HRP20010667B1 - Camptothecin derivatives having antitumor activity - Google Patents

Camptothecin derivatives having antitumor activity

Info

Publication number
HRP20010667B1
HRP20010667B1 HR960321A HRP20010667A HRP20010667B1 HR P20010667 B1 HRP20010667 B1 HR P20010667B1 HR 960321 A HR960321 A HR 960321A HR P20010667 A HRP20010667 A HR P20010667A HR P20010667 B1 HRP20010667 B1 HR P20010667B1
Authority
HR
Croatia
Prior art keywords
antitumor activity
camptothecin derivatives
camptothecin
derivatives
antitumor
Prior art date
Application number
HR960321A
Other languages
English (en)
Inventor
Sergio Penco
Lucio Merlini
Franco Zunino
Paolo Carminati
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of HRP20010667A2 publication Critical patent/HRP20010667A2/hr
Publication of HRP20010667B1 publication Critical patent/HRP20010667B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR960321A 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity HRP20010667B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
PCT/EP2000/001570 WO2000053607A1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Publications (2)

Publication Number Publication Date
HRP20010667A2 HRP20010667A2 (en) 2002-08-31
HRP20010667B1 true HRP20010667B1 (en) 2003-06-30

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960321A HRP20010667B1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Country Status (38)

Country Link
US (2) US6242457B1 (cs)
EP (1) EP1044977B1 (cs)
JP (1) JP4610743B2 (cs)
KR (1) KR100702085B1 (cs)
CN (1) CN1139592C (cs)
AR (1) AR022860A1 (cs)
AT (1) ATE216998T1 (cs)
AU (1) AU774174B2 (cs)
BG (1) BG65032B1 (cs)
BR (1) BR0008840B1 (cs)
CA (1) CA2362760C (cs)
CO (1) CO5180590A1 (cs)
CZ (1) CZ304465B6 (cs)
DE (1) DE69901379T2 (cs)
DK (1) DK1044977T3 (cs)
EA (1) EA003605B1 (cs)
EE (1) EE04679B1 (cs)
EG (1) EG23999A (cs)
ES (1) ES2175919T3 (cs)
HR (1) HRP20010667B1 (cs)
HU (1) HU229506B1 (cs)
IL (2) IL144958A0 (cs)
IS (1) IS2003B (cs)
ME (2) ME00017B (cs)
MX (1) MXPA01009081A (cs)
NO (1) NO328363B1 (cs)
NZ (1) NZ513393A (cs)
PE (1) PE20001485A1 (cs)
PL (1) PL222208B1 (cs)
PT (1) PT1044977E (cs)
RS (1) RS50405B (cs)
SI (1) SI1044977T1 (cs)
SK (1) SK287561B6 (cs)
TN (1) TNSN00045A1 (cs)
TR (1) TR200102603T2 (cs)
TW (1) TWI272272B (cs)
WO (1) WO2000053607A1 (cs)
ZA (1) ZA200107408B (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4790911B2 (ja) 1999-01-13 2011-10-12 アルケミア オンコロジー ピーティワイ リミテッド 薬物の効力を増強するための組成物および方法
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN1929842A (zh) * 2004-03-26 2007-03-14 诺瓦提斯公司 喜树碱衍生物以固定给药方案治疗增生性疾病的用途
EP1744780B1 (en) 2004-04-27 2013-08-07 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
WO2006065780A2 (en) * 2004-12-15 2006-06-22 Novartis Ag Combinations of therapeutic agents for treating cancer
BRPI0515832A (pt) * 2004-12-21 2008-08-05 Sigma Tau Ind Farmaceuti processo estereosseletivo e formas cristalinas de uma camptotecina
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
ATE540698T1 (de) 2005-07-14 2012-01-15 Wellstat Biologics Corp Krebsbehandlung mit viren, fluoropyrimidinen und camptothecinen
WO2007012133A1 (en) * 2005-07-27 2007-02-01 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
US20080213385A1 (en) * 2005-08-10 2008-09-04 Oskar Kalb Formulations for 7- (T-Butoxy) Iminomethyl Camptothecin
BRPI0615619A2 (pt) * 2005-09-07 2011-05-24 Alchemia Oncology Pty Ltd composições terapêuticas que compreendem hialuronana e anticorpos terapêuticos bem como métodos de tratamento
SI1962850T1 (sl) * 2005-12-21 2012-06-29 Sigma Tau Ind Farmaceuti Zdravljenje tumorjev, odpornih proti zdravilom
CA2642717C (en) * 2006-02-17 2015-08-18 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
CN101652125A (zh) * 2007-02-01 2010-02-17 希格马托制药工业公司 包含喜树碱衍生物的药物组合物
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
EA015933B1 (ru) * 2007-08-01 2011-12-30 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Лечение детских опухолей
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
JP6877049B2 (ja) 2015-09-25 2021-05-26 ゼットワイ セラピューティクス インク．Ｚｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
ATE247471T1 (de) * 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
BR9711319B1 (pt) * 1996-08-19 2009-08-11 derivados de camptotecina altamente lipofìlicos.

