FI960136A - Kompositioner och förfaranden för stimulering av megakaryocytisk tillväxt och differentiering - Google Patents
Kompositioner och förfaranden för stimulering av megakaryocytisk tillväxt och differentiering Download PDFInfo
- Publication number
- FI960136A FI960136A FI960136A FI960136A FI960136A FI 960136 A FI960136 A FI 960136A FI 960136 A FI960136 A FI 960136A FI 960136 A FI960136 A FI 960136A FI 960136 A FI960136 A FI 960136A
- Authority
- FI
- Finland
- Prior art keywords
- disclosed
- stimulating
- methods
- growth
- mgdfs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22176894A | 1994-03-31 | 1994-03-31 | |
US25262894A | 1994-05-31 | 1994-05-31 | |
US08/321,488 US5795569A (en) | 1994-03-31 | 1994-10-12 | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
US34778094A | 1994-11-30 | 1994-11-30 | |
PCT/US1995/003776 WO1995026746A1 (en) | 1994-03-31 | 1995-03-30 | Compositions and methods for stimulating megakaryocyte growth and differentiation |
Publications (2)
Publication Number | Publication Date |
---|---|
FI960136A0 FI960136A0 (sv) | 1996-01-11 |
FI960136A true FI960136A (sv) | 1996-03-11 |
Family
ID=27499246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI960136A FI960136A (sv) | 1994-03-31 | 1996-01-11 | Kompositioner och förfaranden för stimulering av megakaryocytisk tillväxt och differentiering |
Country Status (32)
Country | Link |
---|---|
US (1) | US5766581A (sv) |
EP (3) | EP0690127B1 (sv) |
JP (2) | JP2996415B2 (sv) |
KR (2) | KR100303810B1 (sv) |
CN (2) | CN1229385C (sv) |
AT (1) | ATE169335T1 (sv) |
AU (1) | AU691606B2 (sv) |
BG (1) | BG62685B1 (sv) |
BR (1) | BR9506017A (sv) |
CA (1) | CA2167090C (sv) |
CZ (2) | CZ288926B6 (sv) |
DE (1) | DE69503849T2 (sv) |
DK (1) | DK0690127T3 (sv) |
EE (1) | EE9600121A (sv) |
ES (1) | ES2119250T3 (sv) |
FI (1) | FI960136A (sv) |
GE (1) | GEP20002180B (sv) |
GR (1) | GR3027593T3 (sv) |
HK (2) | HK1004231A1 (sv) |
HU (1) | HU218893B (sv) |
IL (1) | IL113206A0 (sv) |
LV (2) | LV11783B (sv) |
MY (1) | MY113048A (sv) |
NO (1) | NO960111L (sv) |
NZ (1) | NZ283863A (sv) |
PL (1) | PL182567B1 (sv) |
RO (1) | RO115788B1 (sv) |
SI (1) | SI0690127T1 (sv) |
SK (1) | SK166695A3 (sv) |
TW (3) | TW414799B (sv) |
WO (1) | WO1995026746A1 (sv) |
YU (1) | YU20095A (sv) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
WO1996017062A1 (en) * | 1994-11-30 | 1996-06-06 | Zymogenetics, Inc. | Low molecular weight thrombopoietin |
US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
TW387940B (en) * | 1995-01-17 | 2000-04-21 | Kirin Brewery | Anti-tpo monodonal antibody |
CA2212006A1 (en) | 1995-02-03 | 1996-08-08 | G.D. Searle & Co. | Novel c-mpl ligands |
EP0811064B1 (en) * | 1995-02-15 | 2006-04-19 | Amgen Inc., | Mpl ligand analogs |
US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
US5696250A (en) * | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
CN1315870C (zh) | 1995-06-07 | 2007-05-16 | 葛兰素集团有限公司 | 结合血小板生成素受体的肽和化合物 |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
AU722759B2 (en) * | 1995-10-05 | 2000-08-10 | G.D. Searle & Co. | Novel C-MPL receptor agonists |
US6066318A (en) | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
AU4344697A (en) * | 1996-10-04 | 1998-04-24 | Amgen, Inc. | Pharmaceutical compositions containing an mpl ligand |
US5914251A (en) * | 1996-10-22 | 1999-06-22 | Amgen Inc. | Nucleic acid molecules encoding placental-derived growth factors |
EP0983082A1 (en) * | 1997-05-21 | 2000-03-08 | Genentech, Inc. | Novel administration of thrombopoietin |
AU2006201129B2 (en) * | 1997-05-21 | 2008-03-13 | Genentech, Inc. | Novel administration of thrombopoietin |
PL196533B1 (pl) * | 1998-04-28 | 2008-01-31 | Applied Research Systems | Sposób stopniowego przyłączania ugrupowań poli (glikolu etylenowego) (PEG) szeregowo do polipeptydu |
US20030228666A1 (en) | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
MY126795A (en) | 1998-10-23 | 2006-10-31 | Amgen K A Inc | Dimeric thrombopoietic peptide mimetics binding to mp1 receptor and having thrombopoietic activity. |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
WO2000057891A1 (en) | 1999-03-30 | 2000-10-05 | Trustees Of Boston University | Compositions and methods for producing platelets and/or proplatelets from megakaryocytes |
US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
JP4799801B2 (ja) | 2000-08-11 | 2011-10-26 | 協和発酵キリン株式会社 | リン酸代謝、カルシウム代謝、石灰化及びビタミンd代謝を調節するポリペプチド並びにそれをコードするdna |
WO2002015926A1 (fr) * | 2000-08-24 | 2002-02-28 | Kirin Beer Kabushiki Kaisha | Compositions medicinales contenant des ligands c-mpl, destinees a l'augmentation des plaquettes et des erythrocytes |
UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
EP1234583A1 (en) * | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
WO2004014938A2 (en) * | 2002-08-09 | 2004-02-19 | Xencor | Thrombopoiesis-stimulating proteins having reduced immunogenicity |
WO2004026332A1 (en) | 2002-09-18 | 2004-04-01 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
PL396711A1 (pl) * | 2002-12-26 | 2011-12-19 | Mountain View Pharmaceuticals, Inc. | Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia |
EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
MXPA05008531A (es) * | 2003-02-11 | 2005-11-17 | Irm Llc | Compuestos biciclicos novedosos y composiciones. |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
MXPA05009429A (es) * | 2003-03-05 | 2005-12-12 | Halozyme Inc | Glicoproteina hialuronidasa soluble (shasegp), proceso para preparar la misma, usos y composiciones farmaceuticas que la comprenden. |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US7871607B2 (en) * | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
AU2004227937B2 (en) * | 2003-03-31 | 2007-09-20 | Xencor, Inc | Methods for rational pegylation of proteins |
US7610156B2 (en) * | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
US7642340B2 (en) | 2003-03-31 | 2010-01-05 | Xencor, Inc. | PEGylated TNF-α variant proteins |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
MXPA06002292A (es) | 2003-08-28 | 2006-09-04 | Johnson & Johnson | Peptidos y compuestos que se unen a un receptor. |
WO2005035564A2 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders |
BRPI0418326A (pt) | 2003-12-30 | 2007-05-02 | Bionethos Holding Gmbh | método de regeneração de tecidos |
WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
WO2005123113A2 (en) * | 2004-06-14 | 2005-12-29 | Intermune, Inc. | Interferon compositions and methods of use thereof |
MX2007000216A (es) | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
DE602005025355D1 (de) * | 2004-07-16 | 2011-01-27 | Nektar Therapeutics San Carlos | Konjugate enthaltend gm-csf und ein polymer |
DE602005024599D1 (de) * | 2004-10-25 | 2010-12-16 | Ligand Pharm Inc | Verbindungen modulierende thrombopoietinaktivität und verfahren |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
US8318153B2 (en) * | 2006-06-29 | 2012-11-27 | Nalin David R | Method of medically treating an individual |
MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
KR20100135291A (ko) | 2008-04-14 | 2010-12-24 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
US8927249B2 (en) | 2008-12-09 | 2015-01-06 | Halozyme, Inc. | Extended soluble PH20 polypeptides and uses thereof |
CN102245675B (zh) | 2008-12-16 | 2013-08-14 | 道康宁公司 | 硅氧烷的制备 |
EP2390261A4 (en) | 2009-01-20 | 2012-11-14 | Hanall Biopharma Co Ltd | MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND METHOD FOR THE PRODUCTION THEREOF |
US8680150B2 (en) * | 2009-05-28 | 2014-03-25 | Ligand Pharmaceuticals, Inc. | Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors |
AU2010254046C1 (en) | 2009-05-29 | 2014-03-06 | Novartis Ag | Methods of administration of thrombopoietin agonist compounds |
US9084743B2 (en) | 2009-09-17 | 2015-07-21 | Baxter International Inc. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
KR101809878B1 (ko) | 2010-07-20 | 2017-12-15 | 할로자임, 아이엔씨 | 항-히알루로난제 투여와 관련된 유해 부작용의 치료 |
WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
AU2012271361B2 (en) | 2011-06-17 | 2017-03-02 | Halozyme, Inc. | Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme |
US20130071394A1 (en) | 2011-09-16 | 2013-03-21 | John K. Troyer | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use |
WO2013063155A2 (en) | 2011-10-24 | 2013-05-02 | Halozyme, Inc. | Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof |
MX361727B (es) | 2011-12-30 | 2018-12-14 | Halozyme Inc | Variantes de polipeptido ph20, formulaciones y usos de las mismas. |
AU2013243873B2 (en) | 2012-04-04 | 2016-08-25 | Halozyme, Inc. | Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane |
WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
TR201907471T4 (tr) | 2014-08-28 | 2019-06-21 | Halozyme Inc | Bir hiyalüronan ayrıştırıcı enzim ve bir bağışıklık kontrol noktası inhibitörüyle kombinasyon terapisi. |
ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
MX2019015402A (es) | 2017-06-22 | 2020-07-20 | Catalyst Biosciences Inc | Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso. |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
CN113661239A (zh) | 2018-12-28 | 2021-11-16 | 催化剂生物科学公司 | 经修饰的尿激酶型纤溶酶原激活物多肽和使用方法 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
DE3572982D1 (en) * | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
EP0206448B1 (en) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
US4894440A (en) * | 1986-09-17 | 1990-01-16 | Massachusetts Institute Of Technology | Method of isolating megakaryocyte stimulatory factor |
ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
CA1340810C (en) * | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
IL90719A0 (en) * | 1988-06-28 | 1990-01-18 | Yissum Res Dev Co | Novel nuclei acids and polypeptides encoded thereby |
US5128449A (en) * | 1988-07-05 | 1992-07-07 | The University Of Tennessee Research Corporation | Polypeptide and a method for its production |
WO1990003397A1 (en) * | 1988-09-21 | 1990-04-05 | Meiji Seika Kaisha, Ltd. | Novel megakaryocytic colony stimulating factor and process for its preparation |
GB8824591D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
US5087448A (en) * | 1989-02-02 | 1992-02-11 | The Board Of Regents Of The University Of Oklahoma | Enhancing growth of megakaryocytes in mammals using interleuking 6 |
US5032396A (en) * | 1989-02-17 | 1991-07-16 | Immunex Corporation | IL-7 to stimulate platelet production |
US5260417A (en) * | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
JPH04506513A (ja) * | 1989-04-03 | 1992-11-12 | ジェネティックス・インスティテュート・インコーポレイテッド | 巨核球増殖促進活性 |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US6433142B1 (en) * | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
AU640686B2 (en) * | 1989-08-08 | 1993-09-02 | Genetics Institute, Llc | A megakaryocytopoietic factor |
US5215895A (en) * | 1989-11-22 | 1993-06-01 | Genetics Institute, Inc. | Dna encoding a mammalian cytokine, interleukin-11 |
JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
AU7972991A (en) * | 1990-05-31 | 1991-12-31 | Meiji Seika Kaisha Ltd. | Novel megakaryocyte colony stimulating factor and production thereof |
KR930701475A (ko) * | 1990-07-02 | 1993-06-11 | 원본미기재 | 사람의 거핵구-집락 촉진 인자(hMeg-CSF) 및 그것의 생산방법 |
IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
AU639378B2 (en) * | 1990-10-05 | 1993-07-22 | Systemix, Inc. | Megakaryocyte and platelet growth, production and composition |
JPH05503302A (ja) * | 1990-10-12 | 1993-06-03 | アムジエン・インコーポレーテツド | 巨核球成熟因子 |
WO1992007074A1 (fr) * | 1990-10-19 | 1992-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Polypeptide de la famille d'un recepteur de facteur de croissance, application au diagnostic et a la therapie des maladies myeloproliferatives |
CA2073177A1 (en) * | 1990-12-28 | 1992-06-29 | Shuhei Kondo | Megakaryocyte potentiator and method for producing the same |
JP3283288B2 (ja) * | 1991-03-08 | 2002-05-20 | 電気化学工業株式会社 | 生理活性ペプチド製剤 |
JPH04295500A (ja) * | 1991-03-26 | 1992-10-20 | Asahi Chem Ind Co Ltd | 新規な巨核球増幅因子とその製法 |
CA2112492A1 (en) * | 1991-06-28 | 1993-01-07 | Hava Avraham | A differentiated megakaryocyte line producing novel megakaryocyte differentiation factors |
WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
US5250732A (en) * | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
NZ244778A (en) * | 1991-10-21 | 1994-03-25 | Ortho Pharma Corp | Peg imidates and protein derivatives thereof |
JP3328341B2 (ja) * | 1991-12-27 | 2002-09-24 | 中外製薬株式会社 | 新規な巨核球増幅因子 |
WO1993016106A1 (en) * | 1992-02-07 | 1993-08-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel megakaryocyte amplifier and production thereof |
AU4190893A (en) * | 1992-07-17 | 1994-01-20 | Suntory Limited | Megakaryocyte differentiation factor |
SG47030A1 (en) * | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
EP0723456A1 (en) * | 1994-02-14 | 1996-07-31 | The University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
NZ271230A (en) * | 1994-02-14 | 1998-03-25 | Zymogenetics Inc | Hematopoietic proteins, production and use |
SG79882A1 (en) * | 1994-02-14 | 2001-04-17 | Kirin Brewery | Protein having tpo activity |
WO1995021919A2 (en) * | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
US5547931A (en) * | 1994-02-23 | 1996-08-20 | Immtech International Inc. | Methods of stimulatory thrombocytopoiesis using modified C-reactive protein |
US5571686A (en) * | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
-
1995
- 1995-03-30 JP JP7525783A patent/JP2996415B2/ja not_active Expired - Fee Related
- 1995-03-30 CZ CZ19953505A patent/CZ288926B6/cs not_active IP Right Cessation
- 1995-03-30 EE EE9600121A patent/EE9600121A/xx unknown
- 1995-03-30 DK DK95104745T patent/DK0690127T3/da active
- 1995-03-30 ES ES95104745T patent/ES2119250T3/es not_active Expired - Lifetime
- 1995-03-30 TW TW084103273A patent/TW414799B/zh not_active IP Right Cessation
- 1995-03-30 DE DE69503849T patent/DE69503849T2/de not_active Expired - Fee Related
- 1995-03-30 HU HU9600059A patent/HU218893B/hu not_active IP Right Cessation
- 1995-03-30 AT AT95104745T patent/ATE169335T1/de not_active IP Right Cessation
- 1995-03-30 CN CNB011166304A patent/CN1229385C/zh not_active Expired - Fee Related
- 1995-03-30 YU YU20095A patent/YU20095A/sh unknown
