UY26317A1 - Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo - Google Patents

Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo

Info

Publication number
UY26317A1
UY26317A1 UY26317A UY26317A UY26317A1 UY 26317 A1 UY26317 A1 UY 26317A1 UY 26317 A UY26317 A UY 26317A UY 26317 A UY26317 A UY 26317A UY 26317 A1 UY26317 A1 UY 26317A1
Authority
UY
Uruguay
Prior art keywords
cells
thrombopoyetine
mammals
cultivation
human
Prior art date
Application number
UY26317A
Other languages
English (en)
Inventor
Alfonso Cayota Carlos Pritsch
Original Assignee
Alfonso Cayota Carlos Pritsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfonso Cayota Carlos Pritsch filed Critical Alfonso Cayota Carlos Pritsch
Priority to UY26317A priority Critical patent/UY26317A1/es
Publication of UY26317A1 publication Critical patent/UY26317A1/es
Priority to ARP010103408A priority patent/AR035341A1/es
Priority to MXPA03002762A priority patent/MXPA03002762A/es
Priority to CA002457165A priority patent/CA2457165A1/en
Priority to BR0113789-1A priority patent/BR0113789A/pt
Priority to AU2001282376A priority patent/AU2001282376B9/en
Priority to CN01815039A priority patent/CN1451040A/zh
Priority to JP2002524072A priority patent/JP2004507269A/ja
Priority to KR10-2003-7003058A priority patent/KR20030029894A/ko
Priority to US10/362,882 priority patent/US7371569B2/en
Priority to EP01960992A priority patent/EP1315805B1/en
Priority to PCT/IB2001/001518 priority patent/WO2002018569A2/en
Priority to NZ524924A priority patent/NZ524924A/en
Priority to DE60115063T priority patent/DE60115063T2/de
Priority to DK01960992T priority patent/DK1315805T3/da
Priority to AT01960992T priority patent/ATE310081T1/de
Priority to ES01960992T priority patent/ES2253411T3/es
Priority to AU8237601A priority patent/AU8237601A/xx
Priority to IL15469001A priority patent/IL154690A0/xx
Priority to ZA200302414A priority patent/ZA200302414B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand

Abstract

La presente invención hace referencia a un sistema de producción de trombopoyetina humana biológicamente activa por células de mamíferos en cultivo, las cuales fueron modificadas genéticamente por introducción del gen de la htpo bajo forma de una construcción de adn conteniendo todos los elementos necesarios para la expresión de una htpo completa. Por otro lado la presente invención concierne a los usos potenciales del producto obtenido por este sistema en la estimulación de la diferenciación y proliferación de células hematopoyeticas de la línea megacariótica tanto in vitro como in vivo.
UY26317A 2000-08-30 2000-08-30 Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo UY26317A1 (es)

Priority Applications (20)

Application Number Priority Date Filing Date Title
UY26317A UY26317A1 (es) 2000-08-30 2000-08-30 Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
ARP010103408A AR035341A1 (es) 2000-08-30 2001-07-17 Sistema de produccion de trombopoyetina humana por celulas de mamifero en cultivo
IL15469001A IL154690A0 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
KR10-2003-7003058A KR20030029894A (ko) 2000-08-30 2001-08-23 포유동물 세포 배양물을 이용하여 인간의 트롬보포에틴폴리펩타이드를 제조하는 방법
PCT/IB2001/001518 WO2002018569A2 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
BR0113789-1A BR0113789A (pt) 2000-08-30 2001-08-23 Métodos para preparação de polipeptìdeos de trombopoietina por culturas de células de mamìferos
AU2001282376A AU2001282376B9 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
CN01815039A CN1451040A (zh) 2000-08-30 2001-08-23 通过哺乳动物细胞的培养制备人血小板生成素多肽的方法
JP2002524072A JP2004507269A (ja) 2000-08-30 2001-08-23 哺乳細胞培養によるヒトトロンボポイエチンポリペプチドの製造方法
MXPA03002762A MXPA03002762A (es) 2000-08-30 2001-08-23 Sistema de produccion de trombopoyetina humana por celulas de mamifero en cultivo.
US10/362,882 US7371569B2 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
EP01960992A EP1315805B1 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
CA002457165A CA2457165A1 (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
NZ524924A NZ524924A (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
DE60115063T DE60115063T2 (de) 2000-08-30 2001-08-23 Verfahren zur herstellung von thrombopoietin-polypeptiden
DK01960992T DK1315805T3 (da) 2000-08-30 2001-08-23 Fremgangsmåder for fremstilling af humane thrombopoietin polypeptider af pattedyrcellekultur
AT01960992T ATE310081T1 (de) 2000-08-30 2001-08-23 Verfahren zur herstellung von menschlichen thrombopoietin-polypeptiden durch säugetierzellkulturen
ES01960992T ES2253411T3 (es) 2000-08-30 2001-08-23 Metodos para preparar polipeptidos de trombopoyetina humana mediante cultivos de celulas de mamiferos.
AU8237601A AU8237601A (en) 2000-08-30 2001-08-23 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
ZA200302414A ZA200302414B (en) 2000-08-30 2003-03-27 Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY26317A UY26317A1 (es) 2000-08-30 2000-08-30 Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo

Publications (1)

Publication Number Publication Date
UY26317A1 true UY26317A1 (es) 2000-10-31

Family

ID=25546891

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26317A UY26317A1 (es) 2000-08-30 2000-08-30 Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo

Country Status (19)

Country Link
US (1) US7371569B2 (es)
EP (1) EP1315805B1 (es)
JP (1) JP2004507269A (es)
KR (1) KR20030029894A (es)
CN (1) CN1451040A (es)
AR (1) AR035341A1 (es)
AT (1) ATE310081T1 (es)
AU (2) AU8237601A (es)
BR (1) BR0113789A (es)
CA (1) CA2457165A1 (es)
DE (1) DE60115063T2 (es)
DK (1) DK1315805T3 (es)
ES (1) ES2253411T3 (es)
IL (1) IL154690A0 (es)
MX (1) MXPA03002762A (es)
NZ (1) NZ524924A (es)
UY (1) UY26317A1 (es)
WO (1) WO2002018569A2 (es)
ZA (1) ZA200302414B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009273239B2 (en) * 2008-07-23 2015-07-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel regulatory elements
CN112779284B (zh) * 2019-11-01 2022-12-20 百奥赛图(北京)医药科技股份有限公司 Thpo基因人源化的非人动物的构建方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1297434C (en) * 1986-04-14 1992-03-17 Kenji Murakami Method of producing peptides, recombinant plasmid for use in the same and animal cells transformed with the same
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
EP0755263A4 (en) * 1994-03-31 2005-02-09 Amgen Inc COMPOUNDS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND THEIR DIFFERENTIATION
DE19541450C2 (de) * 1995-11-07 1997-10-02 Gsf Forschungszentrum Umwelt Genkonstrukt und dessen Verwendung
US6015662A (en) * 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls

Also Published As

Publication number Publication date
AU2001282376B2 (en) 2006-11-09
EP1315805A2 (en) 2003-06-04
KR20030029894A (ko) 2003-04-16
AU8237601A (en) 2002-03-13
JP2004507269A (ja) 2004-03-11
AR035341A1 (es) 2004-05-12
IL154690A0 (en) 2003-09-17
WO2002018569A2 (en) 2002-03-07
US20040072326A1 (en) 2004-04-15
DE60115063T2 (de) 2006-08-03
BR0113789A (pt) 2004-08-17
NZ524924A (en) 2005-09-30
DK1315805T3 (da) 2006-03-27
EP1315805B1 (en) 2005-11-16
ES2253411T3 (es) 2006-06-01
ZA200302414B (en) 2004-07-05
WO2002018569A3 (en) 2003-01-09
DE60115063D1 (de) 2005-12-22
CA2457165A1 (en) 2002-03-07
AU2001282376B9 (en) 2006-12-07
US7371569B2 (en) 2008-05-13
ATE310081T1 (de) 2005-12-15
MXPA03002762A (es) 2005-06-30
CN1451040A (zh) 2003-10-22

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Legal Events

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110 Patent granted

Effective date: 20100701

VENC Patent expired

Effective date: 20200830