FR2665444B1 - Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. - Google Patents

Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.

Info

Publication number
FR2665444B1
FR2665444B1 FR9010036A FR9010036A FR2665444B1 FR 2665444 B1 FR2665444 B1 FR 2665444B1 FR 9010036 A FR9010036 A FR 9010036A FR 9010036 A FR9010036 A FR 9010036A FR 2665444 B1 FR2665444 B1 FR 2665444B1
Authority
FR
France
Prior art keywords
alkyl
opt
substd
phenyl
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9010036A
Other languages
English (en)
French (fr)
Other versions
FR2665444A1 (fr
Inventor
Gubin Jean
Lucchetti Jean
Inion Henri
Chatelain Pierre
Rosseels Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR9010036A priority Critical patent/FR2665444B1/fr
Priority to IE259591A priority patent/IE912595A1/en
Priority to CA002047773A priority patent/CA2047773C/en
Priority to TW080105820A priority patent/TW199095B/zh
Priority to US07/736,580 priority patent/US5223510A/en
Priority to ZA915934A priority patent/ZA915934B/xx
Priority to IL9899191A priority patent/IL98991A/en
Priority to AU81428/91A priority patent/AU648569C/en
Priority to MYPI91001385A priority patent/MY107655A/en
Priority to NZ239232A priority patent/NZ239232A/xx
Priority to FI913704A priority patent/FI114914B/fi
Priority to BR919103354A priority patent/BR9103354A/pt
Priority to PL91291334A priority patent/PL168044B1/pl
Priority to MA22528A priority patent/MA22249A1/fr
Priority to SK2427-91A priority patent/SK283527B6/sk
Priority to OA60058A priority patent/OA09513A/fr
Priority to NO913033A priority patent/NO179042C/no
Priority to SU5001351/04A priority patent/RU2095357C1/ru
Priority to YU134891A priority patent/YU48714B/sh
Priority to JP3195431A priority patent/JP2795759B2/ja
Priority to PT98576A priority patent/PT98576B/pt
Priority to CS19912427A priority patent/CZ288527B6/cs
Priority to ES91402201T priority patent/ES2096639T3/es
Priority to KR1019910013726A priority patent/KR100190673B1/ko
Priority to SG1996007597A priority patent/SG49205A1/en
Priority to AT91402201T priority patent/ATE145645T1/de
Priority to TNTNSN91070A priority patent/TNSN91070A1/fr
Priority to DK91402201.7T priority patent/DK0471609T3/da
Priority to HU610/91A priority patent/HU218271B/hu
Priority to EP91402201A priority patent/EP0471609B1/fr
Priority to DE69123304T priority patent/DE69123304T2/de
Publication of FR2665444A1 publication Critical patent/FR2665444A1/fr
Application granted granted Critical
Publication of FR2665444B1 publication Critical patent/FR2665444B1/fr
Priority to HU95P/P00633P priority patent/HU211656A9/hu
Priority to GR970400278T priority patent/GR3022593T3/el
Priority to HK97101577A priority patent/HK1000108A1/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
FR9010036A 1990-08-06 1990-08-06 Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. Expired - Lifetime FR2665444B1 (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
FR9010036A FR2665444B1 (fr) 1990-08-06 1990-08-06 Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
IE259591A IE912595A1 (en) 1990-08-06 1991-07-23 Derivatives of benzofuran, benzothiophene, indole and¹indolizine, process for their preparation as well as the¹compositions containing them
CA002047773A CA2047773C (en) 1990-08-06 1991-07-24 Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
TW080105820A TW199095B (cg-RX-API-DMAC7.html) 1990-08-06 1991-07-26
US07/736,580 US5223510A (en) 1990-08-06 1991-07-26 Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and compositions containing them
ZA915934A ZA915934B (en) 1990-08-06 1991-07-29 Derivatives of benzofuran,benzothiophene,indole and indolizine,process for their preparation and the compositions containing them
IL9899191A IL98991A (en) 1990-08-06 1991-07-29 Derivatives of benzofuran benzothiophene indole and indolizine their preparation and pharmaceutical compositions containing them
AU81428/91A AU648569C (en) 1990-08-06 1991-07-30 Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
MYPI91001385A MY107655A (en) 1990-08-06 1991-07-31 Derivatives of benzofuran,benzothiophene,indole and indolizine,process for their preparation as well as the compositions containing them
FI913704A FI114914B (fi) 1990-08-06 1991-08-02 Menetelmä terapeuttisesti käyttökelpoisten bentsofuraani-, bentsotiofeeni-, indoli- tai indolitsiinijohdannaisten valmistamiseksi
NZ239232A NZ239232A (en) 1990-08-06 1991-08-02 Benzofuran, benzothiophene, indole, indolizine derivatives and pharmaceutical compositions
JP3195431A JP2795759B2 (ja) 1990-08-06 1991-08-05 ベンゾフラン、ベンゾチオフェン、インドールおよびインドリジン誘導体、製法および組成物
MA22528A MA22249A1 (fr) 1990-08-06 1991-08-05 Procede de preparation de derives de benzofuranne, benzothiophene indole ou indolizine ainsi que des compositions les contenant
SK2427-91A SK283527B6 (sk) 1990-08-06 1991-08-05 Deriváty benzofuránu, benzothiofénu, indolu alebo indolizínu, spôsoby ich prípravy ako i prípravky, ktoré tieto látky obsahujú
OA60058A OA09513A (fr) 1990-08-06 1991-08-05 Dérivés de benzofuranne benzothiophène indole ou indolizine leur procédé de préparation ainsi que les compositions les contenant
NO913033A NO179042C (no) 1990-08-06 1991-08-05 Analogifremgangsmåte for fremstilling av derivater av benzofuran, benzotiofen, indol eller indolizin
SU5001351/04A RU2095357C1 (ru) 1990-08-06 1991-08-05 Производные бензофурана, бензотиофена, индола или индолизина, способы их получения, композиция, обладающая антиаритмическим действием
YU134891A YU48714B (sh) 1990-08-06 1991-08-05 Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje
BR919103354A BR9103354A (pt) 1990-08-06 1991-08-05 Derivados de benzofurano,benzotiofeno,indol ou indolizina,processo para sua preparacao,composicao farmaceuticas ou veterinarias,e utilizacao de pelo menos um tal derivado
PT98576A PT98576B (pt) 1990-08-06 1991-08-05 Processo de preparacao de derivados de benzofurano benzotiofeno indole ou indolizina assim como das composicoes que os contem
CS19912427A CZ288527B6 (cs) 1990-08-06 1991-08-05 Derivát benzofuranu, benzothiofenu, indolu nebo indolizinu, způsob jejich přípravy, jejich použití a farmaceutický prostředek, který je obsahuje
PL91291334A PL168044B1 (pl) 1990-08-06 1991-08-05 Sposób wytwarzania pochodnych benzofuranu, benzotiofenu, indolu lub indolizyny PL PL PL
SG1996007597A SG49205A1 (en) 1990-08-06 1991-08-06 Derivatives of benzofuran benzothiophene indole and indolizine process for their preparation as well as the compositions containing them
ES91402201T ES2096639T3 (es) 1990-08-06 1991-08-06 Derivados de benzofurano, benzotiofeno, indol o indolizina, su procedimiento de preparacion, asi como las composiciones que los contienen.
AT91402201T ATE145645T1 (de) 1990-08-06 1991-08-06 Benzofuranderivate, benzothiophene, indole oder indolizine, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen
TNTNSN91070A TNSN91070A1 (fr) 1990-08-06 1991-08-06 Procede de preparation de derives de benzofuranne, bentothiophene indole ou indolizine ainsi que des compositions les contenant.
DK91402201.7T DK0471609T3 (da) 1990-08-06 1991-08-06 Derivater af benzofuran, benzothiophen, indol eller indolizin, fremgangsmåde til fremstilling af derivaterne og sammenætninger indeholdende disse
HU610/91A HU218271B (en) 1990-08-06 1991-08-06 Process for producing benzofuran, benzothiophene, indole and indolizine derivatives and pharmaceutical compositions comprising the same
EP91402201A EP0471609B1 (fr) 1990-08-06 1991-08-06 Dérivés de Benzofuranne, Benzothiophène, Indole ou Indolizine, leur procédé de préparation ainsi que les compositions les contenant
DE69123304T DE69123304T2 (de) 1990-08-06 1991-08-06 Benzofuranderivate, Benzothiophene, Indole oder Indolizine, Verfahren zu ihrer Herstellung und diese enthaltende Zusammensetzungen
KR1019910013726A KR100190673B1 (ko) 1990-08-06 1991-08-06 벤조푸란, 벤조 티오펜, 인돌 및 인돌리진의 유도체, 그것들의 제조방법 및 그것들을 함유한 조성물
HU95P/P00633P HU211656A9 (en) 1990-08-06 1995-06-30 Derivatives of benzofurane, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
GR970400278T GR3022593T3 (en) 1990-08-06 1997-02-19 Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them
HK97101577A HK1000108A1 (en) 1990-08-06 1997-07-18 Benzofuran derivatives, benzothiophenes, indoles or indolizines, process for production and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9010036A FR2665444B1 (fr) 1990-08-06 1990-08-06 Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.

Publications (2)

Publication Number Publication Date
FR2665444A1 FR2665444A1 (fr) 1992-02-07
FR2665444B1 true FR2665444B1 (fr) 1992-11-27

Family

ID=9399463

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9010036A Expired - Lifetime FR2665444B1 (fr) 1990-08-06 1990-08-06 Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.

Country Status (32)

Country Link
US (1) US5223510A (cg-RX-API-DMAC7.html)
EP (1) EP0471609B1 (cg-RX-API-DMAC7.html)
JP (1) JP2795759B2 (cg-RX-API-DMAC7.html)
KR (1) KR100190673B1 (cg-RX-API-DMAC7.html)
AT (1) ATE145645T1 (cg-RX-API-DMAC7.html)
BR (1) BR9103354A (cg-RX-API-DMAC7.html)
CA (1) CA2047773C (cg-RX-API-DMAC7.html)
CZ (1) CZ288527B6 (cg-RX-API-DMAC7.html)
DE (1) DE69123304T2 (cg-RX-API-DMAC7.html)
DK (1) DK0471609T3 (cg-RX-API-DMAC7.html)
ES (1) ES2096639T3 (cg-RX-API-DMAC7.html)
FI (1) FI114914B (cg-RX-API-DMAC7.html)
FR (1) FR2665444B1 (cg-RX-API-DMAC7.html)
GR (1) GR3022593T3 (cg-RX-API-DMAC7.html)
HK (1) HK1000108A1 (cg-RX-API-DMAC7.html)
HU (2) HU218271B (cg-RX-API-DMAC7.html)
IE (1) IE912595A1 (cg-RX-API-DMAC7.html)
IL (1) IL98991A (cg-RX-API-DMAC7.html)
MA (1) MA22249A1 (cg-RX-API-DMAC7.html)
MY (1) MY107655A (cg-RX-API-DMAC7.html)
NO (1) NO179042C (cg-RX-API-DMAC7.html)
NZ (1) NZ239232A (cg-RX-API-DMAC7.html)
OA (1) OA09513A (cg-RX-API-DMAC7.html)
PL (1) PL168044B1 (cg-RX-API-DMAC7.html)
PT (1) PT98576B (cg-RX-API-DMAC7.html)
RU (1) RU2095357C1 (cg-RX-API-DMAC7.html)
SG (1) SG49205A1 (cg-RX-API-DMAC7.html)
SK (1) SK283527B6 (cg-RX-API-DMAC7.html)
TN (1) TNSN91070A1 (cg-RX-API-DMAC7.html)
TW (1) TW199095B (cg-RX-API-DMAC7.html)
YU (1) YU48714B (cg-RX-API-DMAC7.html)
ZA (1) ZA915934B (cg-RX-API-DMAC7.html)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114566T3 (es) * 1991-08-09 1998-06-01 Nycomed Innovation Ab Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear.
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
DE4420925A1 (de) * 1994-06-16 1995-12-21 Bayer Ag Verfahren zur Herstellung von Benzthiophenderivaten
US5596106A (en) * 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5856339A (en) * 1995-02-28 1999-01-05 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5998441A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5977093A (en) * 1995-02-28 1999-11-02 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5856340A (en) * 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US5998401A (en) 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
US5919800A (en) * 1995-02-28 1999-07-06 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
WO1996028156A1 (en) * 1995-03-13 1996-09-19 Eli Lilly And Company Novel benzothiophene compounds and methods
FR2735365B1 (fr) * 1995-06-14 1997-09-05 Sanofi Sa Utilisation d'un antagoniste de l'angiotensine ii et d'un derive du benzofurane pour la preparation d'un medicament utile dans le traitement des affections cardiovasculaires
US6432982B1 (en) * 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
FR2746013B1 (fr) * 1996-03-18 1998-05-29 Sanofi Sa Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus
AU5258696A (en) * 1996-03-19 1997-10-10 Eli Lilly And Company Synthesis of 3-{4-(2-aminoethoxy)-benzoyl}-2-aryl-6-hydroxy-benzo{b}thiop henes
US5958969A (en) * 1996-10-10 1999-09-28 Eli Lilly And Company Benzo b!thiophene compounds, intermediates, formulations, and methods
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
JP2001522372A (ja) * 1997-04-30 2001-11-13 イーライ・リリー・アンド・カンパニー ベンゾチオフェンの製造方法
AU7261498A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and processes for preparing benzo{b}thiophenes
CA2287918A1 (en) * 1997-04-30 1998-11-05 John Mcneill Mcgill Iii A regioselective alkylation process for preparing substituted benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
JP2001524114A (ja) * 1997-04-30 2001-11-27 イーライ・リリー・アンド・カンパニー ベンゾ［ｂ］チオフェン類の製造における中間体および方法
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
FR2764800B1 (fr) 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
EP1075470B1 (en) * 1998-05-04 2003-08-13 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US6391899B1 (en) * 1998-07-17 2002-05-21 North Shore—Long Island Jewish Research Institute Compounds and compositions for treating tissue ischemia
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
EP1223808B1 (en) 1999-10-18 2007-03-07 The University Of Connecticut Peripheral cannabinoid receptor (cb2) selective ligands
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
WO2001028557A1 (en) * 1999-10-18 2001-04-26 University Of Connecticut Cannabimimetic indole derivatives
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
FR2800064B1 (fr) * 1999-10-21 2002-10-11 Rhodia Chimie Sa Procede de preparation d'un compose de type benzofurane ou benzothiophene
FR2809397B1 (fr) * 2000-05-24 2002-07-19 Rhodia Chimie Sa Procede de preparation d'un compose de type benzofuranne ou benzothiophene
CN1200935C (zh) 1999-10-21 2005-05-11 罗狄亚化学公司 制备苯并呋喃或苯并噻吩类型化合物的方法
FR2800067B1 (fr) * 1999-10-21 2004-12-17 Rhodia Chimie Sa Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations
FR2803846B1 (fr) * 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation
FR2813308B1 (fr) * 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2813307B1 (fr) * 2000-08-23 2002-11-08 Sanofi Synthelabo Aminoalkenylbenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813306B1 (fr) * 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
WO2002041889A2 (en) * 2000-11-24 2002-05-30 Smithkline Beecham P.L.C. Indolsulfonyl compounds useful in the treatment of cns disorders
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
DE60237431D1 (de) 2001-01-29 2010-10-07 Univ Connecticut Rezeptor-selektive cannabimimetische aminoalkylindole
DE10129119B4 (de) * 2001-06-16 2007-10-04 Schwarz Pharma Ag Kristalline Salze von Benzoylbenzofuran-Derivaten, insbesondere von[2-(4-{1-[2-((S)-sec.-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]-methanoyl}-2,6-diiod-phenoxy)-ethyl]-diethylamino und [2-(4-{1-[(3-Methyl-2-(S)-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]- methanoyl}-2,6-diiodphenoxy)-ethyl]-diethylamino, deren Verwendung und Herstellung sowie diese Salze enthaltende Arzneimittel
ATE527247T1 (de) 2001-07-05 2011-10-15 Takeda Pharmaceutical Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
CA2452881C (en) * 2001-07-13 2012-03-06 University Of Connecticut Novel bicyclic and tricyclic cannabinoids
WO2003035005A2 (en) * 2001-10-26 2003-05-01 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
IL146389A0 (en) * 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833262A1 (fr) * 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de monosulfonylation d'un compose de type aminobenzofuranne ou aminobenzothiophene
FR2833263A1 (fr) * 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de preparation d'un compose de type aminobenzofuranne ou aminobenzothiophene
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
US7183313B2 (en) 2002-08-23 2007-02-27 University Of Connecticut Keto cannabinoids with therapeutic indications
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
AU2004249529A1 (en) * 2003-06-23 2004-12-29 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
ES2222827B1 (es) * 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
FR2859997B1 (fr) * 2003-09-18 2006-02-03 Sanofi Synthelabo Nouveaux derives d'indolizine 1,2,3,6,7,8 substituee, inhibiteurs des fgfs, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2864536B1 (fr) 2003-12-24 2006-03-17 Clariant France Sa Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
FR2893616B1 (fr) * 2005-11-23 2008-01-04 Sanofi Aventis Sa Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant
GB0611210D0 (en) * 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
US20090076137A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched dronedarone
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
CN102065855A (zh) 2008-04-17 2011-05-18 赛诺菲-安万特 决奈达隆在制备用于预防因心血管疾病住院或死亡的药物中的用途
FR2930149B1 (fr) * 2008-04-17 2011-02-18 Sanofi Aventis Association de dronedarone avec au moins un diuretique, son application en therapeutique
EP2116239A1 (en) * 2008-04-29 2009-11-11 Sanofi-Aventis Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment
EP2153830A1 (en) 2008-08-07 2010-02-17 Sanofi-Aventis Use of dronedarone for the preparation of a medicament intended for the prevention of stroke or transient ischemic attack
EP2356100A1 (en) * 2008-10-02 2011-08-17 Cambrex Karlskoga AB New process for preparing diketones and medicaments
JP2012505163A (ja) * 2008-10-10 2012-03-01 ロンザ リミテッド ２−アルキル−３−アロイル−５−ニトロ−ベンゾフランの調製方法
EP2246341A1 (en) 2009-01-23 2010-11-03 Lonza Ltd. Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
PL2417099T3 (pl) * 2009-04-08 2016-06-30 Cambrex Karlskoga Ab Nowy sposób wytwarzania hydroksyloamin i leki
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
TW201111354A (en) * 2009-05-27 2011-04-01 Sanofi Aventis Process for the production of Dronedarone intermediates
CN101993427B (zh) * 2009-08-26 2012-10-10 成都伊诺达博医药科技有限公司 一种制备决奈达隆的方法
HUP0900759A2 (en) * 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
EP2354132A2 (en) 2010-02-05 2011-08-10 Sanofi Crystallized form of dronedarone base
WO2011099010A1 (en) * 2010-02-10 2011-08-18 Mapi Pharma Holdings (Cyprus) Limited Preparation of benzofurans and use thereof as synthetic intermediates
FR2957079B1 (fr) * 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
EP2371808A1 (en) 2010-03-08 2011-10-05 Ratiopharm GmbH Process for preparing dronedarone
EP2371824A1 (en) 2010-03-08 2011-10-05 Ratiopharm GmbH Crystalline dronedarone salts
EP2364703A1 (en) 2010-03-12 2011-09-14 Sanofi Use of dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for administration shortly after amiodarone discontinuation
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958289B1 (fr) * 2010-03-30 2012-06-15 Sanofi Aventis Procede de preparation de derives de 3-ceto-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
WO2011135582A2 (en) 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
WO2011135581A2 (en) 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
EP2386300A1 (en) 2010-05-11 2011-11-16 Sanofi Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality in patients having a first recurrence of atrial fibrillation or atrial flutter
EP2387997A1 (en) 2010-05-18 2011-11-23 Sanofi Use of dronedarone for the preparation of a medicament for the prevention of cardiovascular events in patients who developed permanent atrial fibrillation throughout the period the dronedarone is administered
TW201200131A (en) 2010-05-13 2012-01-01 Sanofi Aventis Use of dronedarone for the preparation of a medicament for the prevention of cardiovacular hospitalizations or death or cardiovascular events in patients with premanent atrial fibrillation
EP2387996A1 (en) 2010-05-17 2011-11-23 Sanofi Use of dronedarone for the preparation of a medicament for the prevention of cardiovascular events in patients with permanent atrial fibrillation
CN102276561A (zh) * 2010-06-09 2011-12-14 江苏恒瑞医药股份有限公司 决奈达隆及其盐的制备方法
WO2011158178A1 (en) 2010-06-14 2011-12-22 Sanofi Use of dronedarone for the preparation of a medicament for use in the treatment of patients
HUP1000330A2 (en) * 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
WO2012004658A2 (en) 2010-07-09 2012-01-12 Frichem Private Limited Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
WO2012007959A1 (en) * 2010-07-16 2012-01-19 Glenmark Generics Limited Process for preparing dronedarone
FR2962731B1 (fr) * 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
EP2431033A1 (en) 2010-08-10 2012-03-21 Sanofi Dronedarone for preventing cardiovascular hospitalization or mortality in patients with lone atrial fibrillation
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) * 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
WO2012013750A1 (en) 2010-07-29 2012-02-02 Sanofi Use of dronedarone for the preparation of a medicament for the hospitalization burden in patient with atrial fibrillation
WO2012020377A1 (en) * 2010-08-11 2012-02-16 Sanofi Use of dronedarone for the preparation of a medicament for rhythm- and rate-controlling in patients with atrial fibrillation
JP2013535516A (ja) 2010-08-17 2013-09-12 ルピン・リミテッド ドロネダロンの制御放出製剤
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
EP2428511A1 (en) 2010-09-09 2012-03-14 USV Limited Synthesis of dronedarone and salts thereof
CN101948455B (zh) * 2010-10-18 2012-11-14 山东邹平大展新材料有限公司 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法
EP2447256A1 (en) 2010-10-21 2012-05-02 Laboratorios Lesvi, S.L. Process for obtaining dronedarone
WO2012061951A1 (zh) * 2010-11-08 2012-05-18 山东邹平大展新材料有限公司 一种盐酸决奈达隆的制备方法
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
FR2967412B1 (fr) * 2010-11-17 2012-12-14 Sanofi Aventis Nouveaux derives d'indolizine, leur preparation et leur application en therapeutique
EP2469281A1 (en) 2010-12-24 2012-06-27 Sanofi Method for managing the risk of liver injury in patients receiving treatment with dronedarone
EP2476417A1 (en) 2011-01-14 2012-07-18 Sanofi Method for managing the risk of liver injury in patients receiving treatment with dronedarone
JP2013544870A (ja) 2010-12-10 2013-12-19 サノフイ 肝障害のリスク管理に使用する薬剤の調製のためのドロネダロンの使用
EP2468175A1 (en) 2010-12-24 2012-06-27 Sanofi Method for managing the risk of liver injury in patients receiving treatment with dronedarone
EP2469280A1 (en) 2010-12-24 2012-06-27 Sanofi Method for managing the risk of liver injury in patients receiving treatment with dronedarone
CN102180847A (zh) * 2010-12-31 2011-09-14 江苏万全特创医药生物技术有限公司 一种决奈达隆新关键中间体的制备方法
CN102180848A (zh) * 2010-12-31 2011-09-14 江苏万全特创医药生物技术有限公司 一种新型抗心律失常药决奈达隆的制备方法
CN102070577B (zh) * 2011-01-19 2016-03-09 上海医药工业研究院 2-正丁基-3-(4-取代丙氧基苯甲酰基)-5-取代氨基苯并呋喃及其应用
CN102070578B (zh) * 2011-01-19 2015-10-14 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-烷酰基氨基苯并呋喃的制备方法
CN102070581B (zh) * 2011-01-19 2015-11-25 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-氨基苯并呋喃的制备
CN102070580B (zh) * 2011-01-19 2015-05-20 上海医药工业研究院 2-正丁基-3-(4-(3-二正丁基氨基丙氧基)苯甲酰基)-5-取代氨基苯并呋喃的制备
CN102108070B (zh) * 2011-01-26 2013-05-22 上海优贝德生物医药有限公司 5-氨基苯并呋喃-2-甲酸酯及其中间体的制备方法
CN102153531B (zh) * 2011-01-31 2013-05-22 金春华 一种用于制备决奈达隆的中间体及其制备方法
CN102653530A (zh) * 2011-03-04 2012-09-05 浙江省医学科学院 一种苯并呋喃衍生物的制备方法及其应用
WO2012120544A2 (en) 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
CN102690249B (zh) * 2011-03-22 2014-09-17 江苏康缘药业股份有限公司 一种决奈达隆的制备方法
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100166A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
WO2012153225A1 (en) * 2011-05-09 2012-11-15 Alembic Pharmaceuticals Limited Improved processes for obtaining high purity of dronedarone hydrochloride
CN102321057A (zh) * 2011-06-02 2012-01-18 北京阳光诺和药物研究有限公司 N-取代的甲磺酰基胺基-苯并呋喃衍生物、其制备方法及用途
WO2012171135A1 (zh) * 2011-06-13 2012-12-20 山东邹平大展新材料有限公司 一种苯并呋喃化合物、其制备方法及用途
EP2543362A1 (en) * 2011-07-07 2013-01-09 Sanofi Sustained release pharmaceutical oral solid dosage form of dronedarone or one of its pharmaceutically acceptable salts
EP2543361A1 (en) * 2011-07-07 2013-01-09 Sanofi Sustained release pharmaceutical oral solid dosage forms of dronedarone or one of its pharmaceutically acceptable salts
FR2977495B1 (fr) 2011-07-07 2014-03-07 Sanofi Sa Composition pharmaceutique et forme galenique solide a haute teneur en dronedarone et son procede de preparation
US20130116586A1 (en) 2011-07-07 2013-05-09 Sanofi Use of dronedarone or a pharmaceutically acceptable salt thereof for the preparation of a drug for the prevention of atrial fibrillation
EP2543363A1 (en) * 2011-07-07 2013-01-09 Sanofi Sustained release pharmaceutical oral solid dosage forms of dronedarone or one of its pharmaceutically acceptable salts
WO2013014478A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
WO2013014480A1 (en) 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound
WO2013014479A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
WO2013024411A1 (en) 2011-08-12 2013-02-21 Lupin Limited Co-milled formulation of dronedarone
ITMI20111672A1 (it) * 2011-09-16 2013-03-17 Olon Spa Metodo efficiente per la preparazione di dronedarone cloridrato
CN102382087A (zh) * 2011-10-20 2012-03-21 南京工业大学 一种盐酸决奈达隆的制备方法
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
CA2864858A1 (en) 2012-02-20 2013-08-29 Lupin Limited Bilayer tablet of dronedarone
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013182423A1 (en) 2012-05-22 2013-12-12 Sanofi Dronedarone for use in leishmaniasis, formulations and associations for use in leishmaniasis.
CN102718735B (zh) * 2012-05-28 2014-04-23 沈阳药科大学 2-乙基-3-（4-羟基）苯甲酰基苯并呋喃类化合物、组合物及其制备方法
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN102731452A (zh) * 2012-07-25 2012-10-17 中国药科大学 一种维拉唑酮中间体的制备方法
WO2014203058A1 (en) 2013-06-17 2014-12-24 Aurobindo Pharma Limited An improved process for preparing benzofuran compound
TW201536763A (zh) * 2013-08-27 2015-10-01 Gilead Sciences Inc 製備決奈達隆或其鹽類之製程
CN105315245B (zh) * 2014-06-16 2018-10-12 华润赛科药业有限责任公司 苯并呋喃类衍生物、其制备方法和应用
WO2016120299A1 (en) 2015-01-28 2016-08-04 Sanovel Ilac Sanayi Ve Ticaret A.S. Orally disintegrating formulations of dronedarone
TR201501970A2 (en) 2015-02-19 2016-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical combinations of dronedarone.
TR201502223A2 (tr) 2015-02-25 2016-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dronedaron ve dabigatranın farmasötik kombinasyonları.
TR201503136A2 (tr) 2015-03-16 2016-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dronedaron ve esansiyel yağ asitlerinin farmasötik kompozisyonları.
CN104844498B (zh) * 2015-04-07 2017-10-20 陕西师范大学 一种3‑取代吲哚甲胺衍生物的制备方法
EP3334713B1 (en) 2015-08-12 2021-07-21 Memorial Sloan Kettering Cancer Center Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases
CN105753822B (zh) * 2016-02-24 2018-04-03 华润赛科药业有限责任公司 一种苯并呋喃类衍生物、其制备方法和应用
CN106432159B (zh) * 2016-07-14 2019-07-12 华润赛科药业有限责任公司 一种新型苯并呋喃类衍生物、其制备方法和应用
CN113200947B (zh) * 2021-05-11 2022-11-15 广州医科大学 苯并呋喃类化合物及其应用
JP7684660B2 (ja) * 2022-04-28 2025-05-28 国立大学法人富山大学 トランスサイレチンアミロイドーシス治療用医薬組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
US4117128A (en) * 1976-08-03 1978-09-26 Smithkline Corporation Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity
US4520026A (en) * 1981-02-06 1985-05-28 S. A. Labaz N.V. Indolizine derivatives and use as cardiovascular agents
EP0094744A1 (en) * 1982-04-23 1983-11-23 Beecham Group Plc Azabicyclobenzamides, their preparation and their pharmaceutical compositions
US4567270A (en) * 1984-09-17 1986-01-28 G. D. Searle & Co. Hexahydroindolizinones useful for treating cardiac arrhythmia, thrombotic disorders in mammals
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4831156A (en) * 1987-09-30 1989-05-16 The University Of Tennessee Research Corp. 3-substituted 2-alkyl indole derivatives
AU2543388A (en) * 1987-09-30 1989-04-18 University Of Tennessee Research Corporation, The Certain 3-substituted 2-alkyl benzothiophene derivatives
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2633622B1 (fr) * 1988-07-04 1991-05-17 Sanofi Sa Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2642755B1 (cg-RX-API-DMAC7.html) * 1989-02-07 1993-11-05 Sanofi

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IE912595A1 (en) 1992-02-12
HU218271B (en) 2000-07-28
YU48714B (sh) 1999-07-28
KR100190673B1 (ko) 1999-06-01
MY107655A (en) 1996-05-30
DE69123304D1 (de) 1997-01-09
PT98576B (pt) 1999-01-29
TNSN91070A1 (fr) 1992-10-25
CZ288527B6 (cs) 2001-07-11
NO179042C (no) 1996-07-24
GR3022593T3 (en) 1997-05-31
BR9103354A (pt) 1992-05-05
CA2047773C (en) 2000-09-12
EP0471609A1 (fr) 1992-02-19
NO913033D0 (no) 1991-08-05
HU912610D0 (en) 1992-01-28
FR2665444A1 (fr) 1992-02-07
OA09513A (fr) 1992-11-15
FI114914B (fi) 2005-01-31
PL168044B1 (pl) 1995-12-30
HUT62280A (en) 1993-04-28
TW199095B (cg-RX-API-DMAC7.html) 1993-02-01
DE69123304T2 (de) 1997-06-12
KR920004371A (ko) 1992-03-27
US5223510A (en) 1993-06-29
ATE145645T1 (de) 1996-12-15
MA22249A1 (fr) 1992-04-01
CA2047773A1 (en) 1992-02-07
HU211656A9 (en) 1995-12-28
PT98576A (pt) 1992-06-30
IL98991A (en) 1995-12-08
RU2095357C1 (ru) 1997-11-10
ZA915934B (en) 1993-03-31
PL291334A1 (en) 1992-10-19
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NO179042B (no) 1996-04-15
AU648569B2 (en) 1994-04-28
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NO913033L (no) 1992-02-07
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