WO1998059040A3 - Human catalytic telomerase sub-unit and its diagnostic and therapeutic use - Google Patents

Human catalytic telomerase sub-unit and its diagnostic and therapeutic use Download PDF

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Publication number
WO1998059040A3
WO1998059040A3 PCT/EP1998/003468 EP9803468W WO9859040A3 WO 1998059040 A3 WO1998059040 A3 WO 1998059040A3 EP 9803468 W EP9803468 W EP 9803468W WO 9859040 A3 WO9859040 A3 WO 9859040A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic
unit
therapeutic use
human catalytic
catalytic telomerase
Prior art date
Application number
PCT/EP1998/003468
Other languages
German (de)
French (fr)
Other versions
WO1998059040A2 (en
Inventor
Gustav Hagen
Hans-Ulrich Siegmund
Walter Weichel
Maresa Wick
Dmitry Zubov
Original Assignee
Bayer Ag
Gustav Hagen
Siegmund Hans Ulrich
Walter Weichel
Maresa Wick
Dmitry Zubov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998116496 external-priority patent/DE19816496A1/en
Application filed by Bayer Ag, Gustav Hagen, Siegmund Hans Ulrich, Walter Weichel, Maresa Wick, Dmitry Zubov filed Critical Bayer Ag
Priority to EP98932142A priority Critical patent/EP0990037A2/en
Priority to JP50368599A priority patent/JP2002508662A/en
Priority to CA002294646A priority patent/CA2294646A1/en
Priority to AU82149/98A priority patent/AU745420B2/en
Publication of WO1998059040A2 publication Critical patent/WO1998059040A2/en
Publication of WO1998059040A3 publication Critical patent/WO1998059040A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to the nucleotide sequence and the protein sequence derived therefrom, which encodes for the human catalytic telomerase sub-unit. The invention furthermore relates to methods involving a pharmaceutical, diagnostic or therapeutic use of this gene/protein, principally for treating cancer and ageing.
PCT/EP1998/003468 1997-06-20 1998-06-09 Human catalytic telomerase sub-unit and its diagnostic and therapeutic use WO1998059040A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98932142A EP0990037A2 (en) 1997-06-20 1998-06-09 Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
JP50368599A JP2002508662A (en) 1997-06-20 1998-06-09 Catalytic subunit of human telomerase and its diagnostic and therapeutic use
CA002294646A CA2294646A1 (en) 1997-06-20 1998-06-09 Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
AU82149/98A AU745420B2 (en) 1997-06-20 1998-06-09 Human catalytic telomerase sub-unit and its diagnostic and therapeutic use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19726329.1 1997-06-20
DE19726329 1997-06-20
DE19813274 1998-03-26
DE19813274.3 1998-03-26
DE19816496.3 1998-04-14
DE1998116496 DE19816496A1 (en) 1998-04-14 1998-04-14 New catalytically active subunit of human telomerase

Publications (2)

Publication Number Publication Date
WO1998059040A2 WO1998059040A2 (en) 1998-12-30
WO1998059040A3 true WO1998059040A3 (en) 1999-07-22

Family

ID=27217480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/003468 WO1998059040A2 (en) 1997-06-20 1998-06-09 Human catalytic telomerase sub-unit and its diagnostic and therapeutic use

Country Status (5)

Country Link
EP (1) EP0990037A2 (en)
JP (1) JP2002508662A (en)
AU (1) AU745420B2 (en)
CA (1) CA2294646A1 (en)
WO (1) WO1998059040A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1867397A (en) 1995-11-16 1997-06-05 Michael W. Dahm Method of quantifying tumour cells in a body fluid and a suitable test kit
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
JP3869092B2 (en) * 1996-10-01 2007-01-17 ジェロン・コーポレーション Human telomerase catalytic subunit
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
EP1571215A3 (en) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (en) * 1997-11-26 1999-06-03 Geron Corporation Mouse telomerase reverse transcriptase
DE19804372A1 (en) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Method for the quantitative determination of tumor cells in a body fluid and suitable test kits
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
WO1999050392A1 (en) 1998-03-31 1999-10-07 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
DE19916929A1 (en) * 1999-04-15 2000-10-19 Bayer Ag New oligonucleotide primers, useful for amplifying human telomerase RNA for diagnosis, prognosis and monitoring of cancer
CN101522706B (en) 2006-10-12 2013-09-04 P.安杰莱蒂分子生物学研究所 Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996019580A2 (en) * 1994-12-19 1996-06-27 Cold Spring Harbor Laboratory Telomerase protein component
WO1996040868A1 (en) * 1995-06-07 1996-12-19 Cold Spring Harbor Laboratory Essential oligonucleotides of vertebrate telomerase
WO1998001543A1 (en) * 1996-07-08 1998-01-15 Tularik, Inc. Human telomerase gene
WO1998014593A2 (en) * 1996-10-01 1998-04-09 Geron Corporation Human telomerase catalytic subunit
WO1998021343A1 (en) * 1996-11-15 1998-05-22 Amgen Inc. Genes encoding telomerase proteins
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996019580A2 (en) * 1994-12-19 1996-06-27 Cold Spring Harbor Laboratory Telomerase protein component
WO1996040868A1 (en) * 1995-06-07 1996-12-19 Cold Spring Harbor Laboratory Essential oligonucleotides of vertebrate telomerase
WO1998001543A1 (en) * 1996-07-08 1998-01-15 Tularik, Inc. Human telomerase gene
WO1998014593A2 (en) * 1996-10-01 1998-04-09 Geron Corporation Human telomerase catalytic subunit
WO1998021343A1 (en) * 1996-11-15 1998-05-22 Amgen Inc. Genes encoding telomerase proteins
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GREIDER C W: "TELOMERE LENGTH REGULATION", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, pages 337 - 365, XP002056801 *
KILIAN, A. ET AL.: "Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.", HUMAN MOLECULAR GENETICS., vol. 6, 12 November 1997 (1997-11-12), OXFORD GB, pages 2011 - 2019, XP002086926 *
MEYERSON M ET AL: "HEST2, THE PUTATIVE HUMAN TELOMERASE CATALYTIC SUBUNIT GENE, IS UP-REGULATED IN TUMOR CELLS AND DURING IMMORTALIZATION", CELL, vol. 90, no. 4, 22 August 1997 (1997-08-22), pages 785 - 795, XP002056804 *
NAKAMURA T M ET AL: "TELOMERASE CATALYTIC SUBUNIT HOMOLOGS FROM FISSION YEAST AND HUMAN", SCIENCE, vol. 277, 15 August 1997 (1997-08-15), pages 955 - 959, XP002056803 *

Also Published As

Publication number Publication date
AU8214998A (en) 1999-01-04
EP0990037A2 (en) 2000-04-05
WO1998059040A2 (en) 1998-12-30
JP2002508662A (en) 2002-03-19
AU745420B2 (en) 2002-03-21
CA2294646A1 (en) 1998-12-30

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