur herstellung von einfachen und substituierten 4-dimethylamino-alpha-halogenstilbenen
JPH06329566A (ja) 1993-05-21 1994-11-29 Asahi Glass Co Ltd ジフルオロスチルベン誘導体化合物およびそれを含有する液晶組成物
TW325458B (en) * 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
JP4022951B2 (ja) 1997-08-06 2007-12-19 大日本インキ化学工業株式会社 ジフルオロスチルベン誘導体の製造方法
AU5822301A (en) * 2000-05-08 2001-11-20 Novozymes A/S Oxidoreductase mediated antimicrobial activity
CA2456411C (en) * 2001-08-27 2011-02-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
SI2213652T1 (sl) * 2004-12-17 2015-03-31 The Trustees Of The University Of Pennsylvania Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents

Also Published As

Publication number Publication date
NZ555942A (en) 2011-01-28
CA2591534C (en) 2013-08-06
EP1838298A2 (en) 2007-10-03
IL206091A (en) 2013-08-29
ES2526655T3 (es) 2015-01-14
EP1841465A2 (en) 2007-10-10
PL2213652T3 (pl) 2015-04-30
JP5128956B2 (ja) 2013-01-23
NO20073650L (no) 2007-09-14
SG194363A1 (en) 2013-11-29
MX2007007380A (es) 2007-10-11
US7807135B2 (en) 2010-10-05
IL183946A (en) 2011-08-31
IL183946A0 (en) 2007-10-31
KR101321619B1 (ko) 2013-10-30
KR20070093427A (ko) 2007-09-18
AU2005316421B2 (en) 2012-04-05
US20100266500A1 (en) 2010-10-21
BRPI0516408B8 (pt) 2021-05-25
BRPI0516408A (pt) 2008-09-02
FR15C0012I2 (fr) 2015-11-20
WO2006066104A3 (en) 2006-08-03
JP2008524243A (ja) 2008-07-10
HUS1500014I1 (hu) 2016-11-28
CA2591534A1 (en) 2006-06-22
NL300719I1 (pl) 2015-12-29
US8465726B2 (en) 2013-06-18
LTC2213652I2 (lt) 2016-12-27
SI2213652T1 (sl) 2015-03-31
US20060269473A1 (en) 2006-11-30
NL300719I2 (pl) 2015-12-29
DK2213652T3 (en) 2015-01-26
FR15C0012I1 (pl) 2015-03-20
EP2213652B1 (en) 2014-10-22
EP1841465A4 (en) 2009-04-01
EA200701299A1 (ru) 2007-12-28
PT2213652E (pt) 2015-01-02
EP1838298A4 (en) 2009-03-04
NO339195B1 (no) 2016-11-14
BRPI0516408B1 (pt) 2021-03-23
EA012334B1 (ru) 2009-08-28
AU2005316421A1 (en) 2006-06-22
WO2006066104A2 (en) 2006-06-22
EP2213652A1 (en) 2010-08-04

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