RS56171B1 - Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova - Google Patents

Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova

Info

Publication number
RS56171B1
RS56171B1 RS20170578A RSP20170578A RS56171B1 RS 56171 B1 RS56171 B1 RS 56171B1 RS 20170578 A RS20170578 A RS 20170578A RS P20170578 A RSP20170578 A RS P20170578A RS 56171 B1 RS56171 B1 RS 56171B1
Authority
RS
Serbia
Prior art keywords
binding
amyloid plaques
styrylpyridine
imaging amyloid
compounds
Prior art date
Application number
RS20170578A
Other languages
English (en)
Inventor
Hank F Kung
Mei-Ping Kung
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of RS56171B1 publication Critical patent/RS56171B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
RS20170578A 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova RS56171B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
EP11152124.1A EP2363392B1 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
RS56171B1 true RS56171B1 (sr) 2017-11-30

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20120077A RS52222B (sr) 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova
RS20170578A RS56171B1 (sr) 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RS20120077A RS52222B (sr) 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba za vezivanje i imidžing amiloidnih plakova

Country Status (34)

Country Link
US (3) US7687052B2 (sr)
EP (3) EP1999109B1 (sr)
JP (1) JP5290954B2 (sr)
KR (1) KR101376807B1 (sr)
CN (1) CN101522624B (sr)
AT (1) ATE539060T1 (sr)
AU (1) AU2007243712B2 (sr)
BR (1) BRPI0710225B1 (sr)
CA (1) CA2644530C (sr)
CR (1) CR10329A (sr)
CY (3) CY1113048T1 (sr)
DK (2) DK1999109T3 (sr)
EA (1) EA017898B1 (sr)
EC (1) ECSP088783A (sr)
ES (2) ES2628882T3 (sr)
FR (1) FR13C0034I2 (sr)
GT (1) GT200800201A (sr)
HR (2) HRP20120135T1 (sr)
HU (2) HUE032660T2 (sr)
IL (1) IL193567A (sr)
LT (1) LT2363392T (sr)
LU (1) LU92232I2 (sr)
MX (1) MX2008012527A (sr)
NO (2) NO342090B1 (sr)
NZ (1) NZ570887A (sr)
PL (2) PL1999109T3 (sr)
PT (2) PT2363392T (sr)
RS (2) RS52222B (sr)
SG (1) SG173338A1 (sr)
SI (2) SI1999109T1 (sr)
TW (1) TWI399366B (sr)
UA (1) UA97802C2 (sr)
WO (1) WO2007126733A2 (sr)
ZA (1) ZA200807955B (sr)

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WO2009004914A1 (ja) * 2007-07-04 2009-01-08 Tohoku University フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
MY162312A (en) * 2008-12-31 2017-05-31 Avid Radiopharmaceuticals Inc Synthesis of 18f-radiolabeled styrylpyridines from tosylate precersors and stable pharmaceutical compositions thereof
KR20120034724A (ko) * 2009-07-10 2012-04-12 바이엘 파마 악티엔게젤샤프트 저압 내지 중간압 액체 크로마토그래피의 사용에 의한 방사성추적자의 정제
ES2620177T3 (es) 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
KR20120098914A (ko) * 2009-12-23 2012-09-05 피라말 이미징 에스에이 소수성 ｐｅｔ 작용제를 갖는 ｐｅｔ 영상화에 적합한 제제
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
PL2579902T5 (pl) 2010-06-04 2020-08-10 Life Molecular Imaging Sa Sposób wytwarzania znakowanych F-18 ligandów amyloidu beta
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
SG185785A1 (en) * 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligand
US20140012032A1 (en) * 2010-06-04 2014-01-09 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
WO2012051170A2 (en) * 2010-10-12 2012-04-19 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
US9272055B2 (en) 2011-04-21 2016-03-01 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
US20140243533A1 (en) 2011-10-19 2014-08-28 Piramal Imaging Sa Method for production of f-18 labeled a-beta ligands
ES2725314T3 (es) 2012-04-10 2019-09-23 Lantheus Medical Imaging Inc Métodos de síntesis radiofarmacéutica
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
CN106459059B (zh) * 2014-05-13 2019-09-24 豪夫迈·罗氏有限公司 氘化杂环化合物和其作为成像剂的用途
AU2016308189B2 (en) * 2015-08-18 2021-03-11 The Regents Of The University Of California Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法

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JPH0545875A (ja) * 1991-08-08 1993-02-26 Konica Corp 感光性組成物
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US20030138374A1 (en) * 2000-03-22 2003-07-24 Yukitsuda Kudo Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same
US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja) 2000-12-18 2002-06-26 Fuji Photo Film Co Ltd 非線形光学材料とその製造方法
EP1432453B1 (en) * 2001-08-27 2013-08-14 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2003105252A2 (en) 2002-06-06 2003-12-18 The Trustees Of The University Of Pennsylvania Ceramic anodes and method of producing the same
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JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
AU2005316421B2 (en) * 2004-12-17 2012-04-05 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化
PL1999109T3 (pl) * 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

Also Published As

Publication number Publication date
US20090123369A1 (en) 2009-05-14
TW200838852A (en) 2008-10-01
LU92232I2 (fr) 2013-08-26
CR10329A (es) 2008-10-29
CY1119048T1 (el) 2018-01-10
IL193567A (en) 2014-03-31
HRP20120135T1 (hr) 2012-03-31
NO2018030I1 (no) 2018-09-11
TWI399366B (zh) 2013-06-21
US8506929B2 (en) 2013-08-13
WO2007126733A2 (en) 2007-11-08
IL193567A0 (en) 2009-05-04
EA200870389A1 (ru) 2009-04-28
FR13C0034I2 (fr) 2014-03-07
CN101522624A (zh) 2009-09-02
ECSP088783A (es) 2008-10-31
LT2363392T (lt) 2017-07-25
AU2007243712A1 (en) 2007-11-08
EA017898B1 (ru) 2013-04-30
MX2008012527A (es) 2008-10-14
DK2363392T3 (en) 2017-07-03
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
UA97802C2 (uk) 2012-03-26
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
KR20080106564A (ko) 2008-12-08
FR13C0034I1 (sr) 2013-08-09
NZ570887A (en) 2011-05-27
HUE032660T2 (en) 2017-10-30
DK1999109T3 (da) 2012-04-02
CY2013024I1 (el) 2015-11-04
PL2363392T3 (pl) 2017-10-31
PT1999109E (pt) 2012-03-16
EP1999109B1 (en) 2011-12-28
US8840866B2 (en) 2014-09-23
NO342090B1 (no) 2018-03-19
ATE539060T1 (de) 2012-01-15
ES2628882T3 (es) 2017-08-04
EP1999109A2 (en) 2008-12-10
SG173338A1 (en) 2011-08-29
CA2644530C (en) 2015-05-19
WO2007126733A3 (en) 2008-03-06
BRPI0710225B1 (pt) 2021-07-13
CY2013024I2 (el) 2015-11-04
US20130129624A1 (en) 2013-05-23
CA2644530A1 (en) 2007-11-08
EP2363391A1 (en) 2011-09-07
GT200800201A (es) 2009-08-20
US7687052B2 (en) 2010-03-30
JP2009532349A (ja) 2009-09-10
CN101522624B (zh) 2013-11-06
AU2007243712B2 (en) 2013-01-10
HRP20170857T1 (hr) 2017-12-01
US20080038195A1 (en) 2008-02-14
HUS1300028I1 (hu) 2017-08-28
JP5290954B2 (ja) 2013-09-18
EP2363392B1 (en) 2017-05-03
EP2363392A1 (en) 2011-09-07
RS52222B (sr) 2012-10-31
ES2378785T3 (es) 2012-04-17
CY1113048T1 (el) 2015-11-04
KR101376807B1 (ko) 2014-03-20
LU92232I9 (sr) 2019-01-15
NO20084590L (no) 2008-12-29
SI1999109T1 (sl) 2012-04-30
BRPI0710225A2 (pt) 2011-08-02

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