ATE290403T1 - Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens - Google Patents

Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens

Info

Publication number
ATE290403T1
ATE290403T1 AT98935066T AT98935066T ATE290403T1 AT E290403 T1 ATE290403 T1 AT E290403T1 AT 98935066 T AT98935066 T AT 98935066T AT 98935066 T AT98935066 T AT 98935066T AT E290403 T1 ATE290403 T1 AT E290403T1
Authority
AT
Austria
Prior art keywords
combination
nucleic acid
cells
pluricecellular
improvement
Prior art date
Application number
AT98935066T
Other languages
English (en)
Inventor
Michel Bureau
Lluis Mir
Daniel Scherman
Original Assignee
Roussy Inst Gustave
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9708232A external-priority patent/FR2765241B1/fr
Application filed by Roussy Inst Gustave, Centre Nat Rech Scient filed Critical Roussy Inst Gustave
Application granted granted Critical
Publication of ATE290403T1 publication Critical patent/ATE290403T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT98935066T 1997-06-30 1998-06-30 Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens ATE290403T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9708232A FR2765241B1 (fr) 1997-06-30 1997-06-30 Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede
US6748797P 1997-12-01 1997-12-01
PCT/FR1998/001399 WO1999001157A1 (fr) 1997-06-30 1998-06-30 Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede

Publications (1)

Publication Number Publication Date
ATE290403T1 true ATE290403T1 (de) 2005-03-15

Family

ID=26233647

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98935066T ATE290403T1 (de) 1997-06-30 1998-06-30 Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens

Country Status (16)

