HK1143543A1 - Lox and loxl2 inhibitors and uses thereof lox loxl2 - Google Patents

Lox and loxl2 inhibitors and uses thereof lox loxl2

Info

Publication number
HK1143543A1
HK1143543A1 HK10110112.0A HK10110112A HK1143543A1 HK 1143543 A1 HK1143543 A1 HK 1143543A1 HK 10110112 A HK10110112 A HK 10110112A HK 1143543 A1 HK1143543 A1 HK 1143543A1
Authority
HK
Hong Kong
Prior art keywords
lox
loxl2
inhibitors
loxl2 inhibitors
lox loxl2
Prior art date
Application number
HK10110112.0A
Other languages
English (en)
Chinese (zh)
Inventor
Victoria Smith
Scott Ogg
Peter Van Vlasselaer
Vivian E Barry
Derek Marshall
Alison Kay Holzer
Hector Rodriguez
Miho Oyasu
Scott Alan Mccauley
Carlos Aurelio Garcia
Donna Hiroko Tokuoka Biermann
Original Assignee
Gilead Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Biologics Inc filed Critical Gilead Biologics Inc
Publication of HK1143543A1 publication Critical patent/HK1143543A1/xx

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/90605—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4)
    • G01N2333/90633—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
HK10110112.0A 2007-08-02 2010-10-27 Lox and loxl2 inhibitors and uses thereof lox loxl2 HK1143543A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US96324807P 2007-08-02 2007-08-02
US96321407P 2007-08-02 2007-08-02
US96324907P 2007-08-02 2007-08-02
US96328207P 2007-08-02 2007-08-02
US96324607P 2007-08-02 2007-08-02
PCT/US2008/072039 WO2009035791A1 (en) 2007-08-02 2008-08-01 Lox and l0xl2 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
HK1143543A1 true HK1143543A1 (en) 2011-01-07

Family

ID=40094743

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10110112.0A HK1143543A1 (en) 2007-08-02 2010-10-27 Lox and loxl2 inhibitors and uses thereof lox loxl2
HK10110176.3A HK1143736A1 (en) 2007-08-02 2010-10-29 Methods and compositions for treatment and diagnosis of fibrosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10110176.3A HK1143736A1 (en) 2007-08-02 2010-10-29 Methods and compositions for treatment and diagnosis of fibrosis

Country Status (16)

Country Link
US (10) US8461303B2 (ja)
EP (4) EP2543389A3 (ja)
JP (8) JP5312459B2 (ja)
CN (6) CN110372795A (ja)
AU (4) AU2008282739B2 (ja)
CA (2) CA2693208A1 (ja)
CY (2) CY1113897T1 (ja)
DK (2) DK2182981T3 (ja)
ES (3) ES2402334T3 (ja)
HK (2) HK1143543A1 (ja)
HR (2) HRP20130287T1 (ja)
HU (1) HUE025283T2 (ja)
PL (2) PL2185198T3 (ja)
PT (3) PT2185198E (ja)
SI (2) SI2185198T1 (ja)
WO (2) WO2009017833A2 (ja)

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GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
HUE025283T2 (en) * 2007-08-02 2016-03-29 Gilead Biologics Inc LOX and LOX2 inhibitors and their use
EP2268604B1 (en) 2008-03-14 2017-02-15 Retrotope, Inc. Therapies for cancer using isotopically substituted lysine
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
CN102439141A (zh) * 2009-02-06 2012-05-02 吉联亚生物科技有限公司 治疗新生血管形成的方法和组合物
JP2012519282A (ja) * 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
CN102803965A (zh) * 2009-05-05 2012-11-28 耶达研究与发展有限公司 用于识别个人心血管疾病的发生的装置和方法
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
WO2011022667A2 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc Catalytic domains from lysyl oxidase and loxl2
AU2010284039A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. In vivo screening assays
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AU2010284000A1 (en) * 2009-08-21 2012-03-22 Gilead Biologics, Inc. In vitro screening assays
US9885711B2 (en) 2009-09-25 2018-02-06 Xoma Technology Ltd. Screening methods
US20110076285A1 (en) * 2009-09-29 2011-03-31 Ingeborg Stalmans Methods and Compositions For Treatment of Ocular Fibrosis
WO2011053870A1 (en) 2009-10-30 2011-05-05 Retrotope, Inc. Alleviating oxidative stress disorders with pufa derivatives
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AU2014215963B2 (en) * 2010-02-04 2016-04-14 Gilead Biologics, Inc Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
AU2011212830B2 (en) * 2010-02-04 2014-05-22 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2) and methods of use therefor
WO2011112903A2 (en) * 2010-03-11 2011-09-15 Board Of Regents, The University Of Texas System Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of breast cancer patients
WO2011132085A2 (en) * 2010-04-21 2011-10-27 Kalluri, Raghu Methods and compositions for treating fibrosis
MX2013009647A (es) 2011-02-21 2014-02-03 Fibrostatin S L Metodos para tratar y diagnosticar enfermedades.
US20140186340A1 (en) * 2011-04-08 2014-07-03 Gilead Biologics, Inc. Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2
WO2012148930A2 (en) 2011-04-26 2012-11-01 Retrotope, Inc. Oxidative retinal diseases
KR102111997B1 (ko) 2011-04-26 2020-05-18 레트로토프 인코포레이티드 Ｐｕｆａ와 관련된 신경퇴행성 질환 및 근육 질환
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JP2018172398A (ja) 2018-11-08
JP2010535205A (ja) 2010-11-18
WO2009035791A9 (en) 2014-06-26
CN101842114A (zh) 2010-09-22
HRP20150208T1 (hr) 2015-06-05
PT2182981E (pt) 2013-04-18
US20140349309A1 (en) 2014-11-27
EP2185198B1 (en) 2015-01-14
CA2693310C (en) 2018-11-27
EP2182981B1 (en) 2013-01-09
PT2537529T (pt) 2018-12-12
JP2013231035A (ja) 2013-11-14
JP2015212281A (ja) 2015-11-26
JP5659014B2 (ja) 2015-01-28
CN105330743A (zh) 2016-02-17
CN101835490A (zh) 2010-09-15
US20090053224A1 (en) 2009-02-26
CN110372795A (zh) 2019-10-25
EP2543389A3 (en) 2013-04-24
CY1116178T1 (el) 2017-02-08
EP2537529A1 (en) 2012-12-26
US20170240649A1 (en) 2017-08-24
EP2543389A2 (en) 2013-01-09
JP5312459B2 (ja) 2013-10-09
AU2017200635B9 (en) 2019-04-18
CA2693208A1 (en) 2009-02-05
AU2008299784B9 (en) 2015-06-18
US8679485B2 (en) 2014-03-25
JP5851555B2 (ja) 2016-02-03
ES2402334T3 (es) 2013-04-30
CN105330743B (zh) 2019-05-28
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AU2014204536B2 (en) 2016-12-01
JP2017214361A (ja) 2017-12-07
JP2014210785A (ja) 2014-11-13
US20120087917A1 (en) 2012-04-12
AU2017200635B2 (en) 2019-04-04
CA2693310A1 (en) 2009-03-19
AU2008282739A1 (en) 2009-02-05
CN105622756B (zh) 2020-07-28
CY1113897T1 (el) 2016-07-27
EP2185198A1 (en) 2010-05-19
WO2009035791A1 (en) 2009-03-19
CN105214085A (zh) 2016-01-06
AU2008299784B2 (en) 2014-04-24
US20130095101A1 (en) 2013-04-18
ES2700141T3 (es) 2019-02-14
US9176139B2 (en) 2015-11-03
DK2185198T3 (en) 2015-04-20
US20130324705A1 (en) 2013-12-05
US10494443B2 (en) 2019-12-03
PT2185198E (pt) 2015-04-20
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WO2009017833A2 (en) 2009-02-05
CN105622756A (zh) 2016-06-01

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