Also Published As

Publication number Publication date
NO20014128D0 (no) 2001-08-24
IS6031A (is) 2001-07-31
HRP20010667A2 (en) 2002-08-31
EE04679B1 (et) 2006-08-15
SK11642001A3 (sk) 2002-01-07
CZ304465B6 (cs) 2014-05-21
ZA200107408B (en) 2002-05-29
DE69901379D1 (de) 2002-06-06
KR20010102519A (ko) 2001-11-15
BR0008840B1 (pt) 2011-12-27
AU3160400A (en) 2000-09-28
BG105810A (en) 2002-06-28
NO20014128L (no) 2001-08-24
SK287561B6 (sk) 2011-02-04
TWI272272B (en) 2007-02-01
PL222208B1 (pl) 2016-07-29
JP2002539128A (ja) 2002-11-19
KR100702085B1 (ko) 2007-04-02
DK1044977T3 (da) 2002-07-08
HK1031222A1 (en) 2001-06-08
BR0008840A (pt) 2002-01-08
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
JP4610743B2 (ja) 2011-01-12
EP1044977B1 (en) 2002-05-02
RS50405B (sr) 2009-12-31
ATE216998T1 (de) 2002-05-15
MXPA01009081A (es) 2002-08-30
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
HU229506B1 (en) 2014-01-28
SI1044977T1 (en) 2002-08-31
US20010008939A1 (en) 2001-07-19
CN1343209A (zh) 2002-04-03
EA003605B1 (ru) 2003-06-26
AR022860A1 (es) 2002-09-04
AU774174B2 (en) 2004-06-17
HUP0200210A3 (en) 2004-03-29
ME00017B (me) 2010-06-10
HUP0200210A2 (hu) 2002-05-29
EP1044977A1 (en) 2000-10-18
CA2362760C (en) 2009-08-18
EE200100466A (et) 2002-12-16
ES2175919T3 (es) 2002-11-16
YU64301A (sh) 2005-07-19
IS2003B (is) 2005-04-15
IL144958A (en) 2009-08-03
CA2362760A1 (en) 2000-09-14
NZ513393A (en) 2003-04-29
EG23999A (en) 2008-03-19
BG65032B1 (bg) 2006-12-29
PL355094A1 (en) 2004-03-22
DE69901379T2 (de) 2002-11-07
EA200100954A1 (ru) 2002-04-25
US6242457B1 (en) 2001-06-05
MEP4008A (xx) 2010-02-10
PE20001485A1 (es) 2000-12-07
TR200102603T2 (tr) 2002-01-21
TNSN00045A1 (fr) 2005-11-10
US6589939B2 (en) 2003-07-08
CN1139592C (zh) 2004-02-25
WO2000053607A1 (en) 2000-09-14
CO5180590A1 (es) 2002-07-30

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