Country Link
US (1) US6528315B2 (de)
EP (1) EP0991425B1 (de)
JP (1) JP4664450B2 (de)
KR (1) KR20010020570A (de)
CN (1) CN1261808A (de)
AT (1) ATE290403T1 (de)
AU (1) AU8444698A (de)
BR (1) BR9810372A (de)
CA (1) CA2294802A1 (de)
CZ (1) CZ299638B6 (de)
DE (1) DE69829287T2 (de)
HU (1) HUP0004728A3 (de)
IL (1) IL133708A0 (de)
NO (1) NO327499B1 (de)
PL (1) PL337584A1 (de)
WO (1) WO1999001157A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884430B1 (en) 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
EA002087B1 (ru) * 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
AU2868200A (en) * 1999-02-08 2000-08-25 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
AU783432B2 (en) * 1999-06-25 2005-10-27 Genetronics, Inc. High efficiency transfection based on low electric field strength, long pulse length
ES2328446T5 (es) * 2000-02-04 2014-02-27 Children's Hospital Research Foundation Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas
ES2368419T3 (es) 2000-03-13 2011-11-17 Cornell Research Foundation, Inc. Bloqueo de la migración de leucocitos y de la inflamación por interferencia con cd99/hec2.
JP2003531149A (ja) 2000-04-13 2003-10-21 ザ・ロツクフエラー・ユニバーシテイ 抗体由来の免疫応答の増強
WO2001089455A2 (en) 2000-05-22 2001-11-29 Merck & Company, Inc. System and method for assessing the performance of a pharmaceutical agent delivery system
WO2002040093A2 (en) 2000-11-17 2002-05-23 Gendel Limited Ablation of cells using combined electric field and ultrasound therapy
US6821274B2 (en) 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
CA2432426A1 (en) 2000-12-28 2002-07-11 Wyeth Recombinant protective protein from streptococcus pneumoniae
US20030039660A1 (en) 2001-03-02 2003-02-27 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
US20040023910A1 (en) * 2001-09-28 2004-02-05 Zhiming Zhang Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
EP1466133B1 (de) 2002-01-17 2007-01-03 York Refrigeration APS Getauchter verdampfer mit integriertem wärmeaustauscher
US20050154434A1 (en) 2002-03-07 2005-07-14 Adam Simon Clinical syringe with electrical stimulation aspects
FR2836831B1 (fr) * 2002-03-07 2004-06-25 Centre Nat Rech Scient Combinaison chimiotherapie et antisens de la dna demethylase
US20030198625A1 (en) * 2002-04-19 2003-10-23 Genteric, Inc. Electroporation-mediated transfection of the salivary gland
EP1506039B1 (de) 2002-05-23 2008-10-29 Gendel Limited Ablationsvorrichtung
CA2484000A1 (en) 2002-05-24 2003-12-04 Schering Corporation Neutralizing human anti-igfr antibody
EP1578974A4 (de) * 2002-12-31 2006-02-08 Univ Johns Hopkins Verfahren und kits zur wundheilung
US20050059999A1 (en) * 2003-09-15 2005-03-17 Mongeon Luc R. Delivering genetic material to a stimulation site
WO2005099367A2 (en) 2004-04-16 2005-10-27 Critical Care Innovations, Inc. Systems and methods for improving image-guided tissue ablation
US7923251B2 (en) * 2005-02-23 2011-04-12 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for avalanche-mediated transfer of agents into cells
US8101169B2 (en) * 2005-02-23 2012-01-24 The Board Of Trustees Of The Leland Stanford Junior University Ocular gene therapy using avalanche-mediated transfection
WO2007005898A2 (en) 2005-07-05 2007-01-11 Cornell Research Foundation, Inc. Blocking leukocyte emigration and inflammation by interfering with cd99l2
WO2007030375A2 (en) * 2005-09-08 2007-03-15 Children's Hospital Medical Center Lysosomal acid lipase therapy for nafld and related diseases
DK1991303T3 (da) 2006-03-03 2021-06-07 Oncosec Medical Inc Fremgangsmåde og anordning til behandling af mikroskopiske resttumorer i væv, der er tilbage efter kirurgisk resektion
US7754213B2 (en) 2006-10-19 2010-07-13 Merck & Co., Inc. High affinity antibody antagonists of interleukin-13 receptor alpha 1
EP2068922B1 (de) 2006-10-19 2012-06-27 CSL Limited Anti-il-13r-alpha-1-antikörper und ihre verwendung
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
WO2009065032A1 (en) * 2007-11-14 2009-05-22 Vgx Pharmaceuticals, Inc. Antibody production elicited by a dna vaccine delivered by electroporation
US8093043B2 (en) 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
WO2010053986A1 (en) 2008-11-05 2010-05-14 Wyeth Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease
ES2994878T3 (en) 2010-08-23 2025-02-03 Wyeth Llc Stable formulations of neisseria meningitidis rlp2086 antigens
KR101584871B1 (ko) 2010-09-10 2016-01-22 와이어쓰 엘엘씨 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
MX359070B (es) 2010-12-01 2018-09-13 Alderbio Holdings Llc Composiciones anti-ngf y uso de las mismas.
US9592398B2 (en) 2011-05-12 2017-03-14 Medtronic, Inc. Leadless implantable medical device with osmotic pump
BR122016004924A2 (pt) 2012-03-09 2019-07-30 Pfizer Inc. Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
EP2964665B1 (de) 2013-03-08 2018-08-01 Pfizer Inc Immunogene fusionspolypeptide
CA2923129C (en) 2013-09-08 2020-06-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10183070B2 (en) 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2021059181A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301794A (en) 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4411657A (en) 1980-05-19 1983-10-25 Anibal Galindo Hypodermic needle
JPS5810066A (ja) 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4476004A (en) 1983-04-08 1984-10-09 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4441972A (en) 1983-04-08 1984-04-10 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
DE3317415A1 (de) 1983-05-13 1984-11-15 Kernforschungsanlage Jülich GmbH, 5170 Jülich Kammer zur behandlung von zellen im elektrischen feld
US4622031A (en) 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4557723A (en) 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4578168A (en) 1984-07-27 1986-03-25 Biotronics Apparatus for fusing live cells with electric fields
US4663292A (en) 1984-12-21 1987-05-05 Wong Daniel T High-voltage biological macromolecule transfer and cell fusion system
US4702732A (en) 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
AT385894B (de) 1985-10-04 1988-05-25 Basem Dr Nashef Schlauchfoermige sonde
US5049488A (en) 1985-11-08 1991-09-17 Genentech, Inc. Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
US4695547A (en) 1986-04-02 1987-09-22 Jeffrey L. Hilliard Probe for electrofusion, electroporation, or like procedure
US4786277A (en) 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation
US5371003A (en) 1987-05-05 1994-12-06 Sandoz Ltd. Electrotransformation process
US5128257A (en) 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US4970154A (en) 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
DE68925030T2 (de) 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5547467A (en) 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5119832A (en) 1989-07-11 1992-06-09 Ravi Xavier Epidural catheter with nerve stimulators
US5124259A (en) 1989-08-23 1992-06-23 Mitsui Toatsu Chemicals, Inc. Method for electroporation
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5081990A (en) 1990-05-11 1992-01-21 New York University Catheter for spinal epidural injection of drugs and measurement of evoked potentials
JPH05507226A (ja) 1990-06-15 1993-10-21 コートラック・メディカル・インコーポレーテッド 薬物投与装置および方法
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5501662A (en) 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
JPH063783A (ja) 1992-06-19 1994-01-14 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
JP3099049B2 (ja) * 1992-07-29 2000-10-16 農林水産省果樹試験場長 電気的細胞融合及び電気的核酸導入のための大量処理用電極
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5688233A (en) 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5464386A (en) 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5318514A (en) 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5462520A (en) 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
JP3351572B2 (ja) 1992-10-05 2002-11-25 井上 聰一 イオンクロマトグラフィーによる分析体の分離・分析方法、イオンクロマトグラフィー用両荷電具備固定相及び多機能液体クロマトグラフィーによる分析体の分離・分析方法
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
GB9317380D0 (en) * 1993-08-20 1993-10-06 Therexsys Ltd Transfection process
US5849719A (en) 1993-08-26 1998-12-15 The Regents Of The University Of California Method for treating allergic lung disease
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
DE4341424A1 (de) 1993-12-04 1995-06-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
EP0765397A1 (de) * 1994-06-17 1997-04-02 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Verfahren zum einfuhren von genetisches material in mikroorganismen und damit hergestellten transformanten
WO1996000111A1 (en) 1994-06-24 1996-01-04 Cygnus, Inc. Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability
IT235163Y1 (it) 1994-10-10 2000-03-31 Ideal Standard Spa Gruppo di tenuta per elementi maschio di stampi per la colatura di apparecchiature igienico-sanitarie
US5641680A (en) * 1994-11-14 1997-06-24 Zhao; Xi Gene transfer apparatus and method for using the same
US5810762A (en) 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
WO1996036714A1 (fr) * 1995-05-18 1996-11-21 Takara Shuzo Co., Ltd. Molecule d'acide nucleique pour le traitement de tumeurs malignes de lymphocytes b, procede pour la produire et son utilisation.
WO1997007826A1 (en) 1995-08-29 1997-03-06 Cbr Laboratories, Inc. In vivo electroporation of cells
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5944726A (en) 1996-08-23 1999-08-31 Scimed Life Systems, Inc. Stent delivery system having stent securement means
US5960974A (en) 1996-10-03 1999-10-05 Advance Engineered Products Ltd. Intermodal bulk container
JPH10234366A (ja) 1997-02-26 1998-09-08 Hisamitsu Pharmaceut Co Inc エレクトロポレーション用電極及びその製法、それを用いた製剤
EA002087B1 (ru) 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
JP2002507985A (ja) * 1997-06-30 2002-03-12 ローヌ−プーラン・ロレ・エス・アー 横紋筋に核酸を導入する改良法およびその組合せ
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
WO1999036563A1 (en) 1998-01-14 1999-07-22 Emed Corporation Electrically mediated cellular expression
JP2003505114A (ja) 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療

Also Published As

Publication number Publication date
JP4664450B2 (ja) 2011-04-06
IL133708A0 (en) 2001-04-30
KR20010020570A (ko) 2001-03-15
NO996541D0 (no) 1999-12-29
CA2294802A1 (fr) 1999-01-14
EP0991425B1 (de) 2005-03-09
BR9810372A (pt) 2000-09-05
CZ475499A3 (cs) 2000-07-12
PL337584A1 (en) 2000-08-28
NO327499B1 (no) 2009-07-20
DE69829287D1 (de) 2005-04-14
NO996541L (no) 2000-02-17
US20020012914A1 (en) 2002-01-31
EP0991425A1 (de) 2000-04-12
HUP0004728A1 (hu) 2001-04-28
US6528315B2 (en) 2003-03-04
JP2002507984A (ja) 2002-03-12
CN1261808A (zh) 2000-08-02
DE69829287T2 (de) 2006-04-13
WO1999001157A1 (fr) 1999-01-14
AU8444698A (en) 1999-01-25
HUP0004728A3 (en) 2003-08-28
CZ299638B6 (cs) 2008-10-01

Similar Documents

Publication Publication Date Title
ATE290403T1 (de) Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
HUP0004589A1 (hu) Javított eljárás nukleinsav bevitelére harántcsikolt izomba és kombinált alkalmazása
PT832264E (pt) Plasmideo para a transferencia de acidos nucleicos a celulas e metodos de utilizacao.
AU5161800A (en) Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
AU2930795A (en) Nucleic acid containing composition, preparation and uses of same
WO1996014408A3 (en) Nucleotide sequence encoding the enzyme i-scei and the uses thereof
DE69534669D1 (de) Nukleinsaeure enthaltende zusammensetzungen, herstellung und verwendung
PL343864A1 (en) Methods of in vivo transferring a gene for wound healing purposes
WO2001070777A3 (en) Leafy cotyledon2 genes and their uses
WO2003014306A3 (en) Antisense modulation of cholesteryl ester transfer protein expression
TR199802648A3 (tr) Gen tedavisi için nüklein asit yapilari.
NZ504445A (en) Nucleic acid sequences of genes of the high mobility group proteins and their use in treating tumours, vascular disorders and as a contraceptive
WO2000008157A3 (en) Human anion transporter genes atnov
AU2002221755A1 (en) Nucleotide and polypeptide sequence of human lysosomal acid lipase
ES2194794T3 (es) Dendrimeros fosforados como agentes de transfeccion.
ID23184A (id) Garam-garam peptida bpc dengan aktivitas organoprotektif proses pembuatan dan penggunaannya dalam terapi
EP1220896A4 (de) NEUE HUMANE LIPASEPROTEINE, DAFüR KODIERENDE NUKLEINSäUREN UND DEREN VERWENDUNGEN
AU2806597A (en) Human DNase II
WO2000058464A3 (en) Rab genes and their uses
AU4395599A (en) (-)-strand rna virus vector for nerve cell
WO2003040320A3 (en) Antisense modulation of human collapsin response mediator protein 2 expression
DE59805112D1 (de) Chimäre oligonucleotide und ihre verwendung
CA2347371A1 (en) HEMATOPOIETIC REGULATION FACTORS AND METHODS OF USE
HUP0100660A1 (hu) Negatív szabályozóelemek alkalmazása transzgének neurospecifikus kifejezésére
WO2002034763A3 (en) Mucin comprising vehicle for the transport of biologically-active agents

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties