WO2001038503A3 - Novel human protein kinases and protein kinase-like enzymes - Google Patents

Novel human protein kinases and protein kinase-like enzymes Download PDF

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Publication number
WO2001038503A3
WO2001038503A3 PCT/US2000/032085 US0032085W WO0138503A3 WO 2001038503 A3 WO2001038503 A3 WO 2001038503A3 US 0032085 W US0032085 W US 0032085W WO 0138503 A3 WO0138503 A3 WO 0138503A3
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Prior art keywords
enzymes
kinase
novel human
protein
protein kinase
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Application number
PCT/US2000/032085
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French (fr)
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WO2001038503A2 (en
Inventor
Gregory D Plowman
David Whyte
Gerard Manning
Sucha Sudarsanam
Ricardo Martinez
Peter Flanagan
Douglas Clary
Original Assignee
Sugen Inc
Gregory D Plowman
David Whyte
Gerard Manning
Sucha Sudarsanam
Ricardo Martinez
Peter Flanagan
Douglas Clary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sugen Inc, Gregory D Plowman, David Whyte, Gerard Manning, Sucha Sudarsanam, Ricardo Martinez, Peter Flanagan, Douglas Clary filed Critical Sugen Inc
Priority to JP2001540254A priority Critical patent/JP2003514583A/en
Priority to CA002394803A priority patent/CA2394803A1/en
Priority to EP00982200A priority patent/EP1240194A2/en
Priority to AU19260/01A priority patent/AU1926001A/en
Publication of WO2001038503A2 publication Critical patent/WO2001038503A2/en
Publication of WO2001038503A3 publication Critical patent/WO2001038503A3/en
Priority to US11/320,072 priority patent/US20060216730A1/en

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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
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Abstract

The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.
PCT/US2000/032085 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes WO2001038503A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001540254A JP2003514583A (en) 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes
CA002394803A CA2394803A1 (en) 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes
EP00982200A EP1240194A2 (en) 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes
AU19260/01A AU1926001A (en) 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes
US11/320,072 US20060216730A1 (en) 1999-12-03 2005-12-29 Novel human protein kinases and protein kinase-like enzymes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16748299P 1999-11-24 1999-11-24
US60/167,482 1999-11-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/320,072 Division US20060216730A1 (en) 1999-12-03 2005-12-29 Novel human protein kinases and protein kinase-like enzymes

Publications (2)

Publication Number Publication Date
WO2001038503A2 WO2001038503A2 (en) 2001-05-31
WO2001038503A3 true WO2001038503A3 (en) 2002-01-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032085 WO2001038503A2 (en) 1999-11-24 2000-11-22 Novel human protein kinases and protein kinase-like enzymes

Country Status (5)

