HK1048768B - 抗病毒组合物 - Google Patents

抗病毒组合物 Download PDF

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Publication number
HK1048768B
HK1048768B HK03100992.5A HK03100992A HK1048768B HK 1048768 B HK1048768 B HK 1048768B HK 03100992 A HK03100992 A HK 03100992A HK 1048768 B HK1048768 B HK 1048768B
Authority
HK
Hong Kong
Prior art keywords
amino
benzonitrile
pyrimidinyl
formula
compound
Prior art date
Application number
HK03100992.5A
Other languages
English (en)
Chinese (zh)
Other versions
HK1048768A1 (en
Inventor
Verreck Geert
Baert Lieven
Original Assignee
詹森药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 詹森药业有限公司 filed Critical 詹森药业有限公司
Publication of HK1048768A1 publication Critical patent/HK1048768A1/xx
Publication of HK1048768B publication Critical patent/HK1048768B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK03100992.5A 1999-09-24 2000-08-31 抗病毒组合物 HK1048768B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99203128 1999-09-24
EP99203128.6 1999-09-24
PCT/EP2000/008522 WO2001022938A1 (en) 1999-09-24 2000-08-31 Antiviral compositions

Publications (2)

Publication Number Publication Date
HK1048768A1 HK1048768A1 (en) 2003-04-17
HK1048768B true HK1048768B (zh) 2006-08-04

Family

ID=8240674

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100992.5A HK1048768B (zh) 1999-09-24 2000-08-31 抗病毒组合物

Country Status (35)

Country Link
US (4) US7241458B1 (cs)
EP (1) EP1225874B1 (cs)
JP (1) JP4919566B2 (cs)
KR (2) KR100820605B1 (cs)
CN (1) CN1234347C (cs)
AP (1) AP1639A (cs)
AT (1) ATE316781T1 (cs)
AU (2) AU775360B2 (cs)
BG (1) BG65754B1 (cs)
BR (1) BRPI0014271B1 (cs)
CA (1) CA2384188C (cs)
CY (1) CY1105268T1 (cs)
CZ (1) CZ300712B6 (cs)
DE (1) DE60025837T2 (cs)
DK (1) DK1225874T3 (cs)
EA (1) EA005423B1 (cs)
EE (1) EE04991B1 (cs)
ES (1) ES2258018T3 (cs)
HK (1) HK1048768B (cs)
HR (1) HRP20020247B1 (cs)
HU (1) HU228449B1 (cs)
IL (1) IL148801A0 (cs)
IS (1) IS2567B (cs)
MX (1) MXPA02003182A (cs)
NO (1) NO333358B1 (cs)
NZ (1) NZ517025A (cs)
OA (1) OA12029A (cs)
PL (1) PL207590B1 (cs)
PT (1) PT1225874E (cs)
SI (1) SI1225874T1 (cs)
SK (1) SK285240B6 (cs)
TR (1) TR200200763T2 (cs)
UA (1) UA74797C2 (cs)
WO (1) WO2001022938A1 (cs)
ZA (1) ZA200202289B (cs)

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