ES2194794T3 - Dendrimeros fosforados como agentes de transfeccion. - Google Patents

Dendrimeros fosforados como agentes de transfeccion.

Info

Publication number
ES2194794T3
ES2194794T3 ES00985306T ES00985306T ES2194794T3 ES 2194794 T3 ES2194794 T3 ES 2194794T3 ES 00985306 T ES00985306 T ES 00985306T ES 00985306 T ES00985306 T ES 00985306T ES 2194794 T3 ES2194794 T3 ES 2194794T3
Authority
ES
Spain
Prior art keywords
dendrimeros
phosphorated
transfer agents
agents
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00985306T
Other languages
English (en)
Inventor
Jean-Pierre Majoral
Bernard Meunier
Anne-Marie Caminade
Christophe Loup
Maria-Antonietta Zanta-Boussif
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2194794T3 publication Critical patent/ES2194794T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2479—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1)
    • C07F9/2491—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1) containing the structure P(=X)n-N-N (X = O, S, Se; n = 0, 1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/65812—Cyclic phosphazenes [P=N-]n, n>=3
    • C07F9/65815—Cyclic phosphazenes [P=N-]n, n>=3 n = 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

Dendrímeros fosforados policatiónicos caracterizados porque están constituidos - por una capa central en forma de un núcleo P0 que comprende 2 a 8 agrupaciones funcionalizadas - por n capas intermedias, idénticas o diferentes, estando constituida cada una de dichas capas intermedias por unidades P1 que responden a la fórmula II: en la que: L es un átomo de oxígeno, fósforo o azufre, M representa uno de los siguientes grupos: u un grupo aromático di-, tri- o tetrasustituido por grupos alquilo, grupos alcoxi, agrupaciones insaturadas de tipo olefínico C1-C12, azoicas o acetilénicas, pudiendo incorporar o no todos estos grupos átomos de fósforo, oxígeno, nitrógeno, azufre o halógeno, o u un grupo alquilo o alcoxi que comprende diversos sustituyentes tales como los definidos cuando M es un grupo aromático.
ES00985306T 1999-11-25 2000-11-23 Dendrimeros fosforados como agentes de transfeccion. Expired - Lifetime ES2194794T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9914864A FR2801592B1 (fr) 1999-11-25 1999-11-25 Dendrimeres phosphores et leurs applications comme agents de transfection

Publications (1)

Publication Number Publication Date
ES2194794T3 true ES2194794T3 (es) 2003-12-01

Family

ID=9552551

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00985306T Expired - Lifetime ES2194794T3 (es) 1999-11-25 2000-11-23 Dendrimeros fosforados como agentes de transfeccion.

Country Status (9)

Country Link
US (1) US6969528B1 (es)
EP (1) EP1232165B1 (es)
JP (1) JP2003514912A (es)
AT (1) ATE239749T1 (es)
CA (1) CA2392697A1 (es)
DE (1) DE60002603T2 (es)
ES (1) ES2194794T3 (es)
FR (1) FR2801592B1 (es)
WO (1) WO2001038335A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2834988B1 (fr) * 2002-01-21 2005-07-08 Centre Nat Rech Scient Utilisation de dendrimeres phosphores comme medicaments
FR2838737B1 (fr) 2002-04-23 2006-02-03 Centre Nat Rech Scient Supports solides fonctionnalises par des dendrimeres phosphores, leur procede de preparation et applications
FR2851565B1 (fr) * 2003-02-26 2005-04-01 Commissariat Energie Atomique Dendrimeres phosphores, leur procede de preparation et leur utilisation pour l'extraction des actinides et des lanthanides
FR2873715B1 (fr) * 2004-07-30 2006-11-17 Centre Nat Rech Scient Cnrse Utilisation de dendrimeres pour stimuler la croissance cellulaire
FR2876916B1 (fr) * 2004-10-25 2007-01-05 Midi Pyrenees Incubateur Produit implantable de surface fonctionnalisee au moyen de dendrimeres a terminaisons anioniques
FR2896251B1 (fr) * 2006-01-13 2008-04-11 Univ Rennes 1 Etablissement Pu Composes fluorescents dendrimeriques et utilisation de tels composes dans le cadre de procedes ou dispositifs multiphotoniques.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0708637B1 (en) * 1993-07-14 2004-01-28 The Regents of the University of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
ZA951877B (en) * 1994-03-07 1996-09-09 Dow Chemical Co Bioactive and/or targeted dendrimer conjugates
US6440405B1 (en) * 1999-06-07 2002-08-27 University Of Delaware Quaternary ammonium functionalized dendrimers and methods of use therefor

Also Published As

Publication number Publication date
CA2392697A1 (en) 2001-05-31
EP1232165B1 (fr) 2003-05-07
US6969528B1 (en) 2005-11-29
EP1232165A1 (fr) 2002-08-21
DE60002603D1 (de) 2003-06-12
JP2003514912A (ja) 2003-04-22
FR2801592A1 (fr) 2001-06-01
WO2001038335A1 (fr) 2001-05-31
DE60002603T2 (de) 2004-02-26
ATE239749T1 (de) 2003-05-15
FR2801592B1 (fr) 2002-02-22

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