GB1524747A - Polypeptide - Google Patents

Polypeptide

Info

Publication number
GB1524747A
GB1524747A GB19327/76A GB1932776A GB1524747A GB 1524747 A GB1524747 A GB 1524747A GB 19327/76 A GB19327/76 A GB 19327/76A GB 1932776 A GB1932776 A GB 1932776A GB 1524747 A GB1524747 A GB 1524747A
Authority
GB
United Kingdom
Prior art keywords
tyr
leu
pro
arg
azgly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19327/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB19327/76A priority Critical patent/GB1524747A/en
Priority to IE808/77A priority patent/IE44426B1/en
Priority to ZA00772433A priority patent/ZA772433B/xx
Priority to US05/790,003 priority patent/US4100274A/en
Priority to CA277,003A priority patent/CA1101844A/en
Priority to NZ183931A priority patent/NZ183931A/xx
Priority to AU24681/77A priority patent/AU508025B2/en
Priority to HU77IE777A priority patent/HU179990B/hu
Priority to CS772980A priority patent/CS199673B2/cs
Priority to PL1977212706A priority patent/PL108860B1/pl
Priority to IL52014A priority patent/IL52014A/xx
Priority to PL1977197889A priority patent/PL104362B1/pl
Priority to DE2720245A priority patent/DE2720245C2/de
Priority to YU1172/77A priority patent/YU40672B/xx
Priority to CH578677A priority patent/CH627151A5/de
Priority to SE7705432A priority patent/SE437837B/xx
Priority to NL7705130A priority patent/NL191793C/xx
Priority to FR7714262A priority patent/FR2351092A1/fr
Priority to FI771480A priority patent/FI64139C/fi
Priority to BE177448A priority patent/BE854467A/xx
Priority to NO771644A priority patent/NO147304C/no
Priority to JP5418677A priority patent/JPS52136172A/ja
Priority to SU772480485A priority patent/SU910116A3/ru
Priority to ES458691A priority patent/ES458691A1/es
Priority to DK207977A priority patent/DK149596C/da
Priority to AT0335877A priority patent/AT379400B/de
Priority to DD77198869A priority patent/DD136738A5/xx
Publication of GB1524747A publication Critical patent/GB1524747A/en
Priority to CS79207A priority patent/CS199674B2/cs
Priority to AT0217979A priority patent/AT365562B/de
Priority to SE8007763A priority patent/SE437993B/sv
Priority to CH447281A priority patent/CH629475A5/de
Priority to NO822984A priority patent/NO149586C/no
Priority to FI830601A priority patent/FI75579C/fi
Priority to DK469983A priority patent/DK149272C/da
Priority to AT328484A priority patent/AT379599B/de
Priority to AT328584A priority patent/AT379600B/de
Priority to AT328684A priority patent/AT379601B/de
Priority to AT328184A priority patent/AT379597B/de
Priority to AT328084A priority patent/AT379596B/de
Priority to AT328384A priority patent/AT379818B/de
Priority to AT327984A priority patent/AT379595B/de
Priority to AT328284A priority patent/AT379598B/de
Priority to BG098123A priority patent/BG60740B2/bg
Priority to NL970002C priority patent/NL970002I2/nl
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • C07K5/06095Arg-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/13Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Plant Substances (AREA)
GB19327/76A 1976-05-11 1976-05-11 Polypeptide Expired GB1524747A (en)

Priority Applications (44)

Application Number Priority Date Filing Date Title
GB19327/76A GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide
IE808/77A IE44426B1 (en) 1976-05-11 1977-04-20 Polypeptide
ZA00772433A ZA772433B (en) 1976-05-11 1977-04-22 Polypeptide
US05/790,003 US4100274A (en) 1976-05-11 1977-04-22 Polypeptide
CA277,003A CA1101844A (en) 1976-05-11 1977-04-26 Polypeptide
NZ183931A NZ183931A (en) 1976-05-11 1977-04-26 Polypeptide analogues of luteinising harmone releasing factor (lh-rf);pharmaceutical veterinary compositions
AU24681/77A AU508025B2 (en) 1976-05-11 1977-04-28 Polypeptide
HU77IE777A HU179990B (en) 1976-05-11 1977-05-04 Process for preparing polypeptides
CS772980A CS199673B2 (en) 1976-05-11 1977-05-05 Method of producing polypeptides
PL1977212706A PL108860B1 (en) 1976-05-11 1977-05-05 Method of producing polypeptides
IL52014A IL52014A (en) 1976-05-11 1977-05-05 Polypeptides having luliberin agonist properties
PL1977197889A PL104362B1 (pl) 1976-05-11 1977-05-05 Sposob wytwarzania polipeptydow
DE2720245A DE2720245C2 (de) 1976-05-11 1977-05-05 Peptide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Zusammensetzungen
YU1172/77A YU40672B (en) 1976-05-11 1977-05-09 Process for obtaining a polypeptide of the formula glu-his-trp-ser-tyr-a-b-argo-pro-e-f
CH578677A CH627151A5 (enExample) 1976-05-11 1977-05-09
SE7705432A SE437837B (sv) 1976-05-11 1977-05-10 Polypeptid for att kontrollera och/eller forbettra reproduktionen hos djur jemte veteriner komposition innehallande nemnda polypeptid som aktiv bestandsdel
NL7705130A NL191793C (nl) 1976-05-11 1977-05-10 Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat.
FR7714262A FR2351092A1 (fr) 1976-05-11 1977-05-10 Polypeptides ayant une activite agoniste de la luliberine
FI771480A FI64139C (fi) 1976-05-11 1977-05-10 Polypeptid med inverkan pao djurens fortplantning
BE177448A BE854467A (fr) 1976-05-11 1977-05-10 Polypeptides
NO771644A NO147304C (no) 1976-05-11 1977-05-10 Polypeptid som har evnen til aa regulere og/eller oeke fruktbarheten hos dyr og/eller aa bedre ufruktbarhet hos menn og kvinner
JP5418677A JPS52136172A (en) 1976-05-11 1977-05-11 Polypeptide* its preparation and medical and veterinary compositions having rulibeline synergistic effect
SU772480485A SU910116A3 (ru) 1976-05-11 1977-05-11 Способ получени полипептидов или их солей
ES458691A ES458691A1 (es) 1976-05-11 1977-05-11 Procedimiento para preparar polipeptidos.
DK207977A DK149596C (da) 1976-05-11 1977-05-11 Lh-rh-analoge nona- eller decapeptider, syreadditionssalte deraf og veterinaert middel til anvendelse til regulering og/eller forbedring af dyrs reproduktion
AT0335877A AT379400B (de) 1976-05-11 1977-05-11 Verfahren zur herstellung eines neuen polypeptids
DD77198869A DD136738A5 (de) 1976-05-11 1977-05-11 Verfahren zur herstellung neuer polypeptide
CS79207A CS199674B2 (cs) 1976-05-11 1979-01-09 Způsob výroby polypeptidů
AT0217979A AT365562B (de) 1976-05-11 1979-03-23 Verfahren zur herstellung eines neuen polypeptids
SE8007763A SE437993B (sv) 1976-05-11 1980-11-05 Sett att framstella en polypeptid med luliberin-agonist-egenskaper
CH447281A CH629475A5 (de) 1976-05-11 1981-07-07 Verfahren zur herstellung von polypeptiden.
NO822984A NO149586C (no) 1976-05-11 1982-09-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive polypeptider
FI830601A FI75579C (fi) 1976-05-11 1983-02-23 Foerfarande foer framstaellning av terapeutiskt anvaendbar polypeptid.
DK469983A DK149272C (da) 1976-05-11 1983-10-12 Analogifremgangsmaade til fremstilling af lhrh-analoge nona- eller decapeptider eller farmaceutisk anvendelige syreadditionssalte deraf
AT328484A AT379599B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328284A AT379598B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328584A AT379600B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328684A AT379601B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328184A AT379597B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328084A AT379596B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT328384A AT379818B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
AT327984A AT379595B (de) 1976-05-11 1984-10-15 Verfahren zur herstellung eines neuen polypeptids
BG098123A BG60740B2 (bg) 1976-05-11 1993-09-24 Полипептид
NL970002C NL970002I2 (nl) 1976-05-11 1997-01-15 Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19327/76A GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide

Publications (1)

Publication Number Publication Date
GB1524747A true GB1524747A (en) 1978-09-13

Family

ID=10127509

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19327/76A Expired GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide

Country Status (27)

Country Link
US (1) US4100274A (enExample)
JP (1) JPS52136172A (enExample)
AT (2) AT379400B (enExample)
AU (1) AU508025B2 (enExample)
BE (1) BE854467A (enExample)
BG (1) BG60740B2 (enExample)
CA (1) CA1101844A (enExample)
CH (2) CH627151A5 (enExample)
CS (1) CS199673B2 (enExample)
DD (1) DD136738A5 (enExample)
DE (1) DE2720245C2 (enExample)
DK (1) DK149596C (enExample)
ES (1) ES458691A1 (enExample)
FI (1) FI64139C (enExample)
FR (1) FR2351092A1 (enExample)
GB (1) GB1524747A (enExample)
HU (1) HU179990B (enExample)
IE (1) IE44426B1 (enExample)
IL (1) IL52014A (enExample)
NL (2) NL191793C (enExample)
NO (2) NO147304C (enExample)
NZ (1) NZ183931A (enExample)
PL (2) PL104362B1 (enExample)
SE (2) SE437837B (enExample)
SU (1) SU910116A3 (enExample)
YU (1) YU40672B (enExample)
ZA (1) ZA772433B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897289B1 (en) 1999-05-20 2005-05-24 Lipotec, S.A. Peptide synthesis procedure in solid phase

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
DE3411224A1 (de) * 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
JPH0284272U (enExample) * 1988-12-20 1990-06-29
JP2672677B2 (ja) * 1989-02-09 1997-11-05 タツプ・フアーマシユーテイカルズ・インコーポレイテツド Lhrh同族体
IL93693A (en) * 1989-03-10 2000-01-31 Endorech Inc Pharmaceutical compositions for the treatment of estrogen sensitive diseases
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
ES2189784T3 (es) * 1989-07-07 2003-07-16 Endorech Inc Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
AU5856090A (en) * 1989-07-07 1991-02-06 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity
GB9112859D0 (en) * 1991-06-14 1991-07-31 Ici Plc Peptide process
SK140494A3 (en) * 1992-05-21 1995-07-11 Endorecherche Inc Inhibitors of testosterone 5-alpha-reductase activity
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
US6448031B1 (en) 1996-06-13 2002-09-10 Itoham Foods Inc. Process for producing LH-RH derivatives
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
AUPR074500A0 (en) * 2000-10-13 2000-11-09 Monash University Treatment of t cell disorders
US20040241842A1 (en) * 1999-04-15 2004-12-02 Monash University Stimulation of thymus for vaccination development
US20050020524A1 (en) * 1999-04-15 2005-01-27 Monash University Hematopoietic stem cell gene therapy
US20040258672A1 (en) * 1999-04-15 2004-12-23 Monash University Graft acceptance through manipulation of thymic regeneration
US20040265285A1 (en) * 1999-04-15 2004-12-30 Monash University Normalization of defective T cell responsiveness through manipulation of thymic regeneration
US20070274946A1 (en) * 1999-04-15 2007-11-29 Norwood Immunoloty, Ltd. Tolerance to Graft Prior to Thymic Reactivation
US20040259803A1 (en) * 1999-04-15 2004-12-23 Monash University Disease prevention by reactivation of the thymus
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
DE10032256C2 (de) * 2000-07-03 2003-06-05 Infineon Technologies Ag Chip-ID-Register-Anordnung
US20060088512A1 (en) * 2001-10-15 2006-04-27 Monash University Treatment of T cell disorders
EP3342411B1 (en) 2001-02-19 2019-08-21 Novartis Pharma AG Rapamycin derivative for treating pancreas cancer
KR20080091866A (ko) 2001-05-16 2008-10-14 노파르티스 아게 Ν-{5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐}-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를 포함하는 배합물
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
NZ560662A (en) 2002-05-16 2009-09-25 Novartis Ag Use of EDG receptor binding agents in cancer
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
NZ544756A (en) 2003-07-22 2009-09-25 Astex Therapeutics Ltd 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
GB0320806D0 (en) * 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
US20080279812A1 (en) * 2003-12-05 2008-11-13 Norwood Immunology, Ltd. Disease Prevention and Vaccination Prior to Thymic Reactivation
RS52545B (sr) 2004-04-07 2013-04-30 Novartis Ag Inhibitori protein apoptoze (iap)
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
BRPI0512397A (pt) * 2004-06-25 2008-03-04 Takeda Pharmaceutical composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexual
EP3103477A1 (en) * 2004-09-17 2016-12-14 Durect Corporation Sustained local anesthetic composition containing saib
GB0425854D0 (en) * 2004-11-25 2004-12-29 Astrazeneca Ab Therapeutic treatment
RU2436575C2 (ru) * 2005-01-21 2011-12-20 Астекс Терапьютикс Лимитед Соединения для использования в фармацевтике
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
EP1845973B1 (en) 2005-01-21 2015-08-12 Astex Therapeutics Limited Pharmaceutical compounds
ES2336826T3 (es) 2005-05-03 2010-04-16 Novetide, Ltd. Procedimientos para la produccion de un peptido que presenta una amida c-terminal.
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
EP1996550A2 (en) 2005-09-27 2008-12-03 Novartis AG Carboxyamine compounds and their use in the treatment of hdac dependent diseases
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
KR20090007635A (ko) 2006-05-09 2009-01-19 노파르티스 아게 철 킬레이터 및 항-신생물 약제를 포함하는 조합물 및 그의용도
RU2009115954A (ru) 2006-09-29 2010-11-10 Новартис АГ (CH) Пиразолопиримидины в качестве ингибиторов липидной киназы р13к
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
PL2117521T3 (pl) 2006-11-03 2012-11-30 Durect Corp Transdermalne systemy dostarczania zawierające bupiwakainę
US20100069458A1 (en) 2007-02-15 2010-03-18 Peter Wisdom Atadja Combination of lbh589 with other therapeutic agents for treating cancer
EP3326621A1 (en) * 2007-12-06 2018-05-30 Durect Corporation Oral pharmaceutical dosage forms
KR101673621B1 (ko) 2008-03-24 2016-11-07 노파르티스 아게 아릴술폰아미드-계 매트릭스 메탈로프로테아제 억제제
PT2260020E (pt) 2008-03-26 2014-10-28 Novartis Ag Inibidores das desacetilases b baseados no hidroxamato
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
AU2009319048B2 (en) * 2008-11-28 2014-01-30 Novartis Ag Pharmaceutical combination comprising a Hsp 90 inhibitor and a mTOR inhibitor
WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
HRP20121006T1 (hr) 2009-01-29 2013-01-31 Novartis Ag Supstituirani benzimidazoli za lijeäśenje astrocitoma
UY32730A (es) 2009-06-26 2011-01-31 Novartis Ag Inhibidores de cyp17
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
CA2770873A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
CA2771432A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
IN2012DN01693A (enExample) 2009-08-26 2015-06-05 Novartis Ag
WO2011029915A1 (en) 2009-09-10 2011-03-17 Novartis Ag Ether derivatives of bicyclic heteroaryls
EA201200651A1 (ru) 2009-11-04 2012-12-28 Новартис Аг Гетероциклические сульфонамидные производные, применимые в качестве ингибиторов мек
US20120289501A1 (en) 2009-11-25 2012-11-15 Novartis Ag Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
ES2484171T3 (es) 2009-12-08 2014-08-11 Novartis Ag Derivados de sulfonamidas heterocíclicas
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
KR101731008B1 (ko) 2010-06-16 2017-04-27 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
EP2582680A1 (en) 2010-06-17 2013-04-24 Novartis AG Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
EP2582681A1 (en) 2010-06-17 2013-04-24 Novartis AG Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
EP2627648A1 (en) 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物
US20130338152A1 (en) 2011-03-08 2013-12-19 Irm Llc Fluorophenyl bicyclic heteroaryl compounds
MX359399B (es) 2011-04-28 2018-09-27 Novartis Ag Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
KR20200016407A (ko) 2011-05-16 2020-02-14 젠자임 코포레이션 Cxcr4 길항제의 용도
KR20140034898A (ko) 2011-06-09 2014-03-20 노파르티스 아게 헤테로시클릭 술폰아미드 유도체
WO2012175487A1 (en) 2011-06-20 2012-12-27 Novartis Ag Cyclohexyl isoquinolinone compounds
US8859535B2 (en) 2011-06-20 2014-10-14 Novartis Ag Hydroxy substituted isoquinolinone derivatives
AU2012277391A1 (en) 2011-06-27 2013-12-19 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
AU2012310168B2 (en) 2011-09-15 2015-07-16 Novartis Ag 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
WO2013080141A1 (en) 2011-11-29 2013-06-06 Novartis Ag Pyrazolopyrrolidine compounds
US20150148377A1 (en) 2011-12-22 2015-05-28 Novartis Ag Quinoline Derivatives
IN2014CN04174A (enExample) 2011-12-22 2015-09-04 Novartis Ag
MX2014007731A (es) 2011-12-23 2015-01-12 Novartis Ag Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
WO2013096055A1 (en) 2011-12-23 2013-06-27 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
BR112014015322A8 (pt) 2011-12-23 2017-06-13 Novartis Ag compostos e composições para inibir a interação de bcl2 com parceiros de ligação
CA2859873A1 (en) 2011-12-23 2013-06-27 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
CN104125955A (zh) 2011-12-23 2014-10-29 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
US8815926B2 (en) 2012-01-26 2014-08-26 Novartis Ag Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
UY34807A (es) 2012-05-16 2013-12-31 Novartis Ag Derivados monocíclicos de heteroarilcicloalquil- diamina
CN104321325B (zh) 2012-05-24 2016-11-16 诺华股份有限公司 吡咯并吡咯烷酮化合物
BR112014031421A2 (pt) 2012-06-15 2017-06-27 Brigham & Womens Hospital Inc composições para tratamento de câncer e métodos para produção das mesmas
WO2014027300A1 (en) 2012-08-13 2014-02-20 Novartis Ag Bicyclic heteroaryl cycloalkyldiamine derivatives as inhibitors of spleen tyrosine kinases (syk)
CN104981458B (zh) 2012-10-02 2017-07-21 吉利德科学公司 组蛋白去甲基化酶抑制剂
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫-吡啶并-□衍生物之固體形式
WO2014115080A1 (en) 2013-01-22 2014-07-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
WO2014115077A1 (en) 2013-01-22 2014-07-31 Novartis Ag Substituted purinone compounds
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
SG10201707027SA (en) 2013-02-27 2017-09-28 Epitherapeutics Aps Inhibitors of histone demethylases
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
WO2015022663A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
WO2015022664A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
KR20160060100A (ko) 2013-09-22 2016-05-27 칼리토르 사이언시즈, 엘엘씨 치환된 아미노피리미딘 화합물 및 이용 방법
MX2016009226A (es) 2014-01-15 2016-10-05 Novartis Ag Combinaciones farmaceuticas.
WO2015148868A1 (en) 2014-03-28 2015-10-01 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
CA2943824A1 (en) 2014-03-31 2015-10-08 Gilead Sciences, Inc. Inhibitors of histone demethylases
MX2016012893A (es) 2014-04-03 2017-05-12 Invictus Oncology Pvt Ltd Sustancias terapéuticas combinadas supramoleculares.
KR20170040805A (ko) 2014-08-27 2017-04-13 길리애드 사이언시즈, 인코포레이티드 히스톤 데메틸라제를 억제하기 위한 화합물 및 방법
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
SG11201811760VA (en) 2016-07-06 2019-01-30 Durect Corp Oral dosage form with drug composition, barrier layer and drug layer
US10683297B2 (en) 2017-11-19 2020-06-16 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
AU2017444054B2 (en) 2017-12-21 2021-10-07 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Class of pyrimidine derivative kinase inhibitors
CA3083040A1 (en) 2018-01-20 2019-07-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
US12433830B2 (en) 2019-09-26 2025-10-07 S.I.S. Shulov Innovative Science Ltd. Anti-aging compositions and methods of use thereof
US20220395553A1 (en) 2019-11-14 2022-12-15 Cohbar, Inc. Cxcr4 antagonist peptides
EP4090353A4 (en) 2020-01-13 2023-08-09 Durect Corporation DELAYED-RELEASE DRUG DELIVERY SYSTEMS WITH REDUCED IMPURITIES AND RELATED PROCEDURES
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005063A (en) * 1973-10-11 1977-01-25 Abbott Laboratories [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US3901872A (en) * 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates
JPS50142563A (enExample) * 1974-04-26 1975-11-17
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3971737A (en) * 1975-03-24 1976-07-27 American Home Products Corporation [2-Methyl-Ala6 ]LRH
US4018726A (en) * 1975-06-12 1977-04-19 Andrew Victor Schally [D-Phe6 ]-LH-RH and intermediates therefor
US4024121A (en) * 1976-01-27 1977-05-17 Schally Andrew Victor (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US3992530A (en) * 1975-12-08 1976-11-16 American Home Products Corporation [D-2-(1,4-Cyclohexadienyl)gly]6 -des-gly10 -lrh nonapeptide amides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897289B1 (en) 1999-05-20 2005-05-24 Lipotec, S.A. Peptide synthesis procedure in solid phase

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SE437993B (sv) 1985-03-25
FI771480A7 (enExample) 1977-11-12
FI64139B (fi) 1983-06-30
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CS199673B2 (en) 1980-07-31
ES458691A1 (es) 1978-08-16
NL970002I1 (nl) 1997-03-03
DD136738A5 (de) 1979-07-25
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NZ183931A (en) 1979-03-16
AU508025B2 (en) 1980-03-06
IE44426B1 (en) 1981-11-18
DK207977A (da) 1977-11-12
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ZA772433B (en) 1978-03-29
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YU117277A (en) 1983-02-28
PL108860B1 (en) 1980-05-31
ATA217979A (de) 1981-06-15
YU40672B (en) 1986-04-30
SE7705432L (sv) 1977-11-12
CH627151A5 (enExample) 1981-12-31
BE854467A (fr) 1977-11-10
BG60740B2 (bg) 1996-01-31
DK149596B (da) 1986-08-04
SE8007763L (sv) 1980-11-05
HU179990B (en) 1983-01-28
CA1101844A (en) 1981-05-26
AT379400B (de) 1985-12-27
NL191793B (nl) 1996-04-01
US4100274A (en) 1978-07-11
AT365562B (de) 1982-01-25
PL104362B1 (pl) 1979-08-31
NL7705130A (nl) 1977-11-15
SE437837B (sv) 1985-03-18
FR2351092B1 (enExample) 1980-02-22
NL970002I2 (nl) 1997-05-01
FI64139C (fi) 1983-10-10
CH629475A5 (de) 1982-04-30
NO771644L (no) 1977-11-14
DE2720245A1 (de) 1977-11-24
IE44426L (en) 1977-11-11
SU910116A3 (ru) 1982-02-28
DK149596C (da) 1987-01-05
AU2468177A (en) 1978-11-02
NO147304C (no) 1983-03-16
JPS52136172A (en) 1977-11-14
FR2351092A1 (fr) 1977-12-09
NO147304B (no) 1982-12-06
ATA335877A (de) 1985-05-15
DE2720245C2 (de) 1986-09-25
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JPS6113480B2 (enExample) 1986-04-14
NO149586C (no) 1984-05-16

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