MX2018001040A - Moleculas de acido nucleico artificiales. - Google Patents

Moleculas de acido nucleico artificiales.

Info

Publication number
MX2018001040A
MX2018001040A MX2018001040A MX2018001040A MX2018001040A MX 2018001040 A MX2018001040 A MX 2018001040A MX 2018001040 A MX2018001040 A MX 2018001040A MX 2018001040 A MX2018001040 A MX 2018001040A MX 2018001040 A MX2018001040 A MX 2018001040A
Authority
MX
Mexico
Prior art keywords
nucleic acid
artificial nucleic
utr
utr element
acid molecules
Prior art date
Application number
MX2018001040A
Other languages
English (en)
Inventor
Schlake Thomas
GRUND Stefanie
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of MX2018001040A publication Critical patent/MX2018001040A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

Abstract

La invención se refiere a una molécula de ácido nucleico artificial que comprende al menos un marco de lectura abierto y al menos un elemento de región 3´ no traducida (elemento 3´-UTR) y/o al menos un elemento de región 5´ no traducida (elemento 5´-UTR), en donde la molécula de ácido nucleico artificial se caracteriza por eficiencia de traducción alta. La eficiencia de traducción es contribuida, al menos en parte, por el elemento 5´-UTR o el elemento 3´-UTR, o tanto el elemento 5´-UTR como el elemento 3´-UTR. La invención se refiere además al uso de esta molécula de ácido nucleico artificial en la terapia génica y/o vacunación genética. Además, se proporcionan elementos 3´-UTRs y elementos 5´-UTRs novedosos.
MX2018001040A 2015-08-28 2016-08-22 Moleculas de acido nucleico artificiales. MX2018001040A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015001755 2015-08-28
PCT/EP2016/001417 WO2017036580A1 (en) 2015-08-28 2016-08-22 Artificial nucleic acid molecules

Publications (1)

Publication Number Publication Date
MX2018001040A true MX2018001040A (es) 2018-06-15

Family

ID=54064264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001040A MX2018001040A (es) 2015-08-28 2016-08-22 Moleculas de acido nucleico artificiales.

Country Status (13)

Country Link
US (1) US20180237786A1 (es)
EP (2) EP4108774A1 (es)
JP (2) JP7304155B2 (es)
KR (1) KR102645398B1 (es)
CN (2) CN114381470A (es)
AU (1) AU2016316439B2 (es)
BR (1) BR112018001995A2 (es)
CA (1) CA2992801A1 (es)
DK (1) DK3341482T3 (es)
ES (1) ES2924739T3 (es)
MX (1) MX2018001040A (es)
SG (1) SG10201913629VA (es)
WO (1) WO2017036580A1 (es)

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Also Published As

Publication number Publication date
BR112018001995A2 (pt) 2018-09-18
EP3341482A1 (en) 2018-07-04
ES2924739T3 (es) 2022-10-10
CN114381470A (zh) 2022-04-22
JP2018529329A (ja) 2018-10-11
JP2021192613A (ja) 2021-12-23
WO2017036580A1 (en) 2017-03-09
AU2016316439B2 (en) 2022-02-24
DK3341482T3 (da) 2022-08-15
KR102645398B1 (ko) 2024-03-07
RU2018110872A (ru) 2019-10-01
AU2016316439A1 (en) 2018-02-08
SG10201913629VA (en) 2020-03-30
EP3341482B1 (en) 2022-07-06
JP7245878B2 (ja) 2023-03-24
CN108026537A (zh) 2018-05-11
KR20180038564A (ko) 2018-04-16
JP7304155B2 (ja) 2023-07-06
CN108026537B (zh) 2022-02-08
CA2992801A1 (en) 2017-03-09
EP4108774A1 (en) 2022-12-28
US20180237786A1 (en) 2018-08-23
RU2018110872A3 (es) 2020-07-24

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