WO2000058464A3 - Rab genes and their uses - Google Patents

Rab genes and their uses Download PDF

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Publication number
WO2000058464A3
WO2000058464A3 PCT/US2000/006330 US0006330W WO0058464A3 WO 2000058464 A3 WO2000058464 A3 WO 2000058464A3 US 0006330 W US0006330 W US 0006330W WO 0058464 A3 WO0058464 A3 WO 0058464A3
Authority
WO
WIPO (PCT)
Prior art keywords
rab
genes
expression
compositions
protein
Prior art date
Application number
PCT/US2000/006330
Other languages
French (fr)
Other versions
WO2000058464A2 (en
Inventor
Maxine Allen
Ken Abel
Brian Mcintosh
Raquel Vega
Marc Rutter
Alan J Buckler
Original Assignee
Axys Pharm Inc
Maxine Allen
Ken Abel
Brian Mcintosh
Raquel Vega
Marc Rutter
Alan J Buckler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc, Maxine Allen, Ken Abel, Brian Mcintosh, Raquel Vega, Marc Rutter, Alan J Buckler filed Critical Axys Pharm Inc
Priority to AU35245/00A priority Critical patent/AU3524500A/en
Publication of WO2000058464A2 publication Critical patent/WO2000058464A2/en
Publication of WO2000058464A3 publication Critical patent/WO2000058464A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Isolated nucleotide compositions and sequences are provided for RAB genes. The RAB nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, RAB; for gene therapy; mapping functional regions of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.
PCT/US2000/006330 1999-03-25 2000-03-13 Rab genes and their uses WO2000058464A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35245/00A AU3524500A (en) 1999-03-25 2000-03-13 (rab) genes and their uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12608399P 1999-03-25 1999-03-25
US60/126,083 1999-03-25

Publications (2)

Publication Number Publication Date
WO2000058464A2 WO2000058464A2 (en) 2000-10-05
WO2000058464A3 true WO2000058464A3 (en) 2001-02-01

Family

ID=22422900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006330 WO2000058464A2 (en) 1999-03-25 2000-03-13 Rab genes and their uses

Country Status (2)

Country Link
AU (1) AU3524500A (en)
WO (1) WO2000058464A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448073B1 (en) * 2000-01-28 2002-09-10 Ludwig Institute For Cancer Research Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
WO2001079478A1 (en) * 2000-04-19 2001-10-25 Dainippon Pharmaceutical Co., Ltd. Factors participating in degranulation of mast cells, dnas encoding the same, method of screening inhibitors of these factors and the inhibitors
US20020142431A1 (en) * 2001-03-27 2002-10-03 Merkulov Gennady V. Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
US11661461B2 (en) 2017-06-16 2023-05-30 Denali Therapeutics Inc. Phospho-Rab antibodies, assays and methods of use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 15 December 1997 (1997-12-15), OHNISHI HIROHIDE ET AL: "Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice.", XP002141144, Database accession no. PREV199800074986 *
ELFERINK L A ET AL: "RAB15 A NOVEL LOW MOLECULAR WEIGHT GTP-BINDING PROTEIN SPECIFICALLY EXPRESSED IN RAT BRAIN", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 9, 1992, pages 5768 - 5775, XP002141141, ISSN: 0021-9258 *
JOURNAL OF CLINICAL INVESTIGATION, vol. 100, no. 12, 15 December 1997 (1997-12-15), pages 3044 - 3052, ISSN: 0021-9738 *
ROBERT STRAUSBERG: "qt09f06.x1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE:1947107 3' similar to gb:X12953 RAS-RELATED PROTEIN RAB-2 (HUMAN)", EMBL DATABASE; ACCESSION NUMBER AI351818, 7 January 1999 (1999-01-07), XP002141143 *
TACHIBANA K. ET AL.: "RAS-RELATED PROTEIN RAB-2", SWISPROT DATABASE ; ACCESSION NUMBER P08886, 1 November 1988 (1988-11-01), XP002141142 *
ZAHRAOUI A ET AL: "THE HUMAN RAB GENES ENCODE A FAMILY OF GTP-BINDING PROTEINS RELATED TO YEAST YPT1 AND SEC4 PRODUCTS INVOLVED IN SECRETION", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 264, no. 21, 25 July 1989 (1989-07-25), XP002015899 *

Also Published As

Publication number Publication date
WO2000058464A2 (en) 2000-10-05
AU3524500A (en) 2000-10-16

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