WO2000070945A3 - Fatty acid elongation genes and uses thereof - Google Patents

Fatty acid elongation genes and uses thereof Download PDF

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Publication number
WO2000070945A3
WO2000070945A3 PCT/EP2000/004371 EP0004371W WO0070945A3 WO 2000070945 A3 WO2000070945 A3 WO 2000070945A3 EP 0004371 W EP0004371 W EP 0004371W WO 0070945 A3 WO0070945 A3 WO 0070945A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
fatty acid
acid elongation
disorders
methods
Prior art date
Application number
PCT/EP2000/004371
Other languages
French (fr)
Other versions
WO2000070945A2 (en
Inventor
Anders Jacobsson
Abulfazl Asadi
Rolf Westerberg
Jan Nedergaard
Petr Tvrdik
Original Assignee
Karolinska Innovations Ab
Anders Jacobsson
Abulfazl Asadi
Rolf Westerberg
Jan Nedergaard
Petr Tvrdik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab, Anders Jacobsson, Abulfazl Asadi, Rolf Westerberg, Jan Nedergaard, Petr Tvrdik filed Critical Karolinska Innovations Ab
Priority to AU53941/00A priority Critical patent/AU5394100A/en
Publication of WO2000070945A2 publication Critical patent/WO2000070945A2/en
Publication of WO2000070945A3 publication Critical patent/WO2000070945A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human and mouse genes involved in fatty acid elongation and related to CIG30. Nucleic acids, polypeptides, oligonucleotide probes and primers, methods of diagnosis or prognosis, and other methods relating to and based on the genes, and generation of animal models for deficiencies in one or more of these genes, useful particularly in study of various disorders, especially skin or eye disorders, and in assay methods for obtaining agents of therapeutic potential in such disorders.
PCT/EP2000/004371 1999-05-20 2000-05-16 Fatty acid elongation genes and uses thereof WO2000070945A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53941/00A AU5394100A (en) 1999-05-20 2000-05-16 Fatty acid elongation genes and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13508499P 1999-05-20 1999-05-20
US60/135,084 1999-05-20

Publications (2)

Publication Number Publication Date
WO2000070945A2 WO2000070945A2 (en) 2000-11-30
WO2000070945A3 true WO2000070945A3 (en) 2001-02-15

Family

ID=22466464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/004371 WO2000070945A2 (en) 1999-05-20 2000-05-16 Fatty acid elongation genes and uses thereof

Country Status (2)

Country Link
AU (1) AU5394100A (en)
WO (1) WO2000070945A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913916B1 (en) 1998-09-02 2005-07-05 Abbott Laboratories Elongase genes and uses thereof
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US20030163845A1 (en) 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
US7070970B2 (en) 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof
WO2001087921A2 (en) * 2000-05-16 2001-11-22 Merck & Co., Inc. Gene responsible for stargardt-like dominant macular dystrophy
US7091005B2 (en) 2000-05-16 2006-08-15 Merck & Co., Inc. Gene responsible for Stargardt-like dominant macular dystrophy
US7297523B2 (en) 2000-11-29 2007-11-20 Xenon Pharmaceuticals Inc. Human elongase genes and uses thereof
WO2002062975A2 (en) * 2001-02-08 2002-08-15 Bayer Aktiengesellschaft Regulation of human elongase hselo1-like protein
WO2002062974A2 (en) * 2001-02-08 2002-08-15 Bayer Aktiengesellschaft Regulation of human elongase hselo1-like protein
AU2002231779A1 (en) * 2001-02-09 2002-08-28 Bayer Aktiengesellschaft Regulation of human long chain polyunsaturated fatty acid elongation enzyme-like protein
AU2002338561A1 (en) * 2001-05-02 2002-11-11 Karolinska Innovations Ab Lipid producing cells and uses thereof
JP4707903B2 (en) * 2001-09-25 2011-06-22 大日本スクリーン製造株式会社 Substrate processing system and substrate processing apparatus management method
WO2003040392A2 (en) * 2001-11-06 2003-05-15 Decode Genetics Ehf. Nucleic acids encoding very long chain fatty acid biosynthesis enzymes
EP1552845A4 (en) * 2002-06-26 2006-06-07 Takeda Pharmaceutical Preventives/remedies for cancer
CN1303102C (en) 2002-11-13 2007-03-07 中国科学院上海生命科学研究院 Method for diagnosing and curing alopecia utilizing the Rhor gene of human and rat and the encoding products
FR2903998B1 (en) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc MODULATORS OF ELOVL5 IN THE TREATMENT OF ACNE OR HYPERSEBORRHEA
US8916361B2 (en) 2006-11-17 2014-12-23 Abbott Laboratories Elongase gene and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012720A2 (en) * 1998-09-02 2000-03-09 Abbott Laboratories Elongase genes and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012720A2 (en) * 1998-09-02 2000-03-09 Abbott Laboratories Elongase genes and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CRYOBIOLOGY, vol. 35, no. 4, December 1997 (1997-12-01), Thirty-fourth Annual Meeting of the Society for Cryobiology;Barcelona, Spain; June 8-12, 1997, pages 319, ISSN: 0011-2240 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; August 1998 (1998-08-01), ASADI ABOLFAZL ET AL: "Regulation, structure and chromosomal mapping of CIG30, a gene involved in the recruitment of brown adipose tissue.", XP002149370, Database accession no. PREV199800533494 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; August 1998 (1998-08-01), WESTERBERG ROLF ET AL: "Identification of a mouse gene family which is possibly involved in the elongation of very long chain fatty acids (VLCFA).", XP002149371, Database accession no. PREV199800533821 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; December 1997 (1997-12-01), NEDERGAARD J ET AL: "The molecular biology of cold acclimation and hibernation: The central role of brown adipose tissue.", XP002149369, Database accession no. PREV199800109314 *
DATABASE CONFERENCE PAPERS INDEX CAMBRIDGE SCI. ABS.; June 1999 (1999-06-01), R. WESTERBERG ET AL.,: "Cig30 deficient mice have disminished subcutaneous fat and abnormal hair growth", XP002149372 *
INTERNATIONAL JOURNAL OF OBESITY, vol. 22, no. SUPPL. 3, August 1998 (1998-08-01), Eighth International Congress on Obesity;Paris, France; August 29-September 3, 1998, pages S5, ISSN: 0307-0565 *
INTERNATIONAL JOURNAL OF OBESITY, vol. 22, no. SUPPL. 3, August 1998 (1998-08-01), Eighth International Congress on Obesity;Paris, France; August 29-September 3, 1998, pages S97, ISSN: 0307-0565 *
P. TVRDIK ET AL.,: "Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 50, 12 December 1997 (1997-12-12), US, pages 31738 - 31746, XP002149368 *
P.H. WEINSTOCK ET AL.,: "Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase", PROC. NAT. ACAD. SCI. USA, vol. 94, September 1997 (1997-09-01), US, pages 10261 - 10266, XP002149367 *

Also Published As

Publication number Publication date
AU5394100A (en) 2000-12-12
WO2000070945A2 (en) 2000-11-30

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