HK1142371A1 - Characterizing prostate disorders by analysis of microvesicles - Google Patents

Characterizing prostate disorders by analysis of microvesicles

Info

Publication number
HK1142371A1
HK1142371A1 HK10108793.0A HK10108793A HK1142371A1 HK 1142371 A1 HK1142371 A1 HK 1142371A1 HK 10108793 A HK10108793 A HK 10108793A HK 1142371 A1 HK1142371 A1 HK 1142371A1
Authority
HK
Hong Kong
Prior art keywords
microvesicles
analysis
prostate disorders
characterizing prostate
characterizing
Prior art date
Application number
HK10108793.0A
Other languages
English (en)
Inventor
Christine Kuslich
George Poste
Michael Klass
Original Assignee
Caris Life Sciences Luxembourg Holdings S A R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42170590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1142371(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caris Life Sciences Luxembourg Holdings S A R L filed Critical Caris Life Sciences Luxembourg Holdings S A R L
Publication of HK1142371A1 publication Critical patent/HK1142371A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
HK10108793.0A 2008-11-12 2010-09-16 Characterizing prostate disorders by analysis of microvesicles HK1142371A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11404508P 2008-11-12 2008-11-12
US11405808P 2008-11-12 2008-11-12
US11406508P 2008-11-13 2008-11-13
US15118309P 2009-02-09 2009-02-09
US27804909P 2009-10-02 2009-10-02
US25045409P 2009-10-09 2009-10-09
US25302709P 2009-10-19 2009-10-19
PCT/US2009/006095 WO2010056337A2 (en) 2008-11-12 2009-11-12 Methods and systems of using exosomes for determining phenotypes

Publications (1)

Publication Number Publication Date
HK1142371A1 true HK1142371A1 (en) 2010-12-03

Family

ID=42170590

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10108793.0A HK1142371A1 (en) 2008-11-12 2010-09-16 Characterizing prostate disorders by analysis of microvesicles

Country Status (10)

Country Link
US (6) US7897356B2 (zh)
EP (3) EP3181705A1 (zh)
JP (3) JP2012508577A (zh)
CN (2) CN102301002A (zh)
BR (1) BRPI0921043A2 (zh)
CA (1) CA2743211A1 (zh)
GB (1) GB2463401B (zh)
HK (1) HK1142371A1 (zh)
IL (3) IL212768A (zh)
WO (1) WO2010056337A2 (zh)

Families Citing this family (360)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US7854756B2 (en) * 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
WO2005121369A2 (en) * 2004-06-02 2005-12-22 Sourcepharm, Inc. Rna-containing microvesicles and methods therefor
EP1799840A4 (en) 2004-09-03 2009-02-18 Univ Columbia ILT3-POLYPEPTIDES AND USES THEREOF
CA2644855C (en) * 2006-03-09 2019-11-19 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
EP1996716B1 (en) 2006-03-20 2011-05-11 The Regents of the University of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
EP2117305A4 (en) * 2007-01-26 2011-03-30 Univ Louisville Res Found MODIFICATION OF EXOXIC COMPONENTS USED AS VACCINE
WO2008147974A1 (en) 2007-05-23 2008-12-04 University Of South Florida Micro-rnas modulating immunity and inflammation
WO2009006258A1 (en) * 2007-07-03 2009-01-08 Spine Tek, Inc. Interspinous mesh
US8216784B2 (en) * 2007-07-25 2012-07-10 University Of Louisville Research Foundation, Inc. Cancer-derived microvesicle-associated microrna as a diagnostic marker
EP2176665B1 (en) 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
EP2197491A4 (en) 2007-09-04 2011-01-12 Univ California HIGHAFFINE ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODIES TO CANCER AND TO THE DETECTION OF CANCER
CN101842484B (zh) 2007-09-14 2015-07-29 俄亥俄州立大学研究基金会 人外周血微泡中的mirna表达和其用途
EP2209498A2 (en) * 2007-10-03 2010-07-28 Cornell University Treatment of proliferative disorders using antibodies to psma
ES2703363T3 (es) * 2008-02-01 2019-03-08 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico y pronóstico de tumores cerebrales
EP2260109A4 (en) * 2008-02-28 2011-06-08 Univ Ohio State Res Found METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR DIAGNOSING, PROGNOSING AND TREATING PROSTATE-RELATED DISORDERS
EP2271772B1 (en) * 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
PE20151924A1 (es) 2008-08-12 2016-01-13 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
KR100928403B1 (ko) * 2008-10-01 2009-11-26 경북대학교 산학협력단 티지비엠 신증의 진단용 조성물 및 키트
US9487837B2 (en) 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US10545149B2 (en) * 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
JP2012507300A (ja) * 2008-10-30 2012-03-29 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Ｒｎａパターンを評価する方法
US20130184169A1 (en) * 2008-10-30 2013-07-18 Caris Life Sciences Luxembourg Holdings a Luxembourg corporation Methods for assessing rna patterns
WO2010054233A1 (en) * 2008-11-08 2010-05-14 The Wistar Institute Of Anatomy And Biology Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
EP3181705A1 (en) * 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
WO2011109440A1 (en) * 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
US20140113310A9 (en) * 2008-12-05 2014-04-24 Myriad Genetics, Incorporated Cancer detection markers
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
JP5906090B2 (ja) * 2009-02-17 2016-04-20 コーネル・リサーチ・ファンデーション・インコーポレイテッドＣｏｒｎｅｌｌ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ， Ｉｎｃｏｒｐｏｒａｔｅｄ 癌の診断のための方法およびキットならびに治療価の推定
EP2414549A4 (en) * 2009-03-31 2013-08-28 Us Health DIFFERENTIAL EXPRESSION MICRO-RNA AS BIOMARKERS IN THE DIAGNOSIS OF SJÖGREN SYNDROME AND TREATMENT THEREOF
GB0906643D0 (en) 2009-04-17 2009-06-03 Wilson Stuart M Detection of bacteria and fungi
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2011031892A1 (en) * 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
EP2316972A1 (en) * 2009-10-29 2011-05-04 Deutsches Krebsforschungszentrum Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer
ES2597554T3 (es) 2009-11-04 2017-01-19 Diamir, Llc Métodos de utilización de micro-ARN de fluidos corporales para el diagnóstico y control del deterioro cognitivo leve
BR112012012887A2 (pt) 2009-12-02 2017-05-02 Imaginab Inc minicorpo e cys-diabody (cysdb) codificados por sequência de nucleótidos, respectivo uso e métodos de diagnósticos e de tratamento de câncer associado com a expressão de psma num sujeito.
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
SG181963A1 (en) * 2010-01-08 2012-08-30 Cavadis B V Determination of exosomel biomarkers for predicting cardiovascular events
CN101955991B (zh) * 2010-03-31 2014-05-28 江苏迈迪基因生物科技有限公司 白血病相关的融合基因的联合检测方法及诊断试剂盒
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
CN101955995B (zh) * 2010-06-17 2013-06-26 江苏迈迪基因生物科技有限公司 淋巴瘤相关的融合基因的诊断试剂盒
WO2011163214A2 (en) * 2010-06-21 2011-12-29 Diogenix, Inc. Microrna profiles for evaluating multiple sclerosis
EP2591359B1 (en) * 2010-07-07 2017-03-01 Aethlon Medical Inc Methods for quantifying exosomes
WO2012010584A1 (en) * 2010-07-20 2012-01-26 Febit Holding Gmbh Complex mirna sets as novel biomarkers for gastric cancer
WO2012017430A2 (en) 2010-08-01 2012-02-09 Tel Hashomer Medical Research Infrastructure And Services Ltd. Microrna patterns for the diagnosis, prognosis and treatment of melanoma
CA2808417A1 (en) * 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2012031008A2 (en) * 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
CA2812287A1 (en) * 2010-09-22 2012-03-29 Dave S.B. Hoon Direct blood assay for detection of circulating microrna in cancer patients
AU2011316477A1 (en) * 2010-10-11 2013-05-02 Medsaic Pty Ltd Assay for disease detection
KR20120037576A (ko) * 2010-10-12 2012-04-20 주식회사 엘지실트론 단결정 잉곳 절단장치 및 단결정 잉곳 절단방법
CN101942523B (zh) * 2010-10-15 2013-04-03 邵棠 一种检测pca3基因、psa基因的液相芯片法及其诊断试剂盒
JP6219721B2 (ja) 2010-11-10 2017-10-25 エキソソーム ダイアグノスティックス インコーポレイテッド 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法
ES2627069T3 (es) * 2010-11-12 2017-07-26 Incelldx, Inc. Métodos y sistemas para predecir si un sujeto tiene una lesión de neoplasia intraepitelial cervical (CIN) a partir de una muestra de células cervicales
MX2013005196A (es) * 2010-11-12 2013-06-28 Endocyte Inc Metodos para tratamiento del cancer.
KR20180050420A (ko) 2011-01-10 2018-05-14 진판델 파마슈티컬스 인코포레이티드 알츠하이머 병 치료를 위한 방법 및 약품
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
SG183579A1 (en) * 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
US20140079717A1 (en) * 2011-02-17 2014-03-20 Cornell University Compositions and Methods to Prevent Cell Transformation and Cancer Metastasis
WO2012110099A1 (en) * 2011-02-18 2012-08-23 Cavadis B.V. Determination of exosomal biomarkers for predicting cardiovascular events
WO2012110253A2 (en) * 2011-02-18 2012-08-23 Cavadis B.V. Exosomal biomarkers for cardiovascular events
EP2678448A4 (en) * 2011-02-22 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L CIRCULATING BIOMARKERS
US10952415B2 (en) * 2011-03-09 2021-03-23 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
ITNA20110012A1 (it) * 2011-03-14 2012-09-15 Amal Raj Delfin Albert Procedura di isolamento e di purificazione degli esosomi urinari per la ricerca di biomarcatori proteici
US20120289420A1 (en) * 2011-03-18 2012-11-15 University Of South Florida Microrna biomarkers for airway diseases
WO2012126118A1 (en) 2011-03-21 2012-09-27 Atlantic Cancer Research Institute Polypeptides with affinity for heat shock proteins (hsps) and hsp associated complexes (hacs) and their use in diagnosis and therapy
US8399262B2 (en) 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
WO2012135844A2 (en) * 2011-04-01 2012-10-04 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
US9556487B2 (en) 2011-04-18 2017-01-31 Diamir, Llc Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and alzheimer's disease (AD)
US8460872B2 (en) 2011-04-29 2013-06-11 Sequenom, Inc. Quantification of a minority nucleic acid species
KR20140064732A (ko) * 2011-05-05 2014-05-28 클리니칼 게노믹스 피티와이. 엘티디. 신생물을 진단하는 방법
US20140212871A1 (en) * 2011-05-11 2014-07-31 Exosome Diagnostics, Inc. Nucleic Acid Extraction from Heterogeneous Biological Materials
WO2012162563A2 (en) * 2011-05-24 2012-11-29 The Regents Of The University Of California Method for exosomal biomarker detection by electric field-induced release and measurement
CN103782174A (zh) * 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 用于癌症的循环生物标志物
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
JP2014519340A (ja) * 2011-06-16 2014-08-14 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． バイオマーカー組成物および方法
EP2723894B1 (en) * 2011-06-27 2016-05-11 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
US20130028895A1 (en) 2011-07-27 2013-01-31 Gerald Wulf Exosome inhibiting agents and uses thereof
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
US20150018227A1 (en) * 2011-08-05 2015-01-15 University Of Louisville Research Foundation, Inc. Microrna biomarkers
WO2013022953A2 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof
CA2844671A1 (en) * 2011-08-08 2013-02-14 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods
DK3156505T3 (da) * 2011-08-19 2019-08-26 Hummingbird Diagnostics Gmbh Komplekse sæt af mirna'er som ikke-invasive biomarkører til coloncancer
WO2013033734A1 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
US20130079241A1 (en) 2011-09-15 2013-03-28 Jianhua Luo Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse
US9417249B2 (en) 2011-09-16 2016-08-16 University Of Louisville Research Foundation, Inc. Methods of predicting and decreasing the risk of pre-term birth
CN103917869A (zh) * 2011-09-22 2014-07-09 洛斯安第斯大学 用于监测、诊断和/或预后早期急性肾损伤的方法
US20130095575A1 (en) * 2011-10-03 2013-04-18 The Board Of Trustees Of The Leland Stanford Junior University Methods for Fractionation, Analysis and Collection of Microvesicles From Patient Samples
