EP1392341A2 - Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes - Google Patents

Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes

Info

Publication number
EP1392341A2
EP1392341A2 EP02732752A EP02732752A EP1392341A2 EP 1392341 A2 EP1392341 A2 EP 1392341A2 EP 02732752 A EP02732752 A EP 02732752A EP 02732752 A EP02732752 A EP 02732752A EP 1392341 A2 EP1392341 A2 EP 1392341A2
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical composition
mrna
composition according
coding
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02732752A
Other languages
German (de)
English (en)
Other versions
EP1392341B1 (fr
Inventor
Florian VON DER MüLBE
Ingmar Hoerr
Steve Pascolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curevac SE
Original Assignee
Curevac AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7687266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1392341(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP10007991.2A priority Critical patent/EP2305699B1/fr
Priority to EP20140002635 priority patent/EP2842964A1/fr
Priority to EP20070000343 priority patent/EP1800697B1/fr
Priority to EP07015835A priority patent/EP1857122B1/fr
Priority to EP07002195A priority patent/EP1832603B1/fr
Priority to EP20070023083 priority patent/EP1903054A3/fr
Priority to EP05004938A priority patent/EP1604688B1/fr
Application filed by Curevac AG filed Critical Curevac AG
Publication of EP1392341A2 publication Critical patent/EP1392341A2/fr
Publication of EP1392341B1 publication Critical patent/EP1392341B1/fr
Application granted granted Critical
Priority to FR21C1007C priority patent/FR21C1007I1/fr
Priority to FR21C1008C priority patent/FR21C1008I1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

L'invention concerne une composition pharmaceutique qui contient un ARNm stabilisé par des modifications de séquence dans la région traduite et optimisé pour la traduction. La composition pharmaceutique selon l'invention convient notamment comme vaccin et comme agent thérapeutique pour la régénération tissulaire. L'invention concerne également un procédé servant à déterminer des modifications de séquence servant à la stabilisation et à l'optimisation en vue de la traduction d'ARNm.
EP02732752A 2001-06-05 2002-06-05 Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes Expired - Lifetime EP1392341B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP05004938A EP1604688B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé codant pour un antigène tumoral avec un contenu G/C augmenté
EP20070000343 EP1800697B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté pour l'utilisation dans la thérapie génique
EP07015835A EP1857122B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé avec un contenu augmenté en G/C, codant pour un antigène virale
EP07002195A EP1832603B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté, codant pour un antigène bactérien et son utilisation
EP20070023083 EP1903054A3 (fr) 2001-06-05 2002-06-05 Composition pharmaceutique contenant une ARNm stabilisée et optimisée pour la translation dans ses zones codées
EP20140002635 EP2842964A1 (fr) 2001-06-05 2002-06-05 Méthode virtuelle de détermination d'une séquence d'ARNm modifiée
EP10007991.2A EP2305699B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisée avec un contenu augmenté en G/C et optimisée pour la translation dans ses zones codées pour la vaccination contre la trypanosomiase, la leishmaniose et la toxoplasmose
FR21C1008C FR21C1008I1 (fr) 2001-06-05 2021-02-15 Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale
FR21C1007C FR21C1007I1 (fr) 2001-06-05 2021-02-15 Arnm stabilise avec un contenu augmente en g/c, codant pour un antigene virale

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10127283 2001-06-05
DE10127283 2001-06-05
PCT/EP2002/006180 WO2002098443A2 (fr) 2001-06-05 2002-06-05 Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes

Related Child Applications (4)

Application Number Title Priority Date Filing Date
EP05004938A Division EP1604688B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé codant pour un antigène tumoral avec un contenu G/C augmenté
EP20140002635 Division EP2842964A1 (fr) 2001-06-05 2002-06-05 Méthode virtuelle de détermination d'une séquence d'ARNm modifiée
EP07002195A Division EP1832603B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté, codant pour un antigène bactérien et son utilisation
EP10007991.2A Division EP2305699B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisée avec un contenu augmenté en G/C et optimisée pour la translation dans ses zones codées pour la vaccination contre la trypanosomiase, la leishmaniose et la toxoplasmose

Publications (2)

