FR21C1008I1 - Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale - Google Patents
Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene viraleInfo
- Publication number
- FR21C1008I1 FR21C1008I1 FR21C1008C FR21C1008C FR21C1008I1 FR 21C1008 I1 FR21C1008 I1 FR 21C1008I1 FR 21C1008 C FR21C1008 C FR 21C1008C FR 21C1008 C FR21C1008 C FR 21C1008C FR 21C1008 I1 FR21C1008 I1 FR 21C1008I1
- Authority
- FR
- France
- Prior art keywords
- wild
- modified mrna
- coding
- increased
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108020004999 messenger RNA Proteins 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 108020004705 Codon Proteins 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000648 anti-parkinson Effects 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 229960001438 immunostimulant agent Drugs 0.000 abstract 1
- 239000003022 immunostimulating agent Substances 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 239000002423 protozoacide Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000012873 virucide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1735—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001189—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001192—Glycoprotein 100 [Gp100]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001196—Fusion proteins originating from gene translocation in cancer cells
- A61K39/001197—Breakpoint cluster region-abelson tyrosine kinase [BCR-ABL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/336—Modified G
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10127283 | 2001-06-05 | ||
EP02732752A EP1392341B1 (fr) | 2001-06-05 | 2002-06-05 | Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes |
EP05004938A EP1604688B1 (fr) | 2001-06-05 | 2002-06-05 | ARNm stabilisé codant pour un antigène tumoral avec un contenu G/C augmenté |
Publications (1)
Publication Number | Publication Date |
---|---|
FR21C1008I1 true FR21C1008I1 (fr) | 2021-03-26 |
Family
ID=7687266
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR21C1007C Active FR21C1007I1 (fr) | 2001-06-05 | 2021-02-15 | Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale |
FR21C1008C Active FR21C1008I1 (fr) | 2001-06-05 | 2021-02-15 | Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR21C1007C Active FR21C1007I1 (fr) | 2001-06-05 | 2021-02-15 | Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale |
Country Status (11)
Country | Link |
---|---|
US (14) | US10188748B2 (fr) |
EP (8) | EP1857122B1 (fr) |
AT (5) | ATE490267T1 (fr) |
AU (2) | AU2007203181B2 (fr) |
CA (2) | CA2457959C (fr) |
DE (5) | DE50214200D1 (fr) |
DK (1) | DK1857122T3 (fr) |
ES (5) | ES2340499T3 (fr) |
FR (2) | FR21C1007I1 (fr) |
PT (1) | PT1857122E (fr) |
WO (1) | WO2002098443A2 (fr) |
Families Citing this family (386)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE50214200D1 (de) | 2001-06-05 | 2010-03-25 | Curevac Gmbh | Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt |
DE10162480A1 (de) * | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
FR2845918A1 (fr) * | 2002-10-16 | 2004-04-23 | Pasteur Institut | Preparations immunogenes et vaccinantes a base d'arn |
WO2003059381A2 (fr) * | 2002-01-18 | 2003-07-24 | Curevac Gmbh | Préparations immunogènes et vaccins à base d'arn |
US7901708B2 (en) | 2002-06-28 | 2011-03-08 | Protiva Biotherapeutics, Inc. | Liposomal apparatus and manufacturing methods |
DE10229872A1 (de) * | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
AU2002953015A0 (en) * | 2002-12-02 | 2002-12-12 | Women's And Children's Hospital | Modified lacz gene |
DE10335833A1 (de) * | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
AU2005327517B2 (en) * | 2004-06-30 | 2011-05-26 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
DE102004035227A1 (de) * | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
ATE449845T1 (de) * | 2004-09-17 | 2009-12-15 | Pasteur Institut | Verfahren zur modulation der entwicklung eines durch eine nukleinsäuresequenz kodierten polypeptids |
DE102005023170A1 (de) * | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimierte Formulierung für mRNA |
ES2735531T3 (es) | 2005-08-23 | 2019-12-19 | Univ Pennsylvania | ARN que contiene nucleósidos modificados y métodos de uso del mismo |
CA2622584C (fr) | 2005-09-15 | 2015-08-11 | Novosom Ag | Ameliorations apportees a des liposomes amphoteres |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
JP2010507361A (ja) | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸 |
WO2008105814A2 (fr) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Dispositif à écoulement latéral miniaturisé pour détection rapide et sensible de protéines ou d'acides nucléiques |
US8980561B1 (en) * | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
EP2094238A2 (fr) | 2006-10-13 | 2009-09-02 | Novosom AG | Améliorations de ou relatives a des liposomes amphotères |
DE102006051516A1 (de) * | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
DE102007029471A1 (de) | 2007-06-20 | 2008-12-24 | Novosom Ag | Neue fakultativ kationische Sterole |
WO2009030254A1 (fr) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes d'arn et de peptides cationiques pour transfection et immunostimulation |
WO2009039198A2 (fr) * | 2007-09-17 | 2009-03-26 | The Trustees Of The University Of Pennsylvania | Production d'arnm hyperstables |
WO2009046739A1 (fr) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition pour traiter le cancer de la prostate (pca) |
EP3222290A1 (fr) | 2007-10-09 | 2017-09-27 | CureVac AG | Composition pour traiter le cancer de la prostate (pca) |
WO2009046738A1 (fr) * | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition pour traiter le cancer du poumon, notamment les cancers du poumon non à petites cellules (nsclc) |
MX2010006019A (es) * | 2007-12-05 | 2010-08-04 | Eyegate Pharma S A S | Metodos para administrar acido ribonucleico pequeño de interferencia (arnsi) mediante iontoforesis. |
US9226959B2 (en) | 2008-01-31 | 2016-01-05 | Curevac Ag | Nucleic acids comprising formula (NuGlXmGnNv)a and derivatives thereof as immunostimulating agent/adjuvant |
WO2009127230A1 (fr) * | 2008-04-16 | 2009-10-22 | Curevac Gmbh | Arn(m) modifié pour supprimer ou éviter une réponse immunostimulante et composition immunosuppressive |
EP3067694A1 (fr) | 2008-05-05 | 2016-09-14 | Los Alamos National Security, LLC | Préparation d'échantillons d'acide nucléique à base de flux latéral et régulation d'écoulement de fluide passif |
WO2010037408A1 (fr) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprenant un arnm complexé et un arnm nu pour déclencher ou augmenter une réponse immunostimulante chez un mammifère et utilisations de ladite composition |
CN201397956Y (zh) * | 2009-03-23 | 2010-02-03 | 富士康(昆山)电脑接插件有限公司 | 电连接器组件 |
BR212012000255U2 (pt) | 2009-07-09 | 2015-11-03 | Marina Biotech Inc | lipossomas anfotéricos compreendendo imino lípidos. |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
NZ700688A (en) | 2009-12-01 | 2016-02-26 | Shire Human Genetic Therapies | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
WO2011069529A1 (fr) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Solution contenant du mannose pour la lyophilisation, la transfection et/ou l'injection d'acides nucléiques |
WO2011069528A1 (fr) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Lyophilisation d'acides nucléiques dans des solutions contenant du lactate |
DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
RS63817B1 (sr) | 2010-07-06 | 2023-01-31 | Glaxosmithkline Biologicals Sa | Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk |
WO2012006369A2 (fr) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation de grands mammifères à l'aide de faibles doses d'arn |
EP2590626B1 (fr) | 2010-07-06 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn |
EP2449113B8 (fr) | 2010-07-30 | 2015-11-25 | CureVac AG | Complexation d'acides nucléiques avec des composants cationiques réticulés par des liaisons disulfure pour la transfection et l'immunostimulation |
US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
WO2012019630A1 (fr) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'une protéine codée |
EP4119155A1 (fr) | 2010-08-31 | 2023-01-18 | GlaxoSmithKline Biologicals S.A. | Liposomes pegylés pour la délivrance d'arn codant pour un immunogène |
HUE058896T2 (hu) | 2010-10-01 | 2022-09-28 | Modernatx Inc | N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai |
TR201903651T4 (tr) * | 2010-10-11 | 2019-04-22 | Glaxosmithkline Biologicals Sa | Antijen uygulama platformları. |
US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
WO2012089225A1 (fr) | 2010-12-29 | 2012-07-05 | Curevac Gmbh | Combinaison de vaccination et d'inhibition de la présentation des antigènes restreinte par le cmh de classe i |
WO2012116715A1 (fr) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination chez des nouveaux-nés et des enfants en bas âge |
WO2012113413A1 (fr) | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Composition de vaccin comprenant des acides nucléiques immunostimulateurs complexés et des antigènes emballés avec des conjugués de polyéthylèneglycol/peptide à liaison disulfure |
WO2012116714A1 (fr) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination chez des patients âgés |
CN103764169B (zh) | 2011-03-31 | 2017-06-13 | 康斯坦策·沙费尔 | 用于非病毒转移核酸的全氟化化合物 |
US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
KR101508670B1 (ko) | 2011-04-20 | 2015-04-07 | 메사 테크 인터내셔널, 인코포레이티드 | 핵산 검출 및 동정을 위한 통합 장치 |
SI3892295T1 (sl) | 2011-05-24 | 2023-09-29 | BioNTech SE | Individualizirana cepiva proti raku |
ME03498B (fr) | 2011-05-24 | 2020-04-20 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Vaccins individualisés pour le cancer |
JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | mRNA送達のための脂質ナノ粒子組成物および方法 |
CA2840989A1 (fr) | 2011-07-06 | 2013-01-10 | Novartis Ag | Compositions de combinaisons immunogenes et utilisations de celles-ci |
JP2014520806A (ja) | 2011-07-06 | 2014-08-25 | ノバルティス アーゲー | Rna分子の送達のための有用なn:p比を有するリポソーム |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
RS62993B1 (sr) | 2011-10-03 | 2022-03-31 | Modernatx Inc | Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe |
CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
WO2013113326A1 (fr) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Composition pharmaceutique comprenant un complexe support polymère - charge et au moins un antigène de protéine ou de peptide |
PL2814962T3 (pl) | 2012-02-15 | 2018-11-30 | Curevac Ag | Kwas nukleinowy zawierający lub kodujący histonowy trzonek-pętlę i sekwencję poli(A) lub sygnał poliadenylacji do zwiększania ekspresji zakodowanego antygenu patogennego |
WO2013120499A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un antigène pathogène codé |
EP3404103B1 (fr) | 2012-02-15 | 2021-03-24 | CureVac AG | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un antigène allergène codé ou d'un autoantigène auto-immun codé |
WO2013120500A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation en vue d'augmenter l'expression d'un antigène tumoral codé |
WO2013120498A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour augmenter l'expression d'un autoantigène auto-immun ou d'un antigène allergène codé |
WO2013120497A1 (fr) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et une séquence poly(a) ou un signal de polyadénylation pour l'augmentation de l'expression d'une protéine thérapeutique codée |
EP3348644B1 (fr) | 2012-02-15 | 2020-02-12 | CureVac AG | Acide nucléique comprenant ou codant pour une tige-boucle d'histone et séquence poly(a) ou signal de polyadénylation pour augmenter l'expression d'une protéine codée |
WO2013143555A1 (fr) | 2012-03-26 | 2013-10-03 | Biontech Ag | Formulation d'arn pour immunothérapie |
MX358706B (es) | 2012-03-27 | 2018-08-31 | Curevac Ag | Moleculas de acido nucleico artificiales que comprenden un top 5´utr. |
EP2831241B1 (fr) | 2012-03-27 | 2017-08-23 | CureVac AG | Molécules d'acide nucléique artificielles pour une expression protéique ou peptidique améliorée |
SG10201607962RA (en) | 2012-03-27 | 2016-11-29 | Curevac Ag | Artificial nucleic acid molecules |
DK3578659T3 (da) | 2012-03-27 | 2024-02-05 | CureVac SE | Kunstige nukelinsyremolekyler til forbedret protein- eller peptidekspression |
JP2015518705A (ja) | 2012-04-02 | 2015-07-06 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
US9649208B2 (en) | 2012-04-13 | 2017-05-16 | Medtronic Vascular, Inc. | Hollow drug-filled stent and method of forming hollow drug-filled stent |
US8998977B2 (en) | 2012-04-13 | 2015-04-07 | Medtronic Vascular, Inc. | Hollow drug-filled stent and method of forming hollow drug-filled stent |
EP3536787A1 (fr) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Polynucléotides résistant aux nucléases et leurs utilisations |
WO2014028429A2 (fr) | 2012-08-14 | 2014-02-20 | Moderna Therapeutics, Inc. | Enzymes et polymérases destinées à la synthèse d'arn |
EP4074834A1 (fr) | 2012-11-26 | 2022-10-19 | ModernaTX, Inc. | Arn à terminaison modifiée |
WO2014082729A1 (fr) | 2012-11-28 | 2014-06-05 | Biontech Ag | Vaccins individualisés contre le cancer |
JP2016504050A (ja) | 2013-01-17 | 2016-02-12 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド |
EP2765137A1 (fr) | 2013-02-07 | 2014-08-13 | Sanofi Pasteur | Induction d'une réponse cellulaire à réactivité croisée contre des antigènes de rhinovirus |
BR122021025267B1 (pt) | 2013-02-22 | 2023-12-05 | Curevac Ag | Partes de kit e composição farmacêutica compreendendo um inibidor da via de pd-1 |
BR112015018989B1 (pt) | 2013-02-22 | 2023-11-14 | Curevac Ag | Combinação de vacina/inibidor da via de pd-1, inibidor da via de pd-1 e vacina de rna |
EP2970955B1 (fr) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Procédés de purification d'arn messager |
US20160032316A1 (en) | 2013-03-14 | 2016-02-04 | The Trustees Of The University Of Pennsylvania | Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides |
EA037922B1 (ru) | 2013-03-14 | 2021-06-07 | Шир Хьюман Дженетик Терапис, Инк. | мРНК CFTR И КОМПОЗИЦИИ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА У МЛЕКОПИТАЮЩЕГО |
EP2971010B1 (fr) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation et administration de compositions de nucléosides, de nucléotides, et d'acides nucléiques modifiés |
WO2014144767A1 (fr) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Purification d'arnm par échange d'ions |
EP2971165A4 (fr) | 2013-03-15 | 2016-11-23 | Moderna Therapeutics Inc | Elimination de fragments d'adn dans des procédés de production d'arnm |
US11377470B2 (en) | 2013-03-15 | 2022-07-05 | Modernatx, Inc. | Ribonucleic acid purification |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2014180490A1 (fr) | 2013-05-10 | 2014-11-13 | Biontech Ag | Prédiction de l'immunogénicité d'épitopes de lymphocytes t |
EP3008191A2 (fr) | 2013-06-13 | 2016-04-20 | Shire Human Genetic Therapies, Inc. | Production virale basée sur l'arn messager |
EP3971287A1 (fr) | 2013-07-11 | 2022-03-23 | ModernaTX, Inc. | Compositions comprenant des polynucléotides synthétiques codant pour des protéines liées à crispr et des arnsg synthétiques et méthodes d'utilisation |
MX369469B (es) | 2013-08-21 | 2019-11-08 | Curevac Ag | Vacuna contra el virus respiratorio sincitial. |
EP3450561A1 (fr) * | 2013-08-21 | 2019-03-06 | CureVac AG | Procédé pour augmenter l'expression des protéines codées par arn |
SG11201510747RA (en) * | 2013-08-21 | 2016-03-30 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
EP3574916A1 (fr) | 2013-08-21 | 2019-12-04 | CureVac AG | Composition et vaccin pour le traitement du cancer du poumon |
CA2915730A1 (fr) | 2013-08-21 | 2015-02-26 | Karl-Josef Kallen | Vaccin combine contre le virus respiratoire syncytial (rsv) et la grippea |
BR112016001192A2 (pt) | 2013-08-21 | 2017-08-29 | Curevac Ag | Vacina contra a raiva |
AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
EP3041938A1 (fr) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Polynucléotides circulaires |
EP3052106A4 (fr) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
US10385088B2 (en) | 2013-10-02 | 2019-08-20 | Modernatx, Inc. | Polynucleotide molecules and uses thereof |
MX2016004249A (es) | 2013-10-03 | 2016-11-08 | Moderna Therapeutics Inc | Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad. |
ES2954366T3 (es) | 2013-10-22 | 2023-11-21 | Translate Bio Inc | Terapia de ácido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa |
CA2928186A1 (fr) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Therapie a l'arnm pour la phenylcetonurie |
BR112016008806A2 (pt) | 2013-11-01 | 2017-10-03 | Pfizer | Vetores para expressão de antígenos associados à próstata |
EP3542802A1 (fr) | 2013-11-01 | 2019-09-25 | CureVac AG | Arn modifié avec des propriétés immunostimulatrices réduites |
CA2925021A1 (fr) | 2013-11-01 | 2015-05-07 | Curevac Ag | Arn modifie a proprietes immunostimulantes reduites |
EP3495486B1 (fr) | 2013-12-30 | 2020-12-16 | CureVac AG | Molécules d'acide nucléique artificiel |
SG11201604198YA (en) | 2013-12-30 | 2016-07-28 | Curevac Ag | Methods for rna analysis |
KR102399799B1 (ko) | 2013-12-30 | 2022-05-18 | 큐어백 아게 | 인공 핵산 분자 |
JP6584414B2 (ja) | 2013-12-30 | 2019-10-02 | キュアバック アーゲー | 人工核酸分子 |
EP3415629A1 (fr) * | 2013-12-30 | 2018-12-19 | CureVac AG | Molécules d'acide nucléique artificiel |
US11254951B2 (en) | 2014-12-30 | 2022-02-22 | Curevac Ag | Artificial nucleic acid molecules |
CA2935878C (fr) | 2014-03-12 | 2023-05-02 | Curevac Ag | Combinaison de vaccination et d'agonistes de ox40 |
WO2015149944A2 (fr) | 2014-04-01 | 2015-10-08 | Curevac Gmbh | Complexe cargo de support polymère à utiliser comme agent immunostimulant ou comme adjuvant |
PT3134131T (pt) | 2014-04-23 | 2022-03-24 | Modernatx Inc | Vacinas de ácidos nucleicos |
ES2750661T3 (es) | 2014-04-25 | 2020-03-26 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
CN107075525B (zh) * | 2014-05-30 | 2021-06-25 | 纽约市哥伦比亚大学理事会 | 改变多肽表达的方法 |
BR112016026980B1 (pt) | 2014-06-10 | 2022-05-03 | Curevac Real Estate Gmbh | Método para sintetizar uma molécula de rna de uma dada sequência |
WO2015196128A2 (fr) | 2014-06-19 | 2015-12-23 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique alternatives et leurs utilisations |
JP2017522028A (ja) | 2014-07-16 | 2017-08-10 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 環状ポリヌクレオチド |
WO2016011226A1 (fr) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Polynucléotides chimériques |
JP6824594B2 (ja) | 2014-09-11 | 2021-02-03 | Jnc株式会社 | 合成遺伝子の設計方法 |
WO2016045732A1 (fr) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Formulations stables de lipides et de liposomes |
WO2016077125A1 (fr) | 2014-11-10 | 2016-05-19 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique de remplacement contenant une quantité réduite d'uracile et utilisations associées |
EP3218508A4 (fr) | 2014-11-10 | 2018-04-18 | Modernatx, Inc. | Optimisation d'acides nucléiques à plusieurs paramètres |
WO2016086988A1 (fr) * | 2014-12-03 | 2016-06-09 | Wageningen Universiteit | Optimisation d'une séquence de codage pour l'expression fonctionnelle de protéines |
ES2791152T3 (es) | 2014-12-12 | 2020-11-03 | Curevac Ag | Moléculas de ácido nucleico artificiales para una expresión proteica mejorada |
EP3240558A1 (fr) | 2014-12-30 | 2017-11-08 | CureVac AG | Molécules d'acide nucléique artificielles |
WO2016128060A1 (fr) | 2015-02-12 | 2016-08-18 | Biontech Ag | Prédiction des épitopes de lymphocytes t utiles pour la vaccination |
EP4353257A2 (fr) | 2015-04-13 | 2024-04-17 | CureVac Manufacturing GmbH | Procédé de production de compositions d'arn |
WO2016165831A1 (fr) | 2015-04-17 | 2016-10-20 | Curevac Ag | Lyophilisation de l'arn |
US10293058B2 (en) | 2015-04-22 | 2019-05-21 | Curevac Ag | RNA containing composition for treatment of tumor diseases |
AU2016253147B2 (en) | 2015-04-24 | 2021-07-22 | Mesa Biotech, Inc. | Fluidic test cassette |
SG11201708867UA (en) | 2015-04-30 | 2017-11-29 | Curevac Ag | Immobilized poly(n)polymerase |
WO2016180430A1 (fr) | 2015-05-08 | 2016-11-17 | Curevac Ag | Procédé de production d'arn |
DK3294326T3 (da) | 2015-05-15 | 2021-05-31 | Curevac Ag | Prime-boost-regimer indbefattende indgivelse af mindst én mrna-konstruktion |
US20200317764A1 (en) * | 2015-05-19 | 2020-10-08 | Morphogenesis, Inc. | Modified mrna for multicell transformation |
EP3916091A3 (fr) | 2015-05-20 | 2022-03-30 | CureVac AG | Composition de poudre sèche comprenant de l'arn à longue chaîne |
CN107530448A (zh) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | 包含长链rna的干粉组合物 |
US11608513B2 (en) | 2015-05-29 | 2023-03-21 | CureVac SE | Method for adding cap structures to RNA using immobilized enzymes |
CN107873055B (zh) | 2015-05-29 | 2021-09-17 | 库瑞瓦格房地产有限公司 | 包括至少一个切向流过滤步骤的产生和纯化rna的方法 |
WO2017009376A1 (fr) | 2015-07-13 | 2017-01-19 | Curevac Ag | Procédé de production d'arn à partir d'adn circulaire et adn matriciel correspondant |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
TW201718638A (zh) | 2015-07-21 | 2017-06-01 | 現代治療公司 | 傳染病疫苗 |
AU2016315444B2 (en) | 2015-08-28 | 2023-02-23 | BioNTech SE | Method for reducing immunogenicity of RNA |
JP7304155B2 (ja) * | 2015-08-28 | 2023-07-06 | キュアバック エスイー | 人工核酸分子 |
WO2017049286A1 (fr) | 2015-09-17 | 2017-03-23 | Moderna Therapeutics, Inc. | Polynucléotides contenant un lieur morpholino |
SI3350157T1 (sl) | 2015-09-17 | 2022-04-29 | Modernatx, Inc. | Sestave za doziranje terapevtskih sredstev v celice |
EP3359670B2 (fr) | 2015-10-05 | 2024-02-14 | ModernaTX, Inc. | Procédés d'administration thérapeutique de médicaments à base d'acide ribonucléique messager |
WO2017059902A1 (fr) * | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | Séquences utr 3' permettant la stabilisation d'arn |
EP3362576A1 (fr) | 2015-10-12 | 2018-08-22 | CureVac AG | Procédé automatisé d'isolement, de sélection et/ou de détection de micro-organismes ou de cellules présents dans une solution |
US20190218546A1 (en) | 2015-10-16 | 2019-07-18 | Modernatx, Inc. | Mrna cap analogs with modified phosphate linkage |
US11866754B2 (en) | 2015-10-16 | 2024-01-09 | Modernatx, Inc. | Trinucleotide mRNA cap analogs |
EP3362460A1 (fr) * | 2015-10-16 | 2018-08-22 | Modernatx, Inc. | Analogues de coiffes arnm et procédés de coiffage d'arnm |
WO2017066782A1 (fr) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Analogues de coiffes d'arnm hydrophobes |
WO2017066791A1 (fr) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Analogues de coiffe d'arnm à substitution sucre |
WO2017066789A1 (fr) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Analogues de coiffe d'arnm avec sucre modifié |
US20180289792A1 (en) | 2015-10-22 | 2018-10-11 | ModernaTX. Inc. | Sexually transmitted disease vaccines |
EP3365009A4 (fr) | 2015-10-22 | 2019-07-03 | ModernaTX, Inc. | Vaccin contre le virus de l'herpès simplex |
KR20180094859A (ko) | 2015-10-22 | 2018-08-24 | 모더나티엑스, 인크. | 수두 대상포진 바이러스 (vzv)를 위한 핵산 백신 |
EP3364950A4 (fr) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | Vaccins contre des maladies tropicales |
CA3002922A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le cytomegalovirus humain |
MA46023A (fr) | 2015-10-22 | 2019-07-03 | Modernatx Inc | Vaccin contre le virus de la grippe à large spectre |
BR112018008102A2 (pt) | 2015-10-22 | 2018-11-06 | Modernatx Inc | vacina de vírus sincicial respiratório |
MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
US20180312545A1 (en) * | 2015-11-09 | 2018-11-01 | Curevac Ag | Optimized nucleic acid molecules |
US11413346B2 (en) | 2015-11-09 | 2022-08-16 | Curevac Ag | Rotavirus vaccines |
JP7114465B2 (ja) | 2015-12-22 | 2022-08-08 | モデルナティエックス インコーポレイテッド | 薬剤の細胞内送達のための化合物および組成物 |
EP3701963A1 (fr) | 2015-12-22 | 2020-09-02 | CureVac AG | Procédé de production de compositions de molécules d'arn |
WO2017109161A1 (fr) | 2015-12-23 | 2017-06-29 | Curevac Ag | Procédé de transcription in vitro d'arn utilisant un tampon contenant un acide dicarboxyliqlue ou un acide tricarboxylique ou un sel de celui-ci |
BR112018014109A2 (pt) | 2016-01-11 | 2018-12-11 | Verndari Inc | composições de microagulhas e métodos de uso das mesmas |