NO3051026T3 (zh) * 2011-10-21 2018-07-28
CA2852098C (en) * 2011-10-21 2023-05-02 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
WO2013070324A1 (en) 2011-11-07 2013-05-16 University Of Louisville Research Foundation, Inc. Edible plant-derived microvesicle compositions for diagnosis and treatment of disease
CN102443649A (zh) * 2011-12-20 2012-05-09 苏州福英基因科技有限公司 各种癌症病理演变前期microrna-141水平原位杂交检测试剂盒及检测方法和应用
JP6029112B2 (ja) * 2011-12-22 2016-11-24 テオリアサイエンス株式会社 エクソソームの分析方法、エクソソーム分析用試薬およびエクソソーム分析装置
PL2809810T3 (pl) 2012-01-06 2020-07-27 Viomics Inc. Układ i sposób wykrywania rna zmienionych przez raka płuca w krwi obwodowej
US9879254B2 (en) 2012-01-18 2018-01-30 The General Hosptial Corporation Targeting RNAs to microvesicles
WO2013119602A1 (en) 2012-02-06 2013-08-15 President And Fellows Of Harvard College Arrdc1-mediated microvesicles (armms) and uses thereof
EP3882633A1 (en) 2012-02-09 2021-09-22 MeMed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
CA2867118A1 (en) * 2012-03-13 2013-09-19 Baylor Research Institute Early detection of tuberculosis treatment response
US20130280720A1 (en) * 2012-03-15 2013-10-24 The University Of Kansas Tissue biomarkers for indication of progression from barrett's esophagus to esophageal adenocarcinoma
MX347850B (es) 2012-05-03 2017-05-16 Medial Res Ltd Métodos y sistemas para evaluar un riesgo de un cáncer gastrointestinal.
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
WO2013170146A1 (en) 2012-05-10 2013-11-14 Uab Research Foundation Methods and compositions for modulating mir-204 activity
JP6518585B2 (ja) 2012-05-14 2019-05-22 リチャード ジー． ペステル がんの治療のためのｃｃｒ５の修飾薬の使用
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US9702886B2 (en) 2012-05-24 2017-07-11 The Broad Institute, Inc. Methods and devices for tuberculosis diagnosis using biomarker profiles
US9493810B2 (en) * 2012-06-07 2016-11-15 Pioma, Inc. 5-ALA for detection of brain tumors
US20150184248A1 (en) * 2012-06-27 2015-07-02 National Cancer Center Method for detecting pancreatic cancer and detection kit
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014015149A2 (en) * 2012-07-18 2014-01-23 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
EP2687607B1 (en) * 2012-07-19 2015-03-04 St. Josef- und St. Elisabeth-Hospital GmbH MicroRNA profiles in the diagnosis of multiple sclerosis
CA2879337C (en) * 2012-07-19 2021-11-30 Atlantic Cancer Research Institute Method for the isolation of microvesicles
EP2885414B1 (en) 2012-08-15 2020-09-23 The University of Chicago Exosome-based therapeutics against neurodegenerative disorders
WO2014028862A1 (en) * 2012-08-17 2014-02-20 Cornell University Use of dna in circulating exosomes as a diagnostic marker for metastasic disease
JP5933010B2 (ja) 2012-08-20 2016-06-08 国立研究開発法人国立がん研究センター 癌治療剤
WO2014059336A1 (en) 2012-10-12 2014-04-17 University Of Notre Dame Du Lac Exosomes and diagnostic biomarkers
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
ES2912033T3 (es) * 2012-10-23 2022-05-24 Caris Science Inc Aptámeros y usos de los mismos
WO2014078420A1 (en) 2012-11-13 2014-05-22 Allan Wu Methods and systems for processing exosomes
KR101984700B1 (ko) 2012-11-19 2019-05-31 삼성전자주식회사 폴리뉴클레오티드 및 그의 용도
WO2014093698A1 (en) * 2012-12-12 2014-06-19 The Methodist Hospital Research Institute Multi-aptamer-based, cell-specific, one-step tumor cell detection assays
EP2746406B1 (en) * 2012-12-18 2017-08-23 Samsung Electronics Co., Ltd. Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same
AU2013361323B2 (en) * 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
EP2943585B1 (en) * 2013-01-09 2018-07-11 Friedrich-Alexander-Universität Erlangen-Nürnberg Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles
HUE049003T2 (hu) 2013-03-13 2020-09-28 Univ Miami Eljárás mikrovezikulumok izolálására és tisztítására sejttenyészet-felülúszóból és biológiai folyadékból
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP2971162B1 (en) * 2013-03-15 2019-05-08 Board Of Regents, The University Of Texas System Mirna biogenesis in exosomes for diagnosis and therapy
JP2016515380A (ja) * 2013-03-15 2016-05-30 ライフ テクノロジーズ コーポレーション 肺癌の分類及び実施可能性インデックス
KR101504817B1 (ko) * 2013-04-05 2015-03-24 연세대학교 산학협력단 국소 진행형 위암에 대한 예후 예측 시스템
JP6386995B2 (ja) * 2013-04-08 2018-09-05 テオリアサイエンス株式会社 大腸がんの検出方法
AU2014251388B2 (en) 2013-04-12 2017-03-30 Evox Therapeutics Limited Therapeutic delivery vesicles
WO2014172390A2 (en) * 2013-04-15 2014-10-23 Cedars-Sinai Medical Center Methods for detecting cancer metastasis
JP6427169B2 (ja) 2013-04-26 2018-11-21 メッド−ロジックス，インク． 組織除去装置、システム、及び方法
JP6297676B2 (ja) 2013-05-06 2018-03-20 日立化成株式会社 標的分子を捕捉するためのデバイス及び方法
WO2014186361A2 (en) * 2013-05-14 2014-11-20 Wei Chen Pharmacogenomic biomarkers for b cell malignancies and methods of use thereof
CA2913285A1 (en) * 2013-05-23 2014-11-27 Iphenotype Llc Methods and systems for assisting persons, product providers and/or service providers
US10961531B2 (en) 2013-06-05 2021-03-30 Agex Therapeutics, Inc. Compositions and methods for induced tissue regeneration in mammalian species
CN104237168B (zh) * 2013-06-21 2017-12-12 国家纳米科学中心 一种检测液体样品中外囊体的方法
US9213029B2 (en) 2013-06-25 2015-12-15 Samsung Electronics Co., Ltd. Method for diagnosing breast cancer by detection of polymeric immunoglobulin receptor in vesicles isolated from patients
RU2016111131A (ru) 2013-08-28 2017-10-03 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Способы конъюгации сайт-специфических антител и композиции
EP3039174B1 (en) * 2013-08-28 2019-10-16 Caris Science, Inc. Oligonucleotide probes and uses thereof
JPWO2015045666A1 (ja) * 2013-09-25 2017-03-09 国立大学法人 東京大学 流体デバイス、エキソソームの分析方法、生体分子分析方法及び生体分子検出方法
WO2015046263A1 (ja) 2013-09-25 2015-04-02 国立大学法人東京大学 溶液混合器、流体デバイス及び溶液の混合方法
RU2663908C1 (ru) * 2013-09-30 2018-08-13 Федеральное государственное бюджетное учреждение науки Институт молекулярной генетики РАН Способ идентификации генетических маркеров поздней формы болезни паркинсона
EP3052661A4 (en) * 2013-10-02 2017-05-31 Hitachi Chemical Company, Ltd. Methods for assessing status of post-transplant liver and determining and administering specific treatment regimens
EP3071712B1 (en) 2013-11-18 2020-06-24 DiamiR, LLC Methods of using mirnas from bodily fluids for detection and monitoring of parkinson's disease (pd)
WO2015074083A1 (en) * 2013-11-18 2015-05-21 The Trustees Of Columbia University In The City Of New York Methods for diagnosing t cell-mediated inflammation
WO2015083731A1 (ja) * 2013-12-04 2015-06-11 独立行政法人産業技術総合研究所 マイクロベシクルに対する核酸アプタマー
WO2015083829A1 (ja) * 2013-12-06 2015-06-11 国立大学法人東京大学 バルブ、流体制御構造、流体デバイス及びバルブの製造方法
CN103714268A (zh) * 2013-12-12 2014-04-09 深圳先进技术研究院 一种筛选多发性硬化疾病生物标志物的方法
CA2935216C (en) 2013-12-30 2021-11-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fusion genes associated with progressive prostate cancer
EP3097202B1 (en) * 2014-01-21 2018-10-31 Morehouse School of Medicine Exosome-mediated detection of infections and diseases
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
EP3108012A4 (en) 2014-02-18 2017-10-11 Baylor Research Institute Mir-320e and colorectal cancer
EP3107576A4 (en) * 2014-02-21 2017-09-06 Abbvie Stemcentrx LLC Anti-dll3 antibodies and drug conjugates for use in melanoma
JP6415829B2 (ja) * 2014-02-28 2018-10-31 キヤノンメディカルシステムズ株式会社 検体に含まれるエキソソームの特性を判定する方法、診断方法および装置
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3122905B1 (en) 2014-03-27 2020-09-09 Yale University Circulating micrornas as biomarkers for endometriosis
WO2015153732A2 (en) * 2014-04-01 2015-10-08 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
CN103954770B (zh) * 2014-04-25 2015-09-30 江南大学 EVs-TRPC5在检测乳腺癌耐药程度中的应用
US20170184613A1 (en) * 2014-05-23 2017-06-29 Georgetown University Exosome and lipid biomarkers for memory loss
WO2015179909A1 (en) * 2014-05-26 2015-12-03 The University Of Melbourne Mirna biomarkers of alzheimer's disease
US20170145515A1 (en) * 2014-06-04 2017-05-25 Atossa Genetics Inc. Molecular mammography
RU2712223C2 (ru) * 2014-06-06 2020-01-27 Экзосомикс С.П.А. Экзосомальные биомаркеры
JP6531171B2 (ja) * 2014-06-27 2019-06-12 エックスワイ エバーグリーン テクノロジー カンパニー Ｃｎｓ由来エクソソームを富化するための方法
US10240127B2 (en) * 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
ES2825708T3 (es) * 2014-07-17 2021-05-17 Univ Pennsylvania Métodos para usar exosomas para monitorizar el estado de órgano trasplantado
EP3193944B1 (en) 2014-07-17 2021-04-07 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of treating cells containing fusion genes
US20180209975A1 (en) * 2014-07-17 2018-07-26 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
WO2016022696A1 (en) * 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
BR112017002888A2 (pt) 2014-08-12 2017-12-05 Nextgen Jane Inc sistema e método para monitoramento de saúde em fluido corpóreo coletado
SG10201404895XA (en) * 2014-08-13 2016-03-30 Agency Science Tech & Res Diagnosis
EP2985289A1 (en) * 2014-08-14 2016-02-17 Miltenyi Biotec GmbH Depletion of mouse cells for generic isolation of human cells upon xenotransplantation
CA3190715A1 (en) 2014-08-14 2016-02-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
US20170283789A1 (en) * 2014-08-29 2017-10-05 Hitachi Chemical Co., Ltd. Methods for collecting cervical-vaginal fluids and isolating exosome and microvesicles for molecular analysis
WO2016033696A1 (en) * 2014-09-05 2016-03-10 Exerkine Corporation Methods of producing and using exersomes and bioengineered exersomes
