BR112021014909A2 - Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes - Google Patents

Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes

Info

Publication number
BR112021014909A2
BR112021014909A2 BR112021014909A BR112021014909A BR112021014909A2 BR 112021014909 A2 BR112021014909 A2 BR 112021014909A2 BR 112021014909 A BR112021014909 A BR 112021014909A BR 112021014909 A BR112021014909 A BR 112021014909A BR 112021014909 A2 BR112021014909 A2 BR 112021014909A2
Authority
BR
Brazil
Prior art keywords
wall
vortex
mixing chamber
systems
associated methods
Prior art date
Application number
BR112021014909A
Other languages
English (en)
Inventor
Benjamin Geldhof
Brie Skinner
Kaelyn Vik
Stephanie Kirby
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of BR112021014909A2 publication Critical patent/BR112021014909A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B01F25/104—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components characterised by the arrangement of the discharge opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)

Abstract

agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes. a presente invenção refere-se a um agitador tipo vórtex (vórtice) (400) podendo ter uma câmara de mistura em vórtice (450) tendo uma primeira parede (451), uma segunda parede (452) e uma parede lateral (453) conectando a primeira parede e a segunda parede. pelo menos duas portas de entrada (405, 410, 415, 520) podem ser configuradas ao longo da parede lateral, cada porta de entrada tendo um canal de entrada conectado à mesma. pelo menos duas portas de entrada podem ser aproximadamente igualmente espaçadas em torno da câmara de mistura em vórtice e configuradas tangencialmente à câmara de mistura em vórtice. uma porta de saída (455) pode ter um canal de saída conectado à mesma. a porta de saída pode ser configurada em um centro radial da segunda parede e o canal de saída pode se estender a partir da porta de saída e para longe da câmara de mistura em vórtice.
BR112021014909A 2019-01-31 2020-01-31 Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes BR112021014909A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962799636P 2019-01-31 2019-01-31
US201962886592P 2019-08-14 2019-08-14
PCT/US2020/016150 WO2020160430A1 (en) 2019-01-31 2020-01-31 Vortex mixers and associated methods, systems, and apparatuses thereof

Publications (1)

Publication Number Publication Date
BR112021014909A2 true BR112021014909A2 (pt) 2021-11-23

Family

ID=69740760

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021014909A BR112021014909A2 (pt) 2019-01-31 2020-01-31 Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes

Country Status (12)

Country Link
US (1) US20220126244A1 (pt)
EP (1) EP3917656A1 (pt)
JP (1) JP7545395B2 (pt)
KR (1) KR20210133218A (pt)
CN (1) CN113710353A (pt)
AU (1) AU2020214425A1 (pt)
BR (1) BR112021014909A2 (pt)
CA (1) CA3128488A1 (pt)
IL (1) IL285214A (pt)
MX (1) MX2021009236A (pt)
SG (1) SG11202108098QA (pt)
WO (1) WO2020160430A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102340408B1 (ko) * 2020-08-05 2021-12-16 건국대학교 산학협력단 용기 고정 장치
CN113908744A (zh) * 2021-11-08 2022-01-11 常州大学 一种微流控混合器及其应用
WO2023193002A1 (en) * 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2024091918A2 (en) * 2022-10-25 2024-05-02 Modernatx, Inc. Methods of lipid nanoparticle production in cross-mixers
JP7457194B1 (ja) 2023-08-18 2024-03-27 旭有機材株式会社 渦流式流体混合器
JP7457193B1 (ja) 2023-08-18 2024-03-27 旭有機材株式会社 渦流式流体混合器

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5405497A (en) * 1990-08-28 1995-04-11 Kamyr, Inc. Method of chemically reacting a liquid with a gas in a vortex
GB9320455D0 (en) * 1993-10-05 1993-11-24 Atomic Energy Authority Uk Vortex mixer
US6310197B1 (en) 1997-11-12 2001-10-30 The Brigham And Women's Hospital, Inc. Translation enhancer element of the human amyloid precursor protein gene
EP1259602A1 (en) 2000-01-28 2002-11-27 The Scripps Research Institute Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same
US7468275B2 (en) 2000-01-28 2008-12-23 The Scripps Research Institute Synthetic internal ribosome entry sites and methods of identifying same
WO2001089675A2 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Jet vortex mixer
EP2305699B1 (de) 2001-06-05 2014-08-13 CureVac GmbH Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose
DE10162480A1 (de) 2001-12-19 2003-08-07 Ingmar Hoerr Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
DE10229872A1 (de) 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
DE10335833A1 (de) 2003-08-05 2005-03-03 Curevac Gmbh Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
DE102004042546A1 (de) 2004-09-02 2006-03-09 Curevac Gmbh Kombinationstherapie zur Immunstimulation
DE102005023170A1 (de) 2005-05-19 2006-11-23 Curevac Gmbh Optimierte Formulierung für mRNA
AU2006283077B2 (en) 2005-08-24 2012-06-28 The Scripps Research Institute Translation Enhancer-Element dependent vector systems
DE102006007433A1 (de) 2006-02-17 2007-08-23 Curevac Gmbh Adjuvanz in Form einer Lipid-modifizierten Nukleinsäure
EP2049665A2 (en) 2006-07-28 2009-04-22 Applera Corporation Dinucleotide mrna cap analogs
EP2046954A2 (en) 2006-07-31 2009-04-15 Curevac GmbH NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
JP5030520B2 (ja) 2006-09-29 2012-09-19 富士フイルム株式会社 流体混合方法及びマイクロデバイス
DE102006051516A1 (de) 2006-10-31 2008-05-08 Curevac Gmbh (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
DE102006061015A1 (de) 2006-12-22 2008-06-26 Curevac Gmbh Verfahren zur Reinigung von RNA im präparativen Maßstab mittels HPLC
DE102007001370A1 (de) 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
WO2008127688A1 (en) 2007-04-13 2008-10-23 Hart Communication Foundation Synchronizing timeslots in a wireless communication protocol
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
CA2904904A1 (en) 2007-12-11 2009-06-18 The Scripps Research Institute Compositions and methods related to mrna translational enhancer elements
AU2009210266B2 (en) 2008-01-31 2015-01-29 CureVac SE Nucleic acids comprising formula (NuGlXmGmGnNv)a and derivatives thereof as an immunostimulating agents/adjuvants
DE102008009199A1 (de) * 2008-02-15 2009-08-27 Forschungszentrum Karlsruhe Gmbh Reaktionsmischersystem zur Vermischung und chemischer Reaktion von mindestens zwei Fluiden
WO2009127230A1 (en) 2008-04-16 2009-10-22 Curevac Gmbh MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
JP4798174B2 (ja) * 2008-05-21 2011-10-19 株式会社日立プラントテクノロジー 乳化装置
PL215513B1 (pl) 2008-06-06 2013-12-31 Univ Warszawski Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
WO2010088927A1 (en) 2009-02-09 2010-08-12 Curevac Gmbh Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
HUE056773T2 (hu) 2009-06-10 2022-03-28 Arbutus Biopharma Corp Továbbfejlesztett lipid készítmény
EP2281579A1 (en) 2009-08-05 2011-02-09 BioNTech AG Vaccine composition comprising 5'-Cap modified RNA
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
KR101148080B1 (ko) * 2009-12-07 2012-06-13 (주)인사이드밸류 유체 혼합장치
WO2011069529A1 (en) 2009-12-09 2011-06-16 Curevac Gmbh Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
WO2011127255A1 (en) * 2010-04-08 2011-10-13 Merck Sharp & Dohme Corp. Preparation of lipid nanoparticles
EP2387999A1 (en) 2010-05-21 2011-11-23 CureVac GmbH Histidine-containing solution for transfection and/or injection of nucleic acids and uses thereof
WO2012009644A2 (en) 2010-07-16 2012-01-19 Arizona Board Of Regents Methods to identify synthetic and natural rna elements that enhance protein translation
DK2449113T3 (en) 2010-07-30 2016-01-11 Curevac Ag Complex formation of nucleic acids with the disulfide cross-linked cationic components for transfection and immunostimulation
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
WO2012089225A1 (en) 2010-12-29 2012-07-05 Curevac Gmbh Combination of vaccination and inhibition of mhc class i restricted antigen presentation
EP3202760B1 (en) 2011-01-11 2019-08-21 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
WO2012116715A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in newborns and infants
WO2012113413A1 (en) 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
WO2012116714A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
WO2013103659A1 (en) 2012-01-04 2013-07-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Stabilizing rna by incorporating chain-terminating nucleosides at the 3'-terminus
EP2623121A1 (en) 2012-01-31 2013-08-07 Bayer Innovation GmbH Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen
WO2013113325A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Negatively charged nucleic acid comprising complexes for immunostimulation
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
JP6301906B2 (ja) 2012-03-27 2018-03-28 キュアバック アーゲー ５’ｔｏｐｕｔｒを含む人工核酸分子
CN104220599A (zh) 2012-03-27 2014-12-17 库瑞瓦格有限责任公司 人工核酸分子
CA2859452C (en) 2012-03-27 2021-12-21 Curevac Gmbh Artificial nucleic acid molecules for improved protein or peptide expression
WO2013174409A1 (en) 2012-05-25 2013-11-28 Curevac Gmbh Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings
SG11201506052PA (en) 2013-02-22 2015-09-29 Curevac Gmbh Combination of vaccination and inhibition of the pd-1 pathway
WO2015002667A1 (en) 2013-07-01 2015-01-08 Myq, Inc. A location regulated point-of-sale system and enhancements
WO2015024668A2 (en) 2013-08-21 2015-02-26 Curevac Gmbh Respiratory syncytial virus (rsv) vaccine
RU2733424C2 (ru) 2013-08-21 2020-10-01 Куревак Аг Способ повышения экспрессии кодируемых рнк белков
CN105517566A (zh) 2013-08-21 2016-04-20 库瑞瓦格股份公司 用于治疗前列腺癌的组合物和疫苗
WO2015024665A1 (en) 2013-08-21 2015-02-26 Curevac Gmbh Rabies vaccine
KR20160042935A (ko) 2013-08-21 2016-04-20 큐어백 아게 폐암 치료를 위한 조성물 및 백신
CA2915730A1 (en) 2013-08-21 2015-02-26 Karl-Josef Kallen A combination rsv/influenza a vaccine
ES2806575T3 (es) 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
US9956532B2 (en) * 2013-11-07 2018-05-01 U.S. Department Of Energy Apparatus and method for generating swirling flow
CN111304231A (zh) 2013-12-30 2020-06-19 库瑞瓦格股份公司 人工核酸分子
WO2015101416A1 (en) 2013-12-30 2015-07-09 Curevac Gmbh Methods for rna analysis
CA2927254C (en) 2013-12-30 2023-10-24 Curevac Ag Artificial nucleic acid molecules
EP3110401A4 (en) 2014-02-25 2017-10-25 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
JP6373749B2 (ja) * 2014-12-19 2018-08-15 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
US10035113B2 (en) * 2015-02-26 2018-07-31 Tokyo Electron Limited Method and system for a spiral mixer
EP3288671A4 (en) 2015-04-28 2019-01-16 The University Of British Columbia DISPOSABLE MICROFLUIDIC CARTRIDGE
JP6925020B2 (ja) 2017-03-22 2021-08-25 国立大学法人横浜国立大学 混合装置及び混合方法

Also Published As

Publication number Publication date
EP3917656A1 (en) 2021-12-08
IL285214A (en) 2021-09-30
CN113710353A (zh) 2021-11-26
MX2021009236A (es) 2021-11-12
JP7545395B2 (ja) 2024-09-04
AU2020214425A1 (en) 2021-08-19
WO2020160430A1 (en) 2020-08-06
KR20210133218A (ko) 2021-11-05
SG11202108098QA (en) 2021-08-30
US20220126244A1 (en) 2022-04-28
CA3128488A1 (en) 2020-08-06
JP2022523117A (ja) 2022-04-21

Similar Documents

Publication Publication Date Title
BR112021014909A2 (pt) Agitadores tipo vórtex e métodos associados, sistemas e aparelhos destes
ATE390203T1 (de) Statischer mikrovermischer
ATE364438T1 (de) Statischer mikrovermischer
BR112018015316A2 (pt) aparelho de separação de partículas e método para separar partículas
RU2010114215A (ru) Динамический смеситель
DK0708681T3 (da) Apparat til blanding af komponenter i en fluidstrøm
BR112017015329A2 (pt) sistema de medição para particulado sólido.
BR112015009408A2 (pt) cabeça de aspersão para misturador de dois componentes
BR112014014584B1 (pt) Dispositivo de separação, e, método de fabricação de um turbilhonador
DE502007000238D1 (de) Milchaufschäumvorrichtung
BR112018000935A2 (pt) ?sistema microfluídico, recipiente, e, método?
HRP20211809T1 (hr) Difuzor zraka
MX2009013968A (es) Dispositivo de agitacion giratorio para tratar metal fundido.
AU2017212686A1 (en) Hollow chamber x-mixer heat exchanger
BR112018000986A2 (pt) dispositivos para produção de vácuo utilizando o efeito venturi, tendo uma pluralidade de subpassagem e saídas motrizes na seção motriz
BR112018006304A2 (pt) aparelho misturador de pós, e método de misturar um pó
KR101479796B1 (ko) 인라인 믹서 장치
BR112018002859A2 (pt) Receptor solar
BR112021012943A2 (pt) Corpo de sonda, sonda óptica, uso do corpo da sonda, e, método
KR101599059B1 (ko) 폐 액형 재료를 줄일 수 있는 이액형 믹싱팁
BR112022020660A2 (pt) Dispositivo de mistura microfluídica e métodos de uso
EP3167954A1 (en) Static mixer
MX2024005549A (es) Desapilador para alimentos cortados.
CL2019003824A1 (es) Distribuidor para un fluido.
BR112017020475A2 (pt) ?dispositivo para reduzir o ruído de jato de um motor de turbina, e, motor de turbina?

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements