SG11201602625YA - Vectors for expression of prostate-associated antigens - Google Patents

Vectors for expression of prostate-associated antigens

Info

Publication number
SG11201602625YA
SG11201602625YA SG11201602625YA SG11201602625YA SG11201602625YA SG 11201602625Y A SG11201602625Y A SG 11201602625YA SG 11201602625Y A SG11201602625Y A SG 11201602625YA SG 11201602625Y A SG11201602625Y A SG 11201602625YA SG 11201602625Y A SG11201602625Y A SG 11201602625YA
Authority
SG
Singapore
Prior art keywords
prostate
vectors
expression
associated antigens
antigens
Prior art date
Application number
SG11201602625YA
Inventor
Joseph John Binder
Helen Kim Cho
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SG11201602625YA publication Critical patent/SG11201602625YA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K39/001195—Prostate specific membrane antigen [PSMA]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
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    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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    • C12Y—ENZYMES
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21077—Semenogelase (3.4.21.77), i.e. prostate specific antigen or PSA or kallikrein 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SG11201602625YA 2013-11-01 2014-10-17 Vectors for expression of prostate-associated antigens SG11201602625YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361898966P 2013-11-01 2013-11-01
PCT/IB2014/065419 WO2015063647A1 (en) 2013-11-01 2014-10-17 Vectors for expression of prostate-associated antigens

Publications (1)

Publication Number Publication Date
SG11201602625YA true SG11201602625YA (en) 2016-05-30

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SG11201602625YA SG11201602625YA (en) 2013-11-01 2014-10-17 Vectors for expression of prostate-associated antigens
SG10201910889VA SG10201910889VA (en) 2013-11-01 2014-10-17 Vectors for expression of prostate-associated antigens

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Country Status (27)

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US (3) US9402901B2 (en)
EP (2) EP3062815B1 (en)
JP (3) JP2016535989A (en)
KR (2) KR102196884B1 (en)
CN (1) CN105682679B (en)
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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE043042T2 (en) 2013-11-01 2019-07-29 Pfizer Vectors for expression of prostate-associated antigens
WO2015142963A1 (en) 2014-03-17 2015-09-24 Tapimmune Inc. Nucleic acid molecule vaccine compositions and uses thereof
TWI595006B (en) 2014-12-09 2017-08-11 禮納特神經系統科學公司 Anti-pd-1 antibodies and methods of use thereof
CN114209841A (en) 2015-06-29 2022-03-22 维瑞斯特姆股份有限公司 Therapeutic compositions, combinations and methods of use
BR112018012374A2 (en) 2015-12-16 2018-12-04 Gritstone Oncology, Inc. identification, manufacture and use of neoantigen
TWI654302B (en) 2016-01-19 2019-03-21 輝瑞股份有限公司 Cancer vaccine
EP3408394B1 (en) * 2016-01-27 2020-08-12 Total Raffinage Chimie Multigene expression in microalgae
CN109312364A (en) * 2016-03-18 2019-02-05 河谷细胞有限公司 For infecting the multi-mode carrier of Dendritic Cells
EP3452081A1 (en) * 2016-05-04 2019-03-13 Transgene SA Combination therapy with cpg tlr9 ligand
CA3026342A1 (en) * 2016-06-03 2017-12-07 Etubics Corporation Compositions and methods for tumor vaccination using prostate cancer-associated antigens
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector
WO2018069316A2 (en) * 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
MA46904A (en) * 2016-11-23 2019-10-02 Gritstone Oncology Inc VIRAL ADMINISTRATION OF NEO-ANTIGENS
CA3056090A1 (en) 2017-03-15 2018-09-20 Novavax, Inc. Methods and compositions for inducing immune responses against clostridium difficile
TW201907937A (en) 2017-05-08 2019-03-01 美商葛利史東腫瘤科技公司 Alpha virus new antigen vector
CN111065408A (en) 2017-07-11 2020-04-24 辉瑞公司 Immunogenic compositions
CA3078744A1 (en) 2017-10-10 2019-04-18 Gritstone Oncology, Inc. Neoantigen identification using hotspots
AU2018373154A1 (en) 2017-11-22 2020-07-02 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
KR20200118029A (en) 2018-01-04 2020-10-14 아이코닉 테라퓨틱스, 인코포레이티드 Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
CN114072516A (en) 2019-05-30 2022-02-18 磨石生物公司 Modified adenoviruses
RU2726541C1 (en) * 2019-11-19 2020-07-14 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Recombinant human breast cancer cell line brcch4e-134, expressing human prostate-specific membrane antigen
CN113088530A (en) * 2020-01-08 2021-07-09 怡道生物科技(苏州)有限公司 Expression vector based on chimpanzee ChAd63 adenovirus and construction method thereof
CN116438308A (en) 2020-08-06 2023-07-14 磨石生物公司 Multi-epitope vaccine box

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US628371A (en) 1898-09-10 1899-07-04 Clark W Thomas Machine for making berry-boxes.
JPS58130841A (en) * 1982-01-29 1983-08-04 Nec Corp Luminescent mark detection device
US5981724A (en) 1991-10-25 1999-11-09 Immunex Corporation DNA encoding CD40 ligand, a cytokine that binds CD40
CA2560114A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
DE69841122D1 (en) 1997-03-10 2009-10-15 Coley Pharm Gmbh Use of non-methylated CpG dinucleotide in combination with aluminum as adjuvants
CA2301575C (en) 1997-05-20 2003-12-23 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
EP2085090A3 (en) 1997-06-06 2012-05-02 The Regents of the University of California Inhibitors of DNA immunostimulatory sequence activity
EP1009382B1 (en) 1997-09-05 2003-06-18 GlaxoSmithKline Biologicals S.A. Oil in water emulsions containing saponins
US6833438B1 (en) 1999-06-01 2004-12-21 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
OA11917A (en) 1998-12-23 2006-04-13 Abgenix Inc Human monoclonal antibodies to ctla-4.
EE05627B1 (en) 1998-12-23 2013-02-15 Pfizer Inc. Human monoclonal antibodies to CTLA-4
EP1159429A2 (en) 1999-02-18 2001-12-05 Compugen Ltd. Psa and klk-2 splicing variants
CA2589418A1 (en) 1999-08-24 2001-03-01 Medarex, Inc. Human ctla-4 antibodies and their uses
WO2001016180A2 (en) 1999-08-27 2001-03-08 Board Of Regents, The University Of Texas System Cd40 agonist compositions and methods of use
ATE369359T1 (en) 2000-02-15 2007-08-15 Sugen Inc PYRROLE SUBSTITUTED INDOLIN-2-ONE PROTEIN KINASE INHIBITORS
EP1276896B1 (en) * 2000-04-28 2010-07-21 Mannkind Corporation Epitope synchronization in antigen presenting cells
RU2192889C1 (en) * 2001-03-16 2002-11-20 Эпштейн Олег Ильич Medicinal preparation and method for treating prostatic diseases
ES2340499T3 (en) 2001-06-05 2010-06-04 Curevac Gmbh TUMOR ANTIGEN ARNM STABILIZED WITH AN INCREASED G / C CONTENT.
BR0210586A (en) 2001-06-22 2005-07-12 Wistar Inst Methods for inducing a cytotoxic immune reaction and useful recombinant simian adenovirus compositions thereof
ATE530672T1 (en) 2001-06-22 2011-11-15 Univ Pennsylvania RECOMBINANT ADENOVIRUSES WITH MONKEY ADENOVIRUS PROTEINS AND USE THEREOF.
JP4302513B2 (en) 2001-07-05 2009-07-29 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Polynucleotides encoding antigenic type B HIV polypeptides and / or antigenic type C HIV polypeptides, polypeptides thereof and uses thereof
JP5033303B2 (en) * 2001-07-05 2012-09-26 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Polynucleotides encoding polypeptides with antigenic type C HIV, polypeptides and uses thereof
CN100439360C (en) 2001-08-15 2008-12-03 法玛西雅厄普约翰美国公司 Crystals including a malic acid salt of a 3-pyrrole substituted 2-indolinone, and compositions thereof
BR0206112A (en) * 2001-10-10 2005-05-10 Centocor Inc Nucleic acid vaccines using tumor antigen-encoding nucleic acids with cytokine helper-encoding nucleic acid
TWI228718B (en) 2001-11-05 2005-03-01 Tdk Corp Manufacturing method and device of mold plate for information medium
SG165153A1 (en) * 2001-11-21 2010-10-28 Univ Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
EP1476443A2 (en) 2002-02-15 2004-11-17 PHARMACIA & UPJOHN COMPANY Process for preparing indolinone derivatives
TW200418836A (en) 2002-09-10 2004-10-01 Pharmacia Italia Spa Formulations comprising an indolinone compound
WO2004067570A2 (en) 2003-01-28 2004-08-12 Proscan Rx Pharma Prostate cancer diagnosis and treatment
ATE541052T1 (en) * 2003-05-30 2012-01-15 Agensys Inc VARIANTS OF PROSTATE STEM CELL ANTIGEN (PSCA) AND PARTIAL SEQUENCES THEREOF
DE10335833A1 (en) 2003-08-05 2005-03-03 Curevac Gmbh Transfection of blood cells with mRNA for immune stimulation and gene therapy
WO2005023765A1 (en) 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Method for catalyzing amidation reactions by the presence of co2
GB0321615D0 (en) * 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
CA2993042A1 (en) * 2004-01-23 2005-08-04 Msd Italia S.R.L. Chimpanzee adenovirus vaccine carriers
ES2361000T3 (en) 2004-04-28 2011-06-13 The Trustees Of The University Of Pennsylvania SEQUENTIAL SUPPLY OF IMMUNOGENIC MOLECULES THROUGH ADMINISTRATIONS OF AN ADENOVIRUS AND AN ADENO-ASSOCIATED VIRUS.
DE102004035227A1 (en) 2004-07-21 2006-02-16 Curevac Gmbh mRNA mixture for vaccination against tumor diseases
JP5405110B2 (en) 2005-09-19 2014-02-05 ベリデックス・エルエルシー Methods and materials for identifying primary lesions of cancer of unknown primary
EP1954311A4 (en) 2005-12-07 2009-12-23 Medarex Inc Ctla-4 antibody dosage escalation regimens
RS51250B (en) 2006-04-28 2010-12-31 The Trustees Of The University Of Pennsylvania Modified adenovirus hexon protein and uses thereof
GB0706914D0 (en) 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
WO2009046739A1 (en) * 2007-10-09 2009-04-16 Curevac Gmbh Composition for treating prostate cancer (pca)
EP2207564B1 (en) * 2007-10-18 2016-10-05 Bavarian Nordic A/S Use of mva to treat prostate cancer
IN2012DN02368A (en) * 2009-09-14 2015-08-21 Baylor Res Insitute
EP3909973A3 (en) * 2010-11-12 2022-01-26 The Trustees Of The University Of Pennsylvania Consensus prostate antigens, nucleic acid molecules encoding the same and uses thereof
WO2012116714A1 (en) * 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
EA027236B1 (en) * 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
CN102294025B (en) * 2011-08-10 2013-06-05 中国人民解放军第三军医大学第三附属医院 Compound of prostate stem cell antigen polypeptide and nucleic acid and preparation method and application thereof
SG10201603896RA (en) * 2012-05-04 2016-07-28 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
HUE043042T2 (en) 2013-11-01 2019-07-29 Pfizer Vectors for expression of prostate-associated antigens

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