WO2008104985A3 - Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers - Google Patents

Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers Download PDF

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Publication number
WO2008104985A3
WO2008104985A3 PCT/IL2008/000261 IL2008000261W WO2008104985A3 WO 2008104985 A3 WO2008104985 A3 WO 2008104985A3 IL 2008000261 W IL2008000261 W IL 2008000261W WO 2008104985 A3 WO2008104985 A3 WO 2008104985A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung
distingushing
methods
smallcell
squamous carcinoma
Prior art date
Application number
PCT/IL2008/000261
Other languages
French (fr)
Other versions
WO2008104985A2 (en
Inventor
Ranit Aharonov
Nitzan Rosenfeld
Shai Rosenwald
Hila Benjamin
Original Assignee
Rosetta Genomics Ltd
Ranit Aharonov
Nitzan Rosenfeld
Shai Rosenwald
Hila Benjamin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Genomics Ltd, Ranit Aharonov, Nitzan Rosenfeld, Shai Rosenwald, Hila Benjamin filed Critical Rosetta Genomics Ltd
Priority to JP2009551310A priority Critical patent/JP2010519899A/en
Priority to EP08710261A priority patent/EP2126116A2/en
Priority to AU2008220449A priority patent/AU2008220449A1/en
Priority to CA002677043A priority patent/CA2677043A1/en
Publication of WO2008104985A2 publication Critical patent/WO2008104985A2/en
Publication of WO2008104985A3 publication Critical patent/WO2008104985A3/en
Priority to IL200245A priority patent/IL200245A0/en
Priority to US12/551,291 priority patent/US8563252B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of specific types of nonsmall-cell lung cancers (NSCLC). The nucleic acid sequences can also be used for prognosis evaluation of a subject based on the expression pattern of a biological sample.
PCT/IL2008/000261 2004-05-14 2008-02-28 Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers WO2008104985A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2009551310A JP2010519899A (en) 2007-03-01 2008-02-28 Methods to distinguish lung squamous cell carcinoma from other non-small cell lung cancer
EP08710261A EP2126116A2 (en) 2007-03-01 2008-02-28 Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers
AU2008220449A AU2008220449A1 (en) 2007-03-01 2008-02-28 Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers
CA002677043A CA2677043A1 (en) 2007-03-01 2008-02-28 Method for distinguishing between lung squamous carcinoma and other non small cell lung cancers
IL200245A IL200245A0 (en) 2007-03-01 2009-08-05 Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers
US12/551,291 US8563252B2 (en) 2004-05-14 2009-08-31 Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90417107P 2007-03-01 2007-03-01
US60/904,171 2007-03-01
US2134608P 2008-01-16 2008-01-16
US61/021,346 2008-01-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/130,645 Continuation-In-Part US7709616B2 (en) 2004-05-14 2005-05-16 Micrornas and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/551,291 Continuation-In-Part US8563252B2 (en) 2004-05-14 2009-08-31 Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers

Publications (2)

Publication Number Publication Date
WO2008104985A2 WO2008104985A2 (en) 2008-09-04
WO2008104985A3 true WO2008104985A3 (en) 2008-11-06

Family

ID=39616499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2008/000261 WO2008104985A2 (en) 2004-05-14 2008-02-28 Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers

Country Status (5)

Country Link
EP (1) EP2126116A2 (en)
JP (1) JP2010519899A (en)
AU (1) AU2008220449A1 (en)
CA (1) CA2677043A1 (en)
WO (1) WO2008104985A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010070637A2 (en) * 2008-12-15 2010-06-24 Rosetta Genomics Ltd. Method for distinguishing between adrenal tumors
CN101475984A (en) * 2008-12-15 2009-07-08 江苏命码生物科技有限公司 Non-small cell lung cancer detection marker, detection method thereof, related biochip and reagent kit
WO2010103522A1 (en) * 2009-03-10 2010-09-16 Rosetta Genomics Ltd. Method for detection of nucleic acid sequences
WO2010120853A2 (en) * 2009-04-16 2010-10-21 Padma Arunachalam Methods and compositions to detect and differentiate small rnas in rna maturation pathway
US9914972B2 (en) * 2011-03-28 2018-03-13 Rosetta Genomics Ltd. Methods for lung cancer classification
WO2017214378A1 (en) 2016-06-08 2017-12-14 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
EP3707262A1 (en) 2017-11-08 2020-09-16 President and Fellows of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007148235A2 (en) * 2006-05-04 2007-12-27 Rosetta Genomics Ltd Cancer-related nucleic acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2295604B1 (en) * 2004-02-09 2015-04-08 Thomas Jefferson University Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007148235A2 (en) * 2006-05-04 2007-12-27 Rosetta Genomics Ltd Cancer-related nucleic acids

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 26 January 2006 (2006-01-26), "Human mir-107 miRNA oligonucleotide, SEQ ID 63.", XP002489968, retrieved from EBI accession no. GSN:AEE04335 Database accession no. AEE04335 *
DATABASE Geneseq [online] 29 July 2004 (2004-07-29), "Human genome derived single exon probe #18136.", XP002489967, retrieved from EBI accession no. GSN:ACH84941 Database accession no. ACH84941 *
JIANG JINMAI ET AL: "Real-time expression profiling of microRNA precursors in human cancer cell lines.", NUCLEIC ACIDS RESEARCH 2005, vol. 33, no. 17, 2005, pages 5394 - 5403, XP002489966, ISSN: 1362-4962 *
PAUL CYNTHIA P: "Subcellular distribution of small interfering RNA: directed delivery through RNA polymerase III expression cassettes and localization by in situ hybridization", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 392, 1 January 2005 (2005-01-01), pages 125 - 145, XP009103657, ISSN: 0076-6879 *
TAKAMIZAWA J ET AL: "Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 64, 1 June 2004 (2004-06-01), pages 3753 - 3756, XP002385720, ISSN: 0008-5472 *
YANAIHARA NOZOMU ET AL: "Unique microRNA molecular profiles in lung cancer diagnosis and prognosis", CANCER CELL, XX, US, vol. 9, no. 3, 1 March 2006 (2006-03-01), pages 189 - 198, XP002467444, ISSN: 1535-6108 *

Also Published As

Publication number Publication date
EP2126116A2 (en) 2009-12-02
CA2677043A1 (en) 2008-09-04
JP2010519899A (en) 2010-06-10
WO2008104985A2 (en) 2008-09-04
AU2008220449A1 (en) 2008-09-04

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