EP3405579A1 (fr) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Acides ribonucléiques messagers pour la production de polypeptides de liaison intracellulaires et leurs procédés d'utilisation |
EP4289965A3 (fr) | 2016-02-12 | 2024-02-21 | CureVac SE | Procédé d'analyse d'arn |
EP3416683A1 (fr) | 2016-02-17 | 2018-12-26 | CureVac AG | Vaccin contre le virus zika |
US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
EP3443001A4 (fr) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | Systèmes de biocircuits régulés |
EP3445392A1 (fr) | 2016-04-22 | 2019-02-27 | CureVac AG | Arn codant pour un antigène tumoral |
EP3448427A1 (fr) | 2016-04-29 | 2019-03-06 | CureVac AG | Arn codant pour un anticorps |
EP3452101A2 (fr) | 2016-05-04 | 2019-03-13 | CureVac AG | Arn codant pour une protéine thérapeutique |
EP3452493A1 (fr) | 2016-05-04 | 2019-03-13 | CureVac AG | Molécules d'acide nucléique et leurs utilisations |
WO2017191258A1 (fr) * | 2016-05-04 | 2017-11-09 | Curevac Ag | Vaccins contre l'arnm de la grippe |
MY201498A (en) | 2016-05-18 | 2024-02-27 | Modernatx Inc | Polynucleotides encoding citrin for the treatment of citrullinemia type 2 |
KR102482867B1 (ko) | 2016-05-18 | 2023-01-02 | 모더나티엑스, 인크. | 면역 조정 폴리펩타이드를 암호화하는 mRNA의 조합물 및 이의 용도 |
EP3458107B1 (fr) | 2016-05-18 | 2024-03-13 | ModernaTX, Inc. | Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille |
EP3458105B1 (fr) | 2016-05-18 | 2024-01-17 | Modernatx, Inc. | Polynucléotides codant pour la galactose-1-phosphate uridylyltransférase destinés au traitement de la galactosémie de type 1 |
SG11201810256XA (en) | 2016-05-18 | 2018-12-28 | Modernatx Inc | Polynucleotides encoding relaxin |
WO2017201332A1 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucléotides codant pour l'acyl-coa déshydrogénase, à très longue chaîne pour le traitement de l'insuffisance en acyl-coa déshydrogénase à très longue chaîne |
CA3024624A1 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides codant pour la porphobilinogene desaminase destines au traitement de la porphyrie intermittente aigue |
MX2018013509A (es) | 2016-05-18 | 2019-03-28 | Modernatx Inc | Polinucleotidos que codifican interleucina-12 (il12) y sus usos de los mismos. |
WO2017201328A1 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucléotides codant pour l'α-galactosidase a pour le traitement de la maladie de fabry |
WO2017212007A1 (fr) | 2016-06-09 | 2017-12-14 | Curevac Ag | Supports cationiques destinés à l'administration d'acides nucléiques |
KR20190029576A (ko) | 2016-06-09 | 2019-03-20 | 큐어백 아게 | 핵산 카고용 하이브리드 담체 |
WO2017212006A1 (fr) | 2016-06-09 | 2017-12-14 | Curevac Ag | Supports hybrides pour charge d'acide nucléique |
WO2017218704A1 (fr) | 2016-06-14 | 2017-12-21 | Modernatx, Inc. | Formulations stabilisées de nanoparticules lipidiques |
SG11201811432WA (en) | 2016-08-19 | 2019-03-28 | Curevac Ag | Rna for cancer therapy |
WO2018041921A1 (fr) | 2016-08-31 | 2018-03-08 | Curevac Ag | Dispositif de mélange pour la production d'une composition d'acide nucléique liquide |
MA46584A (fr) | 2016-10-21 | 2019-08-28 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
KR20190093816A (ko) | 2016-10-26 | 2019-08-26 | 큐어백 아게 | 지질 나노입자 mRNA 백신 |
WO2018089540A1 (fr) | 2016-11-08 | 2018-05-17 | Modernatx, Inc. | Formulations stabilisées de nanoparticules lipidiques |
WO2018087285A1 (fr) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Protéines de liaison à l'antigène or10h1 et leurs utilisations |
WO2018089851A2 (fr) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Vaccin antigrippal |
WO2018096179A1 (fr) | 2016-11-28 | 2018-05-31 | Curevac Ag | Procédé de purification d'arn |
AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
US11542490B2 (en) | 2016-12-08 | 2023-01-03 | CureVac SE | RNAs for wound healing |
EP3808380A1 (fr) | 2016-12-08 | 2021-04-21 | CureVac AG | Arn pour le traitement ou la prophylaxie d'une maladie du foie |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
US11141476B2 (en) | 2016-12-23 | 2021-10-12 | Curevac Ag | MERS coronavirus vaccine |
EP3558355A2 (fr) | 2016-12-23 | 2019-10-30 | CureVac AG | Vaccin contre l'hénipavirus |
EP3558354A1 (fr) | 2016-12-23 | 2019-10-30 | CureVac AG | Vaccin contre le virus de lassa |
CA3051252A1 (fr) | 2017-02-01 | 2018-08-09 | Modernatx, Inc. | Compositions therapeutiques immunomodulatrices d'arnm codant pour des peptides de mutation d'activation d'oncogenes |
EP3577221A4 (fr) | 2017-02-01 | 2020-12-23 | ModernaTX, Inc. | Structure secondaire de polynucléotide |
MA47515A (fr) | 2017-02-16 | 2019-12-25 | Modernatx Inc | Compositions immunogènes très puissantes |
MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
US11407800B2 (en) | 2017-02-28 | 2022-08-09 | Arcturus Therapeutics, Inc. | Translatable molecules and synthesis thereof |
KR20190124750A (ko) | 2017-02-28 | 2019-11-05 | 사노피 | 치료적 rna |
MA52262A (fr) | 2017-03-15 | 2020-02-19 | Modernatx Inc | Vaccin à large spectre contre le virus de la grippe |
DK3596041T3 (da) | 2017-03-15 | 2023-01-23 | Modernatx Inc | Forbindelse og sammensætninger til intracellulær afgivelse af terapeutiske midler |
WO2018170270A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin contre le virus varicelle-zona |
US11969506B2 (en) | 2017-03-15 | 2024-04-30 | Modernatx, Inc. | Lipid nanoparticle formulation |
MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
WO2018167320A1 (fr) | 2017-03-17 | 2018-09-20 | Curevac Ag | Vaccin à arn et inhibiteurs de points de contrôle immunitaires pour une thérapie anticancéreuse combinée |
US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
BR112019015244A2 (pt) | 2017-03-24 | 2020-04-14 | Curevac Ag | ácidos nucleicos codificando proteínas associadas a crispr e usos dos mesmos |
US20200038487A1 (en) | 2017-03-31 | 2020-02-06 | Accanis Biotech F&E Gmbh & Co Kg | Prevention and treatment of non-melanoma skin cancer (nmsc) |
MA48047A (fr) | 2017-04-05 | 2020-02-12 | Modernatx Inc | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
AU2018258575A1 (en) | 2017-04-27 | 2019-11-07 | The Johns Hopkins University | Hepatitis C virus gene sequences and methods of use therefor |
IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr |
WO2018213731A1 (fr) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucléotides codant pour des polypeptides d'interleukine-12 (il12) ancrés et leurs utilisations |
EP3630964A4 (fr) | 2017-05-31 | 2021-03-03 | Ultragenyx Pharmaceutical Inc. | Agents thérapeutiques pour la maladie du stockage du glycogène de type iii |
WO2018232120A1 (fr) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Composés et compositions pour l'administration intracellulaire d'agents |
KR20200024905A (ko) | 2017-07-04 | 2020-03-09 | 큐어백 아게 | 신규 핵산 분자 |
WO2019036638A1 (fr) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | Procédés de préparation d'arn modifié |
US11602557B2 (en) | 2017-08-22 | 2023-03-14 | Cure Vac SE | Bunyavirales vaccine |
US11744801B2 (en) | 2017-08-31 | 2023-09-05 | Modernatx, Inc. | Methods of making lipid nanoparticles |
US10653767B2 (en) | 2017-09-14 | 2020-05-19 | Modernatx, Inc. | Zika virus MRNA vaccines |
KR20200071081A (ko) | 2017-10-19 | 2020-06-18 | 큐어백 아게 | 신규 인공 핵산 분자 |
WO2019092153A1 (fr) | 2017-11-08 | 2019-05-16 | Curevac Ag | Adaptation de séquence d'arn |
EP3723796A1 (fr) | 2017-12-13 | 2020-10-21 | CureVac AG | Vaccin contre les flavivirus |
WO2019122371A1 (fr) | 2017-12-21 | 2019-06-27 | Curevac Ag | Adn linéaire double brin couplé à un support ou une étiquette unique et procédés de production dudit adn linéaire double brin |
EP3508499A1 (fr) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations |
MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
CN108363904B (zh) * | 2018-02-07 | 2019-06-28 | 南京林业大学 | 一种用于木本植物遗传密码子优化的CodonNX系统及其优化方法 |
WO2019193183A2 (fr) | 2018-04-05 | 2019-10-10 | Curevac Ag | Nouvelles molécules d'acide nucléique de fièvre jaune pour la vaccination |
BR112020020933A2 (pt) | 2018-04-17 | 2021-04-06 | Curevac Ag | Moléculas de rna de rsv inovadoras e composições para vacinação |
EP3806888B1 (fr) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Constructions régulatrices dérivées de pde5 et procédés d'utilisation en immunothérapie |
EP3813874A1 (fr) | 2018-06-27 | 2021-05-05 | CureVac AG | Nouvelles molécules d'arn de virus lassa et compositions pour la vaccination |
CN112930396B (zh) | 2018-08-24 | 2024-05-24 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
MA53652A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg de haute pureté et leurs utilisations |
MA53650A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg et leurs utilisations |
CA3113436A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Composes et compositions pour l'administration intracellulaire d'agents therapeutiques |
US20210378980A1 (en) | 2018-09-20 | 2021-12-09 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
EP3870600A1 (fr) | 2018-10-24 | 2021-09-01 | Obsidian Therapeutics, Inc. | Régulation de protéine accordable par er |
ES2960692T3 (es) | 2018-12-06 | 2024-03-06 | Arcturus Therapeutics Inc | Composiciones y métodos para el tratamiento de la deficiencia de ornitina transcarbamilasa |
CN113454227A (zh) | 2018-12-19 | 2021-09-28 | 维萨梅布有限公司 | 编码蛋白质的rna |
BR112021009422A2 (pt) | 2018-12-21 | 2021-10-26 | Curevac Ag | Rna para vacinas contra malária |
BR112021014909A2 (pt) | 2019-01-31 | 2021-11-23 | Modernatx Inc | Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes |
WO2020160397A1 (fr) | 2019-01-31 | 2020-08-06 | Modernatx, Inc. | Procédés de préparation de nanoparticules lipidiques |
CA3125511A1 (fr) | 2019-02-08 | 2020-08-13 | Curevac Ag | Arn codant administre dans l'espace suprachoroidien pour le traitement de maladies ophtalmiques |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
WO2020254535A1 (fr) | 2019-06-18 | 2020-12-24 | Curevac Ag | Vaccin à arnm rotavirus |
EP3987027A1 (fr) * | 2019-06-24 | 2022-04-27 | ModernaTX, Inc. | Arn messager résistant à l'endonucléase et utilisations correspondantes |
WO2021005009A1 (fr) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Anticorps de liant à l'igc2 de l'igsf11 (vsig3) et leurs utilisations |
WO2021028439A1 (fr) | 2019-08-14 | 2021-02-18 | Curevac Ag | Combinaisons d'arn et compositions à propriétés immunostimulatrices réduites |
CA3158491A1 (fr) | 2019-10-24 | 2021-04-29 | Novago Therapeutics Ag | Nouveaux anticorps anti-nogo-a |
EP3822288A1 (fr) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Anticorps ciblant et autres modulateurs de l'antigène cd276 et leurs utilisations |
US20230090515A1 (en) | 2019-12-20 | 2023-03-23 | Curevac Ag | Lipid nanoparticles for delivery of nucleic acids |
JP2023511633A (ja) | 2020-01-28 | 2023-03-20 | モデルナティエックス インコーポレイテッド | コロナウイルスrnaワクチン |
US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
CA3160511A1 (fr) | 2020-02-04 | 2021-08-12 | Susanne RAUCH | Vaccin contre un coronavirus |
US11576966B2 (en) | 2020-02-04 | 2023-02-14 | CureVac SE | Coronavirus vaccine |
CA3170150A1 (fr) | 2020-02-07 | 2021-08-12 | Modernatx, Inc. | Vaccins a domaine arnm anti sars-cov-2 |
TW202204622A (zh) | 2020-04-09 | 2022-02-01 | 大陸商蘇州艾博生物科技有限公司 | 針對冠狀病毒之核酸疫苗 |
JP2023529522A (ja) | 2020-04-09 | 2023-07-11 | スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド | 脂質ナノ粒子組成物 |
GB202307565D0 (en) | 2020-04-22 | 2023-07-05 | BioNTech SE | Coronavirus vaccine |
WO2021222304A1 (fr) | 2020-04-27 | 2021-11-04 | Modernatx, Inc. | Vaccins à arn contre le sars-cov-2 |
WO2021159130A2 (fr) | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Vaccins a arn de coronavirus et procédés d'utilisation |
BR112022024248A2 (pt) | 2020-05-29 | 2023-10-10 | CureVac SE | Vacinas de combinação à base de ácido nucleico |
WO2021245184A1 (fr) | 2020-06-02 | 2021-12-09 | Neurimmune Ag | Anticorps humains contre le coronavirus 2 du syndrome respiratoire aigu sévère (sars-cov-2) |
AU2021301922A1 (en) | 2020-06-30 | 2023-02-02 | Suzhou Abogen Biosciences Co., Ltd. | Lipid compounds and lipid nanoparticle compositions |
EP4175668A1 (fr) | 2020-07-06 | 2023-05-10 | iOmx Therapeutics AG | Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations |
EP4172194A1 (fr) | 2020-07-31 | 2023-05-03 | CureVac SE | Mélanges d'anticorps codés par des acides nucléiques |
TW202214566A (zh) | 2020-08-20 | 2022-04-16 | 大陸商蘇州艾博生物科技有限公司 | 脂質化合物及脂質奈米粒子組合物 |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
CA3170743A1 (fr) | 2020-08-31 | 2022-03-03 | Susanne RAUCH | Vaccins contre le coronavirus a base d'acides nucleiques multivalents |
US20230355743A1 (en) | 2020-09-25 | 2023-11-09 | Modernatx, Inc. | Multi-proline-substituted coronavirus spike protein vaccines |
EP4203997A1 (fr) | 2020-10-26 | 2023-07-05 | Pécsi Tudományegyetem | Plateforme de vaccin |
EP3992205A1 (fr) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Composés de liaison de protéine de spicule du sars coronavirus-2 |
JP2023547507A (ja) | 2020-11-03 | 2023-11-10 | ドイチェス クレブスフォルシュンクスツェントルム スチフトゥング デス エッフェントリヒェン レヒツ | 標的細胞限定的で共刺激性の二重特異性かつ2価の抗cd28抗体 |
WO2022106205A1 (fr) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Composés de liaison à la protéine de spicule du coronavirus |
WO2022106860A1 (fr) | 2020-11-20 | 2022-05-27 | Pécsi Tudományegyetem | Peptides recombinants destinés à être utilisés en thérapie |
MX2023007574A (es) | 2020-12-22 | 2023-09-29 | CureVac SE | "vacuna de arn contra variantes de sars-cov-2. |
WO2022137133A1 (fr) | 2020-12-22 | 2022-06-30 | Curevac Ag | Vaccin à arn contre des variants sras-cov-2 |
WO2022135993A2 (fr) | 2020-12-22 | 2022-06-30 | Curevac Ag | Composition pharmaceutique comprenant des vecteurs lipidique encapsulant de l'arn pour une administration multidose |
WO2022150717A1 (fr) | 2021-01-11 | 2022-07-14 | Modernatx, Inc. | Vaccins contre le virus de la grippe à arn saisonnière |
WO2022152141A2 (fr) | 2021-01-14 | 2022-07-21 | Suzhou Abogen Biosciences Co., Ltd. | Composés lipidiques conjugués polymères et compositions de nanoparticules lipidiques |
WO2022152109A2 (fr) | 2021-01-14 | 2022-07-21 | Suzhou Abogen Biosciences Co., Ltd. | Composés lipidiques et compositions de nanoparticules lipidiques |
AU2022207495A1 (en) | 2021-01-15 | 2023-08-03 | Modernatx, Inc. | Variant strain-based coronavirus vaccines |
AU2022208057A1 (en) | 2021-01-15 | 2023-08-03 | Modernatx, Inc. | Variant strain-based coronavirus vaccines |
CN112735525B (zh) * | 2021-01-18 | 2023-12-26 | 苏州科锐迈德生物医药科技有限公司 | 一种基于分治法的mRNA序列优化的方法与装置 |
CA3170747A1 (fr) | 2021-01-27 | 2022-08-04 | Moritz THRAN | Procede de reduction des proprietes immunostimulatrices d'arn transcrit in vitro |
WO2022177597A1 (fr) * | 2021-02-16 | 2022-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Systèmes et procédés pour améliorer la stabilité et la traduction de l'arn et leurs utilisations |
KR20230150319A (ko) | 2021-03-01 | 2023-10-30 | 사이롬 게임베하 | iRhom2에 대한 인간화 항체 |
EP4301402A1 (fr) | 2021-03-03 | 2024-01-10 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Anticorps bispécifiques améliorant les réponses immunitaires à médiation cellulaire |
US20240181037A1 (en) | 2021-03-26 | 2024-06-06 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
WO2022207652A1 (fr) | 2021-03-29 | 2022-10-06 | Scirhom Gmbh | Méthodes de traitement utilisant des liants protéiques pour des épitopes irhom2 |
WO2022212784A1 (fr) | 2021-03-31 | 2022-10-06 | Flagship Pioneering Innovations V, Inc. | Polypeptides de thanotransmission et leur utilisation dans le traitement du cancer |
EP4312988A2 (fr) | 2021-03-31 | 2024-02-07 | CureVac SE | Seringues contenant des compositions pharmaceutiques comprenant de l'arn |
WO2022214664A1 (fr) | 2021-04-09 | 2022-10-13 | Philogen S.P.A. | Mutant amélioré d'interféron-gamma |
AU2022258335A1 (en) | 2021-04-13 | 2023-11-23 | Modernatx, Inc. | Respiratory virus combination vaccines |
AU2022258463A1 (en) | 2021-04-14 | 2023-11-23 | Modernatx, Inc. | Influenza-coronavirus combination vaccines |
EP4334446A1 (fr) | 2021-05-03 | 2024-03-13 | CureVac SE | Séquence d'acide nucléique améliorée pour l'expression spécifique de type cellulaire |
WO2022245888A1 (fr) | 2021-05-19 | 2022-11-24 | Modernatx, Inc. | Vaccins à arn anti-grippe saisonnière et méthodes d'utilisation |
CN116472275A (zh) | 2021-05-24 | 2023-07-21 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
EP4377331A2 (fr) | 2021-07-30 | 2024-06-05 | CureVac SE | Arnm pour le traitement ou la prophylaxie de maladies hépatiques |
EP4392140A1 (fr) | 2021-08-24 | 2024-07-03 | BioNTech SE | Technologies de transcription in vitro |
CA3230456A1 (fr) * | 2021-08-31 | 2023-03-09 | Weimin Zhang | Compositions et procedes pour la commutation progressive des marqueurs de resistance aux antibiotiques destines a l'integration (mswap-in) |
CN117940158A (zh) | 2021-09-03 | 2024-04-26 | 库瑞瓦格欧洲公司 | 用于核酸递送的包含磷脂酰丝氨酸的新型脂质纳米颗粒 |
IL309505A (en) | 2021-09-03 | 2024-02-01 | CureVac SE | Lipid nanoparticles for nucleic acid delivery |
TW202325263A (zh) | 2021-09-14 | 2023-07-01 | 美商雷納嘉德醫療管理公司 | 非環狀脂質及其使用方法 |
WO2023044333A1 (fr) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Lipides cycliques et leurs procédés d'utilisation |
US20230190806A1 (en) | 2021-10-06 | 2023-06-22 | Immatics Biotechnologies Gmbh | Methods of treating metastatic lesions and compositions thereof |
AR127312A1 (es) | 2021-10-08 | 2024-01-10 | Suzhou Abogen Biosciences Co Ltd | Compuestos lipídicos ycomposiciones de nanopartículas lipídicas |
CN116064598B (zh) | 2021-10-08 | 2024-03-12 | 苏州艾博生物科技有限公司 | 冠状病毒的核酸疫苗 |
EP4204391A1 (fr) | 2021-10-08 | 2023-07-05 | Suzhou Abogen Biosciences Co., Ltd. | Composés lipidiques et compositions de nanoparticules lipidiques |
WO2023064612A2 (fr) | 2021-10-15 | 2023-04-20 | BioNTech SE | Compositions pharmaceutiques pour l'administration d'antigènes viraux et méthodes associées |
KR20240090727A (ko) | 2021-10-22 | 2024-06-21 | 세일 바이오메디슨스, 인크. | Mrna 백신 조성물 |
WO2023073228A1 (fr) | 2021-10-29 | 2023-05-04 | CureVac SE | Arn circulaire amélioré pour exprimer des protéines thérapeutiques |
WO2023092069A1 (fr) | 2021-11-18 | 2023-05-25 | Modernatx, Inc. | Vaccins à domaine arnm de sars-cov-2 et méthodes d'utilisation |
AU2022398450A1 (en) | 2021-11-23 | 2024-06-06 | Sail Biomedicines, Inc. | A bacteria-derived lipid composition and use thereof |
WO2023107999A2 (fr) | 2021-12-08 | 2023-06-15 | Modernatx, Inc. | Vaccins à arnm contre le virus de l'herpès simplex |
WO2023122080A1 (fr) | 2021-12-20 | 2023-06-29 | Senda Biosciences, Inc. | Compositions comprenant de l'arnm et des paquets de messagers végétaux reconstruits lipidiques |
WO2023122752A1 (fr) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Lipides contraints et procédés d'utilisation associés |
CN116332830A (zh) | 2021-12-23 | 2023-06-27 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
WO2023144193A1 (fr) | 2022-01-25 | 2023-08-03 | CureVac SE | Arnm pour le traitement de la tyrosinémie héréditaire de type i |
WO2023147090A1 (fr) | 2022-01-27 | 2023-08-03 | BioNTech SE | Compositions pharmaceutiques pour administration d'antigènes du virus herpès simplex et méthodes associées |
WO2023144330A1 (fr) | 2022-01-28 | 2023-08-03 | CureVac SE | Inhibiteurs de facteurs de transcription codés par un acide nucleique |
WO2023161350A1 (fr) | 2022-02-24 | 2023-08-31 | Io Biotech Aps | Administration nucléotidique d'une thérapie anticancéreuse |
WO2023196931A1 (fr) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | Lipides cycliques et nanoparticules lipidiques (npl) pour l'apport d'acides nucléiques ou de peptides destinés à être utilisés dans la vaccination contre des agents infectieux |
WO2023196914A1 (fr) | 2022-04-08 | 2023-10-12 | Modernatx, Inc. | Compositions d'acides nucléiques de la grippe et leurs utilisations |
WO2023213990A1 (fr) | 2022-05-05 | 2023-11-09 | Etherna Immunotherapies Nv | Construction multi-épitope |
WO2023218431A1 (fr) | 2022-05-13 | 2023-11-16 | BioNTech SE | Compositions d'arn ciblant le vih |
WO2023230481A1 (fr) | 2022-05-24 | 2023-11-30 | Modernatx, Inc. | Vaccins contre l'orthopoxvirus |
WO2023227608A1 (fr) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli |
WO2023230295A1 (fr) | 2022-05-25 | 2023-11-30 | BioNTech SE | Compositions d'arn pour l'administration d'antigènes de la variole du singe et méthodes associées |
WO2023249934A1 (fr) * | 2022-06-20 | 2023-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Méthodes de modification génétique de cellules pour interactions codon-anticodon modifiées |
US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
WO2024015890A1 (fr) | 2022-07-13 | 2024-01-18 | Modernatx, Inc. | Vaccins à arnm de norovirus |
WO2024020346A2 (fr) | 2022-07-18 | 2024-01-25 | Renagade Therapeutics Management Inc. | Composants d'édition génique, systèmes et procédés d'utilisation |
WO2024023246A1 (fr) | 2022-07-28 | 2024-02-01 | Philogen S.P.A. | Anticorps se liant à pd1 |
WO2024033362A1 (fr) | 2022-08-08 | 2024-02-15 | Atb Therapeutics | Anticorps humanisés dirigés contre cd79b |
WO2024037578A1 (fr) | 2022-08-18 | 2024-02-22 | Suzhou Abogen Biosciences Co., Ltd. | Composition de nanoparticules lipidiques |
WO2024050483A1 (fr) | 2022-08-31 | 2024-03-07 | Modernatx, Inc. | Vaccins contre le coronavirus à base de souche variante et utilisations associées |
WO2024063789A1 (fr) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions pour l'administration d'antigènes du paludisme et méthodes associées |
WO2024064934A1 (fr) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions pour administration d'antigènes csp de plasmodium et procédés associés |
WO2024064931A1 (fr) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions pour l'administration d'antigènes du stade hépatique et méthodes associées |
WO2024063788A1 (fr) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions pour l'administration d'antigènes du paludisme et méthodes associées |
WO2024068545A1 (fr) | 2022-09-26 | 2024-04-04 | Glaxosmithkline Biologicals Sa | Vaccins contre le virus de la grippe |
WO2024077191A1 (fr) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Molécules d'acide nucléique codant pour des trif et des polypeptides supplémentaires et leur utilisation dans le traitement du cancer |
WO2024083345A1 (fr) | 2022-10-21 | 2024-04-25 | BioNTech SE | Procédés et utilisations associés à des compositions liquides |
WO2024089229A1 (fr) | 2022-10-28 | 2024-05-02 | CureVac SE | Formulations améliorées comprenant des transporteurs à base de lipides encapsulant de l'arn |
WO2024089638A1 (fr) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique |
WO2024097874A1 (fr) | 2022-11-03 | 2024-05-10 | Modernatx, Inc. | Stabilité chimique de l'arnm |
GB202216449D0 (en) | 2022-11-04 | 2022-12-21 | Io Biotech Aps | TGF-BETA1 vaccine |
WO2024102434A1 (fr) | 2022-11-10 | 2024-05-16 | Senda Biosciences, Inc. | Compositions d'arn comprenant des nanoparticules lipidiques ou des packs de messagers naturels reconstitués en packs lipidiques |
DE102022213056A1 (de) * | 2022-12-05 | 2024-06-06 | Universität Rostock, Körperschaft des öffentlichen Rechts | Innovative antimikrobielle Therapie gegen Streptococcus pneumoniae mittels mRNA kodierter Bakteriophagen-Endolysine/Autolysine |
WO2024133940A2 (fr) | 2022-12-23 | 2024-06-27 | Iomx Therapeutics Ag | Protéines de liaison à un antigène (abp) inter-spécifiques ciblant une sous-famille b1 de récepteur de type immunoglobuline leucocytaire (lilrb1) et lilrb2, combinaisons et utilisations associées |
GB202404607D0 (en) | 2024-03-29 | 2024-05-15 | Glaxosmithkline Biologicals Sa | RNA formulation |
Family Cites Families (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3906092A (en) * | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4401796A (en) | 1981-04-30 | 1983-08-30 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6173986A (ja) * | 1984-09-19 | 1986-04-16 | 塩野義製薬株式会社 | 遺伝子コドン配列教習具 |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US5116943A (en) * | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
US5017691A (en) * | 1986-07-03 | 1991-05-21 | Schering Corporation | Mammalian interleukin-4 |
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
US5153319A (en) | 1986-03-31 | 1992-10-06 | University Patents, Inc. | Process for preparing polynucleotides |
US4879111A (en) * | 1986-04-17 | 1989-11-07 | Cetus Corporation | Treatment of infections with lymphokines |
US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
US5082767A (en) * | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
DE69032284T2 (de) | 1989-03-21 | 1998-10-08 | Vical, Inc., San Diego, Calif. | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
US6214804B1 (en) * | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
EP0625049A4 (fr) | 1992-01-23 | 1995-07-12 | Vical Inc | Transfert de genes ex vivo. |
US6174666B1 (en) * | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
EP0609739A1 (fr) | 1993-02-02 | 1994-08-10 | American Cyanamid Company | Méthode de renversement d'immunosuppresion en vaccins |
ES2224113T5 (es) * | 1994-02-16 | 2009-05-01 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Polipeptido antigenico asociado al melanoma, epitopos del mismo y vacunas contra melanoma. |
IL112820A0 (en) | 1994-03-07 | 1995-05-26 | Merck & Co Inc | Coordinate in vivo gene expression |
HUT76094A (en) * | 1994-03-18 | 1997-06-30 | Lynx Therapeutics | Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties |
WO1995026204A1 (fr) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Stimulation immunitaire par des analogues d'oligonucleotides de phosphorothioate |
GB9406498D0 (en) * | 1994-03-31 | 1994-05-25 | Smithkline Beecham Biolog | Novel compounds |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
US6265387B1 (en) * | 1995-10-11 | 2001-07-24 | Mirus, Inc. | Process of delivering naked DNA into a hepatocyte via bile duct |
US20030143204A1 (en) * | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
US6534312B1 (en) * | 1996-02-22 | 2003-03-18 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
US6090391A (en) * | 1996-02-23 | 2000-07-18 | Aviron | Recombinant tryptophan mutants of influenza |
US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
AU728422B2 (en) * | 1996-06-21 | 2001-01-11 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
ATE292980T1 (de) * | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
EP0839912A1 (fr) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Clones infectieux de virus à ARN, vaccins et essais diagnostiques |
US6204250B1 (en) * | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
EP0855184A1 (fr) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
IL131131A0 (en) | 1997-02-07 | 2001-01-28 | Merck & Co Inc | Synthetic hiv gag genes |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
CA2291483C (fr) | 1997-06-06 | 2012-09-18 | Dynavax Technologies Corporation | Oligonucleotides immunostimulateurs, compositions correspondantes et leurs procedes d'utilisation |
WO1999002694A1 (fr) * | 1997-07-09 | 1999-01-21 | The University Of Queensland | Sequence d'acides nucleiques et procede pour exprimer, de maniere selective, une proteine dans une cellule ou un tissu cible |
EP1021549A2 (fr) | 1997-09-19 | 2000-07-26 | Sequitur, Inc. | THERAPIES GENIQUES A BASE D'ARNm SENS |
BR9812945A (pt) * | 1997-10-20 | 2000-08-08 | Genzyme Transgenics Corp | Sequências de ácido nucléico modificadas e processos para aumentar os nìveis de mrna e expressão de sistemas celulares |
EP1032428B1 (fr) * | 1997-11-20 | 2003-06-18 | Vical Incorporated | Traitement du cancer au moyen de polynucleotides exprimant la cytokine et compositions prevues a cet effet |
US6432925B1 (en) | 1998-04-16 | 2002-08-13 | John Wayne Cancer Institute | RNA cancer vaccine and methods for its use |
IL125608A0 (en) * | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
US6924365B1 (en) * | 1998-09-29 | 2005-08-02 | Transkaryotic Therapies, Inc. | Optimized messenger RNA |
US20090042283A1 (en) * | 1998-09-29 | 2009-02-12 | Shire Human Genetic Therapies, Inc., A Delaware Corporation | Optimized messenger rna |
US6734172B2 (en) * | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
EP1141313A2 (fr) * | 1998-12-31 | 2001-10-10 | Chiron Corporation | Expression amelioree de polypeptides hiv et production de particules de type viral |
CA2358385C (fr) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides codant pour des polypeptides antigeniques du type c du vih; polypeptides et leurs utilisations |
AU4040400A (en) | 1999-03-26 | 2000-10-16 | Walter Reed Army Institute Of Research | Attenuated dengue-4 virus vaccine |
AU778809B2 (en) * | 1999-03-29 | 2004-12-23 | Statens Serum Institut | Method for producing a nucleotide sequence construct with optimised codons for an HIV genetic vaccine based on primary, early HIV isolate and synthetic envelope BX08 constructs |
CA2376634A1 (fr) | 1999-06-08 | 2000-12-14 | Aventis Pasteur | Oligonucleotide immunostimulant |
US6514948B1 (en) * | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
CA2378653A1 (fr) * | 1999-07-09 | 2001-01-18 | American Home Products Corporation | Methodes et compositions empechant la formation d'un arn aberrant pendant la transcription d'une sequence plasmidique |
PT1212358E (pt) * | 1999-08-25 | 2005-04-29 | Merck & Co Inc | Genes sinteticos de papilomavirus humano |
US20050112141A1 (en) * | 2000-08-30 | 2005-05-26 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
US20040106567A1 (en) * | 1999-09-07 | 2004-06-03 | Hagstrom James E. | Intravascular delivery of non-viral nucleic acid |
DE69923840T2 (de) | 1999-09-09 | 2006-04-06 | Curevac Gmbh | Transfer von mRNAs unter Verwendung von polykationischen Verbindungen |
AU7398200A (en) | 1999-09-17 | 2001-04-24 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
WO2002064799A2 (fr) | 1999-09-28 | 2002-08-22 | Transkaryotic Therapies, Inc. | Arn messager optimise |
EP1253947A4 (fr) * | 2000-01-31 | 2005-01-05 | Univ California | Polynucleotides immunomodulateurs dans le traitement d'une infection par un pathogene intracellulaire |
CA2405424A1 (fr) * | 2000-04-07 | 2001-10-18 | The Regents Of The University Of California | Ameliorations synergiques apportees a des vaccins polynucleotidiques |
CA2412026A1 (fr) | 2000-06-07 | 2001-12-13 | Biosynexus Incorporated | Molecules hybrides arn/adn immunostimulatrices |
CN1298738C (zh) * | 2000-06-23 | 2007-02-07 | 惠氏控股有限公司 | 修饰的麻疹病毒v蛋白 |
AU2001276619A1 (en) * | 2000-07-03 | 2002-01-14 | Chiron S.P.A. | Immunisation against chlamydia pneumoniae |
GB0017990D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Papilloma virus sequences |
DK1301614T3 (da) * | 2000-07-21 | 2007-04-02 | Glaxo Group Ltd | Codon-optimerede papillomavirus-sekvenser |
US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
JP2004510714A (ja) * | 2000-10-04 | 2004-04-08 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | フラビウイルス及びペスチウイルス由来のキャプシド蛋白質を使用する組成物及び方法 |
CA2425732A1 (fr) | 2000-10-11 | 2002-08-22 | Transkaryotic Therapies, Inc. | Arn messager optimise |
US20030077604A1 (en) * | 2000-10-27 | 2003-04-24 | Yongming Sun | Compositions and methods relating to breast specific genes and proteins |
US20020132788A1 (en) * | 2000-11-06 | 2002-09-19 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
KR100917939B1 (ko) | 2001-03-09 | 2009-09-21 | 진 스트림 피티와이 리미티드 | 신규한 발현 벡터 |
AUPR446801A0 (en) * | 2001-04-18 | 2001-05-17 | University Of Queensland, The | Novel compositions and uses therefor |
DE10119005A1 (de) | 2001-04-18 | 2002-10-24 | Roche Diagnostics Gmbh | Verfahren zur Proteinexpression ausgehend von stabilisierter linearer kurzer DNA in zellfreien in vitro-Transkription/Translations-Systemen mit Exonuklease-haltigen Lysaten oder in einem zellulären System enthaltend Exonukleasen |
DE50201240D1 (de) * | 2001-04-23 | 2004-11-11 | Amaxa Gmbh | Pufferlössung für die elektroporation und verfahren umfassend die verwendung derselben |
US20030039636A1 (en) * | 2001-05-01 | 2003-02-27 | Genetix Pharmaceuticals, Inc. | Novel self-inactivating (SIN) lentiviral vectors |
EP1399183B1 (fr) * | 2001-05-31 | 2010-06-30 | Novartis Vaccines and Diagnostics, Inc. | Particules de replicon d'alphavirus chimerique |
US20030232324A1 (en) * | 2001-05-31 | 2003-12-18 | Chiron Corporation | Chimeric alphavirus replicon particles |
DE50214200D1 (de) | 2001-06-05 | 2010-03-25 | Curevac Gmbh | Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt |
US7785610B2 (en) * | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
US7547551B2 (en) * | 2001-06-21 | 2009-06-16 | University Of Antwerp. | Transfection of eukaryontic cells with linear polynucleotides by electroporation |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
DE10148886A1 (de) * | 2001-10-04 | 2003-04-30 | Avontec Gmbh | Inhibition von STAT-1 |
US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
WO2003059381A2 (fr) | 2002-01-18 | 2003-07-24 | Curevac Gmbh | Préparations immunogènes et vaccins à base d'arn |
WO2003066649A1 (fr) | 2002-02-04 | 2003-08-14 | Biomira Inc. | Lipido-oligonucleotides covalents et immunostimulants |
GB0202569D0 (en) * | 2002-02-04 | 2002-03-20 | Oxford Biomedica Ltd | Delivery means |
EP1572941A4 (fr) | 2002-02-26 | 2009-03-18 | Maxygen Inc | Nouveaux antigenes de flavivirus |
EP2368431A1 (fr) * | 2002-04-04 | 2011-09-28 | Coley Pharmaceutical GmbH | Oligoribonucléotides contenant G,U immunostimulatrices |
AU2003231083A1 (en) | 2002-04-26 | 2003-11-10 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
US7316925B2 (en) * | 2002-07-16 | 2008-01-08 | Vgx Pharmaceuticals, Inc. | Codon optimized synthetic plasmids |
EP1393745A1 (fr) | 2002-07-29 | 2004-03-03 | Hybridon, Inc. | Modulation des proprietes immunostimulatrices de composes a base d'oligonucleotides par presentation optimale des extremites 5' |
WO2004055161A2 (fr) * | 2002-12-12 | 2004-07-01 | The Board Of Regents Of The University Of Texas System | Production a grande echelle de replicons d'alphavirus encapsules |
JP2006516099A (ja) | 2002-12-23 | 2006-06-22 | ダイナバックス テクノロジーズ コーポレイション | 分枝状の免疫調節化合物及び該化合物の使用方法 |
US20040242502A1 (en) | 2003-04-08 | 2004-12-02 | Galenica Pharmaceuticals, Inc. | Semi-synthetic saponin analogs with carrier and immune stimulatory activities for DNA and RNA vaccines |
DK176326B1 (da) | 2003-05-14 | 2007-08-13 | Smidth As F L | Indretning til at opdele en ström af partikel- eller pulverformet materiale i delströmme |
DE10335833A1 (de) * | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
DE102004035227A1 (de) * | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
US20060241076A1 (en) * | 2005-04-26 | 2006-10-26 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
ES2735531T3 (es) | 2005-08-23 | 2019-12-19 | Univ Pennsylvania | ARN que contiene nucleósidos modificados y métodos de uso del mismo |
AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
-
2002
- 2002-06-05 DE DE50214200T patent/DE50214200D1/de not_active Expired - Lifetime
- 2002-06-05 EP EP07015835A patent/EP1857122B1/fr not_active Expired - Lifetime
- 2002-06-05 ES ES05004938T patent/ES2340499T3/es not_active Expired - Lifetime
- 2002-06-05 ES ES07000343T patent/ES2344078T3/es not_active Expired - Lifetime
- 2002-06-05 WO PCT/EP2002/006180 patent/WO2002098443A2/fr active IP Right Grant
- 2002-06-05 ES ES02732752T patent/ES2240745T3/es not_active Expired - Lifetime
- 2002-06-05 EP EP02732752A patent/EP1392341B1/fr not_active Expired - Lifetime
- 2002-06-05 EP EP05004938A patent/EP1604688B1/fr not_active Expired - Lifetime
- 2002-06-05 EP EP10007991.2A patent/EP2305699B1/fr not_active Expired - Lifetime
- 2002-06-05 DE DE50202634T patent/DE50202634D1/de not_active Expired - Lifetime
- 2002-06-05 EP EP20070023083 patent/EP1903054A3/fr not_active Withdrawn
- 2002-06-05 CA CA2457959A patent/CA2457959C/fr not_active Expired - Fee Related
- 2002-06-05 ES ES07002195T patent/ES2340532T3/es not_active Expired - Lifetime
- 2002-06-05 DE DE50214801T patent/DE50214801D1/de not_active Expired - Lifetime
- 2002-06-05 AT AT07015835T patent/ATE490267T1/de active
- 2002-06-05 DE DE50214201T patent/DE50214201D1/de not_active Expired - Lifetime
- 2002-06-05 AT AT07002195T patent/ATE457029T1/de active
- 2002-06-05 AT AT05004938T patent/ATE456959T1/de active
- 2002-06-05 CA CA2830887A patent/CA2830887C/fr not_active Expired - Fee Related
- 2002-06-05 EP EP20140002635 patent/EP2842964A1/fr not_active Withdrawn
- 2002-06-05 DK DK07015835T patent/DK1857122T3/da active
- 2002-06-05 EP EP20070000343 patent/EP1800697B1/fr not_active Expired - Lifetime
- 2002-06-05 AT AT02732752T patent/ATE291925T1/de active
- 2002-06-05 AT AT07000343T patent/ATE464317T1/de active
- 2002-06-05 DE DE50214379T patent/DE50214379D1/de not_active Expired - Lifetime
- 2002-06-05 EP EP07002195A patent/EP1832603B1/fr not_active Expired - Lifetime
- 2002-06-05 ES ES07015835T patent/ES2356934T3/es not_active Expired - Lifetime
- 2002-06-05 PT PT07015835T patent/PT1857122E/pt unknown
-
2003
- 2003-12-05 US US10/729,830 patent/US10188748B2/en active Active
-
2007
- 2007-07-10 AU AU2007203181A patent/AU2007203181B2/en not_active Ceased
-
2009
- 2009-07-16 AU AU2009202873A patent/AU2009202873B2/en not_active Ceased
-
2010
- 2010-05-26 US US12/787,755 patent/US20100239608A1/en not_active Abandoned
- 2010-05-26 US US12/787,566 patent/US20110077287A1/en not_active Abandoned
-
2011
- 2011-07-18 US US13/185,119 patent/US20110269950A1/en not_active Abandoned
-
2014
- 2014-09-16 US US14/487,425 patent/US11135312B2/en active Active
-
2016
- 2016-01-13 US US14/994,913 patent/US20230181765A2/en not_active Abandoned
- 2016-01-25 US US15/005,753 patent/US20160136243A1/en not_active Abandoned
- 2016-01-25 US US15/005,950 patent/US10568972B2/en not_active Expired - Lifetime
- 2016-01-25 US US15/005,911 patent/US20160136258A1/en not_active Abandoned
- 2016-01-25 US US15/005,863 patent/US20160136263A1/en not_active Abandoned
- 2016-01-25 US US15/005,808 patent/US20160136247A1/en not_active Abandoned
- 2016-01-25 US US15/005,986 patent/US11369691B2/en active Active
- 2016-08-26 US US15/248,902 patent/US20160361438A1/en not_active Abandoned
-
2018
- 2018-08-29 US US16/116,320 patent/US20190134222A1/en not_active Abandoned
-
2021
- 2021-02-15 FR FR21C1007C patent/FR21C1007I1/fr active Active
- 2021-02-15 FR FR21C1008C patent/FR21C1008I1/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR21C1008I1 (fr) | Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale | |
ES2140418T3 (es) | Flavivirus quimericos y/o flavivirus de crecimiento restringido. | |
ECSP093601A (es) | Proteínas derivadas del virus del síndrome de mancha blanca y sus usos | |
DE602006020032D1 (de) | Il-21-varianten | |
GR3019043T3 (en) | Protein having cytokin type activity, recombinant DNA coding for this protein, transformed cells and microorganisms. | |
MXPA02006888A (es) | Flavivirus recombinantes y metodos para utilizar los mismos. | |
DE60318391D1 (de) | Bakteriophagen-lysin | |
BR0213411A (pt) | Proteìna de metabolização de herbicida, seu gene e uso | |
DK1334119T3 (da) | Sammensætninger og fremgangsmåder til modulering af RSV-infektion og -immunitet | |
WO2001096527A3 (fr) | Peptides à activité physiologique | |
AR036793A1 (es) | Vacunas de acido nucleico que utilizan acidos nucleicos que codifican un antigeno de tumor con un acido nucleico que codifica una citoquina como adyuvante | |
GB9320548D0 (en) | Improvements in or relating to organic compounds | |
WO2003093419A3 (fr) | Prevention de lymphoedeme secondaire avec un adn de vegf-d | |
WO2006109174A3 (fr) | Vaccin contre le vih | |
FR2804127B1 (fr) | Gene srn1 implique dans le syndrome nephrotique cortico- resistant, proteine codee par ce gene et utilisations diagnostiques et therapeutiques | |
PT1383796E (pt) | Estirpe neurovirulenta do vírus do nilo ocidental e as suas aplicações | |
GB0409559D0 (en) | Polypeptide | |
AU2014210617B2 (en) | Combination of a recombinant mycobacterium and a biologically active agent as a vaccine | |
WO2004027066A3 (fr) | Protéine recombinante chimérique et diagnostic in vitro du hiv | |
ATE281838T1 (de) | Anti-virales reagens | |
WO2003038095A3 (fr) | Peptide isole du facteur de croissance hepatocytaire et ses variants, procede de preparation et utilisation en therapeutique en tant qu'agents antiangiogeniques | |
Jeong | Upgrade of Periodontal Biotype | |
WO2002029062A3 (fr) | Proteines cytokine |