EP3191841A4 (en) * 2014-09-12 2018-03-14 Panacea Pharmaceuticals, Inc. Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients
WO2016057702A2 (en) 2014-10-07 2016-04-14 Cornell University Methods for prognosing and preventing metastatic liver disease
AU2015330855A1 (en) * 2014-10-09 2017-04-27 Celularity Inc. Placenta-derived adherent cell exosomes and uses thereof
US20170234873A1 (en) 2014-10-14 2017-08-17 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
CN104535766B (zh) * 2014-10-30 2016-04-13 中国人民解放军总医院第一附属医院 外周血exosome来源的肝癌诊断和预后标志物及其应用
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
WO2016077537A1 (en) 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
US10093743B2 (en) * 2014-11-18 2018-10-09 Premkumar Christadoss Muscle specific tyrosine kinase-fluorophore conjugate compositions, kits and methods of using
CN104372004B (zh) * 2014-12-04 2018-04-27 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
CN111624345A (zh) * 2014-12-11 2020-09-04 米密德诊断学有限公司 用于诊断多种感染的标记组合及其使用方法
WO2016121821A1 (ja) * 2015-01-27 2016-08-04 Jsr株式会社 分離方法、検出方法、シグナル測定方法、疾患の判定方法、薬効評価方法、キット、液状組成物及び検体希釈液
US10493165B2 (en) 2015-01-30 2019-12-03 The Johns Hopkins University Extracellular vesicles for agent delivery
CA2975952A1 (en) * 2015-02-24 2016-09-01 Ruprecht-Karls-Universitat Heidelberg Biomarker panel for the detection of cancer
WO2016140388A1 (ko) * 2015-03-05 2016-09-09 경북대학교 산학협력단 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법
EP3112474A1 (en) * 2015-06-29 2017-01-04 Evonik Degussa GmbH Method of detecting avian necrotic enteritis
GB201503792D0 (en) * 2015-03-06 2015-04-22 Imp Innovations Ltd Method
US10571396B2 (en) * 2015-04-08 2020-02-25 Molecular Devices, Llc Methods and systems for fluorescence detection
US11971354B2 (en) 2015-04-08 2024-04-30 Molecular Devices, Llc Methods and systems for fluorescence detection using infrared dyes
US10379046B2 (en) * 2015-04-08 2019-08-13 Molecular Devices, Llc Method and system for multiplexed time-resolved fluorescence detection
US11971402B2 (en) 2015-04-24 2024-04-30 Cornell University Methods and reagents for determination and treatment of organotropic metastasis
EP3093664A1 (en) 2015-05-13 2016-11-16 Miltenyi Biotec GmbH A method for analysing markers on the surface of vesicles
AU2016276750A1 (en) 2015-06-09 2018-01-18 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
AU2016275046B2 (en) 2015-06-10 2022-07-28 Board Of Regents, The University Of Texas System Use of exosomes for the treatment of disease
WO2017004243A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides
WO2017011560A1 (en) * 2015-07-15 2017-01-19 Hycor Biomedical, Llc. Customizable instrument
EP3325006A4 (en) 2015-07-17 2019-03-06 The Trustees of Columbia University in the City of New York METHOD FOR TREATING CD166-EXPRESSIVE CANCER
AU2016298317B2 (en) 2015-07-28 2021-02-18 Caris Science, Inc. Targeted oligonucleotides
WO2017027473A1 (en) 2015-08-07 2017-02-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods for predicting prostate cancer relapse
AU2016304764C1 (en) 2015-08-07 2023-06-01 Imaginab, Inc. Antigen binding constructs to target molecules
JP6606916B2 (ja) * 2015-08-21 2019-11-20 株式会社Ｊｖｃケンウッド エクソソームの捕捉方法
CN105039333B (zh) * 2015-08-21 2018-07-24 天津医科大学 肝癌靶向肽及其应用
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
US10928315B1 (en) 2015-09-22 2021-02-23 Trustees Of Boston University Multiplexed phenotyping of nanovesicles
EP3147370A1 (en) * 2015-09-28 2017-03-29 Rheinische Friedrich-Wilhelms-Universität Bonn Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat)
US20190250147A1 (en) * 2015-10-13 2019-08-15 The Trustees Of The University Of Pennsylvania Methods for using enriched exosomes as a platform for monitoring organ status
KR101785795B1 (ko) * 2015-10-30 2017-10-13 가톨릭대학교 산학협력단 두경부암 예후 예측용 바이오마커 마이크로 rna
US20180321258A1 (en) * 2015-11-06 2018-11-08 The Trustees Of Columbia University In The City Of New York Exosomal Protein Profiling for Detection of Cardiac Transplant Rejection
US20190049467A1 (en) * 2015-11-20 2019-02-14 Exosorme Sciences, Inc. Exosomal tau as a biomarker for brain disorders
EP3387430A4 (en) * 2015-12-11 2019-08-14 Expression Pathology, Inc. SRM / MRM DOSINGS
CN105779586B (zh) * 2015-12-28 2020-02-07 四川农业大学 一种从动物血浆中分离外泌体并进行纯度检测的方法
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
US10962555B2 (en) 2016-01-07 2021-03-30 Temple University-Of The Commonwealth System Of Higher Education Purification, extraction and analyses of fetal neurally-derived exosomes in maternal blood and neonatal neurally-derived exosomes from neonatal blood
US11243215B2 (en) * 2016-01-14 2022-02-08 The Regents Of The University Of California 3D-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids
WO2017136430A1 (en) * 2016-02-01 2017-08-10 The Board Of Trustees Of The Leland Stanford Junior University Exosome-total-isoloation-chip (exotic) device for isolation of exosome-based biomarkers
CA3012212A1 (en) * 2016-02-05 2017-08-10 Nanoview Diagnostics Inc. Detection of exosomes having surface markers
US11466331B2 (en) 2016-03-03 2022-10-11 Memed Diagnostics Ltd. RNA determinants for distinguishing between bacterial and viral infections
WO2017155894A1 (en) 2016-03-07 2017-09-14 Cfgenome, Llc Noninvasive molecular controls
US10295527B2 (en) 2016-03-14 2019-05-21 Bruce Yacyshyn Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis
US11946927B2 (en) 2016-03-14 2024-04-02 Musidora Biotechnology Llc Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment
WO2017160869A1 (en) * 2016-03-15 2017-09-21 Biomerica, Inc. Compositions, devices, and methods of fibromyalgia sensitivity testing
CA3018066A1 (en) 2016-03-18 2017-09-21 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3433381A4 (en) 2016-03-21 2019-10-23 Diamir, LLC METHOD FOR USE OF MIRNAS FROM BODY FLUIDS FOR THE DETECTION AND DIFFERENTIATION OF NEURODEGENATIVE DISEASES
WO2017180909A1 (en) 2016-04-13 2017-10-19 Nextgen Jane, Inc. Sample collection and preservation devices, systems and methods
WO2018057820A1 (en) 2016-09-21 2018-03-29 Predicine, Inc. Systems and methods for combined detection of genetic alterations
WO2017181161A1 (en) 2016-04-15 2017-10-19 Predicine, Inc. Systems and methods for detecting genetic alterations
US11293017B2 (en) 2016-05-25 2022-04-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN105893782A (zh) * 2016-05-26 2016-08-24 江苏省人民医院 前列腺癌风险预测装置
EP3464639A4 (en) 2016-05-31 2020-01-01 Goetzl, Edward, J. DIAGNOSTIC METHOD AND METHOD FOR TESTING THE EFFECTIVENESS OF A MEDICINAL PRODUCT FOR DEMENTIA USING ASTROCYTE-DERIVED EXOSOMES
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
CN109804245B (zh) 2016-07-10 2022-10-25 米密德诊断学有限公司 感染的早期诊断
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
CN106244705B (zh) * 2016-08-29 2019-10-11 北京泱深生物信息技术有限公司 Erc1在制备诊断或治疗下咽癌工具中的应用
SG11201901834WA (en) 2016-08-30 2019-03-28 Univ Yale Micrornas as biomarkers for endometriosis
US10914748B2 (en) 2016-09-08 2021-02-09 UNIVERSITé LAVAL Erythrocyte-derived extracellular vesicles as a biomarker for clinically assessing Parkinson's disease
EP3519833A4 (en) 2016-09-29 2020-06-03 MeMed Diagnostics Ltd. PROGNOSTIC AND TREATMENT METHODS
WO2018060999A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of risk assessment and disease classification
EP3518981A4 (en) 2016-10-03 2020-06-10 President and Fellows of Harvard College DELIVERING THERAPEUTIC RNAS VIA ARRDC1-MEDIATED MICROVESICLES
US20200063208A1 (en) * 2016-10-13 2020-02-27 University Of Louisville Research Foundation, Inc. Exosomal biomarkers for diagnosis and prognosis of cancer and related methods
CN110168069A (zh) * 2016-10-19 2019-08-23 通用自动化实验技术公司 用于筛选微生物和其他高通量微生物学应用的高分辨率系统、试剂盒、设备和方法
US10874610B2 (en) 2016-10-19 2020-12-29 Northwestern University Extracellular vesicle-based diagnostics and engineered exosomes for targeted therapeutics against cancer
JP6712737B2 (ja) * 2016-10-28 2020-06-24 公益財団法人がん研究会 バイオマーカー、疾患関連遺伝子の探索方法、及び腎がんマーカー
JP6280997B1 (ja) * 2016-10-31 2018-02-14 株式会社Ｐｒｅｆｅｒｒｅｄ Ｎｅｔｗｏｒｋｓ 疾患の罹患判定装置、疾患の罹患判定方法、疾患の特徴抽出装置及び疾患の特徴抽出方法
US11274349B2 (en) 2016-11-08 2022-03-15 Cedars-Sinai Medical Center Methods for diagnosing cancer
AU2017365709A1 (en) * 2016-11-24 2019-06-06 The Council Of The Queensland Institute Of Medical Research Determining a cancer prognosis
JP6918062B2 (ja) * 2017-01-19 2021-08-11 シスメックス株式会社 細胞の分化状態を評価する方法
JP6629770B2 (ja) * 2017-01-19 2020-01-15 シスメックス株式会社 細胞の分化状態を評価する方法
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
US20180246112A1 (en) * 2017-02-28 2018-08-30 University Of Kentucky Research Foundation Biomarkers of Breast and Lung Cancer
JP2020079708A (ja) * 2017-03-14 2020-05-28 国立大学法人大阪大学 慢性閉塞性肺疾患バイオマーカー
JP2020076572A (ja) * 2017-03-14 2020-05-21 国立大学法人大阪大学 組織線維化バイオマーカー
JP2020079707A (ja) * 2017-03-14 2020-05-28 国立大学法人大阪大学 閉塞性肺疾患バイオマーカー
IL269483B2 (en) 2017-03-21 2024-04-01 Exoprother Medical Ltd Vesicles from natural cells containing tumor suppressor proteins and their use for therapy
WO2018172384A1 (en) * 2017-03-24 2018-09-27 Biovesicle Inc Methods and kits for exosome isolation and quantification
JP2018178919A (ja) * 2017-04-18 2018-11-15 トヨタ自動車株式会社 車両の制御装置
DK3622082T3 (da) 2017-05-12 2023-06-12 Evonik Operations Gmbh Fremgangsmåde til påvisning af c. perfringens-inducerede sygdomme i en fugleflok
WO2018222069A1 (ru) 2017-06-02 2018-12-06 Общество С Ограниченной Ответственностью "Простагност" Белковый маркер для диагностики рака предстательной железы, способ измерения количества маркера и алгоритм интерпретации результата
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
WO2019008414A1 (en) * 2017-07-05 2019-01-10 Datar Rajan GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
CN111133106A (zh) 2017-07-12 2020-05-08 外来体诊断公司 用于分离和富集生物流体来源的细胞外囊泡的方法及其使用方法
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CN107245529A (zh) * 2017-08-08 2017-10-13 杭州千麦医学检验所有限公司 血液病融合基因筛查方法
US20190049455A1 (en) * 2017-08-11 2019-02-14 Panacea Pharmaceuticals Inc. HAAH and MMP-9 are Complementary Cancer Biomarkers and Predictors of Metastasis when Combined
US11718878B2 (en) * 2017-08-21 2023-08-08 Seattle Children's Research Hospital Exosome profiling for diagnosis and monitoring of vasculitis and vasculopathies including Kawasaki disease
WO2019051546A1 (en) * 2017-09-13 2019-03-21 The Flinders University Of South Australia METHODS AND MARKERS FOR EVALUATING A RESPONSE TO A MEDICINAL PRODUCT
GB2574785A (en) * 2017-09-15 2019-12-25 Jan Loetvall Method and system for identifying membrane proteins on extracellular vesicles
CN107860830A (zh) * 2017-10-10 2018-03-30 暨南大学 一种寻常型银屑病血浆中生物标志物在其靶向药物的应用
WO2019094727A1 (en) * 2017-11-10 2019-05-16 Mayo Foundation For Medical Education And Research Methods and materials for assessing and treating cancer
WO2019109077A1 (en) * 2017-12-01 2019-06-06 Cornell University Nanoparticles and distinct exosome subsets for detection and treatment of cancer
WO2019126168A1 (en) * 2017-12-21 2019-06-27 Proplex Technologies, LLC Sensitive detection of g-protein coupled receptor-associated sorting protein 1 (gasp-1). gasp-1 microvesicles, and gasp-1 exosomes
KR102659652B1 (ko) 2017-12-22 2024-04-22 위스콘신 얼럼나이 리서어치 화운데이션 암 바이오마커 포획을 위해 나노가공된 표면
WO2019139901A1 (en) * 2018-01-12 2019-07-18 Massachusetts Eye And Ear Infirmary Nasal exosomes for non-invasive sampling of cns proteins
CN110133272A (zh) * 2018-02-09 2019-08-16 北京大学 用于从生物体液中富集或检测星形胶质细胞来源的外泌体的方法
CN110157801B (zh) * 2018-02-12 2021-03-09 清华大学 一种组合标志物及其在制备胃癌发生风险预测试剂盒中的应用及其测定系统和方法
CN108103201B (zh) * 2018-03-05 2022-03-01 江苏为真生物医药技术股份有限公司 外泌体microRNA分子标志物的应用及用于诊断食管癌的试剂盒
CN108531586B (zh) * 2018-03-19 2022-03-29 朱伟 一种与乳腺癌辅助诊断相关的位于X染色体上的循环miRNA标志物及其应用
CN108707663B (zh) * 2018-04-19 2022-03-08 深圳华大基因股份有限公司 用于癌症样本miRNA测序定量结果评价的试剂、制备方法和应用
EP3784258A4 (en) * 2018-04-25 2022-08-10 University of Massachusetts ARTIFICIAL EXOSOME COMPOSITION AND RELATED METHODS
WO2019220759A1 (ja) * 2018-05-17 2019-11-21 Ｓｔｅｍｃｅｌｌ株式会社 がんの分析方法、がんの分析システム、プログラムおよびコンピュータ読み取り可能な記録媒体
KR102180117B1 (ko) * 2018-06-14 2020-11-17 가톨릭대학교 산학협력단 간암 특이적 바이오 마커
CN108949973B (zh) * 2018-06-21 2019-10-11 南京市妇幼保健院 滋养细胞侵袭力异常的生物标志物及其应用
JP2021156577A (ja) * 2018-06-27 2021-10-07 国立大学法人大阪大学 閉塞性肺疾患バイオマーカー
CN112423768A (zh) * 2018-06-29 2021-02-26 北卡罗来纳州立大学 通过肺球体细胞分泌因子的吸入来进行治疗性肺修复
US20230026916A1 (en) * 2018-07-05 2023-01-26 Active Genomes Expressed Diagnostics, Inc Viral Oncogene Influences and Gene Expression Patterns as Indicators of Early Tumorigenesis
CN109061178B (zh) * 2018-07-05 2021-04-27 天津渤海水产研究所 一种鉴定半滑舌鳎精液来源外泌体的elisa方法
CN108796070B (zh) * 2018-07-16 2022-09-30 辽宁中医药大学 miR-125a-3p在制备心血管疾病诊断试剂盒中的用途
WO2020018926A1 (en) * 2018-07-19 2020-01-23 Intrexon Corporation Exosome delivery of skin care peptides
KR102211972B1 (ko) * 2018-08-02 2021-02-04 엑소젠 피티이. 엘티디 액체생검 다중 암 유전자 바이오마커를 이용한 유방암 조기진단 및 치료 후 모니터링 방법
CN110824156B (zh) * 2018-08-14 2023-08-11 欧蒙医学诊断（中国）有限公司 神经自身免疫疾病的诊断
EP3844503B1 (en) * 2018-08-31 2024-05-29 F. Hoffmann-La Roche AG Thymidine kinase (tk-1) in prognostic indices for dlbcl
JP6677284B2 (ja) * 2018-10-09 2020-04-08 凸版印刷株式会社 分析対象物の検出方法及びラテラルフロー用テストストリップ
US11315660B2 (en) 2018-10-31 2022-04-26 Dot Laboratories, Inc. Method of detecting and treating endometriosis in a female subject
CN109598709B (zh) * 2018-11-29 2023-05-26 东北大学 基于融合深度特征的乳腺辅助诊断系统及方法
CN109507426B (zh) * 2018-11-29 2022-03-15 上海晟燃生物科技有限公司 前列腺癌诊断、分级或预后标志物、检测试剂或试剂盒、系统及其应用
JP7462632B2 (ja) 2018-11-30 2024-04-05 カリス エムピーアイ インコーポレイテッド 次世代分子プロファイリング
CN109557311B (zh) * 2018-12-13 2022-02-15 中南大学湘雅医院 结直肠癌诊断标志物及结直肠癌的检测产品及其应用
CN109628277B (zh) * 2019-01-23 2022-02-01 东南大学 一种外泌体内肿瘤标志miRNA的分离和检测系统及方法
KR20210125532A (ko) * 2019-02-08 2021-10-18 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 진단 및 치료 목적을 위한 엑소좀 관련 마이크로바이옴의 단리 및 검출
CN109701038B (zh) * 2019-02-22 2021-02-23 上海大学 一种脑部靶向外泌体、其制备方法及应用
WO2020176700A1 (en) * 2019-02-27 2020-09-03 Yale University Compositions and methods for enhancing mucosal immunity
WO2020176745A1 (en) * 2019-02-28 2020-09-03 The Trustees Of Columbia University In The City Of New York Sorting cell-type specific extracellular vesicles
US20220163532A1 (en) * 2019-03-27 2022-05-26 Board Of Regents, The University Of Texas System Nuclear-derived exosomes and methods of use thereof
EP3947732A4 (en) * 2019-04-05 2023-01-11 Arizona Board of Regents on behalf of Arizona State University DIAGNOSTIC FOR THE MATERNAL RISK OF A CHILD WITH AUTISTIC SPECTRUM DISEASE
US20230190819A1 (en) * 2019-05-11 2023-06-22 Youngsuk Yi Compositions and methods containing exosomes
CN110184357A (zh) * 2019-06-13 2019-08-30 徐州医科大学 结肠癌的预后预测诊断用基因标记物及其用途
CN110200986A (zh) * 2019-07-05 2019-09-06 深圳市康宁医院(深圳市精神卫生研究所深圳市精神卫生中心) miR-132在制备用于治疗成瘾的药物中的应用
CN110438053B (zh) * 2019-07-23 2022-03-11 天津大学 一种适用于聚球藻的生物封存系统、构建方法及应用
JP6865800B2 (ja) * 2019-09-30 2021-04-28 勲 岡▲崎▼ 乳がん評価方法、および乳がん評価用の尿検査キット
WO2021076808A1 (en) * 2019-10-15 2021-04-22 Cornell University Methods for detecting and inhibiting brain metastasis
JP6822537B2 (ja) * 2019-10-23 2021-01-27 株式会社Ｊｖｃケンウッド エクソソームの検出方法
WO2021107154A1 (ja) * 2019-11-29 2021-06-03 富士フイルム和光純薬株式会社 アルツハイマー型認知症又は軽度認知障害の診断を補助する方法、バイオマーカー、試薬キット及び装置
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
CN110938687B (zh) * 2019-12-26 2023-06-27 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 胎盘植入性疾病标志物
JPWO2021132352A1 (zh) * 2019-12-27 2021-07-01
CN111208297A (zh) * 2020-01-07 2020-05-29 何凤屏 一种微流控芯片检测外泌体gpc1蛋白的方法及其在胰腺癌早期诊断中的应用
CN111239389A (zh) * 2020-01-20 2020-06-05 复旦大学附属中山医院 区分肝细胞肝癌和正常人的自身抗体标志物及其筛选方法
US20230160864A1 (en) * 2020-02-12 2023-05-25 President And Fellows Of Harvard College Methods of measuring and purifying extracellular vesicles
WO2021162114A1 (ja) * 2020-02-14 2021-08-19 みつる 宮戸 細胞外小胞の製造方法及びその利用
KR102316507B1 (ko) * 2020-02-28 2021-10-22 차의과학대학교 산학협력단 난소 예비력 바이오마커 및 이의 용도
CN111366525B (zh) * 2020-03-12 2021-08-13 西安交通大学 一种快速检测离体血样中SARS-CoV-2病毒感染的方法及应用
CN114214422B (zh) * 2020-03-30 2023-06-27 中国医学科学院肿瘤医院 外泌体miR-106b-3P、ARPC5在肺癌诊断中的应用
CA3177360A1 (en) 2020-04-13 2021-10-21 Exoprother Medical Ltd. Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy
US20210322483A1 (en) 2020-04-16 2021-10-21 Ichilov Tech Ltd. Cell-derived particles presenting heterologous cd24 and use thereof in therapy
EP4136456A1 (en) * 2020-04-17 2023-02-22 Therawis Diagnostics GmbH Method for enriching exosomes
KR20230044429A (ko) * 2020-07-08 2023-04-04 메르시 바이오애널리틱스, 인코포레이티드 폐암의 검출을 위한 조성물 및 방법
CN111965366B (zh) * 2020-07-09 2022-11-29 何凤屏 一种唾液快速检测外泌体肌钙蛋白的方法及试剂盒
WO2022019583A1 (ko) * 2020-07-23 2022-01-27 (주)메디톡스 엑소좀-매개된 질환 치료제
US20220059194A1 (en) * 2020-08-24 2022-02-24 FluoroMe, Inc., 3d pharmacophore model for the rapid computational screening of sars-cov-2 modulators and compositions and methods thereof
IL277743A (en) 2020-10-01 2022-04-01 Yeda Res & Dev A method for diagnosing breast cancer
CN114544826B (zh) * 2020-11-24 2023-12-08 重庆医科大学 检测血浆中组氨酸的试剂在制备抑郁症检测试剂盒中的用途
US20220205992A1 (en) * 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads
CN113177574B (zh) * 2021-03-19 2022-08-16 华中科技大学 用于材料表征图像分析的视觉模型及其分析方法
WO2022226099A1 (en) * 2021-04-20 2022-10-27 The Administrators Of The Tulane Educational Fund Method of detecting disease related biomarkers in bodily fluid sample
CN113504369A (zh) * 2021-06-23 2021-10-15 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种消除标本溶血所致血清神经特异性烯醇化酶检测阳性干扰的个体化纠正公式及其应用
WO2023283410A2 (en) * 2021-07-09 2023-01-12 Board Of Regents, The University Of Texas System Exosomal lipids and metabolites for the early detection of hepatocellular carcinoma
EP4373975A2 (en) * 2021-07-21 2024-05-29 Mercy Bioanalytics, Inc. Compositions and methods for detection of pancreatic cancer
CN114371135B (zh) * 2021-10-25 2024-01-30 孙良丹 一种用于评价银屑病的评价系统及应用
WO2023081299A1 (en) * 2021-11-05 2023-05-11 Spiritus Therapeutics, Inc. A purified enriched population exosomes derived from individuals with a chronic progressive lung disease for noninvasive detection, staging, and medical monitoring of disease progression
WO2023112482A1 (ja) * 2021-12-14 2023-06-22 シスメックス株式会社 細胞外小胞の測定方法、神経変性に関する情報の取得方法、細胞外小胞の単離方法及び試薬キット
CN113960313B (zh) * 2021-12-22 2022-04-12 上海思路迪医学检验所有限公司 一种外泌体alk融合蛋白磁免疫化学发光检测试剂盒
CN114592048A (zh) * 2022-03-10 2022-06-07 天津大学温州安全(应急)研究院 预测复发性流产人群孕期凝血功能异常的方法
WO2023182508A1 (ja) * 2022-03-25 2023-09-28 学校法人国際医療福祉大学 細胞外小胞表面分子を用いた疾患の検査方法及び検査キット
WO2023196586A1 (en) * 2022-04-07 2023-10-12 The Regents Of The University Of Michigan Methods and devices for screening extracellular vesicles
CN114984047B (zh) * 2022-04-29 2023-10-03 山东克洛伊美生物医药科技有限公司 血浆外泌体在制备治疗骨质疏松症药物中的应用
CN114990159A (zh) * 2022-05-18 2022-09-02 昆明理工大学 一种micorRNA206抑制HCV增殖的建立方法
CN115097143B (zh) * 2022-07-11 2023-07-21 东南大学 外周血血浆总外泌体中维生素d结合蛋白在诊断抑郁症中的应用
CN115166260B (zh) * 2022-07-11 2023-06-13 东南大学 血浆脑细胞来源外泌体中维生素d结合蛋白在诊断抑郁症中的应用
CN117024557B (zh) * 2023-10-10 2024-01-30 天津外泌体科技有限公司 14-3-3蛋白theta异构体作为细胞外囊泡支架蛋白的应用和细胞外囊泡