- 1995-03-30 CN CN95190628A patent/CN1103782C/zh not_active Expired - Fee Related
- 1995-03-30 KR KR1019980710986A patent/KR100303810B1/ko not_active IP Right Cessation
- 1995-03-30 SI SI9530160T patent/SI0690127T1/xx not_active IP Right Cessation
- 1995-03-30 WO PCT/US1995/003776 patent/WO1995026746A1/en not_active Application Discontinuation
- 1995-03-30 US US08/413,803 patent/US5766581A/en not_active Expired - Fee Related
- 1995-03-30 BR BR9506017A patent/BR9506017A/pt not_active Application Discontinuation
- 1995-03-30 AU AU22308/95A patent/AU691606B2/en not_active Ceased
- 1995-03-30 SK SK1666-95A patent/SK166695A3/sk unknown
- 1995-03-30 TW TW085116057A patent/TW496870B/zh not_active IP Right Cessation
- 1995-03-30 RO RO96-00063A patent/RO115788B1/ro unknown
- 1995-03-30 EP EP95104745A patent/EP0690127B1/en not_active Expired - Lifetime
- 1995-03-30 KR KR1019960700308A patent/KR100203824B1/ko not_active IP Right Cessation
- 1995-03-30 EP EP95104711A patent/EP0675201A1/en not_active Withdrawn
- 1995-03-30 EP EP95915425A patent/EP0755263A4/en not_active Withdrawn
- 1995-03-30 CA CA002167090A patent/CA2167090C/en not_active Expired - Fee Related
- 1995-03-30 TW TW088113115A patent/TW565568B/zh not_active IP Right Cessation
- 1995-03-30 GE GEAP19953368A patent/GEP20002180B/en unknown
- 1995-03-31 MY MYPI95000831A patent/MY113048A/en unknown
- 1995-03-31 IL IL11320695A patent/IL113206A0/xx unknown
-
1996
- 1996-01-10 NO NO960111A patent/NO960111L/no not_active Application Discontinuation
- 1996-01-11 FI FI960136A patent/FI960136A/sv not_active IP Right Cessation
- 1996-03-12 PL PL95312577A patent/PL182567B1/pl not_active IP Right Cessation
- 1996-03-12 NZ NZ283863A patent/NZ283863A/en unknown
- 1996-05-30 BG BG100625A patent/BG62685B1/bg unknown
- 1996-10-03 LV LVP-96-369A patent/LV11783B/xx unknown
-
1998
- 1998-04-23 HK HK98103418A patent/HK1004231A1/xx not_active IP Right Cessation
- 1998-08-06 GR GR980401561T patent/GR3027593T3/el unknown
-
1999
- 1999-02-04 LV LVP-99-17A patent/LV12275B/en unknown
- 1999-08-18 JP JP23173099A patent/JP3485842B2/ja not_active Expired - Fee Related
-
2000
- 2000-04-03 CZ CZ20001203A patent/CZ288890B6/cs not_active IP Right Cessation
-
2002
- 2002-04-24 HK HK02103111.6A patent/HK1041275B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI960136A0 (sv) | Kompositioner och förfaranden för stimulering av megakaryocytisk tillväxt och differentiering | |
Munksgaard et al. | Collagen synthesis and secretion by rat incisor odontoblasts in organ culture | |
DK0473724T3 (da) | Et humant cytokin, interleukin-9 | |
ATE82495T1 (de) | Verfahren zur herstellung pharmazeutischer mischungen. | |
MX9602259A (es) | Proteina modificada quimicamente en el nitrogeno terminal, composiciones que las incluyen y metodos para su preparacion. | |
ATE246513T1 (de) | Zubereitungen und verfahren für die behandlung von krebs und hyperproliferierenden krankheiten | |
DE68928641T2 (de) | Menschliches IFN-beta2/IL-6, dessen Reinigung und Verwendungen | |
PT87658A (pt) | Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet loesung enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin | |
ATE174756T1 (de) | Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung | |
ATE353340T1 (de) | Mutein von humanem thrombopoietin | |
ES8705466A1 (es) | Un metodo para la preparacion del factor nkbs regulador del cancer humano. | |
DE68917830D1 (de) | Verfahren zur Herstellung einer physiologisch aktiven Substanz mit Antikrebs-Aktivität und so erhaltene Substanz. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |