GB1524747A - Polypeptide - Google Patents

Polypeptide

Info

Publication number
GB1524747A
GB1524747A GB19327/76A GB1932776A GB1524747A GB 1524747 A GB1524747 A GB 1524747A GB 19327/76 A GB19327/76 A GB 19327/76A GB 1932776 A GB1932776 A GB 1932776A GB 1524747 A GB1524747 A GB 1524747A
Authority
GB
United Kingdom
Prior art keywords
tyr
leu
pro
arg
azgly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19327/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB19327/76A priority Critical patent/GB1524747A/en
Priority to IE808/77A priority patent/IE44426B1/en
Priority to ZA00772433A priority patent/ZA772433B/xx
Priority to US05/790,003 priority patent/US4100274A/en
Priority to CA277,003A priority patent/CA1101844A/en
Priority to NZ183931A priority patent/NZ183931A/xx
Priority to AU24681/77A priority patent/AU508025B2/en
Priority to HU77IE777A priority patent/HU179990B/hu
Priority to DE2720245A priority patent/DE2720245C2/de
Priority to CS772980A priority patent/CS199673B2/cs
Priority to IL52014A priority patent/IL52014A/xx
Priority to PL1977197889A priority patent/PL104362B1/pl
Priority to PL1977212706A priority patent/PL108860B1/pl
Priority to CH578677A priority patent/CH627151A5/de
Priority to YU1172/77A priority patent/YU40672B/xx
Priority to FR7714262A priority patent/FR2351092A1/fr
Priority to SE7705432A priority patent/SE437837B/xx
Priority to NO771644A priority patent/NO147304C/no
Priority to NL7705130A priority patent/NL191793C/xx
Priority to BE177448A priority patent/BE854467A/xx
Priority to FI771480A priority patent/FI64139C/fi
Priority to ES458691A priority patent/ES458691A1/es
Priority to AT0335877A priority patent/AT379400B/de
Priority to JP5418677A priority patent/JPS52136172A/ja
Priority to DK207977A priority patent/DK149596C/da
Priority to SU772480485A priority patent/SU910116A3/ru
Priority to DD77198869A priority patent/DD136738A5/xx
Publication of GB1524747A publication Critical patent/GB1524747A/en
Priority to CS79207A priority patent/CS199674B2/cs
Priority to AT0217979A priority patent/AT365562B/de
Priority to SE8007763A priority patent/SE437993B/sv
Priority to CH447281A priority patent/CH629475A5/de
Priority to NO822984A priority patent/NO149586C/no
Priority to FI830601A priority patent/FI75579C/fi
Priority to DK469983A priority patent/DK149272C/da
Priority to AT328184A priority patent/AT379597B/de
Priority to AT328484A priority patent/AT379599B/de
Priority to AT328284A priority patent/AT379598B/de
Priority to AT328684A priority patent/AT379601B/de
Priority to AT328584A priority patent/AT379600B/de
Priority to AT328384A priority patent/AT379818B/de
Priority to AT327984A priority patent/AT379595B/de
Priority to AT328084A priority patent/AT379596B/de
Priority to BG098123A priority patent/BG60740B2/bg
Priority to NL970002C priority patent/NL970002I2/nl
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • C07K5/06095Arg-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/13Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Plant Substances (AREA)
GB19327/76A 1976-05-11 1976-05-11 Polypeptide Expired GB1524747A (en)

Priority Applications (44)

Application Number Priority Date Filing Date Title
GB19327/76A GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide
IE808/77A IE44426B1 (en) 1976-05-11 1977-04-20 Polypeptide
ZA00772433A ZA772433B (en) 1976-05-11 1977-04-22 Polypeptide
US05/790,003 US4100274A (en) 1976-05-11 1977-04-22 Polypeptide
CA277,003A CA1101844A (en) 1976-05-11 1977-04-26 Polypeptide
NZ183931A NZ183931A (en) 1976-05-11 1977-04-26 Polypeptide analogues of luteinising harmone releasing factor (lh-rf);pharmaceutical veterinary compositions
AU24681/77A AU508025B2 (en) 1976-05-11 1977-04-28 Polypeptide
HU77IE777A HU179990B (en) 1976-05-11 1977-05-04 Process for preparing polypeptides
DE2720245A DE2720245C2 (de) 1976-05-11 1977-05-05 Peptide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Zusammensetzungen
CS772980A CS199673B2 (en) 1976-05-11 1977-05-05 Method of producing polypeptides
IL52014A IL52014A (en) 1976-05-11 1977-05-05 Polypeptides having luliberin agonist properties
PL1977197889A PL104362B1 (pl) 1976-05-11 1977-05-05 Sposob wytwarzania polipeptydow
PL1977212706A PL108860B1 (en) 1976-05-11 1977-05-05 Method of producing polypeptides
CH578677A CH627151A5 (enExample) 1976-05-11 1977-05-09
YU1172/77A YU40672B (en) 1976-05-11 1977-05-09 Process for obtaining a polypeptide of the formula glu-his-trp-ser-tyr-a-b-argo-pro-e-f
FR7714262A FR2351092A1 (fr) 1976-05-11 1977-05-10 Polypeptides ayant une activite agoniste de la luliberine
SE7705432A SE437837B (sv) 1976-05-11 1977-05-10 Polypeptid for att kontrollera och/eller forbettra reproduktionen hos djur jemte veteriner komposition innehallande nemnda polypeptid som aktiv bestandsdel
NO771644A NO147304C (no) 1976-05-11 1977-05-10 Polypeptid som har evnen til aa regulere og/eller oeke fruktbarheten hos dyr og/eller aa bedre ufruktbarhet hos menn og kvinner
NL7705130A NL191793C (nl) 1976-05-11 1977-05-10 Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat.
BE177448A BE854467A (fr) 1976-05-11 1977-05-10 Polypeptides
FI771480A FI64139C (fi) 1976-05-11 1977-05-10 Polypeptid med inverkan pao djurens fortplantning
ES458691A ES458691A1 (es) 1976-05-11 1977-05-11 Procedimiento para preparar polipeptidos.
AT0335877A AT379400B (de) 1976-05-11 1977-05-11 Verfahren zur herstellung eines neuen polypeptids
JP5418677A JPS52136172A (en) 1976-05-11 1977-05-11 Polypeptide* its preparation and medical and veterinary compositions having rulibeline synergistic effect
DK207977A DK149596C (da) 1976-05-11 1977-05-11 Lh-rh-analoge nona- eller decapeptider, syreadditionssalte deraf og veterinaert middel til anvendelse til regulering og/eller forbedring af dyrs reproduktion
SU772480485A SU910116A3 (ru) 1976-05-11 1977-05-11 Способ получени полипептидов или их солей
DD77198869A DD136738A5 (de) 1976-05-11 1977-05-11 Verfahren zur herstellung neuer polypeptide
CS79207A CS199674B2 (cs) 1976-05-11 1979-01-09 Způsob výroby polypeptidů
AT0217979A AT365562B (de) 1976-05-11 1979-03-23 Verfahren zur herstellung eines neuen polypeptids
SE8007763A SE437993B (sv) 1976-05-11 1980-11-05 Sett att framstella en polypeptid med luliberin-agonist-egenskaper
CH447281A CH629475A5 (de) 1976-05-11 1981-07-07 Verfahren zur herstellung von polypeptiden.
NO822984A NO149586C (no) 1976-05-11 1982-09-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive polypeptider
FI830601A FI75579C (fi) 1976-05-11 1983-02-23 Foerfarande foer framstaellning av terapeutiskt anvaendbar polypeptid.
DK469983A DK149272C (da) 1976-05-11 1983-10-12 Analogifremgangsmaade til fremstilling af lhrh-analoge nona- eller decapeptider eller farmaceutisk anvendelige syreadditionssalte deraf
AT328184A AT379597B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328084A AT379596B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328484A AT379599B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328284A AT379598B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328684A AT379601B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328584A AT379600B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328384A AT379818B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT327984A AT379595B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
BG098123A BG60740B2 (bg) 1976-05-11 1993-09-24 Полипептид
NL970002C NL970002I2 (nl) 1976-05-11 1997-01-15 Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19327/76A GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide

Publications (1)

Publication Number Publication Date
GB1524747A true GB1524747A (en) 1978-09-13

Family

ID=10127509

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19327/76A Expired GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide

Country Status (27)

Country Link
US (1) US4100274A (enExample)
JP (1) JPS52136172A (enExample)
AT (2) AT379400B (enExample)
AU (1) AU508025B2 (enExample)
BE (1) BE854467A (enExample)
BG (1) BG60740B2 (enExample)
CA (1) CA1101844A (enExample)
CH (2) CH627151A5 (enExample)
CS (1) CS199673B2 (enExample)
DD (1) DD136738A5 (enExample)
DE (1) DE2720245C2 (enExample)
DK (1) DK149596C (enExample)
ES (1) ES458691A1 (enExample)
FI (1) FI64139C (enExample)
FR (1) FR2351092A1 (enExample)
GB (1) GB1524747A (enExample)
HU (1) HU179990B (enExample)
IE (1) IE44426B1 (enExample)
IL (1) IL52014A (enExample)
NL (2) NL191793C (enExample)
NO (2) NO147304C (enExample)
NZ (1) NZ183931A (enExample)
PL (2) PL108860B1 (enExample)
SE (2) SE437837B (enExample)
SU (1) SU910116A3 (enExample)
YU (1) YU40672B (enExample)
ZA (1) ZA772433B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897289B1 (en) 1999-05-20 2005-05-24 Lipotec, S.A. Peptide synthesis procedure in solid phase

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
DE3411224A1 (de) * 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
JPH0284272U (enExample) * 1988-12-20 1990-06-29
JP2672677B2 (ja) * 1989-02-09 1997-11-05 タツプ・フアーマシユーテイカルズ・インコーポレイテツド Lhrh同族体
NZ244499A (en) * 1989-03-10 1999-05-28 Endorecherche Inc Treating breast or endometrial cancer with antiestrogen plus one of an androgen, a progestin and an inhibitor of sex steroid formation or secretion of prolactin, growth hormone or acth
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
ES2189784T3 (es) * 1989-07-07 2003-07-16 Endorech Inc Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
ES2121570T3 (es) * 1989-07-07 1998-12-01 Endorecherche Inc Derivados de androgenos para uso en la inhibicion de la actividad de los esteroides sexuales.
GB9112859D0 (en) * 1991-06-14 1991-07-31 Ici Plc Peptide process
PL175591B1 (pl) * 1992-05-21 1999-01-29 Endorecherche Inc Środek farmaceutyczny do hamowania 5alfa-reduktazy testosteronowej
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
EP1008656A4 (en) 1996-06-13 2000-09-20 Itoham Foods Inc METHOD FOR PRODUCING LH-RH DERIVATIVES
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US20040259803A1 (en) * 1999-04-15 2004-12-23 Monash University Disease prevention by reactivation of the thymus
US20070274946A1 (en) * 1999-04-15 2007-11-29 Norwood Immunoloty, Ltd. Tolerance to Graft Prior to Thymic Reactivation
US20050020524A1 (en) * 1999-04-15 2005-01-27 Monash University Hematopoietic stem cell gene therapy
AUPR074500A0 (en) * 2000-10-13 2000-11-09 Monash University Treatment of t cell disorders
US20040258672A1 (en) * 1999-04-15 2004-12-23 Monash University Graft acceptance through manipulation of thymic regeneration
US20040265285A1 (en) * 1999-04-15 2004-12-30 Monash University Normalization of defective T cell responsiveness through manipulation of thymic regeneration
US20040241842A1 (en) * 1999-04-15 2004-12-02 Monash University Stimulation of thymus for vaccination development
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
US20060088512A1 (en) * 2001-10-15 2006-04-27 Monash University Treatment of T cell disorders
EP2762140B1 (en) 2001-02-19 2017-03-22 Novartis AG Treatment of solid brain tumours with a rapamycin derivative
CA2444867C (en) 2001-05-16 2010-08-17 Novartis Ag Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
WO2003041739A1 (fr) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Agents anticancer
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
BR0311173A (pt) 2002-05-16 2005-03-15 Novartis Ag Uso de agentes de ligação do receptor de edg em câncer
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
HUE026034T2 (en) 2002-12-13 2016-05-30 Durect Corp Oral delivery system containing an oral high-viscosity carrier
BRPI0412259B1 (pt) 2003-07-22 2019-08-20 Astex Therapeutics Limited Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica
GB0320806D0 (en) * 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
US20080279812A1 (en) * 2003-12-05 2008-11-13 Norwood Immunology, Ltd. Disease Prevention and Vaccination Prior to Thymic Reactivation
ME02125B (me) 2004-04-07 2013-04-30 Novartis Ag Inhibitori protein apoptoze (iap)
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
PE20091567A1 (es) * 2004-06-25 2009-11-03 Takeda Pharmaceutical Derivados de metastina en el tratamiento del cancer
LT2767292T (lt) * 2004-09-17 2016-12-12 Durect Corporation Palaikomosios vietinės anestezijos mišinys su saib
GB0425854D0 (en) * 2004-11-25 2004-12-29 Astrazeneca Ab Therapeutic treatment
RU2436575C2 (ru) * 2005-01-21 2011-12-20 Астекс Терапьютикс Лимитед Соединения для использования в фармацевтике
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
CA2594477C (en) 2005-01-21 2016-07-12 Astex Therapeutics Limited Pharmaceutical compounds
EP2119725A1 (en) 2005-05-03 2009-11-18 Novetide Ltd. Methods for the production of leuprolide
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
WO2007038459A2 (en) 2005-09-27 2007-04-05 Novartis Ag Carboxyamine compounds and their use in the treatment of hdac dependent diseases
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
NZ572299A (en) 2006-05-09 2010-07-30 Novartis Ag Combination comprising a substituted 3,5-diphenyl-1,2,4-triazole and a platinum compound and use thereof
AU2007302263A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as P13K lipid kinase inhibitors
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2117521B1 (en) 2006-11-03 2012-06-27 Durect Corporation Transdermal delivery systems comprising bupivacaine
EP2120900A2 (en) 2007-02-15 2009-11-25 Novartis AG Combination of lbh589 with other therapeutic agents for treating cancer
JP2011506318A (ja) * 2007-12-06 2011-03-03 デュレクト コーポレーション 経口医薬製剤
ES2524259T3 (es) 2008-03-24 2014-12-04 Novartis Ag Inhibidores de metaloproteinasa de matriz a base de arilsulfonamida
PL2260020T3 (pl) 2008-03-26 2015-01-30 Novartis Ag Hydroksamianowe inhibitory deacetylaz B
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
DK2370076T3 (en) * 2008-11-28 2017-04-03 Novartis Ag Pharmaceutical combination comprising an Hsp 90 inhibitor and an mTOR inhibitor
WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
SI2391366T1 (sl) 2009-01-29 2013-01-31 Novartis Ag Substituirani benzimidazoli za zdravljenje astrocitomov
WO2010149755A1 (en) 2009-06-26 2010-12-29 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
KR20120089643A (ko) 2009-08-12 2012-08-13 노파르티스 아게 헤테로시클릭 히드라존 화합물, 및 암 및 염증을 치료하기 위한 그의 용도
JP5775871B2 (ja) 2009-08-20 2015-09-09 ノバルティス アーゲー ヘテロ環式オキシム化合物
MX2012002420A (es) 2009-08-26 2012-06-27 Novartis Ag Compuestos de heteroarilo tetra-sustituidos y su uso como moduladores de mdm2 y/o mdm4.
JP2013504543A (ja) 2009-09-10 2013-02-07 ノバルティス アーゲー 二環ヘテロアリール類のエーテル誘導体
NZ599565A (en) 2009-11-04 2013-05-31 Novartis Ag Heterocyclic sulfonamide derivatives useful as mek inhibitors
US20120289501A1 (en) 2009-11-25 2012-11-15 Novartis Ag Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
EA201200823A1 (ru) 2009-12-08 2013-02-28 Новартис Аг Гетероциклические производные сульфонамидов
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
SG186333A1 (en) 2010-06-16 2013-01-30 Endorech Inc Methods of treating or preventing estrogen-related diseases
WO2011157787A1 (en) 2010-06-17 2011-12-22 Novartis Ag Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
US20130085161A1 (en) 2010-06-17 2013-04-04 Novartis Ag Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
CN103108871B (zh) 2010-09-16 2014-09-10 诺华股份有限公司 17α-羟化酶/C17,20-裂合酶抑制剂
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
US20130338152A1 (en) 2011-03-08 2013-12-19 Irm Llc Fluorophenyl bicyclic heteroaryl compounds
EA023064B1 (ru) 2011-04-28 2016-04-29 Новартис Аг ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ
KR20200016407A (ko) 2011-05-16 2020-02-14 젠자임 코포레이션 Cxcr4 길항제의 용도
MX2013014398A (es) 2011-06-09 2014-03-21 Novartis Ag Derivados de sulfonamida heterociclicos.
US8859535B2 (en) 2011-06-20 2014-10-14 Novartis Ag Hydroxy substituted isoquinolinone derivatives
EP2721007B1 (en) 2011-06-20 2015-04-29 Novartis AG Cyclohexyl isoquinolinone compounds
EP2723740A1 (en) 2011-06-27 2014-04-30 Novartis AG Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
US9062045B2 (en) 2011-09-15 2015-06-23 Novartis Ag Triazolopyridine compounds
EP2785717B1 (en) 2011-11-29 2016-01-13 Novartis AG Pyrazolopyrrolidine compounds
WO2013093850A1 (en) 2011-12-22 2013-06-27 Novartis Ag Quinoline derivatives
CA2859764C (en) 2011-12-22 2019-12-31 Novartis Ag Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
MX2014007731A (es) 2011-12-23 2015-01-12 Novartis Ag Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
US9126979B2 (en) 2011-12-23 2015-09-08 Novartis Ag Compounds for inhibiting the interaction of BCL2 with binding partners
MX2014007729A (es) 2011-12-23 2015-01-12 Novartis Ag Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
EA201491259A1 (ru) 2011-12-23 2014-11-28 Новартис Аг Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами связывания
EA201491265A1 (ru) 2011-12-23 2014-11-28 Новартис Аг Соединения для ингибирования взаимодействия bcl-2 с партнерами по связыванию
US8815926B2 (en) 2012-01-26 2014-08-26 Novartis Ag Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
UY34807A (es) 2012-05-16 2013-12-31 Novartis Ag Derivados monocíclicos de heteroarilcicloalquil- diamina
US9365576B2 (en) 2012-05-24 2016-06-14 Novartis Ag Pyrrolopyrrolidinone compounds
AU2013274101B2 (en) 2012-06-15 2017-09-07 The Brigham And Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
EP2882747B1 (en) 2012-08-13 2016-04-27 Novartis AG Bicyclic heteroaryl cycloalkyldiamine derivatives as inhibitors of spleen tyrosine kinases (syk)
HRP20170358T1 (hr) 2012-10-02 2017-04-21 Gilead Sciences, Inc. Inhibitori histonskih demetilaza
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫-吡啶并-□衍生物之固體形式
EP2948451B1 (en) 2013-01-22 2017-07-12 Novartis AG Substituted purinone compounds
US9556180B2 (en) 2013-01-22 2017-01-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
ES2670864T3 (es) 2013-02-27 2018-06-01 Gilead Sciences, Inc. Inhibidores de histonas desmetilasas
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
WO2015022663A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
WO2015022664A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
RU2675105C9 (ru) 2013-09-22 2019-01-09 Саншайн Лейк Фарма Ко., Лтд. Замещенные аминопиримидиновые соединения и способы их использования
MX2016009226A (es) 2014-01-15 2016-10-05 Novartis Ag Combinaciones farmaceuticas.
MX2016012574A (es) 2014-03-28 2017-09-26 Calitor Sciences Llc Compuestos heteroarilo sustituidos y metodos de uso.
JP2017512804A (ja) 2014-03-31 2017-05-25 ギリアード サイエンシーズ, インコーポレイテッド ヒストン脱メチル化酵素の阻害剤
US10426753B2 (en) 2014-04-03 2019-10-01 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics
SG11201701182VA (en) 2014-08-27 2017-03-30 Gilead Sciences Inc Compounds and methods for inhibiting histone demethylases
EP3347097B1 (en) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
US12274794B2 (en) 2016-07-06 2025-04-15 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
JP7254076B2 (ja) 2017-11-19 2023-04-07 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 置換ヘテロアリール化合物及び使用方法
US11602534B2 (en) 2017-12-21 2023-03-14 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Pyrimidine derivative kinase inhibitors
US10751339B2 (en) 2018-01-20 2020-08-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
CA3155594C (en) 2019-09-26 2025-06-17 S.I.S. Shulov Innovative Science Ltd. Topical anti-aging compositions containing a tetrapeptide
US20220395553A1 (en) 2019-11-14 2022-12-15 Cohbar, Inc. Cxcr4 antagonist peptides
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
EP4277702A1 (en) 2021-01-12 2023-11-22 Durect Corporation Sustained release drug delivery systems and related methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005063A (en) * 1973-10-11 1977-01-25 Abbott Laboratories [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US3901872A (en) * 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates
JPS50142563A (enExample) * 1974-04-26 1975-11-17
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3971737A (en) * 1975-03-24 1976-07-27 American Home Products Corporation [2-Methyl-Ala6 ]LRH
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US4018726A (en) * 1975-06-12 1977-04-19 Andrew Victor Schally [D-Phe6 ]-LH-RH and intermediates therefor
US4024121A (en) * 1976-01-27 1977-05-17 Schally Andrew Victor (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates
US3992530A (en) * 1975-12-08 1976-11-16 American Home Products Corporation [D-2-(1,4-Cyclohexadienyl)gly]6 -des-gly10 -lrh nonapeptide amides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897289B1 (en) 1999-05-20 2005-05-24 Lipotec, S.A. Peptide synthesis procedure in solid phase

Also Published As

Publication number Publication date
ATA335877A (de) 1985-05-15
DE2720245A1 (de) 1977-11-24
NL7705130A (nl) 1977-11-15
SE7705432L (sv) 1977-11-12
IE44426L (en) 1977-11-11
DE2720245C2 (de) 1986-09-25
PL104362B1 (pl) 1979-08-31
DD136738A5 (de) 1979-07-25
FR2351092A1 (fr) 1977-12-09
ZA772433B (en) 1978-03-29
NL970002I1 (nl) 1997-03-03
BE854467A (fr) 1977-11-10
SE8007763L (sv) 1980-11-05
NZ183931A (en) 1979-03-16
SE437837B (sv) 1985-03-18
NO771644L (no) 1977-11-14
NO147304C (no) 1983-03-16
ES458691A1 (es) 1978-08-16
DK207977A (da) 1977-11-12
FI771480A7 (enExample) 1977-11-12
SU910116A3 (ru) 1982-02-28
CA1101844A (en) 1981-05-26
YU117277A (en) 1983-02-28
JPS52136172A (en) 1977-11-14
BG60740B2 (bg) 1996-01-31
SE437993B (sv) 1985-03-25
PL108860B1 (en) 1980-05-31
CS199673B2 (en) 1980-07-31
NO147304B (no) 1982-12-06
FI64139B (fi) 1983-06-30
IL52014A0 (en) 1977-07-31
FR2351092B1 (enExample) 1980-02-22
AT379400B (de) 1985-12-27
ATA217979A (de) 1981-06-15
CH627151A5 (enExample) 1981-12-31
DK149596B (da) 1986-08-04
IE44426B1 (en) 1981-11-18
DK149596C (da) 1987-01-05
US4100274A (en) 1978-07-11
NO149586B (no) 1984-02-06
FI64139C (fi) 1983-10-10
YU40672B (en) 1986-04-30
CH629475A5 (de) 1982-04-30
NO149586C (no) 1984-05-16
NL191793C (nl) 1996-08-02
AU508025B2 (en) 1980-03-06
NL970002I2 (nl) 1997-05-01
AU2468177A (en) 1978-11-02
PL197889A1 (pl) 1978-02-13
NL191793B (nl) 1996-04-01
AT365562B (de) 1982-01-25
JPS6113480B2 (enExample) 1986-04-14
NO822984L (no) 1977-11-14
IL52014A (en) 1979-11-30
HU179990B (en) 1983-01-28

Similar Documents

Publication Publication Date Title
GB1524747A (en) Polypeptide
GB1516947A (en) Hentricontapeptides
NISHIMURA et al. New method for removing the Sp-methoxybenzyl and St-butyl groups of cysteine residues with mercuric trifluoroacetate
KR0139632B1 (ko) 브라디키닌 길항 작용을 갖는 펩티드
GB1523623A (en) Activity and process for their manufacture
GB2091740A (en) C-terminal fragment of human chroionic gonadotropin
GB1498048A (en) Decapeptide amides
GB1527252A (en) Cyclization of peptides via cystine linkages
Manning et al. Design of more potent and selective antagonists of the antidiuretic responses to arginine-vasopressin devoid of antidiuretic agonism
Katsoyannis The synthesis of the insulin chains and their combination to biologically active material
GB1528336A (en) Compounds compositions and methods of their use
KR840007569A (ko) Grf 유사체 펩티드의 제법
US4659691A (en) Novel cyclic Hexapeptide LHRH antagonists
GB1440859A (en) Vasopressin-type hormones and a method for their preparation
Sarantakis et al. Total synthesis of hypothalamic “somatostatin”
GB1526367A (en) Polypeptide
US4652627A (en) Calcitonin analogs with C-terminal D-amino acid substituents
OTSUKA et al. Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH), and their biological activities
ES8507474A1 (es) Procedimiento para preparar ciclopeptidos
GB1294771A (en) Thyrocalcitonin derivative
GB1316545A (en) 1-alpha-aminoisobutyric acid-corticotropin peptides
DE3586936D1 (en) Peptide.
GB1523812A (en) Polypeptide
GB1477002A (en) Peptides
SHINODA Amino Acid Sequence of a Human Kappa Type Bence-Jones Protein: II. Chymotryptic Peptides and Sequence of Protein Ni

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB93/052, 930602

CTFG Supplementary protection certificate granted

Free format text: SPC/GB93/052, 931105, EXPIRES:20011130

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB93/052, 970421, EXPIRES:20011130

PE20 Patent expired after termination of 20 years

Effective date: 19970420

SPCE Supplementary protection certificate expired

Free format text: SPC/GB93/052, 20011130

SPCE Supplementary protection certificate expired

Free format text: SPC/GB93/052: 20011130