Country Link
EP (1) EP1240194A2 (en)
JP (1) JP2003514583A (en)
AU (1) AU1926001A (en)
CA (1) CA2394803A1 (en)
WO (1) WO2001038503A2 (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787345B1 (en) 2000-11-15 2004-09-07 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
WO2000073468A1 (en) 1999-05-28 2000-12-07 Immunex Corporation Novel murine and human kinases
EP1484408A1 (en) * 1999-09-28 2004-12-08 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US7241585B2 (en) 2000-02-11 2007-07-10 Millennium Pharmaceuticals, Inc. 14171 protein kinase, a novel human protein kinase and uses thereof
US6630335B1 (en) 2000-02-11 2003-10-07 Millennium Pharmaceuticals, Inc. 14171 protein kinase, a novel human protein kinase and uses thereof
WO2001066762A1 (en) * 2000-03-08 2001-09-13 Merck Patent Gmbh Human extracellular signal regulated kinases
AU4352101A (en) * 2000-03-10 2001-09-24 Lexicon Genetics Inc Novel human g-coupled protein receptor kinases and polynucleotides encoding the same
US20020025931A1 (en) 2000-03-24 2002-02-28 Rachel Meyers 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
WO2001077150A2 (en) * 2000-04-10 2001-10-18 Merck Patent Gmbh Serine-threonine kinase
US20020090701A1 (en) * 2000-04-13 2002-07-11 Rosana Kapeller-Libermann 14257 novel protein kinase molecules and their uses therefor
AU2001255763A1 (en) * 2000-04-25 2001-11-07 Millennium Pharmaceuticals, Inc. 13295 novel protein kinase molecules and uses therefor
WO2001081589A2 (en) * 2000-04-25 2001-11-01 Millennium Pharmaceuticals, Inc. 14911 novel protein kinase molecules and uses therefor
EP1278866A2 (en) * 2000-05-05 2003-01-29 MERCK PATENT GmbH Serine-threonine kinase
US6534299B2 (en) 2000-05-17 2003-03-18 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6482935B1 (en) * 2000-05-24 2002-11-19 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6331423B1 (en) 2000-06-01 2001-12-18 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2001266954A1 (en) * 2000-06-15 2001-12-24 Millennium Pharmaceuticals, Inc. 53070, a novel human protein kinase family member and uses thereof
US7094587B2 (en) 2000-06-27 2006-08-22 Millennium Pharmaceuticals, Inc. 16002 Molecules and uses therefor
AU2001287557A1 (en) * 2000-07-05 2002-01-14 Merck Patent Gmbh Human serine-threonine kinase
AU2001279046A1 (en) * 2000-07-28 2002-02-13 Millennium Pharmaceuticals, Inc. 18431 and 32374, human protein kinase family members and uses therefor
AU9174501A (en) * 2000-08-11 2002-02-25 Merck Patent Gmbh Novel mitogen activated kinase
US6759221B1 (en) * 2000-08-18 2004-07-06 Millennium Pharmaceuticals, Inc. 14189, a novel human kinase and uses thereof
WO2002018555A2 (en) * 2000-08-31 2002-03-07 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
JP2004520813A (en) * 2000-08-31 2004-07-15 インサイト・ゲノミックス・インコーポレイテッド Human kinase
WO2002024889A2 (en) * 2000-09-12 2002-03-28 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Optimized cardiac contraction through differential phosphorylation of myosin
AU2001297794A1 (en) * 2000-10-19 2002-12-03 Millenium Pharmaceuticals, Inc. Methods and compositions of human proteins and uses thereof.
AU2002227352A1 (en) * 2000-10-20 2002-04-29 Incyte Genomics, Inc. Human kinases
ATE349515T1 (en) * 2000-10-23 2007-01-15 Bayer Healthcare Ag 13245, A NEW HUMAN PROTEIN KINASE OF THE MYOTONIC DYSTROPHY TYPE PROTEIN KINASE AND APPLICATIONS THEREOF
CA2430711A1 (en) * 2000-12-07 2002-06-13 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
WO2002055713A2 (en) * 2000-12-08 2002-07-18 Millennium Pharm Inc 58848, a human protein kinase family member and uses therefor
AU2002246858A1 (en) * 2000-12-27 2002-08-06 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
AU2002226393A1 (en) 2001-01-03 2002-07-16 Bayer Aktiengesellschaft Regulation of human serine-threonine protein kinase
US6638745B1 (en) * 2001-03-13 2003-10-28 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002081727A2 (en) 2001-04-03 2002-10-17 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002081670A1 (en) * 2001-04-06 2002-10-17 Lexicon Genetics Incorporated Novel human kinases and polynucleotides encoding the same
WO2002083882A2 (en) * 2001-04-12 2002-10-24 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase-like protein
EP1396545A4 (en) * 2001-06-04 2004-12-08 Taiho Pharmaceutical Co Ltd Cell cycle regulatory factor
AU2002312241A1 (en) * 2001-06-05 2002-12-16 Exelixis, Inc. B3galts as modifiers of the p53 pathway and methods of use
AU2002350399A1 (en) * 2001-06-25 2003-01-08 Bayer Healthcare Ag Regulation of human nek-like serine/threonine protein kinase
WO2003004629A2 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase-short kinase
WO2003004523A1 (en) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase
WO2003007793A2 (en) * 2001-07-17 2003-01-30 Yale University Compositions, methods, and kits related to treating and diagnosing hypertension
WO2003018786A2 (en) * 2001-08-20 2003-03-06 Bayer Healthcare Ag Human serine/threonine kinase
WO2003018815A2 (en) * 2001-08-21 2003-03-06 Bayer Healthcare Ag Regulation of human g protein-couple receptor kinase
AU2002352774A1 (en) * 2001-11-15 2003-05-26 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
WO2003080825A2 (en) * 2002-03-27 2003-10-02 Bayer Healthcare Ag Further bmp-2 inducible kinases and the uses thereof
WO2003084992A1 (en) * 2002-04-05 2003-10-16 Riken Novel proteins and dnas encoding the same
JP2003289876A (en) * 2002-04-05 2003-10-14 Takeda Chem Ind Ltd Preventive and/or therapeutic agent for cancer
US7326781B2 (en) 2002-04-12 2008-02-05 Bristol-Myers Squibb Company Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021
US20040197792A1 (en) * 2002-07-15 2004-10-07 Sugen, Inc. Novel Kinases
US20120045390A1 (en) * 2002-09-11 2012-02-23 Genentech, Inc. Composition and Methods for the Diagnosis and Treatment of Tumor
WO2004024920A1 (en) * 2002-09-13 2004-03-25 Takeda Pharmaceutical Company Limited Preventives/remedies for neurodegenerative diseases
US20040248168A1 (en) 2003-03-25 2004-12-09 Wei Liu Novel brain-localized protein kinases homologous to homeodomain-interacting protein kinases
US20040265961A1 (en) * 2003-03-28 2004-12-30 Wei Liu Novel proteins homologous to kinase suppressor of Ras
WO2006040047A2 (en) * 2004-10-15 2006-04-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with rho/rac-interacting citron kinase (cit)
AU2017376839B2 (en) * 2016-12-16 2021-01-14 IBMC (Instituto de Biologia Molecular e Cellular) Thrombin inhibitors for treatment of stroke and related coagulative disorders
EP3777857A1 (en) 2019-08-12 2021-02-17 Københavns Universitet Targeting wnk1 in blood cancers

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018328A1 (en) * 1993-02-06 1994-08-18 Garvan Institute Of Medical Research Protein kinase c (iota)
WO1995007990A1 (en) * 1993-09-17 1995-03-23 Icos Corporation A novel g protein-coupled receptor kinase grk6
US5747288A (en) * 1995-12-13 1998-05-05 The Regents Of The University Of California Protein kinase required for Ras signal transduction
US6001623A (en) * 1998-07-31 1999-12-14 Smithkline Beecham Corporation Human protein kinase H2LAU20
WO2000017232A2 (en) * 1998-09-19 2000-03-30 Michael Kramer Regulatory protein from human keratinocytes
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018328A1 (en) * 1993-02-06 1994-08-18 Garvan Institute Of Medical Research Protein kinase c (iota)
WO1995007990A1 (en) * 1993-09-17 1995-03-23 Icos Corporation A novel g protein-coupled receptor kinase grk6
US5747288A (en) * 1995-12-13 1998-05-05 The Regents Of The University Of California Protein kinase required for Ras signal transduction
US6001623A (en) * 1998-07-31 1999-12-14 Smithkline Beecham Corporation Human protein kinase H2LAU20
WO2000017232A2 (en) * 1998-09-19 2000-03-30 Michael Kramer Regulatory protein from human keratinocytes
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases

Non-Patent Citations (35)

* Cited by examiner, † Cited by third party
Title
ABE M K ET AL: "EXTRACELLULAR SIGNAL-REGULATED KINASE 7 (ERK7), A NOVEL ERK WITH A C-TERMINAL DOMAIN THAT REGULATES ITS ACTIVITY, ITS CELLULAR LOCALIZATION, AND CELL GROWTH", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 19, no. 2, February 1999 (1999-02-01), pages 1301 - 1312, XP002172155, ISSN: 0270-7306 *
ANAYA P ET AL: "Isolation of the Aspergillus nidulans sudD gene and its human homologue", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 211, no. 2, 12 May 1998 (1998-05-12), pages 323 - 329, XP004120595, ISSN: 0378-1119 *
BATTELLE BARBARA-ANNE ET AL: "A myosin III from Limulus eyes is a clock-regulated phosphoprotein.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 12, 15 June 1998 (1998-06-15), pages 4548 - 4559, XP002177867, ISSN: 0270-6474 *
BECKER WALTER ET AL: "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 235, no. 3, 1996, pages 736 - 743, XP002177864, ISSN: 0014-2956 *
BIELKE W ET AL: "Characterization of a novel murine testis-specific serine/threonine kinase", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 139, no. 2, 1994, pages 235 - 239, XP002174517, ISSN: 0378-1119 *
DATABASE EBI EMBL; 28 October 1998 (1998-10-28), HILLIER L. ET AL.: "WashU-NCI human EST Project", XP002177876 *
DATABASE EBI EMBL; 3 March 2000 (2000-03-03), MIDMER M., HAQ R., ZANKE B.W.: "NKIAMRE a novel kinase deleted in human leukemia", XP002177875 *
DATABASE EMBL EBI; 1 July 1997 (1997-07-01), NAGASE T. ET AL.: "Human mRNA for KIAA0303 gene, partial cds.", XP002177870 *
DATABASE EMBL EBI; 13 September 1999 (1999-09-13), NCI-CGAP: "National Cancer Institute, Cancer Genome Anatomy Project (CGAP)", XP002177877 *
DATABASE EMBL EBI; 15 March 1999 (1999-03-15), MEI G. ET AL.: "Homo sapiens clone 25110 mRNA sequence, full-length", XP002177878 *
DATABASE EMBL EBI; 17 September 1999 (1999-09-17), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 19 clone CTC-492K19", XP002177880 *
DATABASE EMBL EBI; 21 July 2000 (2000-07-21), LI Y. ET AL.: "Homo sapiens HSNFRK (HSNFRK) mRNA, complete cds", XP002177874 *
DATABASE EMBL EBI; 27 January 2000 (2000-01-27), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTD-2201J22", XP002177873 *
DATABASE EMBL EBI; 29 September 2000 (2000-09-29), SUGANO S. ET AL.: "Homo sapiens cDNA: FLJ23292 fis, clone HEP10334", XP002177872 *
DATABASE EMBL EBI; 4 August 1998 (1998-08-04), LEWIS S., WANG Y., ROE B.A.: "Homo sapiens Chromosome 22q11.2 Cosmid Clone cosi In NF1 Region", XP002177883 *
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 19 clone CTD-2537I9", XP002177871 *
DATABASE EMBL EBI; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 5 clone CTC-380F16", XP002177881 *
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), BIRREN B., LINTON L., NUSBAUM C., LANDER E.: "Homo sapiens chromosome 17 clone RP11-231G16", XP002177879 *
DATABASE EMBL EBI; 6 October 1999 (1999-10-06), KAUL R.K. ET AL.: "Homo sapiens chromosome 7 clone RP11-286H14", XP002177884 *
DATABASE EMBL EBI; 8 January 1999 (1999-01-08), NARA K.: "Cloning and characterization of a novel serine/threonine protein kinase gene expressed dominatly in developing brain", XP002177882 *
DI CUNTO FERDINANDO ET AL: "Citron Rho-interacting kinase, a novel tissue-specific Ser/Thr kinase encompassing the Rho-Rac-binding protein citron.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 45, 6 November 1998 (1998-11-06), pages 29706 - 29711, XP002170360, ISSN: 0021-9258 *
FISH KIMBERLY J ET AL: "Isolation and Characterization of Human Casein Kinase I-epsilon (CKI), a Novel Member of the CKI Gene Family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 25, 1995, pages 14875 - 14883, XP002177865, ISSN: 0021-9258 *
HERRING B P ET AL: "DOMAIN CHARACTERIZATION OF RABBIT SKELETAL MUSCLE MYOSIN LIGHT CHAIN KINASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 265, no. 3, 25 January 1990 (1990-01-25), pages 1724 - 1730, XP000979556, ISSN: 0021-9258 *
HOCH BRIGITTE ET AL: "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.", CIRCULATION RESEARCH, vol. 84, no. 6, 2 April 1999 (1999-04-02), pages 713 - 721, XP002177863, ISSN: 0009-7330 *
KLAUCK THERESA M ET AL: "Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 33, 1996, pages 19781 - 19788, XP002177869, ISSN: 0021-9258 *
MAUCUER A ET AL: "KIS is a protein kinase with an RNA recognition motif", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23151 - 23156, XP002125937, ISSN: 0021-9258 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. III. THE CODING SEQUENCES OF 40 NEW GENES (KIAA0081-KIAA0120) DEDUCED BY ANALYSIS OF CDNA CLONES FROM HUMAN CELL LINE KG-1", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 2, no. 1, 28 February 1995 (1995-02-28), pages 37 - 43, XP001011422, ISSN: 1340-2838 *
NAITO YASUHITO ET AL: "Isoform-specific activation and structural diversity of calmodulin kinase I.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 51, 19 December 1997 (1997-12-19), pages 32704 - 32708, XP002177862, ISSN: 0021-9258 *
PARK S ET AL: "THE EEK RECEPTOR, A MEMBER OF THE EPH FAMILY OF TYROSINE PROTEIN KINASES, CAN BE ACTIVATED BY THREE DIFFERENT EPH FAMILY LIGANDS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 14, no. 5, 6 February 1997 (1997-02-06), pages 533 - 542, XP001009718, ISSN: 0950-9232 *
TANAKA HIROMITSU ET AL: "Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17049 - 17057, XP002177866, ISSN: 0021-9258 *
TOKUMITSU HIROSHI ET AL: "Characterization of a Ca-2+/calmodulin-dependent protein kinase cascade: Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 33, 1995, pages 19320 - 19324, XP002177861, ISSN: 0021-9258 *
VERPLOEGEN SANDRA ET AL: "Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent kinase.", BLOOD, vol. 96, no. 9, 1 November 2000 (2000-11-01), pages 3215 - 3223, XP002177860, ISSN: 0006-4971 *
WANG Z-N ET AL: "Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 453, no. 1-2, 18 June 1999 (1999-06-18), pages 135 - 139, XP004259817, ISSN: 0014-5793 *
WEISS ELLEN R ET AL: "The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas.", MOLECULAR VISION, vol. 4, no. 27, 8 December 1998 (1998-12-08), pages NO PAGINATION, XP002177859, ISSN: 1090-0535 *
ZHENG CHAO-FENG ET AL: "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 15, 1993, pages 11435 - 11439, XP002177868, ISSN: 0021-9258 *

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