Family Cites Families (307)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US637619A (en) 1897-02-08 1899-11-21 Lucian A Kimball Self-reefing sail for canoes, &c.
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4551435A (en) 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
US4725550A (en) 1984-01-19 1988-02-16 Research Foundation Of State University Of New York Novel mutation of the c-K-ras oncogene activated in a human lung carcinoma
IL72452A (en) 1984-07-19 1988-04-29 Channa Shalitin Method for the preparation of yeast chromatin and separating p20 polypeptide thereof
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4925788A (en) 1986-10-24 1990-05-15 Immunicon Corporation Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
US5158871A (en) 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US4957859A (en) 1988-02-16 1990-09-18 Hoffmann-La Roche Inc. Antibodies for transforming ras protein
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5153131A (en) 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5026650A (en) 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US6117674A (en) 1988-06-30 2000-09-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Pathogen propagation in cultured three-dimensional tissue mass
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5104802A (en) 1989-07-28 1992-04-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Hollow fiber clinostat for simulating microgravity in cell culture
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5186827A (en) 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US6221620B1 (en) 1991-04-24 2001-04-24 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies specific for human thymidylate synthase
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
JP2001507921A (ja) 1992-04-27 2001-06-19 トラスティーズ オブ ダートマス カレッジ 生物学的液体中の遺伝子配列の検出
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5702941A (en) 1993-09-09 1997-12-30 Synthecon, Inc. Gas permeable bioreactor and method of use
US5437998A (en) 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5610281A (en) 1994-05-03 1997-03-11 Brigham & Women's Hospital, Inc. Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
AU686004B2 (en) 1994-08-12 1998-01-29 Myriad Genetics, Inc. In vivo mutations and polymorphisms in the 17q-linked breast and ovarian cancer susceptibility gene
US5710001A (en) 1994-08-12 1998-01-20 Myriad Genetics, Inc. 17q-linked breast and ovarian cancer susceptibility gene
US5753441A (en) 1994-08-12 1998-05-19 Myriad Genetics, Inc. 170-linked breast and ovarian cancer susceptibility gene
US5747282A (en) 1994-08-12 1998-05-05 Myraid Genetics, Inc. 17Q-linked breast and ovarian cancer susceptibility gene
JP3399539B2 (ja) 1994-08-12 2003-04-21 ミリアド・ジェネティックス・インコーポレイテッド 乳癌および卵巣癌の素因の診断方法
US5693473A (en) 1994-08-12 1997-12-02 Myriad Genetics, Inc. Linked breast and ovarian cancer susceptibility gene
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
GB9422814D0 (en) 1994-11-11 1995-01-04 Medinnova Sf Chemical method
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5523228A (en) 1995-07-07 1996-06-04 Hmri/Clmf Hydrodynamic cell culture environment for three dimensional tissue growth
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
NO954667D0 (no) 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
US5998151A (en) 1995-12-01 1999-12-07 The United States Of America As Represented By The Department Of Health And Human Services Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase
IL124620A0 (en) 1995-12-18 1998-12-06 Myriad Genetics Inc Chromosome 13-linked breast cancer susceptibility gene
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
US6329179B1 (en) 1996-03-26 2001-12-11 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US5895748A (en) 1996-11-27 1999-04-20 Johnson; Keith R. Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6416987B1 (en) 1997-02-04 2002-07-09 Sloan Kettering Institute For Cancer Research Mutants of thymidylate synthase and uses thereof
US6150514A (en) 1997-04-09 2000-11-21 University Of Utah Research Foundation 14 Kilobase deletion in the promoter region of BRCA1 in a breast cancer family
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
GB9715034D0 (en) 1997-07-18 1997-09-24 Zeneca Ltd Assay
US6218114B1 (en) 1998-03-27 2001-04-17 Academia Sinica Methods for detecting differentially expressed genes
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6218122B1 (en) 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
DE19833738A1 (de) 1998-07-27 2000-02-03 Michael Giesing Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens
JP5213202B2 (ja) 1998-10-28 2013-06-19 バイシス・インコーポレーテツド 細胞アレイならびに遺伝障害マーカーの検出および使用方法
BR9916449A (pt) 1998-12-23 2002-01-22 Univ Sydney Dispositivo de ensaio, métodos para determinação de uma condição de doença ou de um distúrbio ou de uma propensão para o desenvolvimento de uma condição de doença ou de um distúrbio e para tratamento de câncer ou de uma propensão para o desenvolvimento de câncer em um animal humano ou não-humano, uso de um arranjo de moléculas, e, método para identificação de uma proteìna mimética em uma amostra quìmica ou biológica
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
JP4523169B2 (ja) 1999-02-04 2010-08-11 プルリステム リミテッド 造血幹細胞および／または前駆細胞を維持および増加するための方法および装置
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6271002B1 (en) 1999-10-04 2001-08-07 Rosetta Inpharmatics, Inc. RNA amplification method
JP3875436B2 (ja) 1999-10-28 2007-01-31 富士通株式会社 ネットワーク管理装置および記録媒体
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7452713B2 (en) 2000-02-29 2008-11-18 Stmicroelectronics S.R.L. Process for manufacturing a microfluidic device with buried channels
US20040033490A1 (en) 2000-03-31 2004-02-19 Laird Peter W. Epigenetic sequences for esophageal adenocarcinoma
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US20040241176A1 (en) 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
US6649359B2 (en) 2000-06-01 2003-11-18 The Brigham & Women's Hospital, Inc. Diagnosis of endometrial precancers
JP2004507731A (ja) 2000-08-23 2004-03-11 イメゴ　アーベー 開閉することができる蓋を有する凹部内にサンプルを捕捉するためのミクロ流体デバイスおよび方法
US20020048821A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
US20020142328A1 (en) 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
WO2002056049A2 (en) 2000-12-01 2002-07-18 Protasis Corp Microfluidic device with multiple microcoil nmr detectors
US7049059B2 (en) 2000-12-01 2006-05-23 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
GB0031566D0 (en) 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
US20020150966A1 (en) 2001-02-09 2002-10-17 Muraca Patrick J. Specimen-linked database
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US20030036077A1 (en) * 2001-05-31 2003-02-20 Chronix Biomedical Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers
WO2002099077A2 (en) * 2001-06-06 2002-12-12 Proteologics, Inc. Methods and compositions related to tagging of membrane surface proteins
US7704964B2 (en) 2001-08-17 2010-04-27 Exothera L.L.C. Methods and compounds for the targeting of protein to exosomes
US7390463B2 (en) 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
DE60237289D1 (de) 2001-09-17 2010-09-23 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
US7253003B2 (en) 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7189580B2 (en) 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
WO2003054774A1 (en) 2001-11-02 2003-07-03 Gene Network Sciences, Inc. Language for networks
US20070203333A1 (en) 2001-11-30 2007-08-30 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
EP1463796B1 (en) 2001-11-30 2013-01-09 Fluidigm Corporation Microfluidic device and methods of using same
AU2002360499A1 (en) 2001-12-05 2003-06-17 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US6958119B2 (en) 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
US7351584B2 (en) 2002-02-26 2008-04-01 In Vitro Technologies, Inc. Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
JP3481231B2 (ja) 2002-03-05 2003-12-22 三洋電機株式会社 有機エレクトロルミネッセンス表示装置およびその製造方法
US7195986B1 (en) 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
EP2258872B1 (en) 2002-03-13 2013-08-14 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US20030194734A1 (en) 2002-03-29 2003-10-16 Tim Jatkoe Selection of markers
US7189581B2 (en) 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
DE60228685D1 (de) 2002-05-16 2008-10-16 Micronit Microfluidics Bv Verfahren zur Herstellung eines mikrofluidischen Bauteiles
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
WO2003104474A2 (en) 2002-06-07 2003-12-18 Myriad Genetics, Inc Large deletions in human brca1 gene and use thereof
AU2003251935A1 (en) 2002-07-15 2004-02-02 James Madison University Hybrid polymers for functional tuning of microfluidic device surfaces
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7135147B2 (en) 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7452509B2 (en) 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
DK1388734T3 (da) 2002-08-01 2004-05-03 Mtm Lab Ag Metode til opløsningsbaseret diagnose
KR100480338B1 (ko) 2002-08-08 2005-03-30 한국전자통신연구원 극소량의 유체제어를 위한 미세 유체제어소자
AT500648B1 (de) 2002-08-12 2010-03-15 Igeneon Krebs Immuntherapie Set zur behandlung von krebspatienten
WO2004021144A2 (en) 2002-08-29 2004-03-11 Gene Network Sciences, Inc. Systems and methods for inferring biological networks
TW536524B (en) 2002-09-17 2003-06-11 Fan-Gen Tzeng Network-type micro-channel device for micro-fluid
US7118661B2 (en) 2002-09-30 2006-10-10 The Regents Of The University Of California Nanolaminate microfluidic device for mobility selection of particles
ES2588905T3 (es) 2002-10-04 2016-11-07 The Regents Of The University Of California Dispositivo microfluídico de compartimentos múltiples para investigación en neurociencias
US20040088116A1 (en) 2002-11-04 2004-05-06 Gene Network Sciences, Inc. Methods and systems for creating and using comprehensive and data-driven simulations of biological systems for pharmacological and industrial applications
WO2004043387A2 (en) 2002-11-13 2004-05-27 Thomas Jefferson University Compositions and methods for cancer diagnosis and therapy
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US7906326B2 (en) 2003-05-07 2011-03-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides associated with alzheimer's disease and uses thereof
FR2848125B1 (fr) 2002-12-04 2006-06-09 Commissariat Energie Atomique Dispositif microfluidique dans lequel l'interface liquide/fluide est stabilisee
US7467928B2 (en) 2002-12-12 2008-12-23 Board Of Trustees Of The University Of Arkansas Microfluidic device utilizing magnetohydrodynamics and method for fabrication thereof
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
JP2007525232A (ja) * 2003-01-17 2007-09-06 イースロン メディカル インコーポレイテッド レクチンアフィニティー血液透析による血液のウイルス除去方法
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
US7413709B2 (en) 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
WO2004073319A2 (en) * 2003-02-14 2004-08-26 Anosys, Inc. Methods and compounds for raising antibodies and for screening antibody repertoires
CA2516553C (en) 2003-02-20 2013-04-16 Genomic Health, Inc. Use of intronic rna to measure gene expression
JP3856763B2 (ja) 2003-03-11 2006-12-13 財団法人川村理化学研究所 マイクロ流体素子の製造方法
CA2519870A1 (en) 2003-04-09 2004-10-28 Genentech, Inc. Use of rituximab intravenous compositions to treat rheumatoid arthritis
US7361460B2 (en) 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
WO2004093808A2 (en) 2003-04-22 2004-11-04 Maxygen, Inc. Novel tumor-associated antigens
US7267950B2 (en) 2003-05-01 2007-09-11 Veridex, Lcc Rapid extraction of RNA from cells and tissues
US7422725B2 (en) 2003-05-01 2008-09-09 Enplas Corporation Sample handling unit applicable to microchip, and microfluidic device having microchips
WO2004111273A2 (en) 2003-05-30 2004-12-23 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
AU2004245094A1 (en) 2003-06-06 2004-12-16 Perkinelmer Health Sciences, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7319007B2 (en) 2003-06-12 2008-01-15 Pomeranian Academy Of Medicine Determining a predisposition to cancer
US20050158718A1 (en) * 2003-06-16 2005-07-21 Taylor Michael D. Diagnostic and therapeutic uses of SUFU gene
EP3170906B1 (en) 2003-06-24 2018-08-22 Genomic Health, Inc. Prediction of likelihood of cancer recurrence
DK1644858T3 (da) 2003-07-10 2018-01-22 Genomic Health Inc Funktionel beklædning med mindst et yderlag og en indermembran.
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
GB0318096D0 (en) 2003-08-01 2003-09-03 Queen Mary & Westfield College Vaccine
US7888497B2 (en) 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
ATE403755T1 (de) 2003-08-28 2008-08-15 Ipsogen Identifizierung einer erbb2- genexpressionssignatur bei brustkrebs
EP1510577A1 (en) 2003-08-29 2005-03-02 Qiagen GmbH Method for magnetic bead isolation of nucleic acids
US7981618B2 (en) 2003-11-05 2011-07-19 Board Of Regents Of The University Of Texas System Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer
FR2862007B1 (fr) 2003-11-12 2005-12-23 Commissariat Energie Atomique Dispositif microfluidique muni d'un nez d'electronebulisation.
US7635586B2 (en) * 2003-11-26 2009-12-22 Broadley-James Corporation Integrated bio-reactor monitor and control system
EP1538219A1 (en) 2003-12-04 2005-06-08 Erasmus University Medical Center Rotterdam Method to diagnose or screen for type 1 diabetes mellitus
US7329391B2 (en) 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1547688A1 (en) 2003-12-23 2005-06-29 STMicroelectronics S.r.l. Microfluidic device and method of locally concentrating electrically charged substances in a microfluidic device
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
CA2453198A1 (en) 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes
US7351380B2 (en) 2004-01-08 2008-04-01 Sandia Corporation Microfluidic structures and methods for integrating a functional component into a microfluidic device
US20050221398A1 (en) 2004-01-16 2005-10-06 Ipsogen, Sas, A Corporation Of France Protein expression profiling and breast cancer prognosis
WO2005067391A2 (en) 2004-01-19 2005-07-28 Technion Research & Development Foundation Ltd. Diagnostic test for parkinson's disease
WO2005078124A2 (de) 2004-02-16 2005-08-25 Proteosys Ag Diagnostische marker für krebs
US8426126B2 (en) 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
WO2005092038A2 (en) 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
US7402229B2 (en) 2004-03-31 2008-07-22 Intel Corporation Fabrication and use of semipermeable membranes and gels for the control of electrolysis in a microfluidic device
EP1744986A2 (en) 2004-04-02 2007-01-24 Eksigent Technologies, LLC Microfluidic device
JP5813908B2 (ja) 2004-04-09 2015-11-17 ジェノミック ヘルス， インコーポレイテッド 化学療法剤に対する応答を予測するための遺伝子発現マーカー
US7419639B2 (en) 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
WO2005114192A1 (en) * 2004-05-13 2005-12-01 Centre National De La Recherche Scientifique A device for binding a target entity to a bait entity and detection methods using the same
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
WO2005121369A2 (en) 2004-06-02 2005-12-22 Sourcepharm, Inc. Rna-containing microvesicles and methods therefor
AU2005250479B2 (en) 2004-06-04 2010-07-22 Veridex, Llc Diagnosing or predicting the course of breast cancer
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
WO2006004910A2 (en) 2004-06-28 2006-01-12 Transtarget Inc. Improved bispecific antibodies
CA2572065A1 (en) * 2004-07-01 2006-01-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Immunosuppressive exosomes
US8048418B2 (en) * 2004-10-29 2011-11-01 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
CA2587765A1 (en) 2004-11-17 2006-05-26 Immunivest Corporation Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
US7488596B2 (en) 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US8071306B2 (en) 2005-01-25 2011-12-06 Merck Sharp & Dohme Corp. Methods for quantitating small RNA molecules
CN101107358A (zh) * 2005-01-25 2008-01-16 天空遗传学公司 用于癌细胞的细胞凋亡的核酸
WO2006087233A2 (en) 2005-02-21 2006-08-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells
US8349555B2 (en) 2005-03-16 2013-01-08 Gennadi V. Glinsky Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures
US9164108B2 (en) * 2005-03-22 2015-10-20 Sri International Liposome-based microarray and methods of use thereof
CN101663576B (zh) 2005-04-12 2012-05-23 卡钳生命科学股份有限公司 用于微流体器件的紧凑型光检测系统
US20090061422A1 (en) 2005-04-19 2009-03-05 Linke Steven P Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US20060275844A1 (en) 2005-04-19 2006-12-07 Linke Steven P Diagnostic markers of breast cancer treatment and progression and methods of use thereof
EP1722231A3 (en) 2005-04-27 2009-03-11 MPB MelTec Patent- und Beteiligungsgesellschaft mbH Method for identification of somatic stem cells
US20090118175A1 (en) 2005-05-06 2009-05-07 Macina Roberto A Compositions and Methods for Detection, Prognosis and Treatment of Breast Cancer
KR100590581B1 (ko) 2005-05-10 2006-06-19 삼성전자주식회사 미세유동장치 및 그 제조방법
JP4992201B2 (ja) 2005-06-07 2012-08-08 富士ゼロックス株式会社 マイクロ流体制御方法、マイクロ流体素子およびその製造方法
PL1913157T5 (pl) 2005-06-28 2017-09-29 Genentech Inc Mutacje EGFR i KRAS do prognozowania reakcji pacjenta na leczenie inhibitorem EGFR
WO2007003343A1 (en) 2005-06-30 2007-01-11 Biocrates Life Sciences Ag Apparatus and method for analyzing a metabolite profile
US20090148460A1 (en) 2005-07-08 2009-06-11 Alain Delcayre Exosome ligands, their preparation and uses
ES2545383T3 (es) 2005-08-01 2015-09-10 The Ohio State University Research Foundation Métodos y composiciones basados en microARN para el diagnóstico, pronóstico y tratamiento de cáncer de mama
WO2007072220A2 (en) 2005-09-12 2007-06-28 Aurelium Biopharma Inc. Focused microarray and methods of diagnosing cancer
WO2007035532A2 (en) 2005-09-15 2007-03-29 Duke University Focused libraries, functional profiling, laser selex and deselex
US20070071762A1 (en) 2005-09-21 2007-03-29 Ccc Diagnostics, Llc Comprehensive diagnostic testing procedures for personalized anticancer chemotherapy (pac)
US20090226902A1 (en) 2005-10-12 2009-09-10 Hemmo Arjan Drexhage Method to Diagnose or Screen for Inflammatory Diseases
US20070092882A1 (en) 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
ES2324435B1 (es) 2005-10-27 2010-05-31 Fundacion Para El Estudio De La Hematologia Y Hemoterapia De Aragon (Fehha) Procedimiento y dispositivo de analisis in vitro de mrna de genes implicados en neoplasias hematologicas.
EP1945754B1 (en) 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20090215642A1 (en) 2005-12-09 2009-08-27 Knudson Alfred G Methods and Compositions for Assessing Alterations in Gene Expression Patterns in Clinically Normal Tissues Obtained from Heterozygous Carriers of Mutant Genes Associated with Cancer and Methods of Use Thereof
TWI274040B (en) 2005-12-23 2007-02-21 Ind Tech Res Inst Microfluidic device and method of manufacturing the same
JP2007175021A (ja) 2005-12-28 2007-07-12 Sysmex Corp 大腸がんのリンパ節転移マーカー
JP5490413B2 (ja) 2006-01-05 2014-05-14 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロｒｎａ発現異常
US7568399B2 (en) 2006-01-05 2009-08-04 Integrated Sensing Systems, Inc. Microfluidic device
US7943318B2 (en) 2006-01-05 2011-05-17 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US7581429B2 (en) 2006-01-06 2009-09-01 Integrated Sensing Systems, Inc. Microfluidic device and method of operation
US7593913B2 (en) 2006-01-11 2009-09-22 Siemens Medical Solutions Usa, Inc. Systems and method for integrative medical decision support
WO2007084962A2 (en) * 2006-01-18 2007-07-26 The Regents Of The University Of California A fluid membrane-based ligand display system for live cell assays and disease diagnosis applications
DK1994410T3 (da) 2006-01-31 2011-01-31 Medical Res Fund Of Tel Aviv Sourasky Medical Ct Fremgangsmåder og kits til tidlig påvisning af cancer eller disposition derfor
US9198981B2 (en) 2006-02-01 2015-12-01 The University Of Kentucky Modulation of angiogenesis
NZ545243A (en) 2006-02-10 2009-07-31 Pacific Edge Biotechnology Ltd Urine gene expression ratios for detection of cancer
ES2300176B1 (es) 2006-02-15 2009-05-01 Consejo Superior Investig. Cientificas Metodo para el diagnostico molecular de cancer de prostata, kit para implementar el metodo.
CN104749378A (zh) 2006-02-16 2015-07-01 文塔纳医疗系统公司 用于癌症预后和病理分期的试剂和方法
EP2522747A1 (en) 2006-03-02 2012-11-14 The Ohio State University MicroRNA expression profile associated with pancreatic cancer
CA2644855C (en) 2006-03-09 2019-11-19 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
EP2605018A1 (en) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
WO2007109571A2 (en) 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
EP1996716B1 (en) * 2006-03-20 2011-05-11 The Regents of the University of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
AU2007249639B2 (en) 2006-03-27 2012-05-31 Globeimmune, Inc. Ras mutation and compositions and methods related thereto
US7890267B2 (en) 2006-03-31 2011-02-15 Ordway Research Institute Prognostic and diagnostic method for cancer therapy
US20090098538A1 (en) 2006-03-31 2009-04-16 Glinsky Gennadi V Prognostic and diagnostic method for disease therapy
US20070238118A1 (en) 2006-04-06 2007-10-11 Ambion, Inc. Methods and kits for sequentially isolating rna and genomic dna from cells
US8758991B2 (en) 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
EP3399450A1 (en) 2006-05-18 2018-11-07 Caris MPI, Inc. System and method for determining individualized medical intervention for a disease state
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US8288369B2 (en) 2006-06-27 2012-10-16 University Of South Florida Delta-tocotrienol treatment and prevention of pancreatic cancer
US7999080B2 (en) 2006-07-13 2011-08-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways
US20080014598A1 (en) 2006-07-13 2008-01-17 Cell Signaling Technology, Inc. Phospho-specific antibodies to pi3k regulatory subunit and uses thereof
EP2041574B1 (en) 2006-07-14 2016-11-16 The Regents of The University of California Cancer biomarkers and methods of use threof
WO2008021483A2 (en) 2006-08-17 2008-02-21 Ordway Research Institute Prognostic and diagnostic method for disease therapy
US20090280493A1 (en) 2006-09-08 2009-11-12 Siemens Healthcare Diagnostics Inc. Methods and Compositions for the Prediction of Response to Trastuzumab Containing Chemotherapy Regimen in Malignant Neoplasia
KR20090071603A (ko) 2006-09-19 2009-07-01 노파르티스 아게 Ｒａｆ 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커
US20100003247A1 (en) 2006-10-27 2010-01-07 George Mason Intellectual Properties, Inc. Assay for metastatic colorectal cancer
US20100248225A1 (en) 2006-11-06 2010-09-30 Bankaitis-Davis Danute M Gene expression profiling for identification, monitoring and treatment of melanoma
US7462489B2 (en) 2006-11-09 2008-12-09 Ley Klaus F Methods for identifying and analyzing biomarkers from plasma-derived microparticles
WO2008063413A2 (en) 2006-11-13 2008-05-29 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of lung cancer
US20100196889A1 (en) 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
US8571803B2 (en) 2006-11-15 2013-10-29 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
AU2007334343A1 (en) 2006-12-15 2008-06-26 Ordway Research Institute, Inc. Treatments of therapy-resistant diseases comprising drug combinations
RU2473555C2 (ru) 2006-12-19 2013-01-27 ДжинГоу, Инк. Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных
EP2109688A4 (en) 2007-01-23 2010-02-17 Univ Virginia GALECTIN-3 BINDING PROTEIN AS BIOMARKER FOR HEART CIRCULATION DISEASES
EP2117305A4 (en) 2007-01-26 2011-03-30 Univ Louisville Res Found MODIFICATION OF EXOXIC COMPONENTS USED AS VACCINE
BRPI0806437A2 (pt) 2007-01-26 2011-09-06 Univ Lousville Res Foundation Inc métodos de detecção de auto-anticorpos para diagnóstico e caracterização de distúrbio
CN105256004A (zh) 2007-01-31 2016-01-20 俄亥俄州立大学研究基金会 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
US20090246289A1 (en) 2007-02-06 2009-10-01 Robert Superko System and method for diagnosing and managing those at risk for cardiovascular disease
WO2008099280A2 (en) 2007-02-15 2008-08-21 Universita' Degli Studi Di Torino Regulation of expression of pi3kb protein in tumors
US20100166747A1 (en) 2007-03-02 2010-07-01 Beltran Pedro J Methods and compositions for treating tumor diseases
WO2008112283A2 (en) 2007-03-12 2008-09-18 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment
EP2118322A2 (en) 2007-03-13 2009-11-18 Amgen Inc. K-ras and b-raf mutations and anti-egfr antibody therapy
CA2680326A1 (en) 2007-03-13 2008-09-18 Amgen Inc. K-ras mutations and anti-egfr antibody therapy
WO2008115419A2 (en) 2007-03-15 2008-09-25 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
EP2130046A2 (en) 2007-03-19 2009-12-09 Cold Spring Harbor Laboratory Identification of genetic alterations that modulate drug sensitivity in cancer treatments
US20100233691A1 (en) 2007-03-30 2010-09-16 Source Precision Medicine, Inc. D/B/A Source Mdx Gene Expression Profiling for Identification, Monitoring and Treatment of Prostate Cancer
EP2142670A1 (en) 2007-04-05 2010-01-13 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of breast cancer
EP2155898A2 (en) 2007-04-05 2010-02-24 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring and treatment of ovarian cancer
US20100330558A1 (en) 2007-04-06 2010-12-30 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Cervical Cancer
EP2145902A3 (en) 2007-04-19 2010-09-29 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
WO2008138578A2 (en) 2007-05-11 2008-11-20 Medical Prognosis Institute Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
CA2688225C (en) 2007-05-31 2017-09-26 Yale University A genetic lesion associated with cancer
US20090104649A1 (en) 2007-06-11 2009-04-23 Garovic Vesna D Markers for preeclampsia
BRPI0813364A2 (pt) 2007-06-15 2014-12-30 Univ South Florida Métodos de diagnóstico e tratamento de câncer.
EP3666284A1 (en) 2007-06-22 2020-06-17 Children's Medical Center, Corp. Methods and uses thereof of a fragment of saposin a
US8216784B2 (en) 2007-07-25 2012-07-10 University Of Louisville Research Foundation, Inc. Cancer-derived microvesicle-associated microrna as a diagnostic marker
WO2009019215A1 (en) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
EP2176665B1 (en) 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
GB0716804D0 (en) 2007-08-29 2007-10-10 Univ Court Of The University O Identifying organ damage
US8076061B2 (en) 2007-09-07 2011-12-13 Ascentgene, Inc. Method and composition for cancer diagnosis and treatment
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験
CN101842484B (zh) 2007-09-14 2015-07-29 俄亥俄州立大学研究基金会 人外周血微泡中的mirna表达和其用途
US20110160072A1 (en) 2007-10-23 2011-06-30 Clinical Genomics Pty. Ltd. Method of diagnosing neoplasms
CA2705016A1 (en) 2007-11-06 2009-05-14 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification of cancer
JP5745273B2 (ja) 2007-11-30 2015-07-08 クラリエント ダイアグノスティック サービシーズ， インコーポレイテッド 化学療法のためのマーカーとしてのｔｌｅ３
EP2225396A4 (en) 2007-11-30 2011-03-02 Univ Ohio State Res Found PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER
EP2238079A4 (en) 2007-12-27 2014-07-02 Aethlon Medical Inc METHOD AND APPARATUS FOR INCREASING CLAIRANCE RATES OF A CONTAMINANT DURING EXTRACORPOREAL TRAFFIC TREATMENT
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
AU2009209415A1 (en) 2008-02-01 2009-08-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions relating to carcinoma stem cells
ES2703363T3 (es) * 2008-02-01 2019-03-08 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico y pronóstico de tumores cerebrales
WO2009103790A2 (en) 2008-02-21 2009-08-27 Universite Libre De Bruxelles Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-positive and her2-positive subtypes with clinical implications
GB0803192D0 (en) 2008-02-22 2008-04-02 Mubio Products Bv SCLC biomarker panel
EP2260109A4 (en) 2008-02-28 2011-06-08 Univ Ohio State Res Found METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR DIAGNOSING, PROGNOSING AND TREATING PROSTATE-RELATED DISORDERS
EP2105511A1 (en) 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung
WO2009124251A1 (en) 2008-04-03 2009-10-08 Sloan-Kettering Institute For Cancer Research Gene signatures for the prognosis of cancer
WO2009126160A1 (en) 2008-04-10 2009-10-15 University Of Florida Research Foundation Compositions and methods for the treatment of prostate carcinoma
US20090269773A1 (en) 2008-04-29 2009-10-29 Nodality, Inc. A Delaware Corporation Methods of determining the health status of an individual
ES2482692T3 (es) 2008-05-12 2014-08-04 Genomic Health, Inc. Pruebas para predecir la receptividad de pacientes con cáncer a opciones de tratamiento con quimioterapia
US20110177054A1 (en) 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
WO2009155505A2 (en) 2008-06-20 2009-12-23 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US20100069298A1 (en) 2008-09-16 2010-03-18 Robert Penny Methods for Detecting Overexpression of SPARC and Therapeutic and Diagnostic Methods Relating to Same
WO2010033773A2 (en) 2008-09-18 2010-03-25 The Ohio State University Research Foundation Diagnostic, prognostic and therapeutic uses of mirs in adaptive pathways and/or disease pathways
US10545149B2 (en) 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
EP3181705A1 (en) * 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
WO2010065968A1 (en) 2008-12-05 2010-06-10 Myriad Genetics, Inc. Cancer detection markers
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
EP2202522A1 (en) 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof

Also Published As

Publication number Publication date
US20100203529A1 (en) 2010-08-12
JP2017167157A (ja) 2017-09-21
GB2463401B (en) 2014-01-29
US20170108503A1 (en) 2017-04-20
EP2350320A2 (en) 2011-08-03
JP2012508577A (ja) 2012-04-12
EP2350320A4 (en) 2012-11-14
US20100184046A1 (en) 2010-07-22
IL244689A0 (en) 2016-04-21
US8278059B2 (en) 2012-10-02
US20110237450A1 (en) 2011-09-29
WO2010056337A3 (en) 2010-09-10
IL212768A (en) 2014-07-31
US8211653B2 (en) 2012-07-03
IL233023A0 (en) 2014-07-31
IL233023A (en) 2016-03-31
GB2463401A8 (en) 2013-05-15
CN102301002A (zh) 2011-12-28
WO2010056337A2 (en) 2010-05-20
CN107254538A (zh) 2017-10-17
US20110151460A1 (en) 2011-06-23
US7897356B2 (en) 2011-03-01
JP2016028572A (ja) 2016-03-03
GB2463401A (en) 2010-03-17
EP2730662A1 (en) 2014-05-14
US20130005599A1 (en) 2013-01-03
CA2743211A1 (en) 2010-05-20
GB0921348D0 (en) 2010-01-20
IL212768A0 (en) 2011-07-31
BRPI0921043A2 (pt) 2018-08-07
EP3181705A1 (en) 2017-06-21

Similar Documents

Publication Publication Date Title
HK1142371A1 (en) Characterizing prostate disorders by analysis of microvesicles
GB2473392B (en) Methods of diagnosis
IL212412A0 (en) Femto-cell location by direct methods
AP3141A (en) Nebulizer
PL2154297T3 (pl) Układ natryskowy
IL209855A0 (en) Supression of neuroedocrine diseases
AP3115A (en) Nebulizer
EP2358731A4 (en) PROCESS RELATED TO MODIFIED GLYCANS
IL218544A0 (en) Dll4-binding molecules
IL218163A0 (en) Boron-cotaining small molecules as antiprotozoal agents
PL2502173T3 (pl) Projektowanie cząsteczek
ZA201102604B (en) Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
EP2300608A4 (en) METHODS OF TREATING SOLID TUMORS
EP2265373A4 (en) HYDROGENATION OF IMINES
EP2249765A4 (en) DAPSONE TO TREAT THE ROSACEA
EP2342355A4 (en) METHODS OF USING BIOMARKERS
PT2277578T (pt) Nebulizador.
EP2588428A4 (en) KINOME ANALYSIS METHODS
PL2103738T3 (pl) Krzyżownica
IL210558A0 (en) Treatment of anxiety disorders
ZA201004979B (en) Extracts of sclerocarya birrea
EP2501803A4 (en) PROCESS FOR PLURIPOTENZINTENSIVATION
IL208918A0 (en) Methods of preparing substituted heterocycles-149
GB2462856B (en) Shower assemblies
PL386302A1 (pl) Nowa pochodna izotiazolopirydyny

Legal Events

Date Code Title Description
CHRG Changes in the register

Free format text: ADDITION OF PRIORITY CLAIMS: 12.11.2008 US 61/114045 - 12.11.2008 US 61/114058 - 13.11.2008 US 61/114065 - 09.02.2009 US 61/151183 - 02.10.2009 US 61/278049 - 09.10.2009 US 61/250454 - 19.10.2009 US 61/253027

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171112