Publication Number Publication Date
EP1392341A2 true EP1392341A2 (fr) 2004-03-03
EP1392341B1 EP1392341B1 (fr) 2005-03-30

Family

ID=7687266

Family Applications (8)

Application Number Title Priority Date Filing Date
EP20070000343 Expired - Lifetime EP1800697B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté pour l'utilisation dans la thérapie génique
EP20070023083 Withdrawn EP1903054A3 (fr) 2001-06-05 2002-06-05 Composition pharmaceutique contenant une ARNm stabilisée et optimisée pour la translation dans ses zones codées
EP07002195A Expired - Lifetime EP1832603B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté, codant pour un antigène bactérien et son utilisation
EP20140002635 Withdrawn EP2842964A1 (fr) 2001-06-05 2002-06-05 Méthode virtuelle de détermination d'une séquence d'ARNm modifiée
EP05004938A Expired - Lifetime EP1604688B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé codant pour un antigène tumoral avec un contenu G/C augmenté
EP10007991.2A Expired - Lifetime EP2305699B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisée avec un contenu augmenté en G/C et optimisée pour la translation dans ses zones codées pour la vaccination contre la trypanosomiase, la leishmaniose et la toxoplasmose
EP02732752A Expired - Lifetime EP1392341B1 (fr) 2001-06-05 2002-06-05 Composition pharmaceutique contenant un arnm stabilise et optimise pour la traduction dans ses regions codantes
EP07015835A Expired - Lifetime EP1857122B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé avec un contenu augmenté en G/C, codant pour un antigène virale

Family Applications Before (6)

Application Number Title Priority Date Filing Date
EP20070000343 Expired - Lifetime EP1800697B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté pour l'utilisation dans la thérapie génique
EP20070023083 Withdrawn EP1903054A3 (fr) 2001-06-05 2002-06-05 Composition pharmaceutique contenant une ARNm stabilisée et optimisée pour la translation dans ses zones codées
EP07002195A Expired - Lifetime EP1832603B1 (fr) 2001-06-05 2002-06-05 ARNm avec un contenu G/C augmenté, codant pour un antigène bactérien et son utilisation
EP20140002635 Withdrawn EP2842964A1 (fr) 2001-06-05 2002-06-05 Méthode virtuelle de détermination d'une séquence d'ARNm modifiée
EP05004938A Expired - Lifetime EP1604688B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé codant pour un antigène tumoral avec un contenu G/C augmenté
EP10007991.2A Expired - Lifetime EP2305699B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisée avec un contenu augmenté en G/C et optimisée pour la translation dans ses zones codées pour la vaccination contre la trypanosomiase, la leishmaniose et la toxoplasmose

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07015835A Expired - Lifetime EP1857122B1 (fr) 2001-06-05 2002-06-05 ARNm stabilisé avec un contenu augmenté en G/C, codant pour un antigène virale

Country Status (11)

Country Link
US (14) US10188748B2 (fr)
EP (8) EP1800697B1 (fr)
AT (5) ATE457029T1 (fr)
AU (2) AU2007203181B2 (fr)
CA (2) CA2457959C (fr)
DE (5) DE50214201D1 (fr)
DK (1) DK1857122T3 (fr)
ES (5) ES2340499T3 (fr)
FR (2) FR21C1008I1 (fr)
PT (1) PT1857122E (fr)
WO (1) WO2002098443A2 (fr)

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WO2011003834A1 (fr) 2009-07-09 2011-01-13 Marina Biotech, Inc. Liposomes amphotères comprenant des lipides imino
WO2012006378A1 (fr) 2010-07-06 2012-01-12 Novartis Ag Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn
EP2462924A2 (fr) 2006-10-13 2012-06-13 Marina Biotech, Inc. Améliorations et ou associées aux liposomes amphotériques
WO2013006825A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Liposomes ayant un rapport n:p utile pour délivrance de molécules d'arn
WO2013151668A2 (fr) 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés destinés à la production de protéines sécrétées
WO2013151666A2 (fr) 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés destinés à la production de produits biologiques et de protéines associées à une maladie humaine
WO2015034928A1 (fr) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Polynucléotides chimériques
US9066867B2 (en) 2005-09-15 2015-06-30 Marina Biotech, Inc. Amphoteric liposomes
WO2017180587A2 (fr) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
US10022436B2 (en) 2016-01-11 2018-07-17 Verndari, Inc. Microneedle compositions and methods of using same
EP2714071B1 (fr) * 2011-05-24 2019-07-10 BioNTech RNA Pharmaceuticals GmbH Vaccins individualisés pour le cancer
WO2019241315A1 (fr) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Constructions régulatrices dérivées de pde5 et procédés d'utilisation en immunothérapie
WO2020086742A1 (fr) 2018-10-24 2020-04-30 Obsidian Therapeutics, Inc. Régulation de protéine accordable par er
US10738355B2 (en) 2011-05-24 2020-08-11 Tron-Translationale Onkologie An Der Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Ggmbh Individualized vaccines for cancer
US11110157B2 (en) 2014-03-12 2021-09-07 Curevac Ag Combination of vaccination and OX40 agonists
WO2022090752A1 (fr) 2020-10-26 2022-05-05 Pécsi Tudományegyetem Plateforme de vaccin
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FR21C1008I1 (fr) 2021-03-26
EP1832603B1 (fr) 2010-02-03
US20110077287A1 (en) 2011-03-31
EP2305699A1 (fr) 2011-04-06
EP1903054A3 (fr) 2008-07-23
AU2007203181A1 (en) 2007-07-26
US20230181765A2 (en) 2023-06-15
PT1857122E (pt) 2011-03-07
US20160136243A1 (en) 2016-05-19
EP2842964A1 (fr) 2015-03-04
CA2830887A1 (fr) 2002-12-12
US20160361438A1 (en) 2016-12-15
US20110269950A1 (en) 2011-11-03
ES2344078T3 (es) 2010-08-17
AU2007203181B2 (en) 2011-01-06
US11369691B2 (en) 2022-06-28
EP1800697A3 (fr) 2007-10-31
EP1857122B1 (fr) 2010-12-01
WO2002098443A2 (fr) 2002-12-12
EP2305699B1 (fr) 2014-08-13
EP1800697B1 (fr) 2010-04-14
US11135312B2 (en) 2021-10-05
FR21C1007I1 (fr) 2021-03-26
WO2002098443A3 (fr) 2003-11-13
US20160136301A1 (en) 2016-05-19
DE50214379D1 (de) 2010-05-27
CA2457959A1 (fr) 2002-12-12
EP1604688A1 (fr) 2005-12-14
US10568972B2 (en) 2020-02-25
DE50214200D1 (de) 2010-03-25
EP1857122A2 (fr) 2007-11-21
AU2009202873A1 (en) 2009-08-06
US20160136258A1 (en) 2016-05-19
AU2009202873B2 (en) 2012-08-16
ATE490267T1 (de) 2010-12-15
US10188748B2 (en) 2019-01-29
US20050032730A1 (en) 2005-02-10
DK1857122T3 (da) 2011-03-21
EP1903054A2 (fr) 2008-03-26
EP1832603A2 (fr) 2007-09-12
ES2340499T3 (es) 2010-06-04
ATE464317T1 (de) 2010-04-15
US20100239608A1 (en) 2010-09-23
ES2340532T3 (es) 2010-06-04
ES2240745T3 (es) 2005-10-16
EP1832603A3 (fr) 2007-10-31
DE50214201D1 (de) 2010-03-25
ATE291925T1 (de) 2005-04-15
CA2457959C (fr) 2014-10-28
EP1392341B1 (fr) 2005-03-30
CA2830887C (fr) 2016-11-29
EP1604688B1 (fr) 2010-02-03
EP1800697A2 (fr) 2007-06-27
ATE456959T1 (de) 2010-02-15
ES2356934T3 (es) 2011-04-14
US20160136263A1 (en) 2016-05-19
US20150104476A1 (en) 2015-04-16
US20160136259A1 (en) 2016-05-19
US20190134222A1 (en) 2019-05-09
DE50202634D1 (de) 2005-05-04
US20160129105A1 (en) 2016-05-12
ATE457029T1 (de) 2010-02-15
AU2009202873A8 (en) 2009-08-13
US20160136247A1 (en) 2016-05-19
DE50214801D1 (de) 2011-01-13
EP1857122A3 (fr) 2008-11-19

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