ATE403755T1 - Identifizierung einer erbb2- genexpressionssignatur bei brustkrebs - Google Patents
Identifizierung einer erbb2- genexpressionssignatur bei brustkrebsInfo
- Publication number
- ATE403755T1 ATE403755T1 AT04769358T AT04769358T ATE403755T1 AT E403755 T1 ATE403755 T1 AT E403755T1 AT 04769358 T AT04769358 T AT 04769358T AT 04769358 T AT04769358 T AT 04769358T AT E403755 T1 ATE403755 T1 AT E403755T1
- Authority
- AT
- Austria
- Prior art keywords
- gene expression
- identification
- breast cancer
- expression signature
- erbb2 gene
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 230000002018 overexpression Effects 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000009274 differential gene expression Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009452 underexpressoin Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49849703P | 2003-08-28 | 2003-08-28 | |
| US10/928,465 US20050089899A1 (en) | 2003-08-28 | 2004-08-27 | Identification of an ERBB2 gene expression signature in breast cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE403755T1 true ATE403755T1 (de) | 2008-08-15 |
Family
ID=34278600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04769358T ATE403755T1 (de) | 2003-08-28 | 2004-08-27 | Identifizierung einer erbb2- genexpressionssignatur bei brustkrebs |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050089899A1 (de) |
| EP (2) | EP1668152B1 (de) |
| AT (1) | ATE403755T1 (de) |
| DE (1) | DE602004015626D1 (de) |
| ES (1) | ES2311852T3 (de) |
| PL (1) | PL1668152T3 (de) |
| WO (1) | WO2005021788A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530075A (ja) * | 2004-04-23 | 2007-11-01 | エグザジェン ダイアグノスティクス インコーポレイテッド | 乳がんの予後診断のための組成物および方法 |
| WO2006135527A2 (en) | 2005-06-10 | 2006-12-21 | Saint Louis University | Methods for the selection of aptamers |
| EP1904645B1 (de) * | 2005-07-08 | 2010-08-04 | Siemens Healthcare Diagnostics GmbH | Verfahren zur vorhersage und überwachung einer unmittelbaren reaktion auf eine krebstherapie |
| NZ594178A (en) * | 2006-02-27 | 2013-02-22 | Targeted Molecular Diagnostics Llc | An ex vivo method of predicting toxicity to tyrosine kinase inhibitors |
| IL282783B2 (en) * | 2006-05-18 | 2023-09-01 | Caris Mpi Inc | A system and method for determining a personalized medical intervention for a disease stage |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| CA2653949A1 (en) * | 2006-06-02 | 2007-12-13 | Glaxosmithkline Biologicals S.A. | Method |
| WO2009049966A2 (en) * | 2007-09-07 | 2009-04-23 | Universite Libre De Bruxelles | Methods and tools for prognosis of cancer in her2+ patients |
| WO2009103790A2 (en) | 2008-02-21 | 2009-08-27 | Universite Libre De Bruxelles | Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-positive and her2-positive subtypes with clinical implications |
| WO2009114534A1 (en) * | 2008-03-14 | 2009-09-17 | The Regents Of The University Of California | Multi-gene classifiers and prognostic indicators for cancers |
| EP3075864A1 (de) * | 2008-10-14 | 2016-10-05 | Caris MPI, Inc. | Gen und genexprimierte zielproteine zur darstellung von biomarkermustern und signatursets nach tumortyp |
| US20100267803A1 (en) * | 2008-11-07 | 2010-10-21 | The Research Foundation Of State University Of New York | Regulators Of Fat Metabolism As Anti-Cancer Targets |
| GB2463401B (en) | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| JP2012511323A (ja) * | 2008-12-10 | 2012-05-24 | イプソゲン | 腫瘍中のｅｒｂｂ２の変化を特定するための方法 |
| EP2253715A1 (de) * | 2009-05-14 | 2010-11-24 | RWTH Aachen | Neue Targets zur Krebstherapie und/oder -diagnose |
| GB0917457D0 (en) * | 2009-10-06 | 2009-11-18 | Glaxosmithkline Biolog Sa | Method |
| CA2787483C (en) | 2010-02-12 | 2018-03-06 | Saint Louis University | Molecular biosensors capable of signal amplification |
| KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| AU2011237669B2 (en) | 2010-04-06 | 2016-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for disease |
| US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
| US10633710B2 (en) | 2014-08-15 | 2020-04-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for characterizing cancer |
| WO2016040830A1 (en) | 2014-09-12 | 2016-03-17 | Mediomics, Llc | Molecular biosensors with a modular design |
| JP6793451B2 (ja) * | 2014-11-14 | 2020-12-02 | キヤノンメディカルシステムズ株式会社 | 被検細胞の細胞特性を評価するための遺伝子マーカー、方法、レポーターベクター、プライマーセットおよびアッセイキット、並びに細胞特性評価装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002010436A2 (en) * | 2000-07-28 | 2002-02-07 | The Brigham And Women's Hospital, Inc. | Prognostic classification of breast cancer |
| US20030096237A1 (en) * | 2000-08-28 | 2003-05-22 | Ulrich Certa | Determination of the ability of patients to respond to a tumor treatment |
| AU2002255478A1 (en) * | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US20070015148A1 (en) * | 2001-01-25 | 2007-01-18 | Orr Michael S | Gene expression profiles in breast tissue |
| US7514209B2 (en) * | 2001-06-18 | 2009-04-07 | Rosetta Inpharmatics Llc | Diagnosis and prognosis of breast cancer patients |
| US20030099974A1 (en) * | 2001-07-18 | 2003-05-29 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20030198972A1 (en) * | 2001-12-21 | 2003-10-23 | Erlander Mark G. | Grading of breast cancer |
| US20030190689A1 (en) * | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
-
2004
- 2004-08-27 PL PL04769358T patent/PL1668152T3/pl unknown
- 2004-08-27 WO PCT/IB2004/002968 patent/WO2005021788A1/en active IP Right Grant
- 2004-08-27 EP EP04769358A patent/EP1668152B1/de not_active Expired - Lifetime
- 2004-08-27 EP EP08007447A patent/EP1980629A3/de not_active Withdrawn
- 2004-08-27 AT AT04769358T patent/ATE403755T1/de not_active IP Right Cessation
- 2004-08-27 ES ES04769358T patent/ES2311852T3/es not_active Expired - Lifetime
- 2004-08-27 DE DE602004015626T patent/DE602004015626D1/de not_active Expired - Lifetime
- 2004-08-27 US US10/928,465 patent/US20050089899A1/en not_active Abandoned
-
2008
- 2008-09-17 US US12/212,282 patent/US20090092983A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2311852T3 (es) | 2009-02-16 |
| US20090092983A1 (en) | 2009-04-09 |
| EP1980629A3 (de) | 2008-12-17 |
| PL1668152T3 (pl) | 2009-06-30 |
| WO2005021788A1 (en) | 2005-03-10 |
| EP1668152A1 (de) | 2006-06-14 |
| EP1980629A2 (de) | 2008-10-15 |
| EP1668152B1 (de) | 2008-08-06 |
| US20050089899A1 (en) | 2005-04-28 |
| DE602004015626D1 (de) | 2008-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |